Digital Commons Network^™

Studies Of Amino Acid Mutations In Drug Resistance Of The Smo Protein, Eunice Wintona

UNO Student Research and Creative Activity Fair

Smoothened receptor (SMO) is a protein that in humans, is encoded by the SMO gene. A systemic mutation in its binding pocket helps predict the sensitivity of mutant proteins to different drugs. Known as a GPCR-like receptor, it is a component of the hedgehog signaling pathway; a pathway involved in body patterning and the regulation of adult stem cells. An uncontrolled or inappropriate activation of the Hedgehog pathway drives tumor progression in cancers and a number of birth defects. To achieve these goals, the molecular modeling software MOE was used to build small molecules and drug molecules like Vismodegib and …

Oral Microbiome Networks And Their Impact On Determining Early Childhood Caries Risk, Carly Johnson

UNO Student Research and Creative Activity Fair

The oral microbiome of humans is known to be important not only to oral health but systemic health as well (1,2). Specifically, bacterial species present have been shown to contribute to the incidence of dental caries (3,4,5). The composition of oral bacteria in children can differ based upon different environmental factors such as birth and infancy feeding type (6,7,8,9,10,11). These factors occur early in a child’s life and therefore may be contributing factors to the development of early childhood caries (ECC). ECC is the most common chronic disease in childhood (4) and has become a major public health issue in …

The Relationship Between Linear And Nonlinear Analysis On Activity Data, Katlyn J. Nimtz

UNO Student Research and Creative Activity Fair

Activity monitoring in older adults is a great way to predict disability without interfering in their daily life. We can analyze that data using linear and nonlinear analysis. While linear analysis measures the variation of activity during a specific period of time (i.e., mean, standard deviation), nonlinear analysis focuses on the evolution of activity over a period of time. Therefore, the purpose of this study was to observe the relationship between linear and nonlinear analysis of activity data obtained by activity monitoring in older adults. Eight participants wore an activity monitor around their waist for seven days. Linear analysis was …

Reprogrammed Lipid Metabolism In Bladder Cancer With Cisplatin Resistance., Min Young Lee, Austin Yeon, Muhammad Shahid, Eunho Cho, Vikram Sairam, Robert Figlin, Khae-Hwan Kim, Jayoung Kim

Articles, Abstracts, and Reports

Due to its tendency to recur and acquire chemoresistance quickly, bladder cancer (BC) remains to be an elusive and difficult disease. Patients with recurrent and chemoresistant BC have an extremely poor prognosis. One possible approach that may provide insightful and valuable information regarding resistance mechanisms is looking into the lipid metabolism of BC cells. Metabolism of lipids is essential for cancer cells and is associated with the regulation of a variety of key cellular processes and functions. This study conducted a comparative lipidomic profiling of two isogenic human T24 bladder cancer cell lines, one of which is clinically characterized as …

Opie’S International Conversation Hour Brings Students, Community Members Of All Backgrounds Together (March 2, 2018), University Communications And Marketing

OHIO News Articles Archive

No abstract provided.

Examining Sense Of Place For Marginalized Communities In Community Gardens, Jocelyn Rodriguez

University Honors Theses

This paper critically examines community garden relationships with particular reference to marginalized communities in Portland, OR. The objective of this study is to explore how gardeners feel about their gardens, why they feel that way and to determine what that garden space does for them. I will discuss the demographics of the neighborhoods the gardens are in to identify the hardships their residents face. Through interviews, I examine relationships participants have with community gardens as spaces that are currently being held by marginalized communities with a sense of place framework.

Learning To Live With Diabetes, Lidia G. Compean-Ortiz, Paulina Aguilera, Jose Rivera, Diane C. Berry

Sigma Foundation for Nursing Research Grant Reports

Aim 1: Determine the feasibility of the intervention, including its acceptability, and further refine intervention materials and study procedures (recruitment, enrollment, intervention, retention, data collection).

Aim 2: Test the initial efficacy of the intervention on participants with T2DM on the following outcomes from Time 1 (Baseline-0 months), Time 2 (Post Intensive Intervention-2 months), and Time 3 (After 3 months on their own-5 months):

Time Course Toward Baseline Of Hand-To-Foot Bia Measures Following An Acute Bout Of Aerobic Exercise, Brett S. Nickerson

International Journal of Exercise Science

International Journal of Exercise Science 11(2): 640-647, 2018. The purpose of this study was to determine the time course of BIA-derived body fat percentage (BF%) and total body water (TBW) values in the 1 h following a moderate bout (60% heart rate reserve [HRR]) of steady state aerobic exercise in apparently healthy men. College-aged adult males (n=15) had their BF% and TBW estimated via BIA before (PRE), immediately (IP), 10 min (10P), 20 min (20P), 30 min (30P), 40 min (40P), 50 min (50P), and 60 min (60P) post a 30 min bout of moderate treadmill exercise. Exercise intensity was …

Research Digest - March 2018, Division Of Public Health Sciences, Department Of Surgery, Washington University School Of Medicine In St. Louis

Newsletters from the Division of Public Health Sciences

No abstract provided.

