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2018

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In The Shadow Of The Ivory Tower: Experiences Of Midwives And Nurses Undertaking Phds, Sadie Geraghty, Kim Oliver Jan 2018

In The Shadow Of The Ivory Tower: Experiences Of Midwives And Nurses Undertaking Phds, Sadie Geraghty, Kim Oliver

Research outputs 2014 to 2021

Aims: The aims of this study were to gain an understanding of the experiences of nurses and midwives enrolled in a PhD, explore any barriers that PhD students encounter whilst completing the degree, and develop recommendations for consideration in formulating support strategies to encourage completion for nurses and midwives enrolled on a PhD degree. Background: It is important to understand what is happening at doctoral level education for nurses and midwives, and how those enrolled on PhD courses can successfully complete their studies, transition learning, and acquire the ability to undertake research into the clinical environments. Design: The criteria for …


The Impact Of Targeted Educational Programmes On Academic Outcomes For African Students In Western Australia, Kwadwo Adusei-Asante Jan 2018

The Impact Of Targeted Educational Programmes On Academic Outcomes For African Students In Western Australia, Kwadwo Adusei-Asante

Research outputs 2014 to 2021

Over the past two decades, people with African backgrounds have become part of Australian society. There have been extensive discussions of the various academic challenges African students experience at all educational levels in Australia. The academic challenges identified range from low academic achievement to unemployment and are particularly prevalent among African students who are refugees or those who have low socio-economic status. This paper argues that targeted educational programmes need to be implemented to support African students who are struggling in their academic pursuits. The positive outcomes and lessons learned from our implementation of the Top-Up Programme, a peer-mentoring educational …


Ransomware Behavioural Analysis On Windows Platforms, Nikolai Hampton, Zubair A. Baig, Sherali Zeadally Jan 2018

Ransomware Behavioural Analysis On Windows Platforms, Nikolai Hampton, Zubair A. Baig, Sherali Zeadally

Research outputs 2014 to 2021

Ransomware infections have grown exponentially during the recent past to cause major disruption in operations across a range of industries including the government. Through this research, we present an analysis of 14 strains of ransomware that infect Windows platforms, and we do a comparison of Windows Application Programming Interface (API) calls made through ransomware processes with baselines of normal operating system behaviour. The study identifies and reports salient features of ransomware as referred through the frequencies of API calls


How Does Destination Social Responsibility Contribute To Environmentally Responsible Behaviour? A Destination Resident Perspective, Lujun Su, Songshan (Sam) Huang, Joanna Pearce Jan 2018

How Does Destination Social Responsibility Contribute To Environmentally Responsible Behaviour? A Destination Resident Perspective, Lujun Su, Songshan (Sam) Huang, Joanna Pearce

Research outputs 2014 to 2021

Based on stakeholder theory and social exchange theory, this study developed an integrated model to demonstrate that destination social responsibility (DSR) influences tourism impacts (both positive and negative impacts), overall community satisfaction, and both directly and indirectly influences resident environmentally responsible behaviour (ERB). The model was examined using a sample of 453 residents living on the Gulangyu Island, a famous island tourism destination of Xiamen, China. Results show that DSR enhances residents’ perception of positive tourism impacts, improves overall community satisfaction and contributes to resident ERB. However, the effect of DSR on negative tourism impacts was not significant. Thus, positive …


Are Current Effectiveness Criteria Fit For Purpose? Using A Controversial Strategic Assessment As A Test Case, Jenny Pope, Alan J. Bond, Carolyn Cameron, François P. Retief, Angus N. Morrison-Saunders Jan 2018

Are Current Effectiveness Criteria Fit For Purpose? Using A Controversial Strategic Assessment As A Test Case, Jenny Pope, Alan J. Bond, Carolyn Cameron, François P. Retief, Angus N. Morrison-Saunders

Research outputs 2014 to 2021

The aim of this paper is to test the broader utility of the sustainability assessment effectiveness framework of Bond et al. (2015) by applying it to a controversial strategic assessment case study. The effectiveness framework comprises six dimensions: procedural effectiveness, substantive effectiveness, transactive effectiveness, normative effectiveness, pluralism, and knowledge and learning. It was originally developed to evaluate sustainability assessment at a system-wide level and it has not been previously applied to a specific case study. The analysis was conducted through document review and the first-hand experience of two of the authors who were involved in the case study …


Women’S Subjective Experiences Of Living With Vulvodynia: A Systematic Review And Meta-Ethnography, Rebekah Shallcross, Joanne M. Dickson, David Nunns, Catharine Mackenzie, Gundi Kiemle Jan 2018

