Digital Commons Network^™

Mechanisms Adopted By Dengue-2 Viruses To Induce Autophagy In Mammalian Cells, Sounak Ghosh Roy

Dissertations, Theses, and Capstone Projects

Dengue, the most rapidly spreading flavivirus, threatens to affect almost half of the human global population. We previously showed that dengue-2 protects canine kidney cells (MDCK) from cytotoxic chemicals. We showed, independently, that cell protection, as well as viral replication and maturation, are positively regulated by PI3K-dependent autophagy. However, we had not identified the specific pathway that induces autophagy in infected cells. The current study explores the role of a specific branch of the endoplasmic reticulum (ER) stress-mediated Unfolded Protein Response (UPR), the PERK/eIF2α/ATF4 pathway in the induction of autophagy by …

New Use Of An Old Discourse Marker: The Interface Of Implicit Attitudes, Explicit Attitudes, And Rapid Language Change Of "So", Syelle Graves

Dissertations, Theses, and Capstone Projects

This dissertation investigates a linguistic feature called “backstory so,” defined as discourse marker so when it prefaces the answer to a question or request for information from an interlocutor. The motivation for its investigation is a collection of highly negative internet comments expressing irritation and insulting attitudes toward this use of so and the people who say it, calling them annoying, inarticulate, and condescending, for example. I also examine controversy in the (limited) literature about whether or not this language feature is new.

I therefore first present findings that this use of so is an instance of rapid language …

Invasive Community Acquired Methicillin-Resistant Staphylococcal Aureus (Ca-Mrsa) Infections In Children, Muhammad Khalid, Samina Junejo, Fatima Mir

Department of Paediatrics and Child Health

Staphylococci are gram-positive bacteria divided into coagulase positive and coagulase negative classes, Staphylococcus aureus is the most important bacterium of this class. Epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) has changed a lot. It is no more the problem of only hospitalised patients. Children coming from community has also been increasingly affected by MRSA-called community acquired methicillin-resistant (CA-MRSA) infection. The higher severity of CA-MRSA is due to its ability to produce the toxin Panton-Valentine Leukocidin (PVL) associated with staphylococcal cassette chromosome mec (SCCmec) type IV gene. Here, we are presenting five cases of CA-MRSA infection in children having age range 0.5 …

To Identify The Features Differentiating Peritoneal Tuberculosis From Carcinomatosis On Ct Scan Abdomen Taking Omental Biopsy As A Gold Standard, Farah Naz Farid, Waseem Akhtar, Nauman Hashmani, Raza Sayani

Department of Surgery Docs

OBJECTIVE:
To differentiate peritoneal tuberculosis from carcinomatosis on computed tomography scan of abdomen, taking omental biopsy as the gold standard.. METHODS:
This retrospective diagnostic accuracy review of cases was conducted at Aga Khan University Hospital, Karachi, and comprised patient's medical record files from February 2007 to February 2016. Computed tomography scan findings were compared with diagnosis made on the basis of histopathology. Multiple logistics regression analysis was done and sensitivity and specificity were tested through Pearson chi square test.
RESULTS:
Of the 98 patients identified, 62(63.2%)were found to be cases of disseminated tuberculosis and 36(36.7%) were diagnosed as malignant on …

Soci 270.01: Introduction To Development Sociology, Teresa R. Sobieszczyk

University of Montana Course Syllabi

No abstract provided.

Governance For A Changing Climate: Adapting Boston’S Built Environment For Increased Flooding, Stephanie Kruel, Rebecca Herst, David Cash

Sustainable Solutions Lab

As the impacts of climate change intensify, coastal cities like Boston face increasing threats from sea level rise, extreme precipitation, and storm surges. This report, produced by the Sustainable Solutions Lab at the University of Massachusetts Boston, examines the role of governance in preparing Boston’s built environment for these evolving risks. Building upon the foundational work of the Climate Ready Boston initiative, the report outlines critical governance functions necessary for climate adaptation, including institutional coordination, regulatory reform, community engagement, and data-driven decision-making. Emphasizing a multiscalar governance approach, it analyzes the tools available at local, regional, state, and federal levels and …

Social Capital – A “Super Connector” For Internationalization And Integration: The Role Of Hong Kong Universities In The Development Of The Greater Bay Area

Journal of Comparative & International Higher Education

No abstract provided.

Biol 368-H01: Ecology & Evolution Of Disease, Gareth Russell

Biology Syllabi

No abstract provided.

