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Prevalence Of Esbl And Ampc Β-Lactamase Production And Biofilm Formation In Burn Isolates Of Pseudomonas Aeruginosa From Rozhawa Hospital In Erbil City, Sayran Hamad Haji

Polytechnic Journal

Pseudomonas aeruginosa has become a major cause of life-threatening nosocomial infections that can rapidly develop resistance to multiple antimicrobial agents, mostly due to its ability to produce extended-spectrum β-lactamase (ESBL),AmpC and metallo-β-lactamase(MBL).Biofilm formation is another important factor contributes to the chronicity of infections as they reduce susceptibility to antimicrobial agents. This study was aimed to find prevalence of ESBL and AmpC β-lactamases production and biofilm formation in burn isolates of P. aeruginosa. Further we find out the potential to form biofilm in relation to antibiotic resistance and β-lactamase productions.A total of 90 isolates of P. aeruginosa were isolated from burn …

Predicting Risk Of Hospitalisation: A Retrospective Population-Based Analysis In A Paediatric Population In Emilia-Romagna, Italy., Daniel Z. Louis, Clara A. Callahan, Mary Robeson, Mengdan Liu, Jacquelyn Mcrae, Joseph S. Gonnella, Marco Lombardi, Vittorio Maio

College of Population Health Faculty Papers

OBJECTIVES: Develop predictive models for a paediatric population that provide information for paediatricians and health authorities to identify children at risk of hospitalisation for conditions that may be impacted through improved patient care.

DESIGN: Retrospective healthcare utilisation analysis with multivariable logistic regression models.

DATA: Demographic information linked with utilisation of health services in the years 2006-2014 was used to predict risk of hospitalisation or death in 2015 using a longitudinal administrative database of 527 458 children aged 1-13 years residing in the Regione Emilia-Romagna (RER), Italy, in 2014.

OUTCOME MEASURES: Models designed to predict risk of hospitalisation or death in …

Changes In The Microbial Community Of Lubomirskia Baicalensis Affected By Red Sponge Disease, Colin Rorex

Electronic Theses and Dissertations

Lake Baikal is the oldest known lake and a unique ecosystem, home to several species of fresh water sponge. A disease outbreak affecting the dominant species, Lubormirskia baialensis, was recently reported. The cause of the disease has not been determined but one of the current hypothesis is that the increase in methane concentration is correlated to the disease outbreak. This pilot study characterized the microbiomes of sick and healthy sponges through the use of 16S rRNA sequencing. Sick sponge microbiomes shared a conserved group of taxa while the healthy sponge microbiomes had greater diversity. Indicator species analysis identified two significant …

Graft-Versus-Host Disease In Recipients Of Male Unrelated Donor Compared With Parous Female Sibling Donor Transplants, Anita J. Kumar, Soyoung Kim, Michael T. Hemmer, Mukta Arora, Stephen R. Spellman, Mitchell S. Cairo, Alison W. Loren

NYMC Faculty Publications

Optimal donor selection is critical for successful allogeneic hematopoietic cell transplantation (HCT). Donor sex and parity are well-established risk factors for graft-versus-host disease (GVHD), with male donors typically associated with lower rates of GVHD. Well-matched unrelated donors (URDs) have also been associated with increased risks of GVHD as compared with matched sibling donors. These observations raise the question of whether male URDs would lead to more (or less) favorable transplant outcomes as compared with parous female sibling donors. We used the Center for International Blood and Marrow Transplant Research registry to complete a retrospective cohort study in adults with acute …

The Undergraduate Training In Genomics (Utrig) Initiative: Early & Active Training For Physicians In The Genomic Medicine Era, Rebecca L. Wilcox, Patricia V. Adem, Ebrahim Afshinnekoo, James B. Atkinson, Leah W. Burke, Hoiwan Cheung, Shoumita Dasgupta, Julia Delagarza, Loren Joseph, Robin Legallo, Madelyn Lew, Christina M. Lockwood, Richard L. Haspel

NYMC Faculty Publications

Genomic medicine is transforming patient care. However, the speed of development has left a knowledge gap between discovery and effective implementation into clinical practice. Since 2010, the Training Residents in Genomics (TRIG) Working Group has found success in building a rigorous genomics curriculum with implementation tools aimed at pathology residents in postgraduate training years 1-4. Based on the TRIG model, the interprofessional Undergraduate Training in Genomics (UTRIG) Working Group was formed. Under the aegis of the Undergraduate Medical Educators Section of the Association of Pathology Chairs and representation from nine additional professional societies, UTRIG's collaborative goal is building medical student …

