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The Influence Of Self-Enhancement And Stress On Weight Gain: A Biopsychosocial Approach, Olivia G. Grondalski

Honors Theses

The current longitudinal study was conducted to test if people perceive their physical body size to be smaller than it is, and if people do self-enhance their body size, then how do body self-enhancement and stress interact to predict subsequent Body Mass Index (BMI). This study toke a biopsychosocial approach to understanding why people make health decisions by measuring participants’ self-enhancement, perceived stress, cortisol baseline levels, and stress reactivity and observing their associations and interactions with subsequent weight gain. Self-enhancement is a type of positive illusion characterized by overly positive attitudes people have towards themselves, which is used for promotion …

Genetic Characterization Of Enterovirus A71 Circulating In Africa, Maria Dolores Fernandez-Garcia, Romain Volle, Marie-Line Joffret, Serge Alain Sadeuh-Mba, Ionela Gouandjika-Vasilache, Ousmane Kebe, Michael R. Wiley, Manasi Majumdar, Etienne Simon-Loriere, Anavaj Sakuntabhai, Gustavo Palacios, Javier Martin, Francis Delpeyroux, Kader Ndiaye, Maël Bessaud

University of Nebraska's National Strategic Research Institute: Publications

We analyzed whole-genome sequences of 8 enterovirus A71 isolates (EV-A71). We confirm the circulation of genogroup C and the new genogroup E in West Africa. Our analysis demonstrates wide geographic circulation and describes genetic exchanges between EV-A71 and autochthonous EV-A that might contribute to the emergence of pathogenic lineages.

Genogroup E was previously identified and characterized only on the basis of VP1 analysis (3). This study confirms the circulation in West and Central Africa of EV-A71 isolates belonging to the new genogroup E on the basis of the characterization of whole genomes. The divergence among isolates indicates that this genogroup …

Bridging The Under-Five Mortality Gap For Africa In The Era Of Sustainable Development Goals: An Ordinary Least Squares (Ols) Analysis, Michael Acheampong, Chukwudi Ejiofor, Abraham A. Salinas-Miranda, Foday M. Jaward, Michael K. Eduful, Qiuyan Yu

School of Geosciences Faculty and Staff Publications

Background: While Africa achieved significant progress in reducing under-five mortality rate (U5MR) in the MDGs era, it did not achieve the set target and still has the highest average of 81 deaths per 1000 live births compared to a global average of 43 deaths. The SDG number 3 has set a new target of reducing U5MR to 25 deaths per 1000 births in the world, which serves a huge challenge, especially for Africa. Socioeconomic inequities that remain unaddressed across countries account for Africa’s high U5MR. Unless there is adequate prioritization of important socioeconomic, healthcare, and environmental factors, the new SDGs …

Outcomes Of Allogeneic Hematopoietic Stem Cell Transplantation For Gata2 And Dock8 Immunodeficiencies: Demographics And Transplantation Variables, Kristen M. Cole, Dnp, Msn, Rn, Bmtcn, Ocn

Doctor of Nursing Practice Projects

Background/Purpose: GATA2 and Dedicator-of-Cytokinesis-8 (DOCK8) deficiencies are two recently described genetic immunodeficiency diseases for which allogeneic hematopoietic stem cell transplant (HSCT) represents the only definitive therapy. The patient characteristics and HSCT variables that relate to the outcomes in these two diseases following HSCT remain unclear. Therefore, we described these variables in these two patient populations and explored their relationships with HSCT outcomes.

Methods: Data were obtained from retrospective chart reviews of all patients with GATA2 deficiency and DOCK8 deficiency who underwent HSCT on clinical research protocols at the National Cancer Institute. The outcomes included overall and disease-free survival status, graftversus-host …

Peer To Peer Review: Professional Development To Improve Feedback Skills And Self-Efficacy, Brittany H. Gnilka, Dnp, Msn, Rn-Bc

Doctor of Nursing Practice Projects

Background: Peer to peer review is the most essential form of peer review as it encourages nurses to evaluate the quality, safety, and effectiveness of nursing care amongst peers. Poor communication skills for providing feedback during peer review is a barrier identified in the literature, which can be addressed in professional development training.

Objectives: The purpose of this study was to evaluate the effect of communication-focused professional development sessions on the ambulatory care nurses’ perceived self-efficacy to successfully provide meaningful feedback during peer to peer review.

