Digital Commons Network^™

The Role Of Peanut Allergy In Anaphylaxis, Jessica Schmelzer

Nursing Student Class Projects (Formerly MSN)

The rise of food allergies directly correlates with the increase in anaphylactic reactions. Food allergies currently affect an estimated 15 million Americans or 4% of children and 1% of adults. Anaphylaxis is a life-threatening reaction that is most commonly caused by food allergies. The top 8 allergens in the United States are: peanut, tree nut, milk, egg, wheat, soy, fish, shellfish. Peanut allergies are on the rise in the United States and are commonly a cause of anaphylaxis. Anaphylaxis causes rapid-onset respiratory compromise, skin/mucosal involvement and hypotensive end-organ dysfunction. Symptoms of anaphylaxis are severe and often occur very quickly after …

Probabilistic Model Of Dengue, German Marcillo, Anibal Munoz, Gerard Olivar Tost

Applied Mathematics & Information Sciences

The article presents the stochastic modeling of a particular dynamic of dengue cases for a constant population with an initial number of susceptible and infected members, a time-dependent force of infection and a probability-generating function from which a linear partial differential equation (PDE) of first order is derived whose solution can assign probabilities to each of the states of the model and the transitions between them. The force of infection is estimated numerically based on a dynamic system of ordinary differential equations. The method of characteristics applied to find the analytical solution of the PDE and subsequently the marginal probabilities …

Macalester Today Summer 2018, Macalester College

Macalester Today

No abstract provided.

Loss Of Marv1 Promotes Chop Signaling In Mouse Liver, Shad Anthony Mitchell

Graduate School of Biomedical Sciences Theses and Dissertations

Metabolic syndrome (MetS) is a term used to define a set of metabolic diseases: obesity, type 2 diabetes (T2D), hyperlipidemia, hypertension, nonalcoholic fatty liver disease (NAFLD), and nonalcoholic hepatosteatosis (NASH). Those with MetS have a higher incidence of cardiovascular disease and stroke. Current drug treatments for MetS treat the individual pathologies associated with the diseases, rather than directly targeting MetS as a whole. We hypothesize that the inhibition of a ubiquitous lipid transporter known as ARV1 can improve pathologies associated with MetS. To test this hypothesis, we utilized liver tissue from mARV1 knockout mice fed a high-fat diet and examined …

Species Distribution And Conservation Genetics Of The Upland And Midland Chorus Frogs (Pseudacris) In Kentucky, Tucker Cambridge

Masters Theses & Specialist Projects

The upland (Pseudacris feriarum) and midland (P. triseriata) chorus frogs are closely related cryptic species that are best distinguished genetically. The distribution of these species within the Commonwealth of Kentucky has previously been defined by only a handful of genetic samples, making delineation of range limits for each species difficult. Accurate understanding of species distributions, and the genetic structure within them, are vitally important for conservation management of amphibian species. In this study, I have collected genetic samples from across the putative ranges of P. triseriata and P. feriarum in Kentucky and used next-generation sequencing technology to generate more fine-scale …

Reducation Of Catheter-Associated Urinary Tract Infections Through A Nurse-Led Collaborative At A Rural Midwestern Hospital, Natalie Pianetto Buck

Doctor of Nursing Practice Scholarly Projects

Catheter-associated urinary tract infections (CAUTIs) contribute to patient discomfort, complications, prolonged hospital stays, increased healthcare costs, and increased mortality (Agency for Healthcare Research and Quality [AHRQ], 2015). Despite the fact that these infections have proven to be preventable, CAUTI rates continue to exceed the national benchmark (Centers for Disease Control and Prevention, 2016a; Meddings et al., 2014). Evidence-based guidelines propose a bundle method is the most effective way to successfully reduce CAUTIs (AHRQ, 2015; Gould et al., 2017; Lo et al., 2014). The purpose of this research was to demonstrate whether a nurse-led collaborative, which bundled evidence-based interventions to reduce …