Sociality And Stress In Female Chacma Baboons (Papio Ursinus) In The Cape Peninsula Of South Africa: Behavioral Flexibility And Coping Mechanisms, Shahrina Chowdhury

Dissertations, Theses, and Capstone Projects

The physiological stress responses that animals exhibit to the myriad stressors in their environment can be used to assess the state of their health and well-being, and even survival capability. Although the stress response is adaptive in many cases, chronic stress responses may be maladaptive in some situations when it leads to dysfunction of the physiological system involved in the stress response itself, and can also cause deleterious effects on health, reproduction and survival. The stress response includes physiological responses to both environmental perturbations and psychosocial stress and anxiety associated with social perturbations. The latter factor is particularly important for …

Evidence For Organelle-Like Extracellular Vesicles From A Parasite Of Drosophila And Their Function In Suppressing Host Immunity, Mary Heavner

Dissertations, Theses, and Capstone Projects

Parasitic wasps act as keystone species in natural ecosystems. Adept at suppressing immunity of their insect hosts, these natural enemies of insect pests are used for biocontrol in many parts of the world. Female parasitic wasps of the closely-related species Leptopilina heterotoma (Lh), a generalist of many Drosophilia flies, and Leptopilina boulardi (Lb), a specialist on flies of the melanogaster subgroup, produce venom and virus-like particles (VLPs) in their long gland-reservoir complexes, a secretory organ connected to ovipositors. Venom and VLPs are deposited, along with wasp eggs, into the body of the wasp’s larval fly host …

Impact Of Telemedicine On Mortality, Length Of Stay, And Cost Among Patients In Progressive Care Units: Experience From A Large Healthcare System, Donna Lee Armaignac, Anshul Saxena, Muni Rubens, Carlos Valle, Lisa-Mae Williams, Emir Veledar, Louis Gidel

All Publications

OBJECTIVES:

To determine whether Telemedicine intervention can affect hospital mortality, length of stay, and direct costs for progressive care unit patients.

DESIGN:

Retrospective observational.

SETTING:

Large healthcare system in Florida.

PATIENTS:

Adult patients admitted to progressive care unit (PCU) as their primary admission between December 2011 and August 2016 (n = 16,091).

INTERVENTIONS:

Progressive care unit patients with telemedicine intervention (telemedicine PCU [TPCU]; n = 8091) and without telemedicine control (nontelemedicine PCU [NTPCU]; n = 8000) were compared concurrently during study period.

MEASUREMENTS AND MAIN RESULTS:

Primary outcome was progressive care unit and hospital mortality. Secondary outcomes were hospital length …

Thiol–Ene Photopolymerization: A Simple Route To Pro-Antimicrobial Networks Via Degradable Acetals (Pandas), William Martin

Honors Theses

The World Health Organization (WHO) has brought the growing epidemic of antibiotic resistance bacteria to the attention of the public and has expressed the need for the development of new methods of defense. In this direction, bioactive aldehyde essential oils have been shown to effectively act as antibiotic and antifungal agents. These bioactive compounds, when used in their pure form, are volatile and lack environmental stability. In this thesis, we describe the synthesis of pro-antimicrobial networks via degradable acetals (PANDAs) using thiol-ene photopolymerization. PANDAs were used as a new model for the high loading and release of bioactive aldehyde-containing compounds …

Disruption Of Rna Metabolism By Zika Virus, Maggie Lea Dickerson

Honors Theses

Flaviviruses are positive, single-stranded, enveloped RNA viruses that are a part of the family, Flaviviridae. West Nile virus, Dengue, Zika virus and more are a part of this family. Mosquitoes are the vectors for these viruses. In order for the virus to infect mosquitoes, it must evade the RNA interference (RNAi), which is the major antiviral immune mechanism of insects. One study found the 3’ untranslated region (UTR) of the West Nile virus that inhibited the RNAi (GP et al. 2016). The goal of this study is to investigate if the 3’ and 5’ UTR region of the Zika virus …

Opportunities For Epidemiologists In Implementation Science: A Primer, Gila Neta, Ross C Brownson, David A Chambers

