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Understanding Why Women Stay: Examining Persistence Factors Of Women Majoring In Science And Technology Programs In Public Ethiopian Universities Using A Mixed Methods Design, Meseret Hailu

Electronic Theses and Dissertations

Amongst African nations, Ethiopia is a unique case in many respects. The country has the second largest population on the continent, is currently experiencing an economic boom, and is a relatively stable nation in the geopolitically volatile "Horn of Africa" region. In the past two decades, the higher education sector in Ethiopia has experienced rapid growth, as evidenced by an increase in both student enrollment and the number of universities. Amongst the various types of higher education institutions, public universities are especially important because they receive the greatest financial support from the Ministry of Education. Moreover, science and technology programs …

Gender Differences In Perceived Stigma Among Sexual Minorities And Their Related Health Practices, Sara Kay Richardson

Dissertations and Theses @ UNI

Stigma, which is partially determined by social norms within specific cultures, can affect individuals in many ways such as direct negative treatment and discrimination as well as medical, social, and psychological disadvantages and problems. Lesbian women, gay men, bisexuals, and pansexuals have endured a long history of stigmatization in the United States (Herek, 1991). There is further evidence suggesting that bisexuals are especially susceptible to stigmatization, not only from heterosexuals (Herek, 2002), but from lesbian women and gay men as well (Ochs, 1996). I hypothesized that among sexual minorities men would report higher levels of perceived stigma than would women, …

Influenza Infection Directly Alters Innate Il-23 And Il-12p70 And Subsequent Il-17a And Ifn-Γ Responses To Pneumococcus In Vitro In Human Monocytes, Sinead T. Loughran, Patrick A. Power, Paula T. Maguire, Samantha L. Mcquaid, Paul J. Buchanan, Ingileif Jonsdottir, Robert W. Newman, Ruth Harvey, Patricia A. Johnson

Articles

It is well accepted that influenza A virus predisposes individuals to often more severe super-infections with Streptococcus pneumonia. However, the mechanisms that lead to this synergy are not clearly understood. Recent data suggests that competent Th17 immunity is crucial to clearance and protection from invasive pneumococcal disease of the lung. We demonstrate that early influenza infection significantly reduced levels of pneumococcus driven IL-12p70, IL-23 and IL-27 in human monocytes with significant impairment of IL-17A and IFN-γ in HKSP-treated allogeneic mixed lymphocyte cultures. We also provide evidence to suggest that the hemagglutinin component of the virus is at least partially responsible …

Epidemiological Model Of The Transmission And Spread Of Hepatitis B Pandemic In Ghana, Kwaafo Akoto Awuah-Mensah

Theses: Doctorates and Masters

The world's attention to the burden and spread of hepatitis B has increased signicantly in the recent past. A number of interventions by way of treatment and immunisation have been initiated to fight the pandemic, especially in high prevalence regions such as Africa and Asia. Lack of good quality information about hepatitis B is a major hindrance to policy direction and comprehensive implementation of interventions in Sub-Saharan Africa designated as an endemic region. Limited studies on hepatitis B, coupled with lack of adequate health care systems and infrastructure, have led to ignorance or misconceptions and stigmatisation about the disease and …

Bowel Sounds Identification And Migrating Motor Complex Detection With Low-Cost Piezoelectric Acoustic Sensing Device, Xuhao Du, Gary Allwood, Katherine Mary Webberley, Adam Osseiran, Barry J. Marshall

Research outputs 2014 to 2021

Interpretation of bowel sounds (BS) provides a convenient and non-invasive technique to aid in the diagnosis of gastrointestinal (GI) conditions. However, the approach’s potential is limited by variation between BS and their irregular occurrence. A short, manual auscultation is sufficient to aid in diagnosis of only a few conditions. A longer recording has the potential to unlock additional understanding of GI physiology and clinical utility. In this paper, a low-cost and straightforward piezoelectric acoustic sensing device was designed and used for long BS recordings. The migrating motor complex (MMC) cycle was detected using this device and the sound index as …