Jackrabbits Script & Scope, College Of Pharmacy And Allied Health Professions

Jackrabbits Script and Scope (Formerly called College of Pharmacy and Allied Health Professions Magazine)

[Page] 4 Mort Takes the Lead
[Page] 8 International Rotation
[Page] 11 Hedge Honored
[Page] 12 Convocation
[Page] 14 White Coat Ceremony
[Page] 16 Distinguished Graduate
[Page] 18 Pharm.D. Class of 2018
[Page] 21 Preceptor of the Year
[Page] 24 Precision Medicine
[Page] 25 Phonathon Changes
[Page] 26 Pharmaogenomics
[Page] 27 Schaefer Joins
[Page] 28 Faculty Honors
[Page] 31 Huether Liked the Lab
[Page] 32 Academic Assessment -Curriculum Report
[Page] 34 Department of Pharmaceutical Sciences
[Page] 35 Department of Pharmacy Practice
[Page] 36 Donors
[Page] 38 Development Director's Report

Vol. 43, No. 3: Summer 2018, School Of Medicine & Health Sciences

North Dakota Medicine Archive

No abstract provided.

Qualitative Profiling Of The Humoral Immune Response Elicited By Rvsv-Δg-Ebov-Gp Using A Systems Serology Assay, Domain Programmable Arrays, Mariano Sanchez-Lockhart, Daniel S. Reyes, Jeanette C. Gonzalez, Karla Y. Garcia, Erika C. Villa, Bradley P. Pfeffer, John C. Trefry, Jeffrey R. Kugelman, Margaret L. Pitt, Gustavo Palacios

University of Nebraska's National Strategic Research Institute: Publications

Development of an effective vaccine became a worldwide priority after the devastating 2013–2016 Ebola disease outbreak. To qualitatively profile the humoral response against advanced filovirus vaccine candidates, we developed Domain Programmable Arrays (DPA), a systems serology platform to identify epitopes targeted after vaccination or filovirus infection. We optimized the assay using a panel of well-characterized monoclonal antibodies. After optimization, we utilized the system to longitudinally characterize the immunoglobulin (Ig) isotype-specific responses in non-human primates vaccinated with rVSV-ΔG-EBOV-glycoprotein (GP). Strikingly, we observed that, although the IgM response was directed against epitopes over the whole GP, the IgG and IgA responses were …

Health Fetishism Among The Nacirema: A Fugue On Jenny Reardon’S "The Postgenomic Condition: Ethics, Justice, And Knowledge After The Genome" (Chicago University Press, 2017) And Isabelle Stengers’ "Another Science Is Possible: A Manifesto For Slow Science" (Polity Press, 2018), Scott F. Gilbert

Biology Faculty Works

Personalized medicine has become a goal of genomics and of health policy makers. This article reviews two recent books that are highly critical of this approach, finding their arguments very thoughtful and important. According to Stengers, biology’s rush to become a science of genome sequences has made it part of the “speculative economy of promise.” Reardon claims that the postgenomic condition is the attempt to find meaning in all the troves of data that have been generated. The current paper attempts to extend these arguments by showing that scientific alternatives such as ecological developmental biology and the tissue organization field …

Unm Pathology Pathfinder Summer 2018, Unm Department Of Pathology

Newsletters

No abstract provided.

Quillen Magazine - Summer 2018, Quillen College Of Medicine, East Tennessee State University

Quillen Magazine

No abstract provided.

