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2018

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Health Administration, Health Promotion Jan 2018

Health Administration, Health Promotion

Program Revisions/Additions

No abstract provided.

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Workplace Standing Desks And Arterial Stiffness, Ian Greenlund Jan 2018

Workplace Standing Desks And Arterial Stiffness, Ian Greenlund

Dissertations, Master's Theses and Master's Reports

Many jobs in today’s society require sitting at a desk with little physical activity. Individuals who engage in ten hours of sedentary behavior per day double their CVD risk. Standing desks are thought to decrease sedentary time and improve cardiovascular health. Acute use of standing desks is shown to lower PWV. However, chronic effects remain unknown. Forty eight participants qualified as seated (19 females, 5 males: age 41 ± 2 years, BMI 25 ± 1 kg/m2) or standing (21 females, 3 males: age 45 ± 2 years, BMI 25 ± 1 kg/m2) groups based on habitual …

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Establishment Of A Human Ipsc- And Nanofiber-Based Microphysiological Blood–Brain Barrier System, Dianjun Qi, Shaohua Wu, Haishuang Lin, Mitchell A. Kuss, Yuguo Lei, Alexey Krasnoslobodtsev, Shaheen Ahmed, Chi Zhang, Hyung Joon Kim, Peng Jiang, Bin Duan Jan 2018

Establishment Of A Human Ipsc- And Nanofiber-Based Microphysiological Blood–Brain Barrier System, Dianjun Qi, Shaohua Wu, Haishuang Lin, Mitchell A. Kuss, Yuguo Lei, Alexey Krasnoslobodtsev, Shaheen Ahmed, Chi Zhang, Hyung Joon Kim, Peng Jiang, Bin Duan

Department of Chemical and Biomolecular Engineering: Faculty Publications

The blood–brain barrier (BBB) is an active and complex diffusion barrier that separates the circulating blood from the brain and extracellular fluid, regulates nutrient transportation, and provides protection against various toxic compounds and pathogens. Creating an in vitro microphysiological BBB system, particularly with relevant human cell types, will significantly facilitate the research of neuropharmaceutical drug delivery, screening, and transport, as well as improve our understanding of pathologies that are due to BBB damage. Currently, most of the in vitro BBB models are generated by culturing rodent astrocytes and endothelial cells, using commercially available transwell membranes. Those membranes are made of …

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Milk Exosomes Are Bioavailable And Distinct Microrna Cargos Have Unique Tissue Distribution Patterns, Sonia Manca, Bijaya Upadhyaya, Ezra Mutai, Amy T. Desaulniers, Rebecca A. Cederberg, Brett R. White, Janos Zempleni Jan 2018

Milk Exosomes Are Bioavailable And Distinct Microrna Cargos Have Unique Tissue Distribution Patterns, Sonia Manca, Bijaya Upadhyaya, Ezra Mutai, Amy T. Desaulniers, Rebecca A. Cederberg, Brett R. White, Janos Zempleni

Department of Nutrition and Health Sciences: Faculty Publications

Exosomes participate in cell-to-cell communication, facilitated by the transfer of RNAs, proteins and lipids from donor to recipient cells. Exosomes and their RNA cargos do not exclusively originate from endogenous synthesis but may also be obtained from dietary sources such as the inter-species transfer of exosomes and RNAs in bovine milk to humans. Here, we assessed the bioavailability and distribution of exosomes and their microRNA cargos from bovine, porcine and murine milk within and across species boundaries. Milk exosomes labeled with fluorophores or fluorescent fusion proteins accumulated in liver, spleen and brain following suckling, oral gavage and intravenous administration in …

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Physiological Responses In Reindeer To The Application Of A Conducted Electrical Weapon, Camilla L. Lieske, Kimberlee B. Beckmen, Larry L. Lewis Jan 2018

Physiological Responses In Reindeer To The Application Of A Conducted Electrical Weapon, Camilla L. Lieske, Kimberlee B. Beckmen, Larry L. Lewis

Human–Wildlife Interactions

Conducted Electrical Weapons (CEWs) have potential as effective alternatives to chemical restraint for short-term non-routine capture and handling as well as aversion hazing of wildlife. To assess immediate and delayed physiologic effects of exposure to a CEW, we assigned 15 captive reindeer (Rangifer tarandus tarandus) to one of three treatment groups: immobilized with carfentanil and xylazine (CX), 10 second exposure to a CEW, or exposure to the CEW while immobilized with CX (CEW+CX). Blood samples were collected pre-treatment, immediately post-intervention, 10 min, 20 min, 4 hours, and 24 hours post-intervention. Physiologic effects were evaluated by analysis of blood, …