Early Diagnosis And Nutritional Treatment Stabilizes Neuropsychiatric Disorders, Ian James Martins

Research outputs 2014 to 2021

The reliable diagnostic identification of neuropsychiatric disorders such as schizophrenia, bipolar disease, and depression has been associated with some biological markers (genomics, proteomics, metabolomics) but to date, these markers do not have the sensitivity/specificity of a diagnostic test. Biomarker tests that are relevant to global chronic disease are now applicable to neuropsychiatric diseases to prevent autoimmune disease, endoplasmic reticulum stress associated mitophagy with relevance to neuron apoptosis. Metabolic abnormalities has been linked to neuropsychiatric disorder with the careful nutritional assessment of patients reported in many published studies. Early interventions with genomic medicine now assist in the prevention of autoimmune disease …

Socio-Economic Predictors And Distribution Of Tuberculosis Incidence In Beijing, China: A Studyusing A Combination Of Spatial Statistics And Gis Technology, Gehendra Mahara, Kun Yang, Sipeng Chen, Wei Wang, Xiuhua Guo

Research outputs 2014 to 2021

Evidence shows that multiple factors, such as socio-economic status and access to health care facilities, affect tuberculosis (TB) incidence. However, there is limited literature available with respect to the correlation between socio-economic/health facility factors and tuberculosis incidence. This study aimed to explore the relationship between TB incidence and socio-economic/health service predictors in the study settings. A retrospective spatial regression analysis was carried out based on new sputum smear-positive pulmonary TB cases in Beijing districts. Global Moran’s I analysis was adopted to detect the spatial dependency followed by spatial regression models (spatial lag model, and spatial error model) along with the …

Unravelling Immunoglobulin G Fc N-Glycosylation: A Dynamic Marker Potentiating Predictive, Preventive And Personalised Medicine, Alyce Russell, Eric Adua, Ivo Ugrina, Simon Laws, Wei Wang

Research outputs 2014 to 2021

Multiple factors influence immunoglobulin G glycosylation, which in turn affect the glycoproteins’ function on eliciting an anti-inflammatory or pro-inflammatory response. It is prudent to underscore these processes when considering the use of immunoglobulin G N-glycan moieties as an indication of disease presence, progress, or response to therapeutics. It has been demonstrated that the altered expression of genes that encode enzymes involved in the biosynthesis of immunoglobulin G N-glycans, receptors, or complement factors may significantly modify immunoglobulin G effector response, which is important for regulating the immune system. The immunoglobulin G N-glycome is highly heterogenous; however, it is …

Randomised Controlled Trial Comparing Daily Versus Depot Vitamin D3 Therapy In 0-16-Year-Old Newly Settled Refugees In Western Australia Over A Period Of 40 Weeks, Ushma D. Wadia, Wayne Soon, Paola T. Chivers, Aesen Thambiran, David P. Burgner, Sarah Cherian, Aris Siafarikas

Research outputs 2014 to 2021

Vitamin D deficiency is highly prevalent in newly settled refugees in Western Australia (WA). If adherence to daily vitamin D therapy is problematic, depot therapy is a therapeutic alternative. The aim of this studywas to compare daily versus depot treatment and factors influencing the therapeutic outcome. Newly settled refugees (n = 151) with 25(OH)D levels less than 78 nmol/L were randomised to receive daily or depot vitamin D therapy with eight weekly interval follow up to 40 weeks. Biochemical and clinical parameters were collected at each visit. Generalized LinearMixedModels (GLMM) examined the longitudinal changes over time controlling for confounders including …

The Epidemiology Of Clostridium Difficile Infection In Japan: A Systematic Review, Thomas V. Riley, Tomomi Kimura