Development Of A Rapid Diagnostic Assay For The Colorimetric Detection Of Bacterial And Viral Pathogens Using Loop-Mediated Isothermal Amplification Coupled With A Peptide Nucleic Acid And Gold Nanoparticle Reporter System, William Brown

All NMU Master's Theses

Detection of pathogenic agents remains pivotal to the control and prevention of infectious disease. While diagnostic methods continue to break barriers, the need for accurate, sensitive, and rapid methods persists. Current methods for pathogen detection, including culture, immunochemical, or molecular-based techniques, are subject to significant limitations that restrict their clinical utility. Point-of-care (POC) tests have received attention for the diagnostic screening of infectious disease, with benefits of simplicity, affordability, and convenience. This study describes the development of a novel loop-mediated isothermal amplification (LAMP) reaction followed by a peptide nucleic acid (PNA) probe and gold nanoparticle (AuNP) detection system that results …

Clark Magazine, Summer 2018, Clark University

Clark Magazine

The Summer 2018 edition of Clark Magazine. Clark Magazine is a twice-yearly publication primarily geared towards Clark University Alumni.

The cover story is 'After Maria: Clark students and alumni were left reeling from Hurricane Maria. As they rebuild, they struggle with the question 'Is this our new normal'?'

The Effect Of Cobra Training On First Responder Self-Confidence To Work In A Toxic Chemical Or Biological Agent Environment, Robert A. Mann

Dissertations

First responders are our nation’s front line defense against intentional or accidental releases of toxic chemical or biological agents. Self-confidence which is a building block of self-efficacy is hypothesized to be malleable and increased through training. The purpose of this study was to determine the change if any, which first responders undergo during Chemical, Ordnance, Biological, and Radiological (COBRA) training, in their self-confidence to operate in a toxic chemical or biological agent environment. That is to determine if there is a correlation between increased self-confidence and COBRA training. The methodology of this study was based on quantitative methods of analysis …

Differential Evolution Of Antiretroviral Restriction Factors In Pteropid Bats As Revealed By Apobec3 Gene Complexity, Joshua A. Hayward, Mary Tachedjian, Jie Cui, Adam Z. Cheng, Adam Johnson, Michelle L. Baker, Reuben S. Harris, Lin-Fa Wang, Gilda Tachedjian

KIP Articles

No abstract provided.

The Influence Of Landscape And Environmental Factors On Ranavirus Epidemiology In A California Amphibian Assemblage, Brian J. Tornabene, Andrew R. Blausten, Cheryl J. Briggs, Dana M. Calhoun, Pieter T. J. Johnson, Travis Mcdevitt-Galles, Jason R. Rohr, Jason T. Hoverman

Integrative Biology Faculty and Staff Publications

1. A fundamental goal of disease ecology is to determine the landscape and environmental processes that drive disease dynamics at different biological levels to guide management and conservation. Although ranaviruses (family Iridoviridae) are emerging amphibian pathogens, few studies have conducted comprehensive field surveys to assess potential drivers of ranavirus disease dynamics.
2. We examined the factors underlying patterns in site‐level ranavirus presence and individual‐level ranavirus infection in 76 ponds and 1,088 individuals representing five amphibian species within the East Bay region of California.
3. Based on a competing‐model approach followed by variance partitioning, landscape and biotic variables explained the most variation in …

Getting To Know Saints: The Story Of The Church Of Jesus Christ In The Latter Days, Steven C. Harper, Scott Hales, Casey Paul Griffiths

Religious Educator: Perspectives on the Restored Gospel

Griffiths: The purpose of this meeting is to explain a little bit about what Saints is and how teachers can use it. Scott, can I start with you? Can you tell us a little bit about Saints and what it is intended to do?

Hales: Saints is a new four-volume narrative history of the Church. It covers Church history from 1815 to the present. Each volume culminates in the completion of a temple and shows Latter-day Saints making and keeping sacred covenants. The first volume covers the organization of the Church and the early years of the Restoration. It begins …

Estimating Epidemiological Parameters Of A Stochastic Differential Model Of Hiv Dynamics Using Hierarchical Bayesian Statistics, Renee Dale, Bei Bei Guo

Faculty Publications

Current estimates of the HIV epidemic indicate a decrease in the incidence of the disease in the undiagnosed subpopulation over the past 10 years. However, a lack of access to care has not been considered when modeling the population. Populations at high risk for contracting HIV are twice as likely to lack access to reliable medical care. In this paper, we consider three contributors to the HIV population dynamics: at-risk population exhaustion, lack of access to care, and usage of anti-retroviral therapy (ART) by diagnosed individuals. An extant problem in the mathematical study of this system is deriving parameter estimates …