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Ample Evidence For Fish Sentience And Pain, Lynne U. Sneddon, David C.C. Wolfenden, Matthew C. Leach, Ana M. Valentim, Peter J. Steenbergen, Nabila Bardine, Donald M. Broom, Culum Brown Jan 2018

Ample Evidence For Fish Sentience And Pain, Lynne U. Sneddon, David C.C. Wolfenden, Matthew C. Leach, Ana M. Valentim, Peter J. Steenbergen, Nabila Bardine, Donald M. Broom, Culum Brown

Animal Sentience

The majority of commentaries are supportive of our position on the scepticism that muddies the waters surrounding fish pain and sentience. There is substantial empirical evidence for pain in fish. Animals’ experience of pain cannot be compared to artificial intelligence (AI) because AI can only mimic responses to nociceptive input on the basis of human observations and programming. Accepting that fish are sentient would not be detrimental to the industries reliant on fish. A more proactive discussion between scientists and stakeholders is needed to improve fish welfare for the benefit of all.

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Touching The Unreal: The Definition, Narrative Strategies, And Aesthetics Of 3d Cartoon Narratives., Nathan Snow Jan 2018

Touching The Unreal: The Definition, Narrative Strategies, And Aesthetics Of 3d Cartoon Narratives., Nathan Snow

Electronic Theses and Dissertations

"Touching the Unreal" follows the structure set out by Scott McCloud in Understanding Comics to argue that understanding cartoons is serious business and requires that we define the art form, outline its basic tenets, and theorize how the mind understands it. The dissertation argues for a new definition of 3D computer generated cartoons, beginning with the most basic definition applicable to all forms of animation and taking into account new technological developments before arriving at the 3D cartoon narratives of today. The dissertation outlines the basic facets of 3D cartoon narratives in terms of narrative and aesthetics, arguing that, in …

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Regulation Of Extra-Pituitary Prolactin In Monocytes And Macrophages, Richard Barrett Jan 2018

Regulation Of Extra-Pituitary Prolactin In Monocytes And Macrophages, Richard Barrett

Electronic Theses and Dissertations

Recently it has been shown that leukocytes are capable of producing prolactin (PRL). Evidence of extra-pituitary PRL (ePRL) production is so far been limited to primates and is not shared across other mammal species such as mice and rats. While ePRL is characterized as an identical protein to traditional pituitary PRL, it is controlled under an alternative promoter and is thus regulated differently from pituitary PRL. Little is known about what regulates ePRL or its direct role in human physiology, but given that PRL has well over 300 described functions, it is likely that the autocrine and paracrine effects of …

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Characterization Of Neural Cells Derived From Reelin-Deficient Schizophrenic Patient Ips Cells, Nicole Roberts Jan 2018

Characterization Of Neural Cells Derived From Reelin-Deficient Schizophrenic Patient Ips Cells, Nicole Roberts

Electronic Theses and Dissertations

Reelin is a large, extracellular glycoprotein that binds to several membrane receptors on neural stem cells (HNSCs), neural progenitor cells (NPCs), and neuroblasts of mammals to direct their migration. Previously, our lab established the presence of Reelin increased migration of wild-type fetal-derived HNSC's, both in vitro and in vivo. In addition, we demonstrated that Reelin protein treatment also increases the formation of radial glia via Notch-1 signaling, in vitro. Radial glia are precursors to NPCs, as well as a scaffold for neuroblast migration during cortical lamination. Reelin has long been associated with Schizophrenia (SZ). Because post-mortem brains are limited to …

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Biom 3110: Medical Physiology (Syllabus), Bradford D. Pendley Jan 2018

Biom 3110: Medical Physiology (Syllabus), Bradford D. Pendley

Biomedical Engineering Syllabi Archive

Course Description: Basic principles of human physiology and how these are applied in medicine and biomedical engineering problem and devices; physiological principles using appropriate mathematical and engineering models to construct an understanding of how the body works as an integrated system.