Results: The results showed a statistical significance difference between the mean pre and postGSES …

Growing A Healthy Future, Spring 2018

Institute of Agriculture and Natural Resources: Institute Publications

Growing Nebraska; From the lab to the field: Center for Plant Science Innovation is transforming agriculture; Translating research to crop improvement through a biotechnology pipeline; Discovering new frontiers for crop improvement; Boosting nutritional properties in crops; Husker researchers on cusp of swine industry protection; Postdoc spotlight: Haiyan Sun; Researchers developing system combining cattle grazing with crop production; Agpocalypse 2050 helps students understand food-energy-water nexus; Increasing participation of women, underrepresented students in agriculture; Helping preschoolers eat healthy can help combat childhood obesity; Makerspace boosting innovation and opportunity in rural Nebraska; Surplus garden produce shared with people in need; Nebraska Master Naturalists …

In Vitro Assay Development As An Alternative To The Use Of Laboratory Animals For Measuring Clostridium Perfingens Type C Toxoid, Lauren M. Wilmes

School of Veterinary and Biomedical Sciences: Dissertations, Theses, and Student Research

Clostridium perfringens type C produces beta toxin, which is a primary virulence determinate that can cause necrotic enteritis in neonatal animals. Vaccines directed against C. perfringens toxins have shown to be efficacious in preventing disease. However, the production of a commercial vaccine requires not only an efficacious antigen, but also testing methods for quantifying antigens and potency on final product. This research was undertaken to fulfill a need for the reduction in small animal usage to produce and deliver vaccines. The current testing methods are performed in vivo according to the Code of Federal Regulations number 9 (9CFR) United …

Neutrophils From Both Susceptible And Resistant Mice Efficiently Kill Opsonized Listeria Monocytogenes, Michelle G. Pitts, Travis A. Combs, Sarah E. F. D'Orazio

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Inbred mouse strains differ in their susceptibility to infection with the facultative intracellular bacterium Listeria monocytogenes, largely due to delayed or deficient innate immune responses. Previous antibody depletion studies suggested that neutrophils (polymorphonuclear leukocytes [PMN]) were particularly important for clearance in the liver, but the ability of PMN from susceptible and resistant mice to directly kill L. monocytogenes has not been examined. In this study, we showed that PMN infiltrated the livers of BALB/c/By/J (BALB/c) and C57BL/6 (B6) mice in similar numbers and that both cell types readily migrated toward leukotriene B4 in an in vitro chemotaxis assay. However, …

Microbiology (Sgsc), Molly Smith, Sara Selby

Biological Sciences Grants Collections

This Grants Collection for Microbiology was created under a Round Six ALG Textbook Transformation Grant.

Affordable Learning Georgia Grants Collections are intended to provide faculty with the frameworks to quickly implement or revise the same materials as a Textbook Transformation Grants team, along with the aims and lessons learned from project teams during the implementation process.

Documents are in .pdf format, with a separate .docx (Word) version available for download. Each collection contains the following materials:

• Linked Syllabus
• Initial Proposal
• Final Report

An Expert Consensus For The Management Of Chronic Hepatitis B In Asian Americans., M. J. Tong, C. Q. Pan, S.-H. B. Han, D. S.-K. Lu, S. Raman, K.-Q. Hu, J. K. Lim, H.W. Hann, A. D. Min

Division of Gastroenterology and Hepatology Faculty Papers

BACKGROUND: Hepatitis B virus (HBV) infection is common with major clinical consequences. In Asian Americans, the HBsAg carrier rate ranges from 2% to 16% which approximates the rates from their countries of origin. Similarly, HBV is the most important cause of cirrhosis, hepatocellular carcinoma (HCC) and liver related deaths in HBsAg positive Asians worldwide.

AIM: To generate recommendations for the management of Asian Americans infected with HBV.

METHODS: These guidelines are based on relevant data derived from medical reports on HBV from Asian countries as well as from studies in the HBsAg positive Asian Americans. The guidelines herein differ from …

Intellectual Property And The Global Crisis Of Noncommunicable Disease, Faisal L. Chaundry

North Carolina Journal of Law & Technology

No abstract provided.