Research outputs 2014 to 2021

To increase understanding of the epidemiology, risks, consequences and resource utilization of Clostridium difficile infection (CDI) in Japan, a systematic literature review was undertaken of relevant publications from January 2006 to November 2017. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and methods, 55 articles met the criteria for full review. The majority (58%) of studies were from a single site, with the most recent data from 2015. The incidence, reported prevalence and recurrence rate of CDI in Japan were 0.8–4.71/10,000 patient-days, 0.3–5.5/1000 patients and 3.3–27.3%, respectively, and varied according to setting, population, CDI definition and …

A Perspective On Incentives For Novel Inpatient Antibiotics: No One-Size-Fits-All, Taimur Bhatti, Ka Lum, Silas Holland, Stephanie Sassman, David Findlay, Kevin Outterson

Faculty Scholarship

The need for new “pull” incentives to stimulate antibiotic R&D is widely recognized. Due to the global diversity of health systems, combined with different challenges faced by antibiotics used in different types of healthcare settings, there is no one-size-fits-all solution. Instead, different “pull” incentives should be tailored to local contexts, priorities, and antibiotic types. Policymakers and industry should collaborate to identify appropriate solutions at the local, regional, and global levels.

Actual Vs. Perceived Hiv Testing Norms, And Personal Hiv Testing Uptake: A Cross-Sectional, Population-Based Study In Rural Uganda, Jessica M. Perkins, Viola N. Nyakato, Bernard Kakuhikire, Pamela K. Mbabazi, H. Wesley Perkins, Alexander C. Tsai, Sv Subramanian, Nicholas A. Christakis, David Bangsberg

OHSU-PSU School of Public Health Faculty Publications and Presentations

HIV testing is an essential part of treatment and prevention. Using population-based data from 1664 adults across eight villages in rural Uganda, we assessed individuals’ perception of the norm for HIV testing uptake in their village and compared it to the actual uptake norm. In addition, we examined how perception of the norm was associated with personal testing while adjusting for other factors. Although the majority of people had been tested for HIV across all villages, slightly more than half of men and women erroneously thought that the majority in their village had never been tested. They underestimated the prevalence …

Diagnostic Performance Of Blood Inflammatory Markers For Tuberculosis Screening In People Living With Hiv, Katherine Farr, Resmi Ravindran, Luke Strnad, Emily Chang, Leah H. Chaisson, Christina Yoon, William Worodria, Alfred Andama, Irene Ayakaka, Priscilla Bbosa Nalwanga, Multiple Additional Authors

OHSU-PSU School of Public Health Faculty Publications and Presentations

Background

Approaches to screening for active tuberculosis (TB) among people living with HIV are inadequate, leading to missed diagnoses and poor implementation of preventive therapy.

Methods

Consecutive HIV-infected adults hospitalized at Mulago Hospital (Kampala, Uganda) between June 2011 and July 2013 with a cough ≥ 2 weeks were enrolled. Patients underwent extensive evaluation for pulmonary TB. Concentrations of 43 cytokines/chemokines were measured at the same time point as C-reactive protein (CRP) in banked plasma samples using commercially-available multiplex kits. Advanced classification algorithms were used to rank cytokines/chemokines for their ability to identify TB, and to model the specificity of the …

You Be The Judge: The Wholesale Implementation Of Bail Schedules By The Judiciary As An Abdication Of Adjudicatory Responsibility Creating A Disparate Impact For African-Americans And Hispanics Accused Of A Criminal Offense, Taurus Myhand

Scholarly Works

The presumption of innocence is not well illustrated in the age-old and widespread use of monetary bail systems by most jurisdictions throughout the United States. In fact, whether a person is detained in jails prior to the final disposition of the case, is not likely to be dependent on the strength of the government’s case toward proving the accusee’s guilt. Rather, pre-trial detention is much more dependent on whether the accusee has the means to pay an amount of money determined by a court.

