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Interferon Gamma And Interleukin 8 Gene Polymorphisms In Patients With Hepatitis C Virus Related Oral Lichen Planus, Enji Ahmed Mahmoud, Noha Adel Azab, Lobna Abdelsalam, Marwa Elsharkawy, Aisha Elsharkawy, Shahira Elashiry

Dentistry

Objectives: This study aimed to determine the association of rs2430561 and rs4073 polymorphisms in the Interferon gamma (IFN-ɤ) and Interleukin 8 (IL-8) genes, respectively, with hepatitis C virus-related oral lichen planus and disease severity. Design: This is a case-control study. 60 subjects were equally divided into patients with and without oral lichen planus. They were further subdivided into hepatitis C virus seropositive and seronegative patients. All patients were genotyped for IFN-γ rs2430561 thymine to adenine (T > A) and IL-8 rs4073 adenine to thymine (A > T) polymorphisms. All patients with oral lichen planus had their lesions measured and documented using the …

Role Of Hepcidin In The Diagnosis Of Sepsis And Septic Shock In Children, Osman Yeşi̇lbaş, Esra Şevketoğlu, Burcu Bursal Duramaz, Hasan Serdar Kihtir, Asuman Gedi̇kbaşi, Mey Tali̇p Petmezci̇, Canan Baydemi̇r

Turkish Journal of Medical Sciences

Background/aim: The purpose of this study is to compare the diagnostic value of hepcidin level with the white blood cell (WBC), C-reactive protein (CRP), procalcitonin (PCT), and interleukin-6 (IL-6) levels in pediatric sepsis and septic shock. Materials and methods: A cohort of 89 individuals were divided into four groups: a healthy control group (HCG, n = 28), pediatric intensive care unit control group (PICUCG, n = 17), sepsis group (SG, n = 23), and septic shock group (SSG, n = 21). WBC, CRP, PCT, IL-6, and hepcidin levels were studied in the PICUCG, SG, and SSG, while hepcidin and IL-6 …

Investigation Of The Effect Of Ss-Lactam Antibiotics And Serum On Growth And Gene Expression In Escherichiacoli Strain Jj1886, Eli̇f Bozçal Dağdevi̇ren

Turkish Journal of Medical Sciences

Background/aim: ß-Lactamase-producing Escherichia coli strain JJ1886 is an epidemic clone with high virulence properties. Because this strain can survive in the bloodstream, we aimed here to understand how ß-lactam antibiotics and human serum affect the growth and gene expression of this bacterium. Materials and methods: We report the time-dependent growth effect of normal human serum and heat-inactivated serum, together with ß-lactam antibiotics (including cefotaxime, ceftazidime, and carbenicillin), for E. coli strain JJ1886. Relative gene expression of ß-lactamase-related genes (encoding the ß-lactamase regulator, CTX-M-15, and peptidoglycan glycosyltransferase) and serum survival- associated genes (encoding lipoprotein NlpI, murein lipoprotein, lipopolysaccharide core heptose (I) …

Algorithms Used To Identify Ventricular Arrhythmias And Sudden Cardiac Death In Retrospective Studies: A Systematic Literature Review, Yizhou Ye, Paul Larrat, Aisling R. Caffrey

Pharmacy Practice and Clinical Research Faculty Publications

Drug-induced QT interval prolongation may increase the risk of sudden cardiac death or ventricular arrhythmias (SCD/VA), and therefore affects the safety profile of medications. Administrative databases can be used to inform pharmacoepidemiologic drug safety studies for such rare events. In order to compare event rates between studies, validated operational definitions of these events are needed. We conducted a systematic literature review in PubMed to identify algorithms for SCD/VA. Twenty-two studies were included in the review. Fifteen (68%) studies evaluated International Classification of Diseases, 9th revision (ICD-9) based medical data, of which six utilized a common, validated operational definition. This algorithm …

1829. A Systems Approach To Nursing Home Antimicrobial Stewardship, Stefan Gravenstein, Manning, Rosa R. Baier, Christopher Crnich, H. Edward Davidson, Kerry L. Laplante, David Dosa, Robin Jump

Pharmacy Practice and Clinical Research Faculty Publications

Background: Up to 70% of nursing home (NH) residents receive one or more courses of antibiotics (ATB) annually, of which over half may be inappropriate and risk harm. The current availability of in-house NH data is often insufficient to measure and track appropriateness, due to incomplete data or unusable formatting. Our 3-year project to improve antimicrobial stewardship (AMS) used the Centers for Disease Control and Prevention’s (CDC) Core Elements of AMS for NHs, with guided input from NH providers to develop and implement an electronic ATB de-escalation decision support tool that also captures otherwise inaccessible data.