Wisehart Cutting Horses Business And Customer Portfolio, Tawni Brook Stoneburner

Agricultural Education and Communication

The cutting horse industry has been around for many years with the first competition being held in 1898, as a way for people to prove their own horses’ ranch talents and has now grown to an industry based on trainers and clients (NCHA, 2018). The main goal of the trainer is to get a horse prepared to show at its best ability and to win the most earnings (Wisehart, E., 2017). According to the American Quarter Horse Handbook, “Judges score the horses on their ability to keep the cow from returning to the herd, cow sense, attentiveness and courage.” (AQHA …

Reentry Resource, Queens Library

Reentry Resources

No abstract provided.

The Level And Structure Of The Incidence Of Children From Specialized Boarding Schools, G.I. Shaykhova, F.L. Azizova, G.S. Avezova

Central Asian Journal of Medicine

To study the general morbidity of children and adolescents raised in specialized boarding schools. Materials and Methods: A copy of the data on the incidence of children of boarding schools studied between 2011-2015 was made. In the development of materials on the incidence of children, the lists of classes and names of diseases were used according to ICD-10. Results: Analysis of the structure and level of the overall incidence of children in selected schools identified some of their characteristics. The common thing is that the structure of the incidence of children in individual schools repeats the structure of the overall …

Hepatoprotection In The Intensive Care Of Patients With Purulent-Septic Infection, V.E. Avakov

Central Asian Journal of Medicine

Aim: Prevention, early detection and timely correction of functional liver disorders in patients with purulent-septic infection. Material and methods: We studied 38 patients with severe purulent-septic infection associated with diabetic foot syndrome (20), acute peritonitis (18) of appendicular origin (8), acute destructive pancreatitis (7) and blunt abdominal trauma with a rupture of the small intestine (3). All the patients described had generalization of the infectious onset with development of sepsis (30 patients) and sepsis syndrome (8 patients). All the patients had generalization of infectious origin with the development of sepsis (30) and sepsis syndrome (8). Result: In the process of …

Growth Hormone Research Society Perspective On Biomarkers Of Gh Action In Children And Adults., Gudmundur Johannsson, Martin Bidlingmaier, Beverly M K Biller, Margaret Boguszewski, Felipe F Casanueva, Philippe Chanson, Peter E Clayton, Catherine S Choong, David Clemmons, Mehul Dattani, Jan Frystyk, Ken Ho, Andrew R Hoffman, Reiko Horikawa, Anders Juul, John J Kopchick, Xiaoping Luo, Sebastian Neggers, Irene Netchine, Daniel S Olsson, Sally Radovick, Ron Rosenfeld, Richard J Ross, Katharina Schilbach, Paulo Solberg, Christian Strasburger, Peter Trainer, Kevin C J Yuen, Kerstin Wickstrom, Jens O L Jorgensen

Neurology

OBJECTIVE: The Growth Hormone Research Society (GRS) convened a Workshop in 2017 to evaluate clinical endpoints, surrogate endpoints and biomarkers during GH treatment of children and adults and in patients with acromegaly.

PARTICIPANTS: GRS invited 34 international experts including clinicians, basic scientists, a regulatory scientist and physicians from the pharmaceutical industry.

EVIDENCE: Current literature was reviewed and expert opinion was utilized to establish the state of the art and identify current gaps and unmet needs.

CONSENSUS PROCESS: Following plenary presentations, breakout groups discussed questions framed by the planning committee. The attendees re-convened after each breakout session to share the group …

Progress Notes, Lehigh Valley Health Network

Progress Notes

No abstract provided.

Spring 2018, Marisela Cadena-Smith

Connection

The Official Community Newsletter for Collin College Connection is the college's award-winning community newsletter published three times a year to inform members of the Collin County community about college news, awards, events, and more.