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Modeling Of Realistic Heart Electrical Excitation Based On Dti Scans And Modified Reaction Diffusion Equation, Ihab Elaff Jan 2018

Modeling Of Realistic Heart Electrical Excitation Based On Dti Scans And Modified Reaction Diffusion Equation, Ihab Elaff

Turkish Journal of Electrical Engineering and Computer Sciences

A new method is proposed for modeling realistic heart activation using diffusion tensor imaging (DTI) scans based on biological properties of its tissues in addition to the working methodology of the DTI scanner. Modeling of the excitation propagation inside the heart is initiated by applying activation at only one pacing site at the root of the conduction network. The excitation propagation has been accomplished based on a proposed conduction system that is extracted from DTI heart scans and a modified version of monodomain reaction diffusion equation (RDE) that considers the heart inhomogeneous--anisotropic material. The Aliev--Panfilov method was used to model …

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Gendered Language And The Construction Of Jewish Identity In 2 Maccabees, Joshua Ezra Burns Jan 2018

Gendered Language And The Construction Of Jewish Identity In 2 Maccabees, Joshua Ezra Burns

Theology Faculty Research and Publications

No abstract provided.

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Triple-Helicate Self-Assembly, Dynamics, And Anion Binding Of Halogen-Bonding M-Arylene-Ethynylene Oligomers, Casey John Massena Jan 2018

Triple-Helicate Self-Assembly, Dynamics, And Anion Binding Of Halogen-Bonding M-Arylene-Ethynylene Oligomers, Casey John Massena

Graduate Student Theses, Dissertations, & Professional Papers

The form and function of biopolymers depend on the precise folding and organization of vast arrays of chemical groups. Hence, the simple yet elegant helix is one of the most pervasive structural elements in nature. Moreover, given the ubiquity and importance of anions, anion-interfacing helical structures hold promise as useful, stimuli-responsive supramolecules. Like metals, anions can powerfully coordinate organic ligands and promote helical self-assembly. However, anion coordination is far less understood than that of metals. Halide ions are an especially challenging target due to their small size, low charge, and variable coordination number/geometry. This work presents a new strategy that …

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Inhibition Of Blood Coagulation Factor Xii: Evaluation Of Flavonoids As A Drug Candidate, Betsy Crosswhite Jan 2018

Inhibition Of Blood Coagulation Factor Xii: Evaluation Of Flavonoids As A Drug Candidate, Betsy Crosswhite

Honors Theses

This study investigated natural product inhibitors of blood coagulation Factor XII (FXII). FXII initiates the Kallikrein Kinin-System (KKS) within the intrinsic coagulation pathway. Increased expression of this system leads to proinflammatory and procoagulant activities. Inflammation occurs through downstream activation in the KKS. Following the activation of FXII-dependent pathway, bradykinin (BK) binds to the BK receptor 2 (B2) and produces inflammatory signaling. Abnormally increased BK can result in life threatening Hereditary Angioedema (HAE), characterized by severe reoccurring swelling. FXII is critical for pathogenic thrombosis, but is dispensable for hemostasis. This unique property of FXII makes it an attractive drug target. We …

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Purification Protocol Development And Analysis Of Binding Properties Of Calmodulin Collagen-Like Protein, Patrick P. Boddie Jan 2018

Purification Protocol Development And Analysis Of Binding Properties Of Calmodulin Collagen-Like Protein, Patrick P. Boddie

Honors Theses

Calmodulin is an intensely studied, intracellular, calcium-binding protein that is involved in diverse physiological processes. When bound to calcium, calmodulin undergoes a conformational change that allows it to bind specific target peptides with high affinity, one being the calmodulin binding region of myosin light chain kinase, herein called M13. This high affinity, calcium dependent association has made it a desirable choice for use in a biomaterial for drug delivery for non-steroidal anti- inflammatory drugs (NSAIDs). Two artificial genes have been designed by our lab for use in the proposed biomaterial: calmodulin collagen-like protein (CCLP), a construct composed of two calmodulin …

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Connecting The Mind And Body In Ancient Greek Medicine, Taylor Ferris Jan 2018

Connecting The Mind And Body In Ancient Greek Medicine, Taylor Ferris

Honors Theses

I investigated Greek medicine and healing shrines in antiquity and focused on the issue of the mind-body connection and how this phenomenon was understood in antiquity. I researched the Athenian plague of 430-425 B.C., sleep and dreams, particularly in the Rites of Incubation, and Hippocratic medicine as well as religious medicine in order to understand more deeply the origins of Greek medicine and how the healing phenomena were practiced and understood. I have come to a greater understanding of this connection between the mind and the body and have come to redefine the placebo effect and argue that the mind …