As the calls for bail reform resurges, many legal professionals are looking for alternatives to monetary …

Winter 2018 Som Alumni Connections, New York Medical College

School of Medicine

• SOM Launches Bench-to-Bedside Seminar Series
• School of Medicine Alumni Celebrate at Reunion Weekend
• Gladys M. Ayala, M.D., M.P.H., is Named Interim Vice Dean for the School of Medicine
• School of Medicine Class of 2021 Officially Dons White Coats for the First Time
• Department of Pediatrics and the Children's Health and Research Foundation Hosts Seventh Annual Assistant Professor Pediatric Research Symposium
• The Music of Mozart Comes Alive at Met
• NYMC Pride Shines at Founder's Dinner
• NYMC Receives $150,000 Grant from Hyundai Hope On Wheels
• Symposium Focuses on Tick-Borne Disease
• Alumni Community Website to Launch January 2018

Multiple Acquisitions Of Pathogen-Derived Francisella Endosymbionts In Soft Ticks, Jonathan G. Gerhart, H. Auguste Dutcher, Amanda E. Brenner, Abraham S. Moses, Libor Grubhoffer, Rahul Raghavan

Biology Faculty Publications and Presentations

Bacterial endosymbionts of ticks are of interest due to their close evolutionary relationships with tick-vectored pathogens. For instance, whereas many ticks contain Francisella-like endosymbionts (FLEs), others transmit the mammalian pathogen Francisella tularensis. We recently sequenced the genome of an FLE present in the hard tick Amblyomma maculatum (FLE-Am) and showed that it likely evolved from a pathogenic ancestor. In order to expand our understanding of FLEs, in the current study we sequenced the genome of an FLE in the soft tick Ornithodoros moubata and compared it to the genomes of FLE-Am, Francisella persica—an FLE in the soft tick Argus (Persicargas) …

Identification Of Novel Mites (Miniature Inverted-Repeat Transposable Elements) In Coxiella Burnetii: Implications For Protein And Small Rna Evolution, Shaun Wachter, Rahul Raghavan, Jenny Wachter, Michael F. Minnick

Biology Faculty Publications and Presentations

Background: Coxiella burnetii is a Gram-negative gammaproteobacterium and zoonotic agent of Q fever. C. burnetii’s genome contains an abundance of pseudogenes and numerous selfish genetic elements. MITEs (miniature invertedrepeat transposable elements) are non-autonomous transposons that occur in all domains of life and are thought to be insertion sequences (ISs) that have lost their transposase function. Like most transposable elements (TEs), MITEs are thought to play an active role in evolution by altering gene function and expression through insertion and deletion activities. However, information regarding bacterial MITEs is limited. Results: We describe two MITE families discovered during research on small non-coding …

Connecting Chemistry To Community With Deliberative Democracy, Regis Komperda, Jack Barbera, Erin Shortlidge, Gwen Shusterman, Stem Education And Equity Institute, Portland State University

Biology Faculty Publications and Presentations

Science education communities have called for rethinking curricula to improve student understanding of the nature of science and the role of science in addressing controversial modern issues such as climate change, energy policy, and pollution levels. One approach to meeting this call is integrating these topics into class activities that require students to use discussion and scientific approaches to solve problems and deliberate potential policy solutions. Deliberative democracy (DD) is one such active learning approach in which students work in peer groups to reach a consensus on a scientific topic relevant to both real-world issues and course content. During DD …

Application Of Microrna Markers For Early Detection Of Latent Tuberculosis Transitioning To Active Tuberculosis, Robert A. Ollar

NYMC Faculty Publications

No abstract provided.