Patterns Of Infant Feeding Practices In The First Six Months Of Life In Fatema Al- Zahra Hospital In Baghdad, Kholod Dhaher Habib, Nagham Kadhum Tayeh, Wafaa Toma Hurmiz

Iraqi Postgraduate Medical Journal

ABSTRACT: BACK GROUND: Breastfeeding is of great benefits to the baby and mother in so many ways. Breastfeeding has been found to provide a measure of protection against the attacks of ear infections, upper respiratory infections, and gastrointestinal disorders. Breastfeeding has an emotional benefit by initiation of bonding between mother and baby .Knowledge of when and why women discontinue breastfeeding is of great important when make a plan aimed at increasing both the initiation and duration of breastfeeding. OBJECTIVE : This study was conducted to, 1. detect Patterns of breastfeeding practice during the first 6 months of life, 2.identify the …

Teaching Population Health: Innovations In The Integration Of The Healthcare And Public Health Systems, Rosemary M. Caron, Anne M. Hewitt, Julie H. Carmalt, Edmond A. Hooker

Faculty Publications

Population health is a critical concept in healthcare delivery today. Many healthcare administrators are struggling to adapt their organization from fee-for-service to value delivery. Payers and patients expect healthcare leaders to understand how to deliver care under this new model. Health administration programs play a critical role in training future leaders of healthcare organizations to be adaptable and effective in this dynamic environment. The purpose of this research was to: (a) engage current educators of health administration students in a dialogue about the best practices of integrating the healthcare and public health systems; (b) identify the content and pedagogy for …

Pedagogy: How To Best Teach Population Health To Future Healthcare Leaders, Rosemary M. Caron, Edmond A. Hooker, Anne M. Hewitt, Julie H. Carmalt

Faculty Publications

Our healthcare system is moving from a fee-for-service reimbursement model to one that provides payment for improvements in three areas related to care: quality, coordination, and cost. Healthcare organizations must use a population health approach when delivering care under this new paradigm. Health administration programs play a critical role in training future leaders of healthcare organizations to be adaptable and effective in this dynamic environment. The purpose of this research was to: (1) engage health administration educators in a dialogue about population health and its relevance to healthcare administration education; (2) describe pedagogical methods appropriate for teaching population health skills …

Outcomes Of Shoulder Arthroplasty Performed For Postinfectious Arthritis., Eric M. Padegimas, Thema A. Nicholson, Stephen Silva, Matthew L. Ramsey, Gerald R. Williams, Mark D. Lazarus, Surena Namdari

Rothman Institute Papers

Background: The purpose of this study was to evaluate the functional outcomes, infection rate, and complications associated with shoulder arthroplasty for sequelae of prior septic arthritis.

Methods: This is a retrospective cohort study of 17 patients who underwent shoulder arthroplasty for sequelae of septic arthritis. Patients were analyzed for patient-reported outcomes, complications, and reoperations.

Results: The 17 patients in this cohort were an average age of 65.4 ± 12.2 years old, were 58.8% male, and had an average body mass index of 27.9 ± 4.1 kg/m

Conclusions: Shoulder arthroplasty after septic arthritis had inconsistent functional outcomes and high complication rates …

Global Pretrial Detention Use: A Cross-National Analysis, Martin Schönteich

Dissertations, Theses, and Capstone Projects

To better understand global pretrial detention patterns, this study explores economic, political, and social factors associated with two measures of pretrial detention: the number of pretrial detainees as a rate of the general population, and the number of pretrial detainees as a proportion of the overall prison population. Through simple correlation analysis, stepwise regression, and moderation analyses, the study identifies factors which are most strongly associated with the two pretrial detention measures. The literature does not report any large-scale cross-national studies on pretrial detention. This study addresses this gap, focusing exclusively on pretrial detention using a large cross-national sample of …

Chikungunya Virus Associated Guillain-Barre Syndrome With Variable Presentation: A Case Series., Salman Farooq, Muhammad Imran, Ejaz Karim, Dureshahwar Kanwar, Muhammad Bilal Tariq

Pakistan Journal of Neurological Sciences (PJNS)

Chikungunya Virus Is A Mosquito-borne Alpha Virus Which Occasionally Causes Neurologic Complications Including Guillain-barre Syndrome, Myelitis, Myopathies And Encephalitis. Pakistan Experienced Its First Chikungunya Outbreak In The Metropolis Of Karachi Officially Confirmed By World Health Organization In December 2016. During This Outbreak, Over 30,000 People Have Been Reported To Be Infected In Different Parts Of Karachi. We Report Four Cases Of Chikungunya Virus Infection Associated Guillain-barre Syndrome Having An Atypical Clinical Presentation And Variable Outcome. Each Case Presented As A Different Variant Of Gbs Including Acute Inflammatory Demyelinating Polyneuropathy, Acute Motor And Sensory Axonal Neuropathy And Pharyngeal-cervical-brachial.

