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Medical School Watercooler Newsletter - December 9, 2018, Lindsey Lyle

Watercooler Newsletter

This is the December 9, 2018 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• USA Faculty Honored at Inventor Recognition Luncheon
• Register Now: Pediatrics Symposium Set for Jan. 18
• 12th Annual COM Research Forum Winners Announced
• Mark Your Calendar: Forum on Community-Engaged Scholarship Set for Jan. 11
• Med School Café: Expert Advice for the Community

International Commission On Trichinellosis: Recommendations For Genotyping Trichinella Muscle Stage Larvae, Edoardo Pozio, Dante Zarlenga

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

Being able to identify the species or genotype of Trichinella is of paramount importance not only for epidemiological studies but to better ascertain the source of outbreaks that still occur worldwide. This has become more critical in recent years given the increase in imported meat products and the relationship that wild animals play in the domestic and sylvatic transmission cycles. In contrast to a time when the genus Trichinella was considered monospecific, research in recent years has revealed that the genus consists of 9 species and at least 3 additional genotypes which have yet to be named. Except for a …

Commencement Convocation Program, Usf, Baccalaureates, December 7, 2018, University Of South Florida

USF Graduation and Convocation Programs

Honorary Doctor of Science - Melanie Sanford; President's Fellow Medallion - Mayor Bob Buckhorn; President's Global Leadership Award - Dyann Wirth; King O'Neal Scholars - Andrea Arciniegas, Jessica Bullock, Anna Eliason, Tiffany Garner, Bailey Gavulic, Victoria Hoang, Stephanie Hogue, Briana Luthman, Asgard Marroquin, Justin Mohr, Jenn Moser, Rida Mughal, Kristiana Nasto, Marilluly Peraza, Kirby Powers, Keska Register, Jordan Stofan, Michael Talavera, Veronica Vazquez, Thomas Vieiera, Rylee Wagner, Savannah Warner, Aubrey Wolfe, David Wylie, and Shahrzad Zamani; Outstanding Graduate - Shahriar "Shawn" Zamani

Progress On Identifying And Characterizing The Human Proteome: 2018 Metrics From The Hupo Human Proteome Project., Gilbert S Omenn, Lydie Lane, Christopher M Overall, Fernando J Corrales, Jochen M Schwenk, Young-Ki Paik, Jennifer E Van Eyk, Siqi Liu, Michael Snyder, Mark S Baker, Eric W Deutsch

Articles, Abstracts, and Reports

The Human Proteome Project (HPP) annually reports on progress throughout the field in credibly identifying and characterizing the human protein parts list and making proteomics an integral part of multiomics studies in medicine and the life sciences. NeXtProt release 2018-01-17, the baseline for this sixth annual HPP special issue of the Journal of Proteome Research, contains 17 470 PE1 proteins, 89% of all neXtProt predicted PE1-4 proteins, up from 17 008 in release 2017-01-23 and 13 975 in release 2012-02-24. Conversely, the number of neXtProt PE2,3,4 missing proteins has been reduced from 2949 to 2579 to 2186 over the past …

Expanding The Use Of Spectral Libraries In Proteomics., Eric W Deutsch, Yasset Perez-Riverol, Robert J Chalkley, Mathias Wilhelm, Stephen Tate, Timo Sachsenberg, Mathias Walzer, Lukas Käll, Bernard Delanghe, Sebastian Böcker, Emma L Schymanski, Paul Wilmes, Viktoria Dorfer, Bernhard Kuster, Pieter-Jan Volders, Nico Jehmlich, Johannes P C Vissers, Dennis W Wolan, Ana Y Wang, Luis Mendoza, Jim Shofstahl, Andrew W Dowsey, Johannes Griss, Reza M Salek, Steffen Neumann, Pierre-Alain Binz, Henry Lam, Juan Antonio Vizcaíno, Nuno Bandeira, Hannes Röst

Articles, Abstracts, and Reports

The 2017 Dagstuhl Seminar on Computational Proteomics provided an opportunity for a broad discussion on the current state and future directions of the generation and use of peptide tandem mass spectrometry spectral libraries. Their use in proteomics is growing slowly, but there are multiple challenges in the field that must be addressed to further increase the adoption of spectral libraries and related techniques. The primary bottlenecks are the paucity of high quality and comprehensive libraries and the general difficulty of adopting spectral library searching into existing workflows. There are several existing spectral library formats, but none captures a satisfactory level …