Women’S Subjective Experiences Of Living With Vulvodynia: A Systematic Review And Meta-Ethnography, Rebekah Shallcross, Joanne M. Dickson, David Nunns, Catharine Mackenzie, Gundi Kiemle

Research outputs 2014 to 2021

Vulvodynia, the experience of an idiopathic pain in the form of burning, soreness, or throbbing in the vulval area, affects around 4–16% of the population. The current review used systematic search strategies and meta-ethnography as a means of identifying, analyzing, and synthesizing the existing literature pertaining to women’s subjective experiences of living with vulvodynia. Four key concepts were identified: (1) Social Constructions: Sex, Women, and Femininity: Women experienced negative consequences of social narratives around womanhood, sexuality, and femininity, including the prioritization of penetrative sex, the belief that it is the role of women to provide sex for men, and media …


Randomised Controlled Trial Comparing Daily Versus Depot Vitamin D3 Therapy In 0-16-Year-Old Newly Settled Refugees In Western Australia Over A Period Of 40 Weeks, Ushma D. Wadia, Wayne Soon, Paola T. Chivers, Aesen Thambiran, David P. Burgner, Sarah Cherian, Aris Siafarikas Jan 2018

Randomised Controlled Trial Comparing Daily Versus Depot Vitamin D3 Therapy In 0-16-Year-Old Newly Settled Refugees In Western Australia Over A Period Of 40 Weeks, Ushma D. Wadia, Wayne Soon, Paola T. Chivers, Aesen Thambiran, David P. Burgner, Sarah Cherian, Aris Siafarikas

Research outputs 2014 to 2021

Vitamin D deficiency is highly prevalent in newly settled refugees in Western Australia (WA). If adherence to daily vitamin D therapy is problematic, depot therapy is a therapeutic alternative. The aim of this studywas to compare daily versus depot treatment and factors influencing the therapeutic outcome. Newly settled refugees (n = 151) with 25(OH)D levels less than 78 nmol/L were randomised to receive daily or depot vitamin D therapy with eight weekly interval follow up to 40 weeks. Biochemical and clinical parameters were collected at each visit. Generalized LinearMixedModels (GLMM) examined the longitudinal changes over time controlling for confounders including …


Towards An Improved Typology Approach To Segmenting Cultural Tourists, Ganghua Chen, Songshan (Sam) Huang Jan 2018

Towards An Improved Typology Approach To Segmenting Cultural Tourists, Ganghua Chen, Songshan (Sam) Huang

Research outputs 2014 to 2021

This study aims to improve the cultural tourist typology methodology that uses cultural centrality and depth of cultural experience in its framework. Using a sample of Chinese tourists in Macau (n = 595) collected via questionnaire surveys, the study confirmed the determination effect of cultural centrality on depth of cultural experience. Subsequently, the study demonstrated an improved approach that eliminates such a determination effect in typology identification. Compared to McKercher's () approach, the improved typology presents a balanced segmentation of cultural tourists and distinguishes the segments more clearly in their sociodemographic characteristics. The improved typology generated more meaningful practical implications.


Advocacy, Support And Survivorship In Prostate Cancer, J. Dunn, C. Casey, D. Sandoe, M. K. Hyde, M. C. Cheron-Sauer, A. Lowe, J. L. Oliffe, Suzanne K. Chambers Jan 2018

Advocacy, Support And Survivorship In Prostate Cancer, J. Dunn, C. Casey, D. Sandoe, M. K. Hyde, M. C. Cheron-Sauer, A. Lowe, J. L. Oliffe, Suzanne K. Chambers

Research outputs 2014 to 2021

Across Australia, prostate cancer support groups (PCSG) have emerged to fill a gap in psychosocial care for men and their families. However, an understanding of the triggers and influencers of the PCSG movement is absent. We interviewed 21 SG leaders (19 PC survivors, two partners), of whom six also attended a focus group, about motivations, experiences, past and future challenges in founding and leading PCSGs. Thematic analysis identified four global themes: illness experience; enacting a supportive response; forming a national collective and challenges. Leaders described men's feelings of isolation and neglect by the health system as the impetus for PCSGs …


Metabolic And Fatigue Profiles Are Comparable Between Prepubertal Children And Well-Trained Adult Endurance Athletes, Anthony Birat, Pierre Bourdier, Enzo Piponnier, Anthony J. Blazevich, Hugo Maciejewski, Pascale Duche, Sebastien Ratel Jan 2018

