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Fluorescent Labeled Inhibitors, Christopher D. Spilling, Benjamin Martin, Stephane Canaan, Jean-Francois Cavalier

UMSL Patents

Provided herein are a series of fluorescently labeled phosphonate and phosphate compounds such as can be used for affinity probes to detect certain enzymes including lipases. Also provided are methods of making and using such compounds.

For the most up-to-date information about these patents, including the availability of Certificates of Correction, be sure to check the United States Patent and Trademark Office's free, publicly accessible database: Patent Public Search https://ppubs.uspto.gov/pubwebapp/static/pages/landing.html

2018 – 2020 Key Strategic Issues List, Antulio J. Echevarria Ii

Articles & Editorials

No abstract provided.

Immune Cells That Create And Sustain Chronic Inflammatory Bowel Disease Identified, Brit Blalock

Browse All News

No abstract provided.

August 14, 2018 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Study Protocol Of "Our Choice": A Randomized Controlled Trial Of The Integration Of Safer Conception Counseling To Transform Hiv Family Planning Services In Uganda., Kathy Goggin, Emily A. Hurley, Jolly Beyeza-Kashesya, Violet Gwokyalya, Sarah Finocchario-Kessler, Josephine Birungi, Deborah Mindry, Rhoda K Wanyenze, Glenn J Wagner

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: About 40% of HIV-positive women in sub-Saharan Africa become pregnant post-diagnosis. Despite about half of their pregnancies being planned, safer conception methods (SCM) are underutilized among serodiscordant couples, partially due to the fact that safer conception counseling (SCC) has not been integrated into routine HIV family planning (FP) services.

METHODS: Our Choice is a comprehensive FP intervention that promotes unbiased childbearing consultations to ensure clients receive SCC or contraception services to achieve their desired reproductive goals. The intervention is theoretically grounded and has demonstrated preliminarily feasibility and acceptance through pilot testing. This three-arm cluster randomized controlled trial compares two …

Niaid Director Will Speak At Inaugural Marchase Interdisciplinary Research Centers Symposium, Aug. 17, Staff

Browse All News

No abstract provided.

The Fda Approved Hbot Indications In Veterinary Medicine And Beyond..., Andrew Turkell

International Symposium for Hyperbaric Medicine

• This presentation is based on the 14 FDA approved, and sometimes insurance reimbursable, HBOT indications in humans and how they are extrapolated into veterinary medicine and utilized for very similar indications in the animal world.
• We will also discuss a much larger group of indications that are not approved in the USA but approved internationally (off label), which may have more compelling scientific evidence than exists for the approved indications.

Pubh 7090– One Health, Jessica Smith Schwind

College of Public Health: Faculty Syllabi (2014-2021)

Our world is becoming increasingly connected due to globalization. As a result, challenges arise that directly affect human, animal, and environmental health. One Health is an integrated approach that focuses on improving communication and collaboration across human, animal, and environmental health sectors. Because emerging infectious diseases, antimicrobial resistance, climate change, and food safety represent a significant threat to health across all populations, the One Health approach is increasingly important to our comprehensive understanding of and response to global health challenges. This course will provide students an introduction to One Health and the skills needed to address issues at the human-animal-environmental …

Functional Genomics And Immunologic Tools: The Impact Of Viral And Host Genetic Variations On The Outcome Of Zika Virus Infection, Sang-Im Yun, Byung-Hak Song, Jordan C. Frank, Justin G. Julander, Aaron L. Olsen, Irina A. Polejaeva, Christopher J. Davies, Kenneth L. White, Young-Min Lee

Animal, Dairy, and Veterinary Science Faculty Publications

Zika virus (ZIKV) causes no-to-mild symptoms or severe neurological disorders. To investigate the importance of viral and host genetic variations in determining ZIKV infection outcomes, we created three full-length infectious cDNA clones as bacterial artificial chromosomes for each of three spatiotemporally distinct and genetically divergent ZIKVs: MR-766 (Uganda, 1947), P6-740 (Malaysia, 1966), and PRVABC-59 (Puerto Rico, 2015). Using the three molecularly cloned ZIKVs, together with 13 ZIKV region-specific polyclonal antibodies covering nearly the entire viral protein-coding region, we made three conceptual advances: (i) We created a comprehensive genome-wide portrait of ZIKV gene products and their related species, with several previously …

Management Implications Of Sex-Specific Habitat Use By Nycticeius Humeralis In North-Central Arkansas, Megan Lynn Buckley

Student Theses and Dissertations

The goal of this study was to evaluate evening bat (Nycticeius humeralis) habitat use and provide a proxy strategy to evaluate habitat use by other species. I used the software Maximum Entropy to evaluate habitat suitability models for evening bats using three different modeling strategies; percent variable contribution, the jackknife test, and variable response curves. The predictors included in the models were 10 land use land cover classes, four forest management strategies, slope, and the normalized difference vegetation index (NDVI). The results of this research showed that distance to burned stands and proximity to edge habitat are the most important …