Incidence Of Acute Kidney Injury Among Patients Treated With Piperacillin-Tazobactam Or Meropenem In Combination With Vancomycin, Wilbur Cliff Rutter, David S. Burgess

Pharmacy Practice and Science Faculty Publications

Acute kidney injury (AKI) increases during empirical antimicrobial therapy with the combination of piperacillin-tazobactam (TZP) and vancomycin (VAN) compared to the number of incidences with monotherapy or the combination of cefepime and VAN. Limited data regarding the impact of meropenem (MEM) combined with VAN exist. This study examined the AKI incidence among patients treated with MEM plus VAN (MEM+VAN) or TZP+VAN. Data were collected from the University of Kentucky Center for Clinical and Translational Science Enterprise Data Trust from September 2007 through October 2015. Adults without previous renal disease who received MEM+VAN or TZP+VAN for at least 2 days were …

The Global Person: Pig-Human Embryos, Personhood, And Precision Medicine, Yvonne Cripps

Indiana Journal of Global Legal Studies

Chimeras, in the form of pig-human embryos engineered by CRISPR-Cas9 and other biotechnologies, have been created as potential sources of organs for transplantation. Against that background, and in an era of "precision medicine," this Article examines the concept of the global genetically modified person and asks whether humanness and personhood are being eroded, or finding new boundaries in intellectual property and constitutional law.

Self-Regulation Of Emotional Responses To Zika: Spiral Of Fear, James Price Dillard, Chun Yang, Ruobing Li

Faculty Publications

Fear of infectious disease can create a variety of problems not the least of which is fear itself. An important question is how individuals attempt to manage their fear. The appearance of Zika in the U.S. presented an opportunity to examine this issue in a consequential natural context. Beginning nine days after the W.H.O. declared Zika a world health crisis, two-waves of survey data were collected from women ages 18–35 who were living in the Southern U.S. (N = 561). Most respondents (71%) used one or more emotion regulation strategies and a plurality (41%) utilized multiple strategies. Fear of Zika …

Children’S Connectedness To Nature And Parental Influence: A Mixed Methods Survey, Meredith Yue

School of Education and Leadership Student Capstone Theses and Dissertations

I conducted a mixed method survey to focus on the question, “What are the ways parents positively shape their children’s connectedness to nature?” There is a national phenomenon on the disconnect between children and the natural world, coined as the “nature deficit disorder.” This disorder has been linked to an increase in obesity, mental health, attention disorders and the overall well-being of children. I administered a quantitative survey for children to measure their connectedness to nature as well as a qualitative survey of parents to gather in-depth information to capture the richness of the nature experience that happens at home. …

Impact Of Outpatient Vs Inpatient Absssi Treatment On Outcomes: A Retrospective Observational Analysis Of Medical Charts Across Us Emergency Departments, P Brandon Bookstaver, Timothy C. Jenkins, Edward Stenehjem, Shira Doron, Jack Brown, Shannon H. Goldwater, Carlos Lopes, Angela Haynes, Chuka Udeze, Yifan Mo, Patrick Gillard, Yan Liu, Katelyn Keyloun

Faculty Publications

Background: The objective of this study was to characterize treatment of patients with acute bacterial skin and skin structure infections (ABSSSIs) and describe the association between hospital admission and emergency department (ED) visits or readmissions within 30 days after initial episode of care (IEC). Methods: This was a retrospective, observational, cohort study of adults with ABSSSI who presented to an ED between July 1, 2012, and June 30, 2013. Patient, health care facility, and treatment characteristics, including unplanned ED visits or readmissions, were obtained through manual chart review and abstraction. Adjusted logistic regression analysis examined likelihood of all-cause unplanned ED …

Introductory Medical Microbiology, Veronica Morin, Andrew Dawson

Biological Sciences Grants Collections

This Grants Collection for Introductory Medical Microbiology was created under a Round Nine ALG Textbook Transformation Grant.