Metabolic And Fatigue Profiles Are Comparable Between Prepubertal Children And Well-Trained Adult Endurance Athletes, Anthony Birat, Pierre Bourdier, Enzo Piponnier, Anthony J. Blazevich, Hugo Maciejewski, Pascale Duche, Sebastien Ratel

Research outputs 2014 to 2021

The aim of this study was to determine whether prepubertal children are metabolically comparable to well-trained adult endurance athletes and if this translates into similar fatigue rates during high-intensity exercise in both populations. On two different occasions, 12 prepubertal boys (10.5 ± 1.1 y), 12 untrained men (21.2 ± 1.5 y), and 13 endurance male athletes (21.5 ± 2.7 y) completed an incremental test to determine the power output at VO2max (PVO2max) and a Wingate test to evaluate the maximal anaerobic power (Pmax) and relative decrement in power output (i.e., the fatigue index, FI). Furthermore, …


Nitrate, The Oral Microbiome, And Cardiovascular Health: A Systematic Literature Review Of Human And Animal Studies, Lauren C. Blekkenhorst, Nicola P. Bondonno, Alex H. Liu, Natalie C. Ward, Richard L. Prince, Joshua R. Lewis, Amanda Devine, Kevin D. Croft, Jonathan M. Hodgson, Catherine P. Bondonno Jan 2018

Nitrate, The Oral Microbiome, And Cardiovascular Health: A Systematic Literature Review Of Human And Animal Studies, Lauren C. Blekkenhorst, Nicola P. Bondonno, Alex H. Liu, Natalie C. Ward, Richard L. Prince, Joshua R. Lewis, Amanda Devine, Kevin D. Croft, Jonathan M. Hodgson, Catherine P. Bondonno

Research outputs 2014 to 2021

Background

Dietary nitrate is an important source of nitric oxide (NO), a molecule critical for cardiovascular health. Nitrate is sequentially reduced to NO through an enterosalivary nitrate-nitrite-NO pathway that involves the oral microbiome. This pathway is considered an important adjunct pathway to the classical l-arginine–NO synthase pathway.

Objective

The objective of this study was to systematically assess the evidence for dietary nitrate intake and improved cardiovascular health from both human and animal studies.

Design

A systematic literature search was performed according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines by using key search terms in Medline and …


On Legitimacy In Impact Assessment: An Epistemologically-Based Conceptualisation, Alan Bond, Jenny Pope, Francois Retief, Angus Morrison-Saunders Jan 2018

On Legitimacy In Impact Assessment: An Epistemologically-Based Conceptualisation, Alan Bond, Jenny Pope, Francois Retief, Angus Morrison-Saunders

Research outputs 2014 to 2021

Impact assessment (IA) is carried out as an ex ante process to inform decision-making. It includes requirements for engagement with stakeholders (including the public) regarding actions proposed by a proponent. A key issue with the various stakeholders involved is the perceived legitimacy of the IA, which can have implications both for the reputation of the proponent, and the likelihood of conflict over the decision. But the understanding of legitimacy in the IA literature has changed over time in line with an ontological shift from positivism (that scientifically generated information leads to better informed decisions) to the post-positivist acknowledgement of the …


Biofilm Associated Proteins In Community Associated Mrsa Usa300 Je2: A Study Of Fnbpa And Fnbpb, Nicholas Gallina Jan 2018

Biofilm Associated Proteins In Community Associated Mrsa Usa300 Je2: A Study Of Fnbpa And Fnbpb, Nicholas Gallina

All-Inclusive List of Electronic Theses and Dissertations

Community-associated methicillin resistant Staphylococcus aureus (CA-MRSA) is a notable human pathogen that is proficient in performing biofilms within the mammalian host. Biofilms are produced in order to protect the organism from extracellular threats such as the hosts immune response. Fibronectin binding protein A (FnBPA) and fibronectin binding protein B (FnBPB) are membrane bound domains noted to be key players in the formation and overall maturation of CA-MRSA biofilms. SAUSA300_2441 (mutant for FnBPA), SAUSA300_2440 (mutant for FnBPB) and USA300 (wild-type) were grown without and with human fibronectin at decreasing percentages. The same procedure was conducted for pooled normal human serum. Congo …