2010-2019 OA Pubs

The field of epidemiology has been defined as the study of the spread and control of disease. However, epidemiology frequently focuses on studies of etiology and distribution of disease at the cost of understanding the best ways to control disease. Moreover, only a small fraction of scientific discoveries are translated into public health practice, and the process from discovery to translation is exceedingly slow. Given the importance of translational science, the future of epidemiologic training should include competency in implementation science, whose goal is to rapidly move evidence into practice. Our purpose in this paper is to provide epidemiologists with …

Serotonin And Serotonin Transporter Levels In Autistic Children, Haidar A. Abdulamir, Omar F. Abdul-Rasheed, Emad A. Abdulghani

Saudi Medical Journal

Objectives To assess the possible correlation between serotonin and serotonin transporter (SERT) with the autism severity and investigate the association between these parameters in autistic children to assess their possible role for diagnosis of autism severity. Methods A comparative cross-sectional study was carried out in the Chemistry and Biochemistry Department, College of Medicine, Al-Nahrain University, Baghdad, Iraq while the samples were taken from 60 male autistic children recruited to the Department of Pediatrics at Al-Sader Hospital, Baghdad, Iraq between November 2014 amd April 2015. Levels of serotonin and serotonin transporters (SERT) were determined in 60 male autistic Iraqi patients classified …

Prevalence Of Hepatitis B, C, And Hiv Among Patients Attending A Teaching Dental Hospital: A 7-Year Retrospective Study From The United Arab Emirates, Suhail H. Al-Amad

Saudi Medical Journal

Objectives To determine the seroprevalence and case characteristics of hepatitis B, C and human immunodeficiency virus (HIV), and their transmissibility from patients to dental personnel following percutaneous and mucocutaneous injuries. Methods All incidents of sharp and splash injuries reported between January 2010 and January 2017 were retrospectively reviewed and analyzed. Descriptive statistics were calculated using the Statistical Package for the Social Science (SPSS). Prevalence was calculated as percentages, and chi-square test was used to assess categorical variables where a p -value of ≤0.05 was considered significant. Results Among the 436 reported incidents, 372 patients underwent serological screening. Fourteen patients (3.8%) …

Pyomyositis Mistaken For Septic Hip Arthritis In Children: The Role Of Mri In Diagnosis And Management, Franklin D. Shuler, Grant S. Buchanan, Cody Stover, Brock Johnson, Milad Modarresi, John J. Jasko

Marshall Journal of Medicine

Septic arthritis is an orthopaedic emergency which requires timely management to prevent joint destruction and poor outcome. Differentiating septic arthritis from transient synovitis in pediatric patients is aided by the use of Kocher criteria which have excellent sensitivity but lack specificity. In addition to these two disorders, primary pyomyositis is bacterial infection of skeletal muscle that most commonly affects children. Patients present with pain, swelling, fever, and elevated inflammatory markers which mimics septic arthritis. If left untreated, pyomyositis can lead to abscess formation and sepsis.

Due to potential for nearly identical presentations of septic arthritis and pyomyositis, differentiation of these …

Bioprospecting Deep-Sea Actinobacteria For Novel Anti-Infective Natural Products, Dongbo Xu, Linna Han, Chunhui Li, Qi Cao, Duolong Zhu, Nolan H. Barrett, Dedra Harmody, Jing Chen, Haining Zhu, Peter J. Mccarthy, Xingmin Sun, Guojun Wang

Molecular and Cellular Biochemistry Faculty Publications

The global prevalence of drug resistance has created an urgent need for the discovery of novel anti-infective drugs. The major source of antibiotics in current clinical practice is terrestrial actinobacteria; the less-exploited deep-sea actinobacteria may serve as an unprecedented source of novel natural products. In this study, we evaluated 50 actinobacteria strains derived from diverse deep water sponges and environmental niches for their anti-microbial activities against a panel of pathogens including Candida albicans, Clostridium difficile, Staphylococcus aureus, and methicillin-resistant S. aureus (MRSA), and Pseudomonas aeruginosa. More than half of the tested strains (27) were identified as …

2018-April-30-Liver Disease Screening Grant, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

Herpes Zoster Patient Education: A Coloring Book Approach, Sophia Charuhas

Senior Honors Theses

Shingles, the disease caused by the herpes zoster virus, is a widespread and widely misunderstood illness in the United States. It is preventable, but many at-risk patients do not know what measures they may take to prevent it. Clear communication from physician to patient is crucial for patient understanding of diseases. Many patient education materials on herpes zoster currently available are often unused. It is therefore beneficial to public health to disseminate new mediums of medical communication, and one way of accomplishing this is through adult coloring books. The pathophysiology of herpes zoster virus is here explored and the idea …