Methods: Our baseline …

Common Diagnoses Among Refugee Populations: Linked Results With Statewide Hospital Discharge Database, Kerui Xu, Shinobu Watanabe-Galloway, Ming Qu, Brandon Grimm, Jungyoon Kim

Journal Articles: Epidemiology

BACKGROUND: According to the U.S. State Department's Refugee Processing Center and the U.S. Census Bureau, in the fiscal year 2016, among all states in the United States, Nebraska resettled the highest number of refugees per capita.

OBJECTIVES: The objectives of this study were to determine the most common reasons for refugees utilizing hospital services in Nebraska between January 2011 and September 2015, and to examine whether refugee patients had increased risks for adverse health conditions compared to non-refugee patients.

METHODS: Statewide linkage was performed between Nebraska Medicaid Program's immigration data, and 2011-2015 Nebraska hospital discharge data inpatient and outpatient files. …

Personal And Family History Of Skin Cancer: A Possible Marker For Increased Internal Cancer Risk And Mortality, James Small

MUSC Theses and Dissertations

A growing body of evidence supports an association between a personal history of skin cancer and increased risk for adverse health outcomes. However, limitations in this evidence remain, such as incomplete control for confounding factors. Further, family history of skin cancer is likely to provide important etiologic clues but has yet to be thoroughly integrated in research to date. To address this gap, this dissertation investigates in a nationally representative cohort both personal and family history of skin cancer in relation to the risk of 1) developing an internal cancer and 2) mortality. Further, we investigate the translational potential of …

Personality Traits, Political Ideology, And Candidate Preference In The Deep South, Cameron D. Mackey, Heidi L. Dempsey

Modern Psychological Studies

Previous studies have shown that disgust sensitivity (DS), right-wing authoritarianism (RWA), religious fundamentalism (RF), and belief in a just world (BJW) are associated with social conservatism and religious questioning (QUEST) is associated with social liberalism. The current study was designed determine whether these personality traits would predict who the student planned to vote for in the 2016 U.S. Presidential primary. Consistent with previous research, DS, RWA, RF, and BJW were positively correlated with social conservatism and QUEST was negatively correlated. Students who were highest on RWA, RF, and lowest on QUEST were most likely to vote for one of the …

Implementation Of An Evidenced-Based Opioid Treatment Program To Improve Maternal-Child Outcomes In Eastern Kentucky, Jordan Rice

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

The Kentucky River Area District Health Department proposes implementation of CHARM-Kentucky, a treatment program for pregnant women with opioid use disorder (OUD), in eastern Kentucky. Over 115 Americans die each day from an opioid overdose, resulting in approximately 42,000 deaths in 2016. In addition to an overall increase in opioid use in recent years, the use of opioids in pregnancy has also increased from 1.19 per 1,000 hospital births in 2000 to 5.63 in 2009. Opioid use during pregnancy results in poor neonatal outcomes including: low birth weight, preterm delivery, small head circumference, increased child maltreatment, and risk for long-term …

Digest Of The Philadelphia College Of Osteopathic Medicine, Philadelphia College Of Osteopathic Medicine

PCOM Digest 2020s

The (2018 No. 1) issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• Updates

• Institutional Heritage: Founders’ Day 2018

• Facing Addiction

• Class Notes

Evaluating The Effects Of Nutritional Intake During Adolescence On Educational Attainment And Labor Market Earnings As An Adult, Mikaela Connell

CMC Senior Theses

In this thesis, I analyze whether nutritional intake at the time of adolescence can impact academic attainment and earnings later on in life. Millions of children in the United States are living in food insecure households and do not have access to an adequate nutritious diet. Since adolescence is a time period of intense growth and development, it is essential to meet nutritional needs at this time. Using data from the Longitudinal Study of Adolescent to Adult Health (Add Health), I measure the nutrition of a nationally representative sample of youth in the United States through their daily food intake, …

Foreign Policy By Fiat: An Examination Of The United States Decision Making Process On Iraq From 1990-1998, Shawn Mcfall