Separation Events In Modern Greek, Vasiliki Lydia Rounti Jan 2018

Separation Events In Modern Greek, Vasiliki Lydia Rounti

Master's Theses

The semantic domain of separation events has been studied for a number of languages. In this thesis, a study on how Modern Greek expresses separation events and how semantically distinct they are from other languages is presented. This is the first study on the semantic features of separation events for Modern Greek. Furthermore, it is the only study so far on separation events for which data have been gathered from a large number of native speakers. Thus, this thesis not only offers a great insight on the language’s semantic structures, but it also presents more concrete observations and conclusions compared …


The Meiosis-Specific Cdc20 Family-Member Ama1 Promotes Binding Of The Ssp2 Activator To The Smk1 Map Kinase., Gregory Omerza, Chong Wai Tio, Timothy Philips, Aviva Diamond, Aaron M. Neiman, Edward Winter Jan 2018

The Meiosis-Specific Cdc20 Family-Member Ama1 Promotes Binding Of The Ssp2 Activator To The Smk1 Map Kinase., Gregory Omerza, Chong Wai Tio, Timothy Philips, Aviva Diamond, Aaron M. Neiman, Edward Winter

Department of Biochemistry and Molecular Biology Faculty Papers

Smk1 is a meiosis-specific MAP kinase (MAPK) in budding yeast that is required for spore formation. It is localized to prospore membranes (PSMs), the structures that engulf haploid cells during meiosis II (MII). Similar to canonically activated MAPKs, Smk1 is controlled by phosphorylation of its activation-loop threonine (T) and tyrosine (Y). However, activation loop phosphorylation occurs via a noncanonical two-step mechanism in which 1) the cyclin-dependent kinase activating kinase Cak1 phosphorylaytes T207 during MI, and 2) Smk1 autophosphorylates Y209 as MII draws to a close. Autophosphorylation of Y209 and catalytic activity for substrates require Ssp2, a meiosis-specific protein that is …


A (Nude) Picture Is Worth A Thousand Words — But How Many Dollars?: Using Copyright As A Metric For Harm In "Revenge Porn" Cases, J. Remy Green Jan 2018

A (Nude) Picture Is Worth A Thousand Words — But How Many Dollars?: Using Copyright As A Metric For Harm In "Revenge Porn" Cases, J. Remy Green

Faculty Scholarship

So-called “Revenge Porn” — pornography published without the subject’s permission — is a growing issue. While much discussion exists about how best to outlaw the practice, less has been said about precisely how to measure the harm done. This paper is grounded in an in-depth analysis of the particular way that the Federal Sentencing Guidelines prioritize financial harms and non-financial harms, specifically looking at how many dollars of harm it takes to buy each additional sentencing point. I graph the enforcement priorities for financial and non-financial harm using the numbers federal agencies use for the value of a statistical life. …


Practice-Based Research Networks And The Mandate For Real-World Evidence, Elizabeth Hall-Lipsy, Leila Barraza, Christopher Robertson Jan 2018

Practice-Based Research Networks And The Mandate For Real-World Evidence, Elizabeth Hall-Lipsy, Leila Barraza, Christopher Robertson

Faculty Scholarship

The 21st Century Cures Act encourages the Food and Drug Administration to consider “real-world evidence” in its regulation of the safety and efficacy of drugs and devices. Many have interpreted this mandate to focus on non-randomized observational research. However, we suggest that regulatory science must also move from rarefied academic hospitals to community-based settings, where the vast majority of patients in fact receive care in the fragmented U.S. healthcare system. This move is especially important if innovations are to reach, and be validated in, more diverse populations. A solution can be found in the 183 Practiced-Based Research Networks (“PBRN”), …


The Reliability Of Evidence In Evidence-Based Legislation, Sean J. Kealy, Alex Fomey Jan 2018

The Reliability Of Evidence In Evidence-Based Legislation, Sean J. Kealy, Alex Fomey

Faculty Scholarship

As evidence-based legislation develops, and as technology puts more information at our fingertips, there should be a better understanding of what exactly constitutes reliable evidence. Robert and Ann Seidman devoted their professional careers to developing the evidence-based Institutional Legislative Theory and Methodology and teaching it to legislative drafters around the world. Although ILTAM was firmly grounded in – and driven by – evidence, the question becomes what evidence is reliable and a worthy input for the methodology. Further, how can the drafter avoid the misuses of evidence such as confirmation bias and naïve beliefs? We aim to give a guide …


Foreword: Benjamin N. Cardozo: Judge, Justice, Scholar, Samuel J. Levine Jan 2018

Foreword: Benjamin N. Cardozo: Judge, Justice, Scholar, Samuel J. Levine

Touro Law Review

No abstract provided.