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High-Throughput Scaffold-Free Microtissues Through 3d Printing, Christen J. Boyer, David H. Ballard, Mansoureh Barzegar, J. Winny Yun, Jennifer E. Woerner, Ghali E. Ghali, Moheb Boktor, Yuping Wang, J. Steven Alexander Jan 2018

High-Throughput Scaffold-Free Microtissues Through 3d Printing, Christen J. Boyer, David H. Ballard, Mansoureh Barzegar, J. Winny Yun, Jennifer E. Woerner, Ghali E. Ghali, Moheb Boktor, Yuping Wang, J. Steven Alexander

Open Access Publications

No abstract provided.

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A Systematic Meta-Analysis Of Oxygen-To-Glucose And Oxygen-To-Carbohydrate Ratios In The Resting Human Brain, Tyler Blazey, Abraham Z. Snyder, Manu S. Goyal, Andrei G. Vlassenko, Marcus E. Raichle Jan 2018

A Systematic Meta-Analysis Of Oxygen-To-Glucose And Oxygen-To-Carbohydrate Ratios In The Resting Human Brain, Tyler Blazey, Abraham Z. Snyder, Manu S. Goyal, Andrei G. Vlassenko, Marcus E. Raichle

Open Access Publications

No abstract provided.

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Treating Outer Space Like A Place: A Case For Rejecting Other Domain Analogies, Elizabeth Mendenhall Jan 2018

Treating Outer Space Like A Place: A Case For Rejecting Other Domain Analogies, Elizabeth Mendenhall

Marine Affairs Faculty Publications

The creation and augmentation of the outer space governance regime during the twentieth century was guided by the use of analogies with other planetary domains. These analogies compare the “target” domain of outer space with various “source” domains, especially airspace, the seabed, the high seas, and Antarctica. These analogies, highlighted at different times to provide guidance on the regulation of existing and emerging space activities, shaped the fundamental principles and rules of the Outer Space Treaty. A survey of contemporary literature demonstrates that analogies continue to be used to structure thinking about outer space activities. This paper argues that such …

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Correlating Residual Stress With Personal And Professional Characteristics In Aircraft Pilots, Erik Eckblad Jan 2018

Correlating Residual Stress With Personal And Professional Characteristics In Aircraft Pilots, Erik Eckblad

Walden Dissertations and Doctoral Studies

Every day aircraft pilots must successfully resolve significant inflight situations and then manage the possibility of residual psychological and physiological stress. Previous research has shown primary attention is given to presignificant event training and stress management, however there remains an important gap in the current literature regarding postsignificant event stress within the aviation profession. The purpose of this cross-sectional quantitative study was to use the observational lens of stress theory and survey U.S. pilots who have experienced an inflight emergency, looking for correlation between factors such as age, gender, flight experience, and training against a pilot's self-reported level of residual …

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Formulation Of Nanoparticle Systems For Drug Delivery Application In Biomedical Sciences, Victor Alfredo Rodriguez Jan 2018

Formulation Of Nanoparticle Systems For Drug Delivery Application In Biomedical Sciences, Victor Alfredo Rodriguez

Open Access Theses & Dissertations

Antibiotic-resistant strains of bacteria may result in serious infections which are difficult to treat. In addition, the poor antibiotic pipeline has also contributed to the crisis. Recently, the complex of furosemide and silver (Ag-FSE) has been reported as a potential antibacterial agent. However, its poor aqueous solubility is limiting its activity as an effective antibacterial agent. The purpose of this study was to encapsulate Ag-FSE into chitosan nanoparticles (CSNPs) and evaluate antibacterial efficacy. Ag-FSE CSNPs were prepared using ionic gelation technique. The particle size, polydispersity index and zeta potential of Ag-FSE CSNPs were determined using dynamic light scattering (DLS) technique. …

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A Continued Musical And Personal Dialogue With The Waves Of Epilepsy., Alan Douglas Miles Jan 2018

A Continued Musical And Personal Dialogue With The Waves Of Epilepsy., Alan Douglas Miles