Grady Health Systems Linen Optimization, Kyleia Hutton, Samira Abdi

Senior Design Project For Engineers

Grady Memorial Hospital, under Grady Health Systems (GHS), is the fifth largest public hospital systems in the United States of America. In the Southeast region, Grady Memorial Hospital is a premier level I trauma institution, that also provides other medical service specialties that accumulate a diverse, and knowledgeable set of medical professionals. Within this report, there are various recommendations that our team has presented based on different scenarios that could be present within the interaction of the linen management department and other departments at Grady Health Systems. These recommendations will aid in determining the best decision that can be made …

49 Armenian Deportees, Krikor Guerguerian

Genocide (Various Languages)

[This is a long document. Please consult the index for full information]

Takvim-i Vekayi, number 3604, 5 July 1919; Takvim-i Vekayi, number 3540, 12 April 1919; Takvim-i Vekayi, number 3571, 26 May 1919

The encrypted telegraph sent by the Aleppo Governor-General Abdulahad Nuri Bey to the Director of the Office of Tribal and Immingrant Settlement Shukru Bey [Şükrü Bey] on 23 November 1915, regarding the sending of the 400 children at the orphanage to the interior of the country.

The encrypted telegraph sent by Assistant Director of the Office of Tribal and Immigrant Settlement on 10 January 1916, stating that …

Exploring Literature For Conceptualisations Of Male Infertility: A Phenomenological Analysis, Sunu C. Thomas

The Qualitative Report

Fathering a child is an important aspect of the identity of a man as motherhood is for a woman. Male factor infertility is one reason for the inability to father a child and this can contribute to many issues for a man at a personal or societal level. Although male infertility is a major contributing factor for the overall infertility for couples, our understanding of it is minimal. The objective of this exercise is to describe the meanings that men attach to their inability to reproduce and the conceptualisations of male infertility. A phenomenological approach has been used to analyse …

Out In Appalachia: Leaving The Closet In The Mountains, Jeffrey C. Cawood

Morehead State Theses and Dissertations

A thesis presented to the faculty of the Caudill College of Arts, Humanities, and Social Sciences at Morehead State University in partial fulfillment of the requirements for the degree of Master of Arts by Jeffrey C. Cawood, Jr. on April 28, 2018.

The Hospital Antimicrobial Use Process: From Beginning To End, William R. Truong, Jason Yamaki

Pharmacy Faculty Articles and Research

Hospital antimicrobial stewardship (AMS) programs are responsible for ensuring that all antimicrobials are utilized in the most appropriate and safe manner to improve patient outcomes, prevent adverse drug reactions, and prevent the development of antimicrobial resistance. This Perspectives article outlines the hospital antimicrobial use process (AUP), the foundational system that ensures that all antimicrobials are utilized in the most appropriate and safe manner. The AUP consists of the following steps: antimicrobial ordering, order verification, preparation and delivery, administration, monitoring, and discharge prescribing. AMS programs should determine how each step contributes to how an antimicrobial is used appropriately or inappropriately at …

6-Day-Old Term Infant With Fever And Lethargy, Gangaram Akangire, Archana Kulkarni, Winston M. Manimtim

Manuscripts, Articles, Book Chapters and Other Papers

Osteomyelitis in the neonatal period can be a diagnostic challenge, especially if it is mimicking brachial plexus palsy. We present a unique case of 6-day-old term infant with lethargy and fever diagnosed with Group B Streptococci (GBS) sepsis and meningitis. Few days later, infant developed right arm immobility leading to hematogenous spread of GBS to right humerus, leading to osteomyelitis and septic arthritis. Infant was treated with intravenous Ampicillin for 4 weeks with full arm mobility and full recovery from sepsis and meningitis. This case provides several clinical vignettes that may be crucial in timely diagnosis and treatment of osteomyelitis …

Investigation Into The Causes And Severity Of The 1918 Influenza Pandemic, Alex T. Freedenberg

The Review: A Journal of Undergraduate Student Research

The 1918 Influenza outbreak is regarded as one of the worst pandemics in human history due to its widespread effects across the globe and its high death rate. This death rate was unusual among influenza infections as most strains do not cause the amount of death that is seen in this outbreak, with 20 million dead as a conservative estimate and 100 million by other estimations. This pandemic was not very well contained for a plethora of reasons. Two main reasons are that it came at a time when understanding viral mechanics still escaped medical professionals, and due to the …