Why Not Believe Women In Sexual Assault Cases?: An Engagement With Professors Tuerkheimer, Colb, And Many Others, Dan Subotnik Jan 2018

Why Not Believe Women In Sexual Assault Cases?: An Engagement With Professors Tuerkheimer, Colb, And Many Others, Dan Subotnik

Touro Law Review

No abstract provided.


Actual Vs. Perceived Hiv Testing Norms, And Personal Hiv Testing Uptake: A Cross-Sectional, Population-Based Study In Rural Uganda, Jessica M. Perkins, Viola N. Nyakato, Bernard Kakuhikire, Pamela K. Mbabazi, H. Wesley Perkins, Alexander C. Tsai, Sv Subramanian, Nicholas A. Christakis, David Bangsberg Jan 2018

Actual Vs. Perceived Hiv Testing Norms, And Personal Hiv Testing Uptake: A Cross-Sectional, Population-Based Study In Rural Uganda, Jessica M. Perkins, Viola N. Nyakato, Bernard Kakuhikire, Pamela K. Mbabazi, H. Wesley Perkins, Alexander C. Tsai, Sv Subramanian, Nicholas A. Christakis, David Bangsberg

OHSU-PSU School of Public Health Faculty Publications and Presentations

HIV testing is an essential part of treatment and prevention. Using population-based data from 1664 adults across eight villages in rural Uganda, we assessed individuals’ perception of the norm for HIV testing uptake in their village and compared it to the actual uptake norm. In addition, we examined how perception of the norm was associated with personal testing while adjusting for other factors. Although the majority of people had been tested for HIV across all villages, slightly more than half of men and women erroneously thought that the majority in their village had never been tested. They underestimated the prevalence …


Diagnostic Performance Of Blood Inflammatory Markers For Tuberculosis Screening In People Living With Hiv, Katherine Farr, Resmi Ravindran, Luke Strnad, Emily Chang, Leah H. Chaisson, Christina Yoon, William Worodria, Alfred Andama, Irene Ayakaka, Priscilla Bbosa Nalwanga, Multiple Additional Authors Jan 2018

Diagnostic Performance Of Blood Inflammatory Markers For Tuberculosis Screening In People Living With Hiv, Katherine Farr, Resmi Ravindran, Luke Strnad, Emily Chang, Leah H. Chaisson, Christina Yoon, William Worodria, Alfred Andama, Irene Ayakaka, Priscilla Bbosa Nalwanga, Multiple Additional Authors

OHSU-PSU School of Public Health Faculty Publications and Presentations

Background

Approaches to screening for active tuberculosis (TB) among people living with HIV are inadequate, leading to missed diagnoses and poor implementation of preventive therapy.

Methods

Consecutive HIV-infected adults hospitalized at Mulago Hospital (Kampala, Uganda) between June 2011 and July 2013 with a cough ≥ 2 weeks were enrolled. Patients underwent extensive evaluation for pulmonary TB. Concentrations of 43 cytokines/chemokines were measured at the same time point as C-reactive protein (CRP) in banked plasma samples using commercially-available multiplex kits. Advanced classification algorithms were used to rank cytokines/chemokines for their ability to identify TB, and to model the specificity of the …


Pre-Service K-8 Teachers’ Professional Noticing And Strategy Evaluation Skills: An Exploratory Study, Vecihi S. Zambak, Marta T. Magiera Jan 2018

Pre-Service K-8 Teachers’ Professional Noticing And Strategy Evaluation Skills: An Exploratory Study, Vecihi S. Zambak, Marta T. Magiera

Mathematical and Statistical Science Faculty Research and Publications

This study sheds light on three teaching competencies: Pre-service teachers’ (PSTs’) professional noticing of student mathematical reasoning and strategies, their ability to assess the validity of student reasoning and strategies, and to select student strategy for class discussion. Our results reveal that PSTs with strong awareness of mathematically significant aspects of student reasoning and strategies (focused noticing) were better positioned to assess the validity of student reasoning and strategies. PSTs with higher strategy evaluation skills were more likely to choose the strategy to engage class in justification or to advance students’ conceptual understanding compared to PSTs with low strategy evaluation …


Super Problems In Superstar Cities, Michael Lewyn, Beth Gazes Jan 2018

Super Problems In Superstar Cities, Michael Lewyn, Beth Gazes

Scholarly Works

Review of Richard Florida's The New Urban Crisis


Law, Religion, And Immigration: Building Bridges With Express Lanes, Mark Goldfeder, Gideon Sapir Jan 2018