Other Faculty of Arts, Humanities and Business Theses

A Continued Musical and Personal Dialogue with the Waves of Epilepsy. In the early hours of the morning several years ago I awoke with paramedics leaning over me. In a state of confusion, my first conscious decision was to enter my music production studio while they attempted to lead me to the ambulance. Music was important to me even in a disorientated post-ictal state (an altered state of consciousness following a seizure). Two weeks later I awoke with paramedics standing over me again. I had started to experience multiple seizures. During the previous weeks, I also experienced numerous incidents of …

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“We’Re Being Left To Blight”: Green Urban Development And Racialized Space In Kansas City, Chhaya Kolavalli Jan 2018

“We’Re Being Left To Blight”: Green Urban Development And Racialized Space In Kansas City, Chhaya Kolavalli

Theses and Dissertations--Anthropology

In this dissertation, I explore ‘green’ urban development and urban agriculture projects from the perspective of residents of an African American majority neighborhood in Kansas City—who reside in an area referred to as a ‘blighted food desert’ by local policy makers. In Kansas City, extensive city government support exists for urban agricultural projects, which are touted not just as a solution to poverty associated issues such food insecurity and obesity, but also as a remedy for ‘blight,’ violence and crime, and vacant urban land. Specific narratives of Kansas City’s past are used to prop up and legitimate these future visions …

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Reduced Graphene Oxide-Modified Screen-Printed Carbon Electrode For Determination Of Homocysteine Using Catechol, Suchapa Naranaruemol Jan 2018

Reduced Graphene Oxide-Modified Screen-Printed Carbon Electrode For Determination Of Homocysteine Using Catechol, Suchapa Naranaruemol

Chulalongkorn University Theses and Dissertations (Chula ETD)

Homocysteine (Hcy), also known as 2-amino-4-mercaptobutyric acid, is a biomarker that is directly associated with an increased risk of cardiovascular diseases (CVDs). In this work, catechol (CA), which is redox active, had been used as an electron transfer mediator to facilitate the oxidation of Hcy. Typically, CA was first electrochemically immobilized onto the surface of screen-printed carbon electrode; however, the obtained CA-functionalized electrode did not show the electrocatalytic activity towards the detection of Hcy. Therefore, the deter– mination of Hcy was investigated in the solution containing CA using differential pulse voltammetry (DPV) at the reduced graphene oxide-modified screen-printed carbon electrode …

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Pm10 And Pm2.5 Concentrations In Bangkok Over 10 Years And Implications For Air Quality, Tin Thongthammachart Jan 2018

Pm10 And Pm2.5 Concentrations In Bangkok Over 10 Years And Implications For Air Quality, Tin Thongthammachart

Chulalongkorn University Theses and Dissertations (Chula ETD)

Atmospheric particulate matter particles with a diameter less than 10 micron (PM10) and less than 2.5 micron (PM2.5) have been adverse human health effect. Ambient air pollution data in Central Business District (CBD) of Bangkok monitored by Pollution Control Department and Bangkok Metropolitan Administration were collected over ten years in Bangkok from 2008 to 2017. Trend of the particulate matter concentrations data were investigated over ten year for implications of activities related to air pollution. Daily average air pollution data between year 2015 and year 2017 were used as the dependent variables to develop mathematic models with multiple linear regression …

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Gastrointestinal Microbiota Modulate Antinociceptive Tolerance Development In Mice With Chronic Morphine Exposure, Ryan A. Mischel Jan 2018

Gastrointestinal Microbiota Modulate Antinociceptive Tolerance Development In Mice With Chronic Morphine Exposure, Ryan A. Mischel

Theses and Dissertations

In October 2017, the United States government declared a state of public health emergency in response to the burgeoning prescription opioid epidemic. Opioid analgesics are the gold standard of therapy for moderate to severe pain, but their clinical utility is greatly limited by analgesic tolerance – a primary driver of diminished pain control and opioid dose escalations. Integral in this process are primary afferent sensory neurons in dorsal root ganglia (DRG), the first-order components of nociceptive sensation. With surmounting evidence that morphine and other narcotics can alter gut microbial composition and promote bacterial translocation to other tissues, a question arises …

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Effects Of The Na-Cl Co-Transporter (Ncc) In Western Diet Induced Metabolic And Cardiac Dysfunction, Zachary S. Cutter Jan 2018

Effects Of The Na-Cl Co-Transporter (Ncc) In Western Diet Induced Metabolic And Cardiac Dysfunction, Zachary S. Cutter