The Relationship Between Mortality And Microbiological Parameters In Febrile Neutropenic Patients With Hematological Malignancies, Şebnem Çalık, Alpay Arı, Oktay Bilgir, Tugba Cetintepe, Reyhan Yis, Ufuk Sonmez, Selma Tosun

Saudi Medical Journal

Objectives: To determine effective risk factors on mortality in febrile neutropenic cases with hematologic malignancy. Patients with hematologic diseases are more prone to infections and those are frequent causes of mortality. Methods: This retrospective study was performed using data of 164 febrile neutropenic cases with hematologic malignancies who were followed up in a hematology clinic of a tertiary health care center between 2011-2015. The relationship between descriptive and clinical parameters rates and rates of mortality on the 7 th and the 21 st days were investigated. Results: Patients with absolute neutrophil count<100/mm 3 , duration of neutropenia longer than 7 days, pneumonia or gastrointestinal foci of infection, central catheterization ( p =0.025), isolation of Gram (-) bacteria in culture, carbapenem resistance, septic shock, and bacterial growth during intravenous administration of antibiotic treatment were under more risk for mortality on both the 7 th and the 21 st days. The final multivariate logistic regression results showed that pneumonia ( p <0.0001), septic shock ( p =0.004) and isolation of Gram-negative bacteria ( p =0.032) were statistically significant risk factors. Conclusion: Early diagnosis and appropriate treatment of serious infections, which are important causes of morbidity and mortality, are crucial in patients with febrile neutropenia. Thus, each center should closely follow up causes of infection and establish their empirical antibiotherapy protocols to accomplish better results in the management of febrile neutropenia.

Influenza Virus Infectivity Is Retained In Aerosols And Droplets Independent Of Relative Humidity, Karen A. Kormuth, Kaisen Lin, Aaron J. Prussin, Eric P. Vejerano, Andrea J. Tiwari, Steve S. Cox, Micheal M. Myerburg, Seema S. Lakdawala, Linsey C. Marr

Faculty Publications

Pandemic and seasonal influenza viruses can be transmitted through aerosols and droplets, in which viruses must remain stable and infectious across a wide range of environmental conditions. Using humidity-controlled chambers, we studied the impact of relative humidity on the stability of 2009 pandemic influenza A(H1N1) virus in suspended aerosols and stationary droplets. Contrary to the prevailing paradigm that humidity modulates the stability of respiratory viruses in aerosols, we found that viruses supplemented with material from the apical surface of differentiated primary human airway epithelial cells remained equally infectious for 1 hour at all relative humidities tested. This sustained infectivity was …

Relationship Between Human Leukocyte Antigen Drb1 And Psoriasis In Iraqi Patients, Haider H. Zalzala, Galawish A. Abdullah, Mohammed Y. Abbas, Hyam R. Mohammedsalih, Batool M. Mahdi

Saudi Medical Journal

Objectives: To investigate the role of Human leukocyte antigen (HLA) Class II DRB1 in susceptibility to psoriasis in Iraqi patients. Methods: A cross-sectional comparative study including 40 patients with psoriasis attending the Department of Dermatology, Al-Kindy teaching hospital in Baghdad, Iraq, between September 2013-2015. Patient selection was carried out by the dermatologists. Ninety healthy individuals were included in the study. Human leukocyte antigen genotyping was carried out by the sequence specific oligonucleotide (SSO) method using Auto LiPA 48 (Innogenetics, Belgium) in the HLA typing research unit of the Al-Kindy College of Medicine, Baghdad, Iraq. Results: There is an increased frequency …

Phage Therapy And Development Of Delivery Systems For Gram-Positive Phage Endolysins, Jude Ajuebor