Flexible And Fast Mapping Of Peptides To A Proteome With Proteomapper., Luis Mendoza, Eric W Deutsch, Zhi Sun, David S Campbell, David Shteynberg, Robert L Moritz

Articles, Abstracts, and Reports

Bottom-up proteomics relies on the proteolytic or chemical cleavage of proteins into peptides, the identification of those peptides via mass spectrometry, and the mapping of the identified peptides back to the reference proteome to infer which possible proteins are identified. Reliable mapping of peptides to proteins still poses substantial challenges when considering similar proteins, protein families, splice isoforms, sequence variation, and possible residue mass modifications, combined with an imperfect and incomplete understanding of the proteome. The ProteoMapper tool enables a comprehensive and rapid mapping of peptides to a reference proteome. The indexer component creates a segmented index for an input …

Business Not As Usual: How Multisectoral Collaboration Can Promote Transformative Change For Health And Sustainable Development, Shyama Kuruvilla, Rachael Hinton, Ties Boerma, Ryan Bunney, Nuria Casamitjana, Rafael Cortez, Patrizia Fracassi, Jennifer Franz-Vasdeki, Daniel Helldén, Joanne Mcmanus, Jai K. Das

Department of Paediatrics and Child Health

No abstract provided.

Kaposi’S Sarcoma-Associated Herpesvirus-Encoded Viral Il-6 (Vil-6) Enhances Immunoglobulin Class-Switch Recombination, Santas Ana Rosario

Open Access Dissertations

Kaposi's sarcoma-associated herpesvirus (KSHV) is an oncogenic gamma-herpesvirus that causes several AIDS-defining malignancies, including Kaposi's sarcoma (KS) and other lymphoproliferative disorders. These malignancies continue to burden AIDS patients, particularly one-seventh of the world’s population in sub-Saharan Africa, where highly active antiretroviral therapy (HAART) is poorly accessible. To successfully establish lifelong persistence within a host, KSHV employs several strategies, including mimicry of host cytokines, to modulate the immune response and usurp cellular signaling pathways. One crucial cytokine is vIL-6, a viral homolog to human IL-6 (hIL-6) and mouse IL-6 (mIL-6). Although the immune system plays a pivotal role in the pathogenesis …

New Jersey's Legal Duty To Manage Its Coastline In Preparation For The Wrath Of Climate Change, Sarah Weiss Rozalis

Villanova Environmental Law Journal (1991 - )

No abstract provided.

Concurrent Atlantoaxial Septic Arthritis And Septic Thrombosis Of The Ophthalmic Vein Due To Staphylococcus Aureus: A Case Report And Review Of The Literature, Robin L.P. Jump

Faculty Scholarship

Atlantoaxial joint septic arthritis and superior ophthalmic vein thrombosis are uncommon manifestations of Staphylococcus aureus infection. A 68-year-old man presented with acute-onset neck pain and diplopia. Imaging studies revealed atlantoaxial septic arthritis and right superior ophthalmic vein thrombosis. Blood cultures grew methicillin-susceptible S. aureus. We review the literature describing these 2 uncommon manifestations of a common pathogen.

Instances Of Influenza In The United States Visualized, Parth Patel

Publications and Research

The Tycho Project collects large data sets related to healthcare and in particular, instances and geographical information of diseases. We look at the instance counts and locations of Influenza from 1919-1951 across the United States. We hope to find seasonal and geographical insight to the spread of the disease.

Canvass: A Crowd-Sourced, Natural-Product Screening Library For Exploring Biological Space, Sara E. Kearney, Gergely ZahoráNszky-KőHalmi, Kyle R. Brimacombe, Mark J. Henderson, Caitlin Lynch, Tongan Zhao, Kanny K. Wan, Zina Itkin, Christopher Dillon, Min Shen, Dorian M. Cheff, Tobie D. Lee, Danielle Bougie, Ken Cheng, Nathan P. Coussens, Dorjbal Dorjsuren, Richard T. Eastman, Ruili Huang, Michael J. Iannotti, Surendra Karavadhi, Carleen Klumpp-Thomas, Jacob S. Roth, Srilatha Sakamuru, Wei Sun, Steven A. Titus, Adam Yasgar, Ya-Qin Zhang, Jinghua Zhao, Rodrigo B. Andrade, M. Kevin Brown, Robert B. Grossman