The Evolution Of Floral Sonication, A Pollen Foraging Behavior Used By Bees (Anthophila), Sophie Cardinal, Stephen L. Buchmann, Avery L. Russell

College of Natural and Applied Sciences

Evolution published by Wiley Periodicals, Inc. on behalf of The Society for the Study of Evolution. Over 22,000 species of biotically pollinated flowering plants, including some major agricultural crops, depend primarily on bees capable of floral sonication for pollination services. The ability to sonicate (“buzz”) flowers is widespread in bees but not ubiquitous. Despite the prevalence of this pollinator behavior and its importance to natural and agricultural systems, the evolutionary history of floral sonication in bees has not been previously studied. Here, we reconstruct the evolutionary history of floral sonication in bees by generating a time-calibrated phylogeny and reconstructing ancestral …

A Comparative Analysis Of Microbial Profile Of Guinea Fowl And Chicken Using Metagenomic Approach, Sarayu Bhogoju, Samuel N. Nahashon, Xiaofei Wang, Carl E. Darris, Agnes Kilonzo-Nthenge

Agricultural and Environmental Sciences Faculty Research

Probiotics are live microbial feed supplements that promote growth and health to the host by minimizing non-essential and pathogenic microorganisms in the host’s gastrointestinal tract (GIT). The campaign to minimize excessive use of antibiotics in poultry production has necessitated development of probiotics with broad application in multiple poultry species. Design of such probiotics requires understanding of the diversity or similarity in microbial profiles among avian species of economic importance. Therefore, the objective of this research was to establish and compare the microbial profiles of the GIT of Guinea fowl and chicken and to establish the microbial diversity or similarity between …

My Total Health, Lehigh Valley Health Network

My Total Health

No abstract provided.

A Two-Tiered Strategy For Preventing Complications Of Bereavement In The First Thirteen Months Post-Loss: A Pilot Study Using Peer Supports With Professional Therapist Back-Up, Mark D. Miller, Jacqueline Stack, Charles F. Reynolds Iii

Clinical and Translational Science Institute

This feasibility and acceptance pilot study for preventing complications of bereavement within the first year post loss recruited 20 adult grievers within 9 months of becoming bereft and assigned consenting subjects to peer supporters trained by a non-profit bereavement support organization for weekly or bi-weekly telephone-based peer support until month 13 post-loss. Subjects who met DSM-5 criteria for major depressive disorder or showed an Inventory of Complicated Grief (ICG) score exceeding 19, 6 months or more post loss, were assigned to 12 to 16 weeks of interpersonal psychotherapy (IPT) with an experienced therapist. Eight and six subjects completed the protocol …

Treating Women With Opioid Use Disorder During Pregnancy In Appalachia: Initial Neonatal Outcomes Following Buprenorphine + Naloxone Exposure, Linda Nguyen, Laura R. Lander, Kevin E. O'Grady, Patrick J. Marshalek, Adrienne Schmidt, Audra K. Kelly, Hendrée E. Jones

Clinical and Translational Science Institute

Background and Objectives—Rising concerns regarding diversion and misuse of monobuprenorphine for treatment of pregnant women with opioid use disorders have sparked interest in the use of buprenorphine +naloxone to reduce misuse and diversion rates. Examined the relationship of prenatal buprenorphine +naloxone exposure to neonatal outcomes. Methods—This is a retrospective chart review of 26 mother infant dyads in comprehensive medication-assisted treatment with buprenorphine +naloxone during pregnancy. Results—All neonatal birth outcome parameters were within normal ranges, albeit on the lower side of normal for gestational age and birth weight. Only 19% of neonates required morphine pharmacology for NAS. Conclusions—Use of buprenorphine +naloxone …

The Effects Of A Korean Ginseng, Ginst15, On Perceptual Effort, Psychomotor Performance, And Physical Performance In Men And Women, Lydia K. Caldwell, William H. Dupont, Matthew K. Beeler, Emily M. Post, Emily C. Barnhart, Vincent H. Hardesty, John P. Anders, Emily C. Borden, Jeff S. Volek, William J. Kraemer

Health and Sport Sciences Faculty Scholarship

The purpose of this double-blind, placebo-controlled investigation was to examine the effects of a Korean Ginseng (GINST15) on measures of perception and physical performance following an acute bout of resistance exercise. Ten women (age: 38.7 ± 7.8 years; height: 1.64 ± 0.05 m; body mass: 76.0 ± 11.6 kg) and nine men (age: 41.2. ± 9.7 years; height: 1.77 ± 0.05 m; body mass: 88.5 ± 5.0 kg) completed the investigation. Participants were randomized to a three-cycle testing scheme consisting of high dose ginseng (HIGH: 960 mg/day), low dose ginseng (LOW: 160 mg/day) and placebo (PBO: 0 mg/day). After 14 …

Understanding The Relationship Between Food Variety, Food Intake, And Energy Balance, Hollie A. Raynor, Maya Vadiveloo

Nutrition Faculty Publications

Purpose of Review:

In accordance with US dietary guidance, incorporating variety into the diet can align with energy balance, though greater food variety in some categories may make energy balance more challenging. Thus, experimental and epidemiologic evidence is summarized on the relationship between food variety, food and energy intake, and energy balance.