Syrian Refugees In Egypt: Perceptions Of Healthcare Access, Kholoud H. Sheba

Student Theses and Dissertations

Since its start in 2011 as a civil uprising and as a part of the wider wave of protests movements of the Arab spring, Syria has been witnessing a civil war with an escalating tone that took the country into a dark tunnel that doesn’t seem to have an end. This study aimed to explore the perceptions of Syrians refugees about the health services they now receive in Egypt as a hosting country. To achieve this, quantitative survey and in-depth interviews were conducted among 141 adult Syrian refugees residing in Cairo and Alexandria, Egypt throughout a one-month-long period in summer …

Screening Tools In Adolescent Health Care, David L. Wood

ETSU Faculty Works

Learning Objectives: (1) Identify three primary care friendly screening tools useful for identifying behavioral health concerns in adolescents. (2) Describe how a "champion" (quality improvement) team can help facilitate implementation of a screener in a primary care.

Hbot + Stem Cells In Near Fatal Congenital Cardiomyopathy And Some Other Intractable Disorders, Arun Mukherjee, Vinod Sharma, Mehnaz Atiq, Indrajit N. Roy, Meena Gupta

International Symposium for Hyperbaric Medicine

No abstract provided.

Grounding Frequent Flyers: Understanding High Er Utilization And Developing Primary Care Solutions, Jillian Millares

Master's Projects and Capstones

Background: Regular access to primary care can positively impact long-term, chronic conditions. However, medically underserved individuals, particularly individuals with Severe Mental Illnesses(SMI), typically underutilize primary care. Root causes include client level factors such as socioeconomic barriers, provider level issues such as lack of training or general knowledge of SMI issues, and system level factors such as a lack of coordinated services. Methods: The present study conducted a needs assessment to identify the most influential of these factors on clients at an Acute Residential Treatment Center in San Francisco, California. The needs assessment consisted of semi-structured client and staff interviews. Results: …

Yardwork: A Biography Of An Urban Place By Daniel Coleman, Vivian M. Hansen

The Goose

Review of Daniel Coleman's Yardwork: A Biography of an Urban Place.

Next Generation Sequencing Methods For Coastal Zone Water Quality Monitoring, Catherine Iskrenko

HCNSO Student Capstones

When analyzing the water quality of the coastal zone, culture-based techniques have been utilized most often to identify Fecal Indicator Bacteria in samples. Since the advent of the Sanger Method for DNA sequencing, other techniques have arisen that provide significantly more information on the microorganisms in sample, but they are still not the mainstream for water quality analysis. This capstone reviews and compares culture-based techniques, DNA sequencing, RNA sequencing, qPCR for biomarker, and 16S rDNA sequencing to highlight their merits and shortcomings for analyzing environmental water samples. The technique presented that provides the broadest range of information (including the identification …

Educational Prevention Program Of Surgical Site Infections (Ssi), Carena Leung

Master's Projects and Capstones

Surgical site infections (SSI) cause negative health care effects to patients and hospitals. SSI is one of the most common types of healthcare-associated infections (HAI) accounting for 31% among hospitalized patients (Centers for Disease Control and Prevention [CDC], 2012). It is associated with prolonged length of stays (LOS), higher morbidity and mortality, and increased healthcare costs. The purpose of this quality improvement project is to decrease SSI rates by enhancing patient education and engagement in preoperative care and hygiene before surgery. In a metropolitan pediatric hospital, a microsystem analysis of the preoperative unit was conducted before generating the SSI Prevention …

Congenital Zika Virus Infection In Immunocompetent Mice Causes Postnatal Growth Impediment And Neurobehavioral Deficits, Fengwei Bai, Amber Paul, Dhiraj Acharya, Biswas Neupane, E.A. Thompson, Gabriel Gonzalez-Fernandez, Katherine Copeland, Melanae Garrett, Haibei Liu, Mariper Lopez, Matthew De Cruz, Alex S. Flynt, Jun Liao, Yan-Lin Guo, Federico Gonzalez-Fernandez, Parminder Vig

Faculty Publications

A small percentage of babies born to Zika virus (ZIKV)-infected mothers manifest severe defects at birth, including microcephaly. Among those who appeared healthy at birth, there are increasing reports of postnatal growth or developmental defects. However, the impact of congenital ZIKV infection in postnatal development is poorly understood. Here, we report that a mild congenital ZIKV-infection in pups born to immunocompetent pregnant mice did not display apparent defects at birth, but manifested postnatal growth impediments and neurobehavioral deficits, which include reduced locomotor and cognitive deficits that persisted into adulthood. We found that the brains of these pups were smaller, had …