Chasing Plenty: A Documentary On Food Security In Montana, Kurt Swimley, Colin Brust, Aspen Anderson, John Potenberg, Nathaniel Smith

University of Montana Conference on Undergraduate Research (UMCUR)

Chasing Plenty: A Documentary on Food Security in Montana Our GLI group aims to examine the following question: how will climate change impact food security? To address this question we are conducting interviews in Montana. Despite being an agricultural state, many Montanans struggle with food insecurity, and are left without plentiful or healthy options for food. We aim to research this issue by interviewing local community members involved in food distribution. The interview data will be compiled in a short documentary discussing current issues in food security, how these problems are likely to evolve in the future, and propose solutions …

Polystyrene Surface-Absorbed Trehalose Diester As A Means For Performing Pulldown Assays, Alexander S. Riffey, Roman Schoener, Robert Child

University of Montana Conference on Undergraduate Research (UMCUR)

In 2016, over 10.4 million people contracted Tuberculosis (TB) infections for the first time, resulting in the deaths of 1.7 million people worldwide. Despite the existence of a vaccine, TB remains the number one cause of death from a single infectious disease according to the 2017 report from the World Health Organization. As a result, research and development of a new TB vaccine is ongoing, as it is suspected the currently available formulation does not contain an adjuvant which produces the necessary TH-17 response. In the search for new drugs to combat this epidemic, knowledge of how a compound triggers …

Factors Involved In Suppression Of Human Vγ9vδ2 T-Lymphocytes And Impact Of Checkpoint Blockades On The Effector Functions Of Vγ9vδ2 T-Lymphocytes, Minji Choi, Andrew Wiemer, Andrea Hubbard, Brian Aneskievich

University Scholar Projects

Chronic antigenic stimulation leads to T cell exhaustion, which drastically dampens T cell effector functions. Upon exhaustion, T cells progressively lose their proliferative capacity, cytokine production, and cytotoxic effector functions against tumors. T cell exhaustion involves programmed cell death-1 (PD-1), which is an inhibitory co-stimulation receptor. Limited scope of studies has been done regarding impact of PD-1 expression on the effector functions of γδ T cells. In this study, we investigated expression of PD-1 and its impact on effector functions of human γδ T cells. When γδ T cells were stimulated with phosphoantigens (HMBPP and POM₂-C-HMBP) and analyzed …

Genotype-Specific Insertion Of Cytotoxic Genetic Elements Into Cancer Cells, Ryan Englander

University Scholar Projects

The new gene editing system CRISPR/Cas9, composed of a complex composed of a guide RNA and the Cas9 endonuclease, promises to revolutionize biological research and potentially allow clinicians to directly modify patient DNA in vivo. While its applications in the treatment of genetic diseases and in modifying immune cells for immunotherapy are currently being explored, CRISPR/Cas9’s potential utility as a modular system for targeting tumor-specific mutated sequences has not as of yet been explored. While CRISPR/Cas9 is specific enough to target small insertions and deletions or gross chromosomal rearrangements, it is not specific enough to reliably restrict editing to …

A Journey Through Homelessness: A Photovoice Project With Youth Experiencing Homelessness In Minnesota, Bonnie D. Paulsen

Theses and Graduate Projects

The purpose of this project was to conduct a photovoice project with youth experiencing homelessness who frequent a drop-in center in the Midwest. Youth experiencing homelessness are a marginalized population whose numbers continue to grow. Photovoice is a method by which marginalized populations have an opportunity to express their lived experiences through photographs and what those photographs mean to them. Four youth from the drop-in center in the Midwest participated in the photovoice project. The youths were given cameras and instructions to take photographs of three broad areas: what homelessness means to them, their dreams for their futures and how …

Can The Philanthropic Imperative Enhance International Health Care?, Paul Carrick

Philosophy Faculty Publications

Elsewhere I have argued that, historically, the public and private funding of health care has been fueled primarily by four mixed motives, namely, the redemptive, the utilitarian, the prudential, and the charitable motives. In this paper, I further explore what I call the unifying moral force of the philanthropic imperative. The philanthropic imperative interfaces these four motives by potentially appealing to the consciences of wealthier Northern countries to provide medical resources to the sick and hurting in the typically poorer South. This, as a matter of our collective duty to others consistent with the teachings of Immanuel Kant, Thich Nhat …