CMC Senior Theses

This thesis explores how the United States identified Iraq as a threat to its national interest from 1990 to 1998. The international relations literature is heavily skewed toward exploring the question of why states engage in conflict and neglecting how a country identifies a threat. Therefore, this thesis focuses on the threat identification policy process. This thesis examines two security moves – the Gulf War and the Iraq Liberation Act – and uses primary documents to reveal how the foreign policy apparatus concluded that Iraq was a threat. Through the two cases, I found that foreign policy decisions were made …

The Politics Of U.S. Food Policy, Evan Murphy

CMC Senior Theses

Throughout the 20th century, American farmlands, agricultural policy, and diets have seen dramatic transformations. The number of farms in America has decreased, but the average size of farms has increased. These larger farms are increasingly more industrialized and produce a short list of profitable, subsidized commodity crops. Similarly, changes in the American diet throughout the 20th and 21st centuries have reflected these shifts in the landscape of American farmland. Simultaneous to the evolution of American farms was an increase in federal involvement in American agriculture through policy that seems to encourage these trends. Although separating out the causes from the …

Two Patients With Daptomycin Induced Eosinophilic Pneumonia With Different Presentations And Treatment, Yonas Raru, Fuad Zeid, Shannon L. Browning, Elizabeth Saunders

Pulmonology

We present two cases of daptomycin-induced eosinophilic pneumonia with characteristic chest x ray, CT scan and bronchoalveolar lavage (BAL) findings. It is not a commonly seen complication of Daptomycin but when it happens, it could cause a diagnostic and treatment dilemma. Patients could present acutely with hypoxic respiratory failure or a less dramatic chronic presentation is also possible. Our two patients presented with acute hypoxic respiratory failure and presentation resembles that of an infectious etiology. Diagnosis is confirmed by bronchoscopy with BAL in one of them and the other was treated empirically as the clinical and radiologic presentation was typical. …

The Response Of Unpolarized Macrophages (Raw 264.7)/Keratinocytes (Pam-212) Monolayer And Co-Culture System To Herpes Simplex Virus Type 1 (Hsv-1) Replication During The Infection., Fahad Mohammed Alradi

Browse all Theses and Dissertations

Keratinocytes and neurons cells are the main target for Herpes Simplex Virus Type 1 (HSV-1) invasion. Moreover, keratinocytes are the most abundant cell types in the epidermis layer in the skin. Therefore, they are the first cells to encounter HSV-1 in the primary infection. Next, the virus reaches the nerve endings and is transferred to neuronal cells as a result from the primary infection. In between these two events, innate immune cells including monocytes and macrophages response is activated and recruited to the infection site. In this study, keratinocytes (PAM-212) and murine macrophage (RAW 264.7) cell lines were utilized to …

Virus Production And Cell Viability Of Hsv-1-Infected Murine Keratinocytes (Hel-30) Co-Cultured With Murine Macrophages (Raw 264.7), Barry Graffagna

Browse all Theses and Dissertations

Keratinocytes are the most abundant type of cell in the outer layer of skin, the epidermis, and provide barrier against pathogens from invading. However, Herpes Simplex Virus Type 1 (HSV-1) targets these keratinocytes for infection, and later infects neurons to establish lifelong latency. The keratinocytes stimulate the innate immune system to engage and to destroy the virus. Among the cells of the innate immune system to respond to the viral invasion is the macrophage. In this study, RAW 264.7 macrophage and HEL-30 keratinocyte monolayers were challenged in vitro with HSV-1 at a multiplicity of infection (MOI) of 0.1 to investigate …

An Assessment Of Agreement In Detection Methods For Histophilus Somni In Bovine Lungs, Laura Michelle Arnold

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Objectives: To examine the inter-laboratory agreement between multiplex realtime quantitative polymerase chain reaction (qPCR) assay results and aerobic culture results on bovine lung samples for detection of Histophilus somni (HS), and to assess associations of laboratory-derived factors on test agreement.