Theses and Dissertations

Interleukin-18 (IL-18) is a pro-inflammatory cytokine known to be involved in maintaining metabolic homeostasis; however, also capable of inducing cardiac dysfunction. Additionally, IL-18, has been shown to bind to a novel receptor, the Na-Cl Co-transporter (NCC). We hypothesized that NCC mediates IL-18 metabolic and cardiac signaling in mice. Using male C57BL/6J mice, we compared the metabolic and cardiac function changes after at least 8 weeks of high-saturated fat high sugar diet (Western Diet) in NCC knockout (NCCKO), IL-18 knockout (IL-18KO), and wild-type mice. We show that NCCKO mice have significantly increased body weight gain from baseline, no difference in fasting …

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The Protective Effects Of Chrysin And Flunixin Meglumine Against Excess Copper In Male Rats, Pinar Tatli Seven, Burcu Gül Baykalir, İsmai̇l Seven, Tuba Parlak Ak, Neşe Başak Türkmen, Hakan Güllüoğlu Jan 2018

The Protective Effects Of Chrysin And Flunixin Meglumine Against Excess Copper In Male Rats, Pinar Tatli Seven, Burcu Gül Baykalir, İsmai̇l Seven, Tuba Parlak Ak, Neşe Başak Türkmen, Hakan Güllüoğlu

Turkish Journal of Veterinary & Animal Sciences

Thirty-six Sprague Dawley male rats were housed in individual cages and randomly divided into six groups: control, copper sulfate (Cu; 500 ppm body weight (BW)/day), flunixin meglumine (FM; 2.2 ppm BW/day), chrysin (chrysin; 50 ppm BW/day), copper sulfate + FM (Cu + FM; 500 ppm BW/day of copper sulfate and 2.2 ppm BW/day of FM), and copper sulfate + chrysin (Cu + Chrysin; 500 ppm BW/day of copper sulfate and 50 ppm BW/day of chrysin). Feed intake (FI) in the Cu + Chrysin group significantly increased in comparison with that of the Cu group (P < 0.01). Cu excess significantly increased malondialdehyde, indicating oxidative stress. Chrysin and FM administration significantly decreased malondialdehyde levels and increased the superoxide dismutase and catalase activities in the liver and kidney tissues (P < 0.001). Serum TNF-α levels were significantly lower in the Cu + FM and Cu + Chrysin groups in comparison to the Cu group (P < 0.001). It was seen that FM and chrysin treatments alleviated degeneration, necrosis, and apoptosis in the liver and kidney tissues of the Cu-treated rats. Chrysin appeared to ameliorate the adverse effects on FI and liver and kidney tissues by scavenging where the free radicals are located and increasing the activity of antioxidants.

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Neurochemistry, Physiology, And Behavior In A Model Of Gulf War Illness, Victoria A. Macht Jan 2018

Neurochemistry, Physiology, And Behavior In A Model Of Gulf War Illness, Victoria A. Macht

Theses and Dissertations

Upon returning from the first Gulf War, soldiers cited a plethora of unexplained physical and cognitive deficits which have since been termed Gulf War Illness (GWI). Presentation of GWI is positively correlated with pyridostigmine bromide (PB) use, which was prophylactically administered to soldiers in response to threats of chemical warfare. To test the overarching hypothesis that PB interacted with stress of deployment to alter neural, endocrine, and immune systems, the following studies used a 2×2 rodent model with 14 days of drug treatment (vehicle; PB) and 10 days of repeated restraint stress (stressed) or non-stressed-control conditions. Results indicate that PB …

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The Influence Of Instructional Design Decisions On Student Motivation In Online Courses, Robin E. Youger Jan 2018

The Influence Of Instructional Design Decisions On Student Motivation In Online Courses, Robin E. Youger

Graduate Theses, Dissertations, and Problem Reports (ETD)

The goal of higher education is to educate, train, and motivate people (Hunt, 1998). Typically, best practices and accepted design strategies are used to develop online courses that fulfill the needs of the university, faculty, and student stakeholders. This study examines two methods of instructional design -- the Quality Matters (QM) process, and Keller's ARCS motivational design process -- to understand if instructional design decisions have influence on student motivation in online courses. Quality Matters (QM) offers a well-researched process of designing online courses based on nationally-recognized standards. The QM format provides an ideal objectives-based course design; however, it does …

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