Stress And Frailty In Medieval Prussia: Interpretations From Skeletal Remains At Bezławki, Katherine E. Gaddis

Cal Poly Humboldt theses and projects

Health is routinely studied in living populations using quantifiable measurements such as allostatic load and frailty. In recent years, particularly since the introduction of the osteological paradox, there has been increased interest among bioarchaeologists in how these concepts can be applied to the study of health in past populations. Although health is not directly observable in skeletal remains, assessment of frailty can be useful for understanding the implications of long-term exposures to stress on well-being and mortality. This study builds upon past research in this area by incorporating commonly observed indicators of physiological stress, such as dental disease and osteoarthritis, …

The Effects Of Descending Resistance Sets Compared To Constant Resistance Sets On The Volume Completed During A High Intensity Free Weight Back Squat Exercise, Jason E. Meyer

Cal Poly Humboldt theses and projects

Improving anabolic hormone production is an important training adaptation in resistance training; however, no previous research has developed optimized descending resistance sets to increase training volume. The purpose of this research was to compare two different loading protocols of constant resistance sets (CRS) and descending resistance sets (DRS) on the free weight back squat. Eleven resistance trained male participants (mean ± SD, age = 22 ± 3 yr, and back squat 1RM ratio (1RM/body weight) = 1.65 ± 0.2) completed 4 experimental sessions over 2 weeks, during which 4 sets of the back squat were performed with 85% 1RM and …

New Medical Indications For Thalidomide And Its Derivatives, Chaya Newfield

The Science Journal of the Lander College of Arts and Sciences

Thalidomide is an anti-inflammatory and an anti-angiogenesis drug that is being used around the world for a variety of malignant and inflammatory diseases. Is it justified to continue prescribing and developing thalidomide given the discovery of many well-known side effects including catastrophic birth defects? To answer this question, this paper will discuss the pharmacology and history of thalidomide, as well as many of its proposed mechanisms of action.The medical indications for the current use of thalidomide as well as for several newer and more potent derivatives are mentioned for their therapeutic results, as well as their adverse side effects.

Xenotransplantation:The Science, The Advantages, The Ethics, Chana Erlbaum

The Science Journal of the Lander College of Arts and Sciences

Xenotransplantation is a breakthrough medicinal technology that is an attempt to change the lives of millions of people. The problems in the current organ transplant system risk the lives of patients each and every day. Intense waiting periods and extremely costly procedures exemplify the stress and pressure that these patients face as an attempt to save their own lives. Xenotransplantation is the idea of growing human organs in a different species, using incredible stem-cell and CRISPR technology. This can introduce an answer to some of the issues in the current transplant system. Many technical and ethical issues are becoming relevant …

Proceedings Of The Cuny Games Conference 4.0: The Interactive Course, Robert O. Duncan, Joe Bisz, Julie Cassidy, Kathleen Offenholley, Maura A. Smale, Carolyn Stallard, Deborah Sturm, Anders A. Wallace, Cuny Games Network

Publications and Research

Proceedings of the CUNY Games Conference, held from January 22-23, 2018, at the CUNY Graduate Center and Borough of Manhattan Community College.

Critical Play with History (Panel) - Composition & Storytelling - Health & Cognitive Sciences - Gaming Anthropology: Teaching Culture and Power Through Games and Design (Panel) - Twine & Writing Games - Easy Ideas II - STEM Games - Global Games for Change Catalog (Panel) - Comics & Active Learning - Fact Checking & Research - Computer Science & Game Design - SimGlobal: Building a Serious Roleplay Course for the Social Sciences (Panel) - Role Playing Games, Narrative, …

The Effects Of Maternal Diet On Passive Transfer Of Immunity To The Neonatal Beef Calf, And Calf Immune Response To Vaccination And Immunostimulants, James Joseph Gaspers