Law, Religion, And Immigration: Building Bridges With Express Lanes, Mark Goldfeder, Gideon Sapir

Scholarly Works

This Article asks whether it can ever be moral or legal to use certain criteria, including nationality and/or religion, in formulating preferential immigration policies. In order to answer the question, it presents an in-depth look at the controversial "right of return, " focusing in particular on the example of the Israeli Law of Return. It contains a detailed history of the law and its development; a defense of the right of return in general; the principle and contextual arguments in favor of an amendment to or abrogation of Israel’s law; and a theoretical and practical defense of the law, with …


Will The Jury System Survive The Peña-Rodriguez Exception To Rule 606(B)?: The Court’S Response To Racial Discrimination By A Juror Leaves The Future Of The American Jury Trial System In Jeopardy, Taurus Myhand Jan 2018

Will The Jury System Survive The Peña-Rodriguez Exception To Rule 606(B)?: The Court’S Response To Racial Discrimination By A Juror Leaves The Future Of The American Jury Trial System In Jeopardy, Taurus Myhand

Scholarly Works

The enforcement of no-impeachment rules has been a long-standing tradition in the United States preventing jurors from offering testimony as to impeach their own verdict. In March 2017, the Supreme Court changed course from centuries of jurisprudence and superseded the Federal Rules of Evidence with a new exception to Rule 606(b) in the Court’s decision in Peña-Rodriguez v. Colorado. The Court’s effort to “root out” racial bias in the justice system resulted in the debunking of the legislative authority granted to the Congress while creating an exception that does little, if anything, toward eliminating racial bias during jury deliberations. In …


A Tale Of Two Casinos: Unequal Spaces Of Local Governance, Alexandra Flynn Jan 2018

A Tale Of Two Casinos: Unequal Spaces Of Local Governance, Alexandra Flynn

All Faculty Publications

Local actors, including resident and business associations, do not simply influence decision-makers, but can also reshape the purportedly neutral governance model within which decision-making takes place. In big cities like Toronto, this reshaping exacerbates the existing geographic and socio-economic unevenness. The work of James Scott, Mariana Valverde, and Cheryl Teelucksingh helps to explain how local actors interface with seemingly neutral governance bodies to have their interests heard, particularly in relation to locally undesirable land uses. The paper considers two case studies detailing the governance practices at work in differing decisions about casinos in the City of Toronto. A 2012-2013 debate …


Distributed Query-Aware Quantization For High-Dimensional Similarity Searches, Gheorghi Guzun, Guadalupe Canahuate Jan 2018

Distributed Query-Aware Quantization For High-Dimensional Similarity Searches, Gheorghi Guzun, Guadalupe Canahuate

Faculty Research, Scholarly, and Creative Activity

The concept of similarity is used as the basis for many data exploration and data mining tasks. Nearest Neighbor (NN) queries identify the most similar items, or in terms of distance the closest points to a query point. Similarity is traditionally characterized using a distance function between multi-dimensional feature vectors. However, when the data is high-dimensional, traditional distance functions fail to significantly distinguish between the closest and furthest points, as few dissimilar dimensions dominate the distance function. Localized similarity functions, i.e. functions that only consider dimensions close to the query, quantize each dimension independently and only compute similarity for the …


Chironian 2018, New York Medical College Jan 2018

Chironian 2018, New York Medical College

The Chironian

No abstract provided.


Comparative Genetic And Genomic Analysis Of The Novel Fusellovirus Sulfolobus Spindle-Shaped Virus 10, David Andrew Goodman, Kenneth M. Stedman Jan 2018

Comparative Genetic And Genomic Analysis Of The Novel Fusellovirus Sulfolobus Spindle-Shaped Virus 10, David Andrew Goodman, Kenneth M. Stedman

Biology Faculty Publications and Presentations

Viruses that infect thermophilic Archaea are unique in both their structure and genetic makeup. The lemon-shaped fuselloviruses—which infect members of the order Sulfolobales, growing optimally at 80 C and pH 3—are some of the most ubiquitous and best studied viruses of the thermoacidophilic Archaea. Nonetheless, much remains to be learned about these viruses. In order to investigate fusellovirus evolution, we have isolated and characterized a novel fusellovirus, Sulfolobus spindle-shaped virus 10 (formerly SSV-L1). Comparative genomic analyses highlight significant similarity with both SSV8 and SSV9, as well as conservation of promoter elements within the Fuselloviridae. SSV10 encodes five ORFs with no …