Recent Findings:

Lab-based, experimental research consistently demonstrates that greater variety within foods or sensory characteristics of food increases food and energy intake within an eating occasion. Epidemiologic evidence is less consistent, potentially driven by differing methodologies, particularly in defining and measuring food variety. Moreover, the effect of variety …

Agribusiness, Food Insecurity, And Chronic Diet-Related Ailments In Worcester, Ma: Toward A Nuanced Narrative, Adam Wriggins

Sustainability and Social Justice

The following research paper begins with an acknowledgement of the global food crisis and, more specifically, the agribusiness model of food production and distribution in the United States. It then zeroes in on the fundamental issues with many of the United States food movements. It then outlines a narrative with the frame that food security is a human right by elucidating concepts of food justice and food sovereignty. Once this foundation has been laid, the paper examines chronic food-related ailments (diabetes and coronary heart disease) in Worcester, Massachusetts, and how these ailments are related to racial/ethnic minorities (Black and Hispanic/Latino …

Gendered Lived Experiences In Urban Cape Town: Urban Infrastructure As Equal Opportunity, Social Justice, And Crime Prevention, Becky Jacobs

Scholarly Works

The body of 19-year-old Sinoxolo Mafevuka was found in a communal toilet in the Cape Town, South African urban township of Khayelitsha. Sinoxolo had been viciously raped, strangled to death, and her body discarded, with her head under the toilet seat and her genitals displayed openly. Tragically, while Sinoxolo’s murder is a particularly brutal example, using a neighborhood toilet in many informal settlements is an incredibly dangerous activity, and there are estimates that 10.5 million South Africans do not have ready access to toilets. “Women, children and men of all ages are frequently robbed, raped, assaulted and murdered on the …

New Dentist News (March 2018), Ada Committee On The New Dentist

New Dentist News

New Dentist News offers timely information on scientific, social, educational, political and economic developments affecting new dentists. This collection is historical and items may not reflect current standards. For up-to-date information contact the ADA. The New Dentist News was alternately titled ADA Lifeline, 1997-June 2001.

An Analysis Of Breastfeeding Initiation Trends Of Shelby County, Tn Women From 2007 To 2015, Anna Church

QuaesitUM

No abstract provided.

The Triple Bind Of Single-Parent Families: Resources, Employment And Policies To Improve Wellbeing, Rense Nieuwenhuis, Laurie C. Maldonado

Open-Access Books by Faculty

Editors: Rense Nieuwenhuis and Laurie C. Maldonado

Authors are listed in order of appearance in text. Author/Editor details at time of book publication.

Available Open Access under CC-BY-NC licence. This book presents evidence from over 40 countries that shows how single parents face a triple bind of inadequate resources, employment and policies, which in combination further complicate their lives.

This book - multi-disciplinary and comparative in design - shows evidence from over 40 countries, along with detailed case studies of Sweden, Iceland, Scotland, and the UK. It covers aspects of well-being that include poverty, good quality jobs, the middle class, …

Understanding Hiv/Aids In The African Context, Eileen Stillwaggon, Larry Sawers

Economics Faculty Publications

This book of readings is intended for courses in Global Health. The editors asked Prof. Stillwaggon to contribute a chapter summarizing her years of work on the spread of HIV/AIDS in populations among whom bacterial, fungal, parasitic, and viral diseases are extremely common, particularly in sub-Saharan Africa. Her work has demonstrated that differences in behavior cannot explain differences in HIV rates between world regions.

Is It Time To Revisit Vitamin B12 For Mental Health And Cognitive Functions In Elderly?, Lina Begdache, Rani Marhaba

Health & Wellness Studies Faculty Scholarship

Decline in cognitive and motor functions and in mental health are commonly seen with aging. Although many reports attribute their etiology to aging, these conditions may have vitamin B12 deficiency as an underlying mechanism. Laboratory tests to assess vitamin B12 deficiency lack sensitivity and specificity largely due to absence of a gold standard for diagnosis. Additionally, patients with subclinical vitamin B12 deficiency have typically normal serum concentration levels and do not exhibit the classical symptoms of vitamin B12 deficiency. Furthermore, many comorbidities that exist with aging decrease vitamin B12 and bioavailaibility from the gut. If left untreated, vitamin B12 deficiency …