Methods: A survey of records from the University of Kentucky Veterinary Diagnostic Laboratory (UKVDL) was conducted to evaluate test results from grossly pneumonic bovine lung samples submitted during the period April 1, 2015 through August 31, 2018. Cohen’s kappa coefficient with 95% confidence interval (CI) was calculated to describe the extent of agreement. Animal, environmental and laboratory factors were examined …

Witch Doctors, Zombies, And Oracles: Rethinking Health In America, Ali S. Khan

Health Matrix: The Journal of Law-Medicine

To the extent we can even refer to an American healthcare "system," it functions brilliantly ... to make money. The system is designed to reward executives or major shareholders of pharmaceutical & health insurance companies, healthcare facilities, and related entities. With a rapidly aging population, healthcare will soon surpass a fifth of our economy. Of course, the American healthcare system does not function brilliantly when one considers the perspective of patients and over-extended primary care providers. Prices are growing faster than inflation or wages, healthcare is twice as costly as other comparable nations, and one third is a result of …

An Idea Model Analysis Of Instructional Risk Communication Messages In The Time Of Ebola, Deborah Sellnow-Richmond, Amiso George, Deanna Sellnow

SIUE Faculty Research, Scholarship, and Creative Activity

The Ebola outbreak and its rapid spread throughout West Africa and other countries was a megacrisis that imposed numerous challenges to those communicating to nonscientific publics about the epidemic. This article examines the instructional risk messages offered in the days that followed the 2014 infection and death of Liberian national Thomas Eric Duncan in Dallas, Texas. More specifically, we apply the IDEA model for effective instructional risk and crisis communication embellished by exemplification theory to conduct a thematic analysis of messages offered locally (Dallas news stories and press releases), nationally (Centers for Disease Control and Prevention Live Chat Twitter posts), …

Detection Of Cyanotoxins (Microcystins/Nodularins) In Hepatic Tissues And Epidermal Mats Of Stranded Bottlenose Dolphins (Tursiops Truncatus) In Northeast Florida, Amber Brown

UNF Graduate Theses and Dissertations

The St. Johns River (SJR; Jacksonville, FL, USA) is a large, brackish, estuarine system characterized by considerable anthropogenic pollution, recurrent harmful algal blooms (HABs), and diverse toxin-producing cyanobacteria. The most prevalent toxins in SJR water samples are microcystins/nodularins (MCs/NODs). Additionally, the SJR provides critical habitat for a genetically and behaviorally distinct estuarine community of bottlenose dolphins (Tursiops truncatus) that routinely uses and strands in low mesohaline and oligohaline areas of the river. This population has been subject to two unusual mortality events (UME) since 2010 and has since been described as having substantial declines in population health, characterized …

Establishing Relationships Among Environmental Stressors, Host Immune Status, And Wasting Disease Susceptibility In The Dominant Seagrass Species Thalassia Testudinum, Paige Joy Duffin

UNF Graduate Theses and Dissertations

A growing body of evidence supports the observation that marine disease outbreaks, especially those caused by opportunistic pathogens, are increasing in frequency and severity. One genus of such pathogens, Labyrinthula, has been identified as the causative agent of seagrass wasting disease, an epidemic that has historically plagued seagrass beds around the world. It is suspected that pathogenicity is intimately linked to the ability of the host to initiate defense responses, but a lack of compelling evidence prevents any meaningful application of preliminary observations. This body of work investigated the roles of host genotype, host immune status, and environmental stressors …

A Psychometric Investigation Of The Short Interpersonal Reactions Inventory: An Exploratory Factor Analysis Of The Short Interpersonal Reactions Inventory And An Assessment Of The Validity Of The Type 1 (Cancer-Prone) Personality Category, Jason Taller

Dissertations

Purpose

The purpose of this study was to determine if the 6 personality Types, as measured by Grossarth-Maticek and Eysenck’s (1990) Short Interpersonal Reactions Inventory (SIRI), were present in a sample of cancer and cancer-free individuals and to examine if the Type 1 personality category (cancer-prone personality) could significantly differentiate cancer from cancer-free subjects. Using an ex post facto research design and a sample of 648 English speaking adults selected from North America, overall findings from a confirmatory factor analysis suggested that contrary to results from some prior studies which validated the 6-personality factor structure of the SIRI, the six …

Comparative Analysis Of Low Molecular Weight Fraction Of Conditioned Media Derived From Starvation-Dormant And Anaerobically-Dormant Mycobacterium Avium Subsp. Paratuberculosis, Marina Buciuc

All Graduate Theses, Dissertations, and Other Capstone Projects

Johne's disease (JD) caused by Mycobacterium avium subsp. paratuberculosis (MAP) is a contagious chronic enteritis affecting all ruminants and causing economic loss of at least $250 million annually in the US dairy industry. One of the major limitations in the diagnosis of JD is the low sensitivity of fecal culture in animals with no clinical signs of the disease, but who are actively shedding MAP. Persistence of MAP in the host with no apparent signs of infection is attributed to its ability to enter a dormant state wherein the bacterium is viable, but is not able to replicate until conditions …