PhDs

This thesis focussed on Gram positive phages and their endolysins. Here, two similar kay-like staphylococcal phages B1 (vB_SauM_B1) and JA1 (vB_SauM_JA1) were isolated from a commercial therapeutic phage mix. Their host range was established on the Irish National MRSA bank, which included twenty one sequence types in addition relevant control strains. Based on this, distinct phages were identified and subjected to genome sequencing. The sequences were compared with the sequence of phage K (vB_SauM_K), which was also determined in this work. All three phages had a genome size of at least 139 kb, although some key differences were identified between …

Governance For A Changing Climate: Adapting Boston’S Built Environment For Increased Flooding, Stephanie Kruel, Rebecca Herst, David Cash

School for the Environment General Publications

Climate Change is impacting everything in our society and in our world. The changes we are already experiencing are starting to multiply and accelerate. Determining how to respond to this new reality wisely within the governance and governmental structures that we have built is a complex challenge. Some might argue it is humankind’s greatest test. Given the monumental size of this task, it is difficult to simultaneously address all of the related issues both broadly and deeply. This is the third and final in a series of reports from the Sustainable Solutions Lab that were sponsored by the Boston Green …

Development And Implementation Of A Mobile Device-Based Pediatric Electronic Decision Support Tool As Part Of A National Practice Standardization Project, Russell J. Mcculloh, Sarah Fouquet, Joshua Herigon, Eric A. Biondi, Brandan Kennedy, Ellen Kerns, Adrienne G. Deporre, Jessica L. Markham, Y Raymond Chan, Krista Nelson, Jason G. Newland

Manuscripts, Articles, Book Chapters and Other Papers

© The Author(s) 2018.

Objective: Implementing evidence-based practices requires a multi-faceted approach. Electronic clinical decision support (ECDS) tools may encourage evidence-based practice adoption. However, data regarding the role of mobile ECDS tools in pediatrics is scant. Our objective is to describe the development, distribution, and usage patterns of a smartphone-based ECDS tool within a national practice standardization project.

Materials and Methods: We developed a smartphone-based ECDS tool for use in the American Academy of Pediatrics, Value in Inpatient Pediatrics Network project entitled "Reducing Excessive Variation in the Infant Sepsis Evaluation (REVISE)." The mobile application (app), PedsGuide, was developed using evidence-based …

September 2018 News Releases, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.

Letting Go: Conceptualizing Intervention De-Implementation In Public Health And Social Service Settings, Virginia R Mckay, Alexandra B Morshed, Ross C Brownson, Enola K Proctor, Beth Prusaczyk

Open Access Publications

The discontinuation of interventions that should be stopped, or de-implementation, has emerged as a novel line of inquiry within dissemination and implementation science. As this area grows in human services research, like public health and social work, theory is needed to help guide scientific endeavors. Given the infancy of de-implementation, this conceptual narrative provides a definition and criteria for determining if an intervention should be de-implemented. We identify three criteria for identifying interventions appropriate for de-implementation: (a) interventions that are not effective or harmful, (b) interventions that are not the most effective or efficient to provide, and (c) interventions that …

Neurological Complications In Patients With Plasmodium Vivax Malaria From Karachi, Pakistan, Mohammad Asim Beg, A Akhlaq, Najia Karim Ghanchi, B Usmani, R Shahzad, A Rahim, Mohammad Wasay

Department of Pathology and Laboratory Medicine

Background: Malaria remains an endemic disease in Pakistan with an estimated healthcare burden of 1.6 million cases annually, with Plasmodium vivax accounting for 67% of reported cases. P. vivax is the most common species causing malaria outside of Africa, with approximately 13.8 million reported cases worldwide.
Method: We report a series of P. vivax cases with cerebral involvement that presented at Aga Khan University Hospital, Karachi, Pakistan.
Results: The majority of the patients presented with high-grade fever accompanied by projectile vomiting and abnormal behaviour, seizures, shock and unconsciousness. Seven of 801 patients with P. vivax monoinfection presented or developed cerebral …

Designing For Sustainable Outcomes: Espousing Behavioral Change Into Co-Production Programs, Ishani Mukherjee, Nilanjana Mukherjee

Research Collection School of Social Sciences

This paper uses a policy design perspective with which to examine the formulation of programmes that are based on the concept of co-production. In doing so, the paper reviews essential literature on policy design and co-production to identify that a limited focus on outcomes and specifically how behavioural change can make these outcomes sustainable represents a major gap in the current discussion of co-production. We firstly argue that in designing programmes involving co-production, outcomes need to be considered at the initial design stages where broad policy objectives are being defined. Secondly, we argue that for these outcomes to be sustainable, …