Antigen Presenting Cells-Mediated Innate And Adaptive Immune Responses To Live Attenuated Edwardsiella Ictaluri Vaccines In Channel Catfish, Adef Kordon

Theses and Dissertations

Vaccination against intracellular pathogens requires generation of pool of memory T cells, which can respond upon infection and mediate immune responses by either killing of infected host cells or induce killing mechanisms in infected cells. T cell-inducing vaccines aim to deliver the antigen to antigen presenting cells (APCs) by presenting on MHC molecules thus bridging innate and adaptive immunity. The intracellular pathogen Edwardsiella ictaluri causes enteric septicemia of catfish (ESC), which is a devastating disease in catfish industry. E. ictaluri can survive in professional phagocytes and use them as an infection source. Two new live attenuated vaccine (LAV) strains, EiDELTAevpB …

Development And Visualization Of Bioluminescent Virulent Aeromonas Hydrophila In Live Catfish, Eda Ozdemir

Theses and Dissertations

Virulent Aeromonas hydrophila (vAh) is an important emerging bacterial pathogen causing motile Aeromonas septicemia (MAS) in farmed catfish. Understanding the pathogenicity of the disease is essential for the development of preventive measures. In this study, we aimed to develop a bioluminescent virulent A. hydrophila (BvAh) strain to understand the pathogen-host interactions during infection. To achieve this, a new bioluminescence expression plasmid, pAKgfplux3, was constructed and mobilized to vAh. Catfish were challenged with BvAh using immersion, injection, and adipose fin clip procedures, and bioluminescence signal was tracked in live catfish during infection. We developed a novel BvAh strain for the first …

Comparative Genome Analysis Of Fish Pathogens In The Flavobacterium Genus, Salih Kumru

Theses and Dissertations

Aquaculture has potential to support the food supply of increasing world population. Flavobacterial diseases pose a serious problem in wild and aquacultured fish stocks throughout the world. Flavobacterium columnare, F. branchiophilum, and F. psychrophilum are well-known Flavobacterium species that cause important fish losses. Recently, new Flavobacterium species, isolated from diseased fish, have been reported, but their virulence mechanisms are not clear. Thus, the goal of this study was to understand pathogenicity of Flavobacterium species. To this goal, 86 Flavobacterium genomes were analyzed by comparative genomics. Predicted virulence genes were identified for all genomes. For each species, unique and shared virulence …

Writing A Moral Code: Algorithms For Ethical Reasoning By Humans And Machines, James F. Mcgrath, Ankur Gupta

Scholarship and Professional Work - LAS

The moral and ethical challenges of living in community pertain not only to the intersection of human beings one with another, but also our interactions with our machine creations. This article explores the philosophical and theological framework for reasoning and decision-making through the lens of science fiction, religion, and artificial intelligence (both real and imagined). In comparing the programming of autonomous machines with human ethical deliberation, we discover that both depend on a concrete ordering of priorities derived from a clearly defined value system.

An Expanded Toolkit For Gene Tagging Based On Mimic And Scarless Crispr Tagging In, David Li-Kroeger, Oguz Kanca, Pei-Tseng Lee, Sierra Cowan, Michael T Lee, Manish Jaiswal, Jose Luis Salazar, Yuchun He, Zhongyuan Zuo, Hugo J Bellen

Faculty, Staff and Students Publications

We generated two new genetic tools to efficiently tag genes in Drosophila. The first, Double Header (DH) utilizes intronic MiMIC/CRIMIC insertions to generate artificial exons for GFP mediated protein trapping or T2A-GAL4 gene trapping in vivo based on Cre recombinase to avoid embryo injections. DH significantly increases integration efficiency compared to previous strategies and faithfully reports the expression pattern of genes and proteins. The second technique targets genes lacking coding introns using a two-step cassette exchange. First, we replace the endogenous gene with an excisable compact dominant marker using CRISPR making a null allele. Second, the insertion is replaced …

Improve Effectiveness In Trauma Teamwork, Ginger Miramontes

Master's Projects and Capstones

On average, each Ventilator-Associated Event (VAE) is anticipated to increase the length of stay in the Intensive Care Unit (ICU), resulting in potential adverse events and cost to the organization. The Center for Disease Control (CDC) defines VAE as the increase of daily minimum positive end-expiratory pressure (PEEP) and fraction of inspired oxygen (FiO2) values, after a baseline period of patient stability or improvement on the ventilator (CDC, 2018). Standard endotracheal tube designs have led to the incidence of VAE because of the accumulation of subglottic secretions in the trachea. Untreated VAE can later result in Ventilator Associated Pneumonia (VAP). …