Aspergillus Sinusitis Complicated With Meningitis And Multiple Cerebral Infarctions In Immunocompetent Patient, Ahmad Alhaj Houssen, Fahad Algreeshah

Neurosciences

This is a case of a 33-year-old male complaining of severe headache, neck pain, photophobia, vomiting and high-grade fever of several days. He had history of nasal polyp removal and recurrent sinusitis in the last 8 years. On examination: conscious with glasco coma scale (GCS) 15/15 and normal limbs strength but with positive Babinski sign. For further observation, he was admitted and full work-up was done. Even though full empirical antibiotics were started, there was no immediate improvement and he deteriorated dramatically developing ocular deficit, hydrocephalus and lower level of consciousness with multiple infarctions found at different areas in brain. …

Mass Gathering Health: Considering Triggering Factors Associated With Acute Cardiovascular Events Using Linked Registry Data, Tanvir C. Turin, Mohammad Al Mamun

Neurosciences

No abstract provided.

Etsu Health Annual Report - 2018, 2018

ETSU Health Annual Reports

No abstract provided.

Autonomic Dysreflexia After Spinal Cord Injury: Systemic Pathophysiology And Methods Of Management, Khalid C. Eldahan, Alexander G. Rabchevsky

Physiology Faculty Publications

Traumatic spinal cord injury (SCI) has widespread physiological effects beyond the disruption of sensory and motor function, notably the loss of normal autonomic and cardiovascular control. Injury at or above the sixth thoracic spinal cord segment segregates critical spinal sympathetic neurons from supraspinal modulation which can result in a syndrome known as autonomic dysreflexia (AD). AD is defined as episodic hypertension and concomitant baroreflex-mediated bradycardia initiated by unmodulated sympathetic reflexes in the decentralized cord. This condition is often triggered by noxious yet unperceived visceral or somatic stimuli below the injury level and if severe enough can require immediate medical attention. …

Distribution Of Porcine Endogenous Retrovirus (Perv) Variants In Domestic And Feral Pigs, Rashmi Acharya

Master's Theses or Doctor of Nursing Practice

Xenotransplantation is considered an alternative to allotransplantation to relieve the current shortage of human organs. Due to their similar size and physiology, the organs of pigs are of particular interest for this purpose. Endogenous retroviruses are a result of integration of retroviral genomes into the genome of infected germ cells as DNA copies (proviruses), which are then carried in all cells of the offspring of the organism. Porcine Endogenous Retroviruses (PERVs) are of special concern because they are found in pig organs and tissue that might be used for xenotransplantation. PERV proviruses, already incorporated into the pig’s genome, can be …

Severe Liver Disease Outcomes And Mortality Among Patients With Chronic Hepatitis B Who Completed An In-Depth Health And Behavior Survey In 2012, P R. Spradling, J Xing, A C. Moorman, Loralee B. Rupp, Stuart C. Gordon, J A. Boscarino, M A. Schmidt, Y Daida, Mei Lu, E H. Teshale, S D. Holmberg

Gastroenterology Meeting Abstracts

Background: Understanding factors associated with liver disease progression among patients with chronic hepatitis B (CHB) is vital for clinical decision-making. We examined liver related outcomes and mortality among CHB patients using clinical and laboratory data, supplemented by an in-depth health and behavior survey conducted in 2011-2012.

Methods: CHB patients at four large U.S. healthcare systems completed a cross-sectional survey of demographic characteristics, smoking history, drug/alcohol use, coffee intake, and physical and psychosocial functioning. We reviewed survey responses and electronic medical records (EMRs) to examine clinical outcomes, including death, and determined patient characteristics at the time of survey associated with progression …

Identification And Characterization Of Tri-Colored Bat Hibernaculum In Russell County, Kansas, Angelica Sprague

Master's Theses or Doctor of Nursing Practice

Caves are often essential during hibernation, a sensitive stage in the life cycle of bats. Caves offer more stable conditions, such as temperature and relative humidity, during the changing seasons when food supply is limited, and weather is unstable. As caves in North-Central Kansas are sparse, the hibernating status of tri-colored bat (Perimyotis subflavus) is not well known. Bats are experiencing substantial population declines within the United States, caused primarily by white nose-syndrome, as well as habitat loss and degradation, and increased wind-power facilities. In the winter seasons of 2015 and 2016, I studied tri-colored bat hibernacula. A man-made “cave” …