Fungal Osteomyelitis In A Patient With Chronic Granulomatous Disease: Case Report And Review Of The Literature, Muhammad Khalid, Syed Asad Ali

Department of Paediatrics and Child Health

Chronic granulomatous disease (CGD) is the most common of the primary immunodeficiency in children. It is caused by single gene defect resulting in dysfunctional nicotinamide adenine dineucleotide phosphate (NADPH) oxidase complex causing recurrent bacterial and fungal infections. Here we present the case of a 9 year old boy who was a known case of CGD since three years of age. He presented with recent history of fever, left sided pain in the scapular region and difficulty in breathing. Chest imaging revealed developing left upper lobe consolidation and erosion of the 3rd posterior rib. The child underwent video assisted thoracoscopic surgery …

Pathophysiology Of Environmental Enteric Dysfunction And Its Impact On Oral Vaccine Efficacy, Chelsea Marie, Syed Asad Ali, Kanta Chandwe, William Petri Jr A, Paul Kelly

Department of Paediatrics and Child Health

Environmental enteric dysfunction (EED) refers to a subclinical disorder of intestinal function common in tropical countries and in settings of poverty and economic disadvantage. The enteropathy that underlies this syndrome is characterized by mucosal inflammation and villus blunting mediated by T cell activation. Epithelial cell disruption and microbial translocation drive systemic inflammation. EED in young children is associated geographically with growth failure, malnutrition, and greatly impaired responses to oral vaccines, notably rotavirus and poliovirus vaccines. In this review, we describe the pathophysiology of EED and examine the evidence linking EED and oral vaccine failure. This evidence is far from conclusive. …

Swine First Aid, Basic Care, And Common Diseases In Show Hogs, Flip Booklet, Karah Nay, Dennis Worwood, Kerry A. Rood

All Current Publications

This flip book provides guidelines for swine first aid, basic care, and common diseases of show hogs.

Sex Offender Civil Commitment To Prison Post-Kingsley, Arielle W. Tolman

Northwestern University Law Review

Today, an estimated 5400 people are civilly committed under state and federal sex offender programs. This Note surveys these civil commitment regimes and finds that seventeen jurisdictions (sixteen states and the federal government) have enacted legislative schemes that authorize the indefinite civil detention of people charged with, or previously convicted of, sex offenses to prisons or prison-like facilities—often for their entire lives. By charting the pervasiveness of sex offender civil commitment to prison, this Note provides new evidence that these sex offender civil commitment statutes are, in fact, punitive and, therefore, unconstitutional. Moreover, this Note argues that the Supreme Court’s …

Efficacy Of Rotavirus Vaccination In Prevention Of Hospital Admission Of Gastroenteritis Among Children Under Two Years Of Age, Saba Abbas Fadhil, Suzan Salam M. Hussein, Raed Yehya Salman

Iraqi Postgraduate Medical Journal

ABSTRACT: BACKGROUND: Rotavirus is the most common cause of acute gastroenteritis in children. OBJECTIVE : To find out the efficasy of rotavirus vaccine in prevention or reduce the number of cases and hospital admission of gastroenteritis among children under two years of age. PATIENTS AND METHODS: A cross-sectional study was conducted in Central Teaching Hospital of Pediatric in Baghdad,from the first of February to 31st of May 2016,on a total of(524) child under two years of age, grouped into two groups,first group(260)vaccinated with rotavirus vaccine,second group(264)non-vaccinated. RESULTS: According to development of gastroenteritis and vaccination state of rotavirus vaccine,the acute gastroenteritis …

Microbiological And Clinical Profile Of Infective Endocarditis Patients: An Observational Study Experience From Tertiary Care Center Karachi Pakistan, Uzma Shahid, Hasanat Sharif, Joveria Farooqi, Bushra Jamil, E. Khan

Department of Pathology and Laboratory Medicine

Background:
The study analyzed microbiological and antimicrobial susceptibility profile of organisms isolated from patients with infective endocarditis (2015–17) and compared disease outcomes in cohorts of endocarditis patient with history of prior invasive vascular intervention (high risk group) vs those without (native valve group). We hypothesized that high risk group would be more likely to have severe disease outcomes.
Methods:
This was a prospective cohort study (2015–17). All blood and cardiac tissue samples of enrolled patients suspected of endocarditis according to modified Duke’s criteria were followed for microbiological and antimicrobial susceptibility profile. The high risk group was compared with the native …