Optimization Of Microfluidic Chip Fabrication Via Femtosecond Laser Ablation, Kenneth Aycock

Senior Theses

Microfluidic devices have become staple tools in biomedical research and have a promising future as low cost, point-of-care (POC) diagnostic devices. Despite the advancements in microfluidic device technology, the manipulation and fabrication of these systems can be tedious and expensive. Repeatable techniques in which computer-aided designs are translated into microfluidic systems in a matter of minutes are highly desirable both for researchers and manufacturers. Laser ablation of tape substrates has shown promise in producing cost-effective, rapidly manipulable devices, but the work done thus far has utilized continuous wave lasers that perform suboptimally due to the relatively short wavelengths used and …

Multiplexed Optofluidics For Single-Molecule Analysis, Matthew Alan Stott

Theses and Dissertations

The rapid development of optofluidics, the combination of microfluidics and integrated optics, since its formal conception in the early 2000's has aided in the advance of single-molecule analysis. The optofluidic platform discussed in this dissertation is called the liquid core anti-resonant reflecting optical waveguide (LC-ARROW). This platform uses ARROW waveguides to orthogonally intersect a liquid core waveguide with solid core rib waveguides for the excitation of specifically labeled molecules and collection of fluorescence signal. Since conception, the LC-ARROW platform has demonstrated its effectiveness as a lab-on-a-chip fluorescence biosensor. However, until the addition of optical multiplexing excitation waveguides, the platform lacked …

Early Relapse After Autologous Hematopoietic Cell Transplantation Remains A Poor Prognostic Factor In Multiple Myeloma But Outcomes Have Improved Over Time, Shaji K. Kumar, Angela Dispenzieri, Raphael Fraser, Fei Mingwei, Gorgun Akpek, Robert Cornell, Mohamed Kharfan-Dabaja, Cesar Freytes, Shahrukh Hashmi, Gerhard C. Hildebrandt, Leona Holmberg, Robert Kyle, Hillard Lazarus, Cindy Lee, Jospeh Mikhael, Taiga Nishihori, Jason Tay, Saad Usmani, David Vesole, Ravi Vij, Baldeep Wirk, Amrita Krishnan, Cristina Gasparetto, Tomer Mark, Yago Nieto, Parameswaran Hari, Anita D'Souza

Internal Medicine Faculty Publications

Duration of initial disease response remains a strong prognostic factor in multiple myeloma (MM) particularly for upfront autologous hematopoietic cell transplant (AHCT) recipients. We hypothesized that new drug classes and combinations employed prior to AHCT as well as after post-AHCT relapse may have changed the natural history of MM in this population. We analyzed the Center for International Blood and Marrow Transplant Research database to track overall survival (OS) of MM patients receiving single AHCT within 12 months after diagnosis (N=3256) and relapsing early post-AHCT (< 24 months), and to identify factors predicting for early vs late relapses (24−48 months post-AHCT). Over three periods (2001–2004, 2005–2008, 2009–2013), patient characteristics were balanced except for lower proportion of Stage III, higher likelihood of one induction therapy with novel triplets and higher rates of planned post-AHCT maintenance over time. The proportion of patients relapsing early was stable over time at 35–38%. Factors reducing risk of early relapse included lower stage, chemosensitivity, transplant after 2008 and post-AHCT maintenance. Shorter post-relapse OS was associated with early relapse, IgA MM, Karnofsky < 90, stage III, > 1 line of induction and lack of maintenance. Post-AHCT early relapse remains …

Assisted Death: Historical, Moral And Theological Perspectives Of End Of Life Options, Catherine Bando

LMU Theses and Dissertations

The paper explores historical positions on suicide and philosophical, theological, and moral positions on physician-assisted suicide and euthanasia. In 1900, most people died from infectious diseases, which have relatively short periods of morbid decline. With advances in the biomedical sciences, people are living longer, and most people die from chronic diseases, which are usually accompanied by prolonged periods of morbid decline. In addition to living longer, people today are generally more individualist and seek methods to control many aspects of life. While assisted death is rarely used, it represents a means to control end-of-life suffering. The paper demonstrates that there …

Microbial Co-Infection Alters Macrophage Polarization, Phagosomal Escape, And Microbial Killing, Nikita H. Trivedi, Jieh-Juen Yu, Chiung-Yu Hung, Richard P. Doelger, Christopher S. Navara, Lisa Y. Armitige, Janakiram Seshu, Anthony P. Sinai, James P. Chambers, M. Neal Guentzel, Bernard P. Arulanandam

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Macrophages are important innate immune cells that respond to microbial insults. In response to multi-bacterial infection, the macrophage activation state may change upon exposure to nascent mediators, which results in different bacterial killing mechanism(s). In this study, we utilized two respiratory bacterial pathogens, Mycobacterium bovis (Bacillus Calmette Guẻrin, BCG) and Francisella tularensis live vaccine strain (LVS) with different phagocyte evasion mechanisms, as model microbes to assess the influence of initial bacterial infection on the macrophage response to secondary infection. Non-activated (M0) macrophages or activated M2-polarized cells (J774 cells transfected with the mouse IL-4 gene) were first infected with BCG for …