Chemistry Faculty Publications

Natural products and their derivatives continue to be wellsprings of nascent therapeutic potential. However, many laboratories have limited resources for biological evaluation, leaving their previously isolated or synthesized compounds largely or completely untested. To address this issue, the Canvass library of natural products was assembled, in collaboration with academic and industry researchers, for quantitative high-throughput screening (qHTS) across a diverse set of cell-based and biochemical assays. Characterization of the library in terms of physicochemical properties, structural diversity, and similarity to compounds in publicly available libraries indicates that the Canvass library contains many structural elements in common with approved drugs. The …

Retrospective Review Of Alternative Antibiotic Use In Patients With A Reported Penicillin Allergy At A Community Hospital, Rita Chamoun, Monica Tadros, Amy Montes, Heidi Clarke, Radhan Gopalani

All Publications

No abstract provided.

Campus Assembly Minutes 12/04/2018, Campus Assembly

Campus Assembly

No abstract provided.

The Indiana Statesman, December 4, 2018, Indiana State University

Student Newspaper

Concert inspires young children with instrument petting zoo; It’s a Charlie Brown Christmas; Indiana State’s MBA ranked No. 6 nationally; Xpressions showcases fashion and dance moves fit for a music video

Sitc 2018 Workshop Report: Immuno-Oncology Biomarkers: State Of The Art., Lisa H Butterfield, Mary L Disis, Bernard A Fox, David R Kaufman, Samir N Khleif, Ena Wang

Articles, Abstracts, and Reports

Identification of biomarkers in cancer immunotherapy that predict therapeutic response and/or limit adverse events are a critical need in the field. To address recent progress and hurdles around cancer biomarker development and utilization, the Society for Immunotherapy of Cancer (SITC) convened a workshop, "Immuno-Oncology Biomarkers: State of the Art," on May 16-17, 2018. Topics discussed included challenges in handling biospecimens, identification and validation of new biomarkers, data sharing, and collaborating across disciplines to advance biomarker development. Panel discussions followed session presentations to help foster participant conversation and discuss future projects and collaborations. The results of the Workshop include the development …

Hiv Virologic Response Better With Single-Tablet Once Daily Regimens Compared To Multiple-Tablet Daily Regimens, Shashi N. Kapadia, Robert R. Grant, Susan B. German, Baljinder Singh, Amy L. Davidow, Shobha Swaminathan, Sally Hodder

Clinical and Translational Science Institute

Background: Single-tablet regimens are preferred prescription choices for HIV treatment, but there are limited outcomes data comparing single-tablet regimens to multiple-tablet regimens. Methods: We retrospectively assessed treatment-naïve patients at a single urban HIV clinic in the United States for viral load suppression at 6 and 12months after initiating either single-tablet or multiple-tablet regimens. Multivariate regression was performed to obtain relative risks and adjust for potential confounders. Results: Of 218 patients, 47% were on single-tablet regimens and 53% on multiple-tablet regimens; 77% of single-tablet regimen patients had undetectable viral load at 6months compared to 61% of multiple-tablet regimen patients (p=0.012). At …

γ-Aapeptides With Potent And Broad-Spectrum Antimicrobial Activity, Jianfeng Cai, Youhong Niu, Haifan Wu, Shruti Padhee

USF Patents

The present invention is directed to a novel class of antimicrobial agents called γ-AApeptides. The current invention provides various categories of γ-AApeptides, for example, linear γ-AApeptides, cyclic γ-AApeptides, and lipidated γ-AApeptides. γ-AApeptides of the current invention are designed to exert antimicrobial activity while being stable and non-toxic. γ-AApeptides also do not appear to lead to the development of microbial resistance in treated microorganisms. Thus, the disclosed γ-AApeptides can be used for the treatment of various medical conditions associated with pathogenic microorganisms.

Antimicrobials From An Epigenetics Based Fungal Metabolite Screening Program, Danielle H. Demers, Bill J. Baker, Ala Azhari, Renee M. Fleeman, Dennis E. Kyle, Lindsey Neil Shaw

USF Patents

Novel antimicrobial compounds against drug targets such as Eskape pathogens, Leishmania donovani, Mycobacterium tuberculosis, Clostridium difficile, Naegleria fowleri, and cancer are presented herein.

Unh Veterinary Pathologist Identifies First Case Of Skunk Adenovirus-1 In U.S., Third In World, Lori Tyler Gula

UNH Today Archive

No abstract provided.

A New Era 邁向新里程, Rachel Duffell

AMBROSIA 客道 : The Magazine of The International Culinary Institute

The International Culinary Institute's new campus combines professional culinary training with practical facilities, in a design that is in harmony with the historic surroundings.