Animal Sciences

To investigate the effects of maternal diet on passive transfer of immunity to the neonatal beef calf, and calf immune response to vaccination and immunostimulants, three experiments (Exp.) were completed. Results from Exp. 1 indicated that there was no effect of supplemental starch to cows on colostrum production, offspring birth weight, incidence of dystocia, respiratory acidosis, and the passive transfer of immunity. Results from Exp. 2 indicated that both the needle – free injection devices (NFs) and needle and syringe (NS) initiate a haptoglobin (Hp) inflammatory response (P < 0.001). After injection bovine viral diarrhea virus (BVDV) type 2 antibody titers continually declined from d 0, 7, 28, and 115 across both NS and NF treatment groups (P < 0.001). After secondary booster vaccination on d 115, BVDV type 2 antibody titers significantly increased by d 143 (P < 0.001). The use of NFs will maintain a level of immunity that has been seen by the use of conventional NS vaccine administration methods. In Exp. 3, treatments containing a modified live vaccine (MLV) antigen initiated an Hp inflammatory response over time (P < 0.001). Interferon gamma was not significantly different across treatment over time (P = 0.39); however, there was a threefold increase in treatment three over time. Treatments containing a MLV BVDV antigen maintained BVDV type 2 antibodies over time (P <0.001). Feed intake and feeding behavior were unaffected by the use of the vaccine and/or immunostimulant.

Epithelial Cell Lysates Induce Exos Expression And Secretion By Pseudomonas Aeruginosa, Victoria Hritonenko, Matteo Metruccio, David J. Evans, Suzanne Fleiszig

Faculty Publications & Research of the TUC College of Pharmacy

No abstract provided.

Il-1r And Myd88 Contribute To The Absence Of A Bacterial Microbiome On The Healthy Murine Cornea, Stephanie J. Wan, Aaron B. Sullivan, Peyton Shieh, Matteo M. E. Metruccio, David J. Evans, Carolyn R. Bertozzi, Suzanne M. J. Fleiszig

Faculty Publications & Research of the TUC College of Pharmacy

Microbial communities are important for the health of mucosal tissues. Traditional culture and gene sequencing have demonstrated bacterial populations on the conjunctiva. However, it remains unclear if the cornea, a transparent tissue critical for vision, also hosts a microbiome. Corneas of wild-type, IL-1R (-/-) and MyD88 (-/-) C57BL/6 mice were imaged after labeling with alkyne-functionalized D-alanine (alkDala), a probe that only incorporates into the peptidoglycan of metabolically active bacteria. Fluorescence in situ hybridization (FISH) was also used to detect viable bacteria. AlkDala labeling was rarely observed on healthy corneas. In contrast, adjacent conjunctivae harbored filamentous alkDala-positive forms, that also labeled …

Against Seminal Principles: Ethics, Hubris, And Lessons To Learn From Illicit Inseminations, Jody L. Madeira, Steven R. Lindheim Md, Mark V. Sauer Md

Articles by Maurer Faculty

This short essay addresses the ethical implications of Illicit inseminations, instances of fertility fraud in which a physician uses his own gametes to impregnate a patient.

Does Enforcement Reduce Voluntary Tax Compliance?, Leandra Lederman

Articles by Maurer Faculty

Governments generally use enforcement methods, such as audits and the imposition of penalties, to deter noncompliance with tax laws. Although this approach is consistent with most economic modeling of tax compliance, some scholars caution that enforcement may backfire, “crowding out” taxpayers’ intrinsic motivations to pay taxes to such an extent that they reduce their tax payments. This article analyzes the existing evidence to determine if this occurs. In fact, field studies suggest that enforcement tools, such as audits, are effective deterrents, generally greatly increasing tax collections. A few recent studies have found that audits have a negative effect on the …

The Cryopreservation Of Human Semen, And Subsequent Evaluation Of A Commercially-Available Device To Isolate Motile Sperm, Callum Andrew Robinson

Theses: Doctorates and Masters

The cryopreservation of human semen is a vital asset in assisted reproductive technologies (ART). Although advances have been in the freezing of sperm, further refinement is both necessary and ongoing. Computer-assisted semen analysis (CASA) has been increasingly utilised in both research and diagnostic however there are a range of variables that must first be controlled in order to produce reliable measurements. Following thawing, sperm must be isolated from both the original seminal plasma and the cryoprotectants; the two most used isolation methods include density gradient centrifugation (DGC) and the swim-up method.

The present thesis sought to investigate the following areas …