Nurse Practitioner Clinical Education: Evaluation Of A Clinical Residency Model, Lisa Wilson Hood

Doctoral Projects

A new clinical residency education model was developed and implemented in response to a family nurse practitioner program’s difficulty in securing and maintaining qualified preceptors and clinical sites for students in the program, and a community hospital’s shortage of nurse practitioners for their rural healthcare clinics. This Doctor of Nursing Practice project conducted an evaluation on this new model. The evaluation results showed that the clinical residency model met standards of nurse practitioner education, incorporated nursing leader recommendations for new clinical models, and proved to be an effective model for clinical education.

Dipl 6130 Na International Security, Brian K. Muzas Phd

Diplomacy Syllabi

This course offers a comprehensive overview of the study of international conflict and security. The goal is to provide students with a solid theoretical and conceptual foundation for understanding the causes, nature, and consequences of key issues related to international war and peace. It is important not only to understand what scholars have learned about the big theoretical and empirical questions of the past but also to gain a toolkit that will allow students to approach solve contemporary and future issues.

The course introduces influential theories of international security. While these perspectives derive mainly from the study of traditional interstate …

Quarantine And The Federal Role In Epidemics, Michael R. Ulrich, Wendy K. Mariner

Faculty Scholarship

Every recent presidential administration has faced an infectious disease threat, and this trend is certain to continue. The states have primary responsibility for protecting the public’s health under their police powers, but modern travel makes diseases almost impossible to contain intrastate. How should the federal government respond in the future? The Ebola scare in the U.S. repeated a typical response—demands for quarantine. In January 2017, the Department of Health and Human Services and the Centers for Disease Control and Prevention issued final regulations on its authority to issue Federal Quarantine Orders. These regulations rely heavily on confining persons who may …

Human Rights And The Global Climate Change Regime, Atieno Mboya Samandari

Natural Resources Journal

This article discusses human rights implications of the market-based mechanisms operationalized under the global climate change regime. It examines greenhouse gas emissions rights created by the Kyoto Protocol and continued by the Paris Agreement. This article discusses implications of these rights for the protection and realization of human rights in the wake of climate change and argues that greenhouse gas emissions rights, as currently constituted, are incompatible with human rights protections. While the Paris Agreement’s recognition of human rights is a significant development, the protection and realization of human rights by states under a free-market approach to climate change remains …

Selection Of Potential Therapeutic Bacteriophages That Lyse A Ctx-M-15 Extended Spectrum Β-Lactamase Producing Salmonella Enterica Serovar Typhi Strain From The Democratic Republic Of The Congo, Elene Kakabadze, Khatuna Makalatia, Nino Grdzelishvili, Nata Bakuradze, Marina Goderdzishvili, Ia Kusradze, Marie France Phoba, Octavie Lunguya, Cédric Lood, Rob Lavigne, Jan Jacobs, Stijn Deborggraeve, Tessa De Block, Sandra Van Puyvelde, David Lee, Aidan Coffey, Anahit Sedrakyan, Patrick Soentjens, Daniel De Vos, Jean Paul Pirnay, Nina Chanishvili

Department of Biological Sciences Publications

© 2018 by the authors. Licensee MDPI, Basel, Switzerland. Recently, a Salmonella Typhi isolate producing CTX-M-15 extended spectrum β-lactamase (ESBL) and with decreased ciprofloxacin susceptibility was isolated in the Democratic Republic of the Congo. We have selected bacteriophages that show strong lytic activity against this isolate and have potential for phage-based treatment of S. Typhi, and Salmonella in general.

Impact Of Suspended Particles On Bacterial Concentrations In Great Bay Estuary Oysters, Audrey Berenson

Inquiry Journal 2018

Vibrio parahaemolyticus bacteria are naturally occurring in marine ecosystems globally. However, with recent environmental changes, such as increased water temperature, they have an increasing presence in northeast United States waters, including the Great Bay Estuary in New Hampshire. Due to the accumulation of bacteria in filter feeders that are often consumed, such as oysters, surveillance is necessary to monitor bacteria. I spent the summer of 2017 collecting plankton, water, suspended solids (floating material), sediment, and oysters from the Great Bay Estuary to characterize how suspended solids might impact V. parahaemolyticus concentrations in oysters. I hypothesized that when the mass of …

Upper And Lower Gastrointestinal Endoscopic Findings In Hiv-Infected Patients In The Era Of Highly Active Antiretroviral Therapy., Russell Parvin, Sindhura Kolli, Jamil Shah, Manan Jhaveri, Madhavi Reddy

Articles, Abstracts, and Reports

Background: Endoscopic evaluation with biopsies are instrumental in the diagnosis and management of gastrointestinal (GI) disorders in the setting of human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS), especially in the era of highly active antiretroviral therapy (HAART).