Promoting Adherence To Best Practice Related To Urine Reflex To Culture Testing, Maykel Verdecia Alonso Ba,Rn-Cphn

Nursing and Health Professions Faculty Research and Publications

Over a two week period, the infection control nurse, from a trauma designated facility located in norther California, planned a practice improvement project in collaboration with the laboratory microsystem to educate referring physicians and increase adherence to the Centers for Disease Control (CDC) protocol, which delineates recommended best practices related to urine reflex to culture testing. Urinalysis (UA) is a test that triggers a reflex urine culture when pyuria is present. Frequent urine culturing without the presence of pyuria can cause unnecessary treatment with antimicrobials. From January 2017 to December 2017, 10% of UAs from 200 urine samples from asymptomatic …

Teamworks, Metro Edition, 1999 November 2, Advocate Aurora Health

Aurora Health Care Books, Documents, and Pamphlets

Aurora Health Care, Milwaukee, WI: November 2, 1999 Metro Edition of Teamworks, a newsletter for Aurora Health Care Metro Region employees and volunteers. Article topics include Aurora Pulse action planning, St. Luke's organ transplant program, recent news and events in Aurora Metro region, JCAHO article series, service awards, Aurora Credit Union, and Aurora Libraries Intranet Site.

Effect Of Torpor On Host Transcriptomic Responses To A Fungal Pathogen In Hibernating Bats, Kenneth A. Field, Brent J. Sewall, Jenni M. Prokkola, Gregory G. Turner, Marianne Gagnon, Thomas M. Lilley, J Paul White, Joseph S. Johnson, Christopher L. Hauer, Deeann M. Reeder

Faculty Journal Articles

Hibernation, the use of prolonged torpor to depress metabolism, is employed by mammals to conserve resources during extended periods of extreme temperatures and/or resource limitation. Mammalian hibernators arouse to euthermy periodically during torpor for reasons that are not well understood and these arousals may facilitate immune processes. To determine if arousals enable host responses to pathogens, we used dual RNA‐Seq and a paired sampling approach to examine gene expression in a hibernating bat, the little brown myotis (Myotis lucifugus). During torpor, transcript levels differed in only a few genes between uninfected wing tissue and adjacent tissue infected with …

Exploring H.Pylori Seropositivity As A Risk Factor For Type 2 Diabetes, Virginia Chaidez, Yumou Qiu

Journal of Health Disparities Research and Practice

Background: In the US, the percentage of adults with diagnosed diabetes are higher in members of racial and ethnic minority groups compared to non-Latino Whites. Understanding why such disparities exist has been less forthcoming.

Methods: Secondary data analysis was conducted using the National Health and Nutrition Examination Survey (NHANES) 1999-2000 cross-sectional data.

Results: H.pylori seropositivity was highest in Mexican Americans (43.7%), lowest in non-Hispanic Whites (18.1%). Diabetes was highest in non-Hispanic Blacks (5.9%); lowest in non-Hispanic whites (4.3%). H.pylori seropositivity was associated with greater likelihood of having type 2 diabetes (1.927, 95% CI 1.142, 3.257) compared to H.pylori negative in …

Implementing A Pre-Exposure Prophylaxis Intervention For Safer Conception Among Hiv Serodiscordant Couples: Recommendations For Health Care Providers, Mari-Lynn Drainoni, Dea L. Biancarelli, Ashley A. Leech, Meg Sullivan, Angela R. Bazzi

Journal of Health Disparities Research and Practice

Couples in HIV serodiscordant relationships frequently desire children. Although partners who are virally suppressed pose almost no risk of transmitting HIV to their partners, partners who are inconsistently on therapy may transmit HIV to their partners when attempting to conceive. Pre-exposure prophylaxis (PrEP) is an available safer conception strategy for these couples but is not consistently offered. We sought to better understand barriers to PrEP implementation for couples seeking conception and patient perceptions on what providers could do to encourage use. We conducted in-depth, qualitative interviews with 11 participants representing six couples taking PrEP for safer conception in a safety-net …

Human Papillomavirus Infections In The Southern And Other United States Regions, Dudith Pierre-Victor, Mary Jo Trepka, Dionne Stephens, Tan Li, Timothy Page, Purnima Madhivanan

Journal of Health Disparities Research and Practice

Human papillomavirus (HPV) infection is the most common sexually transmitted infection worldwide and has been linked to several cancers, including cervical cancer. In the United States, the Southern region has a disproportionate burden of cervical cancer, and research about the epidemiology of HPV in the region is scarce. This study estimates the prevalence and correlates of HPV infection among 14–59 year-old females.

Data from 4,250 females aged 14–59 years collected during the 2007–2010 National Health and Nutrition Examination Survey (NHANES) were used. We estimated the prevalence of HPV infection for the South and the rest of the country. We performed …