隨著位於牛奶公司舊址的新校舍投入運作，國際廚藝學院將繼往開來，為香港款待服務及餐飲業培育人才。

Ambrosia Autumn 2018 Special Opening Edition Full Issue

AMBROSIA 客道 : The Magazine of The International Culinary Institute

No abstract provided.

Social Context: A Review Of Autobiography Of A Disease, Sean N. Halpin

The Qualitative Report

Autobiography of Disease by Patrick Anderson thoroughly examines the author’s life threatening experience with Staphylococcus aureus (MRSA) osteomyelitis. Through notes kept by the author and caregiver/mother Anderson tells an evocative ethnography as told from the perspective of MRSA itself. This complex weaving of narratives highlights how multiple social and environmental considerations interact to impact Anderson's experience with illness. This book may be of interest to anyone seeking to learn more about the social context of illness.

The Classic, Winter 2018-19, Public Relations

The Classic, 2010-2019

Zwemer View: The Way Forward; Around the Green: Northwestern to Start Physician Assistant Master's Program; In Box; Crossing Borders in the Classroom; Enrollment Fourth Largest; Geneticist Nominated for Young Alumni Reward; We're on the List; Campus LIfe: A Taste of Home; New STEM Programs; AD Accolades; Nostalgic Notes; A Summer for Success; Faith Focus Recognized; Face Value: Robert Winn; MCAT Score Success; The Numbers Don't Lie; Musical Mission; Leading by Example; Investing in the Mission; Red Zone; The Sounds of Our Times; 1,000 Words: Yeehaw!; Living Faith: Northwestern helps high school students dig into the Bible; Raider Nation in the …

Evaluation Of Antibiotic Prescribing Patterns For Community Acquired Pneumonia, Gregory Schaefer, Ann Wigton

Pharmacy Posters

Purpose: To evaluate duration of antibiotic therapy and prescribing patterns for non-ICU CAP at St Cloud Hospital, a tertiary community hospital.

Mole Street Journal, December 2018, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry

Mole Street Journal

No abstract provided.

Subacute Physical Rehabilitation For A Young Adult With A Hypoxic Brain Injury Resulting In Severe Myoclonic Movements And Ataxia: A Case Report, Chelsea Vandriel

Case Report Papers

Background and Purpose: An acquired brain injury is an injury to the brain that is not hereditary, congenital, degenerative in nature or induced by birth. Hypoxic/anoxic ischemic brain injuries (HIBI) result from global lack of oxygen to the brain from events such as drowning, choking, and cardiac or respiratory arrest. Limited research has been done regarding physical therapy (PT) interventions to improve functional mobility, gait, and tolerance to activity in an inpatient rehabilitation facility (IRF) with this patient population. Thus, the purpose of this case report is to provide PT interventions that were utilized in an IRF setting for a …

Progress Notes, Lehigh Valley Health Network

Progress Notes

No abstract provided.

Wet Markets And Avian Influenza: Public Policy Decisions In Hong Kong, Shawn C. Smallman Ph.D.

Journal of International and Global Studies

After the emergence of H5N1 avian influenza in 1997 Hong Kong implemented a sophisticated system to regulate live poultry markets. While this system is well implemented and thorough, it also has limitations. The rise of H7N9 avian influenza (which is typically acquired through contact with poultry, including in live markets) makes this an appropriate time to revisit the ethical and practical issues related to this trade. Based on data from field observations of live markets in Hong Kong, and interviews with experts in the field, this paper recommends that the government of Hong Kong create a committee to examine the …

Distribution Of Dengue And Zika Virus Igg Immunoglobulin, Madison Smith, Awadalkareem Adam, Anuja Mathew

Senior Honors Projects

Introduction. Dengue Virus (DENV) and Zika Virus (ZIKV) are viruses that belong to the Flavivirus family. They are transmitted by the Aedes aegypti species of mosquitoes. Infection with DENV can result in no symptoms, mild symptoms which include fever, rash, and headache (dengue fever) or more severe symptoms which include hemorrhage, dengue hemorrhagic fever (DHF) and shock, dengue shock syndrome (DSS). ZIKV, until recently caused mild disease but an outbreak in Brazil was associated with fetal complications such as microcephaly or Guillain-Barré syndrome in adults. Due to the similarity between ZIKV and DENV, antibodies (Abs) generated in humans to these …