Methods: A retrospective chart review of 304 HIV-positive and 199 HIV-negative patients who had undergone upper and/or lower endoscopy in an urban community hospital from the years 2012 - 2017 was performed. Inclusion criteria included men and women between the ages of 45 to 75 years, which had undergone colonoscopies between within 2012 - 2017 and had tested positive for HIV. …

Canina Fossa Abscess And Treatment, Muhammad H. Chanda

Journal of Dentomaxillofacial Science

Objective: Canina fossa abscesses are rarely reported in the literature. Tooth infection is often derived from bacteria associated with the abscess. Canina fossa abscesses can lead to the development of secondary abscesses, infection of incisors and canines in the upper jaw and maxillary sinusitis infection.

Methods: Odontogenic infections can easily spread throughout the muscles and the face, which can cause abscesses mucolabial or accumulation of pus in the eyelid and face.

Results: Patients experienced a history of pain and fever. Physical examination showed enlargement and swelling of the right cheek and panoramic radiographs appear radiolucent on the apex of tooth …

Study Of Abc Membrane Transporters In Single Live Cells, Preeyaporn Songkiatisak

Chemistry & Biochemistry Theses & Dissertations

The multidrug ATP-binding cassette (ABC) membrane transporters (efflux pumps) are found in both prokaryotes and eukaryotes and they can extrude diverse structurally unrelated substrates, such as antibiotics and chemotherapeutic agents out of the cells. The efflux pumps are responsible for multidrug resistance (MDR) and the failure of numerous treatments in infections and cancers. All ABC membrane transporters share a common modular topology containing two transmembrane domains (TMDs) and two nucleotide binding domains (NBDs). The underlying molecular mechanisms regarding how the similar structural ABC membrane transporters could selectively extrude a wide variety of substrates and cause MDR, are not yet fully …

Nurses’ Perception And Attitudes Towards Oral Care Practices For Mechanically Ventilated Patients, Mahmoud A. Alja’Afreh, Sultan M. Mosleh, Sakhaa S. Habashneh

Saudi Medical Journal

Objectives: To explore the perception and attitudes of intensive care unit (ICU) nurses towards oral care practice for mechanically ventilated (MV) patients. Method: A descriptive cross-sectional design was used in this study. A convenience sample of 96 ICU nurses completed a questionnaire on their perception and attitudes towards oral care. The study setting was 3 representative Jordanian hospitals in Al-Karak and the capital, Amman, over a 6-month period between February and September 2016. Results: Ninety-six nurses participated in the study. The response rate was 76.8%. The results revealed that 65% only follow a specific oral care protocol. Nurses did not …

Rural And Urban Injection Drug Use In Puerto Rico: Network Implications For Human Immunodeficiency Virus And Hepatitis C Virus Infection, Courtney Thrash, Melissa L. Welch-Lazoritz, G. Robin Gauthier, Bilal Khan, Roberto Abadie, Kirk Dombrowski, Sandra Miranda De Leon, Yadira Rolon Colon

Department of Sociology: Faculty Publications

Understanding the short- and long-term transmission dynamics of blood-borne illnesses in network contexts represents an important public health priority for people who inject drugs and the general population that surrounds them. The purpose of this article is to compare the risk networks of urban and rural people who inject drugs in Puerto Rico. In the current study, network characteristics are drawn from the sampling “trees” used to recruit participants to the study. We found that injection frequency is the only factor significantly related to clustering behavior among both urban and rural people who inject drugs.

Concepts In Animal Parasitology: References Style Guide, Sue Ann Gardner, Scott Lyell Gardner

Concepts in Animal Parasitology

References style guide for authors of the Concepts in Animal Parasitology free, online textbook.

Concepts In Animal Parasitology: Instructions For Authors, Sue Ann Gardner, Scott Lyell Gardner

Concepts in Animal Parasitology

Instructions for authors for the Concepts in Animal Parasitology free, online textbook.

Concepts In Animal Parasitology: Manuscript Preparation Guidelines, Paul Royster, Sue Ann Gardner, Scott Lyell Gardner

Concepts in Animal Parasitology

Zea Books manuscript preparation guidelines for authors of the Concept in Animal Parasitology free, online textbook.