Affordable Learning Georgia Grants Collections are intended to provide faculty with the frameworks to quickly implement or revise the same materials as a Textbook Transformation Grants team, along with the aims and lessons learned from project teams during the implementation process.

Documents are in .pdf format, with a separate .docx (Word) version available for download. Each collection contains the following materials:

• Linked Syllabus
• Initial Proposal
• Final Report

A New Security Framework For Geoengineering, Elizabeth L. Chalecki, Lisa L. Ferrari

Political Science Faculty Publications

As the national security ramifications of climate change grow more pronounced, climate manipulation technologies, called geoengineering, will become more attractive as a method of staving off climate-related security emergencies. Geoengineering includes methods of carbon dioxide removal and/or solar radiation management and can theoretically achieve significant reductions in warming-related environmental changes, but they are scientifically untested. Geoengineering technologies have the potential to disrupt the global ecological status quo and mount a potentially coercive threat with implications as serious as those in wartime. Several of these technologies can be deployed from the global commons, but international law provides no more than indirect …

The Utilization Of Laryngeal Mask Airways Vs. Endotracheal Tubes In Pediatrics With Upper Respiratory Tract Infection In Reducing Airway Complications, Ruby Foster

Nurse Anesthesia MSNA Student Capstones

According to Tait & Malviya, (2005) children typically experience six to eight upper respiratory infections (URIs) per year with ninety-five percent being viral in etiology (Tait & Malvia, 2005). URIs commonly occur in the pediatric population (Bernando-Ocampo, 2012). An issue surrounding the debate on whether a child with upper respiratory infection (URI) should proceed with surgery or cancel surgery is a debate that has been ongoing for several years (Tait el al. 2005). This review examines whether children who have an URI scheduled for surgery are at an increased risk for adverse respiratory complications when the laryngeal mask airway (LMA) …

Hiv/Aids Knowledge & Perceptions On A College Campus, Gabriel Navarro

Honors College Theses

Our research project surveyed students at Pace University (both on the New York City and Pleasantville campuses) and looked into their understanding of Human Immunodeficiency Virus (HIV) & Acquired Immunodeficiency Syndrome (AIDS). The goal was to better understand students’ knowledge regarding HIV/AIDS, and the ways in which they might be misinformed. Our research looked to see if there was any stigma surrounding student’s perceptions of the virus and its transmission. The study also asked students about their sexual practices. Specifically, we utilized an Institutional Review Board approved survey, to ask students about their sexual behavior to see if they were …

The Diversity Found Among Carbapenem-Resistant Bacteria, Galen Edward Card

Theses and Dissertations

This work will look at two factors that add to the diversity of carbapenem resistant bacteria. First, it focuses on the diversity of carbapenemase resistance plasmids. 446 plasmids were characterized by size, gene content and replicon groups. We identified that on average, over 30% of the encoded proteins on each plasmid have an unknown function. Plasmid sizes ranged from 1.6kb to 500kb, with an average of around 100kb and median of 80kb. Additionally, six replicon groups account for 80% of all the carbapenemase resistance plasmids. We also highlight the lack of data available for carbapenemase carrying plasmids from bacterial genera …

Wildlife Carcass Disposal, Stephen M. Vantassel, Mark A. King

Wildlife Damage Management Technical Series

Many wildlife management situations require the disposal of animal carcasses. These can include the lethal removal of wildlife to resolve damage or conflicts, as well as clean-up after mortalities caused by vehicle collisions, disease, oil spills (Figure 1) or other natural disasters. Carcasses must be disposed of properly to protect public sensitivities, the environment, and public health. Improper disposal of carcasses can result in public outrage, site contamination, injury to animals and people, and the attraction of other animals that may lead to wildlife damage issues. Concern over ground water contamination and disease transmission from improper carcass disposal has resulted …