Digital Commons Network^™

Absolute Oral Bioavailability Of Creatine Monohydrate In Rats: Debunking A Myth, Eman A. Alraddadi, Ryan Lillico, Jonathan L. Vennerstrom, Ted M. Lakowski, Donald W. Miller

Journal Articles: Pharmaceutical Sciences

Creatine is an ergogenic compound used by athletes to enhance performance. Supplementation with creatine monohydrate (CM) has been suggested for musculoskeletal and neurological disorders. Until now, little is known about its pharmacokinetic profile. Our objective was to determine the oral bioavailability of CM and the influence of dose on oral absorption. Rats were dosed orally with low dose (10 mg/kg) or high dose (70 mg/kg)

Human Anatomy Lab Manual, Malgosia Wilk-Blaszczak

Mavs Open Press Open Educational Resources - Archive

This is a lab manual for a college-level human anatomy course. Mastery of anatomy requires a fair amount of memorization and recall skills. The activities in this manual encourage students to engage with new vocabulary in many ways, including grouping key terms, matching terms to structures, recalling definitions, and written exercises. Most of the activities in this manual utilize anatomical models, and several dissections of animal tissues and histological examinations are also included. Each unit includes both pre- and post-lab questions and six lab exercises designed for a classroom where students move from station to station. The vocabulary terms used …

Towards A Rule-Based Model Of Human Choice: On The Nature Of Homo Constitutionalus, Roger Congleton

Economics Faculty Working Papers Series

Anglo-American jurisprudence emphasizes the rule of reason; it grossly neglects the reason of rules. We play socioeconomic-legal-political games that can be described empirically only by their rules. But most of us play without an understanding or ap-preciation of the rules, how they came into being, how they are enforced, how they can be changed, and most important, how they can be normatively evaluated. (Bren-nan and Buchanan, 1985, preface).

Health Promotion Community Health Option, Health Promotion

Program Revisions/Additions

No abstract provided.

Health Promotion Bs Community Health, Health Promotion

Program Revisions/Additions

No abstract provided.

Design And Development Of Simulation-Based Instruction On Meaningful Use And Interprofessionalism Core Competencies In A Healthcare Team-Based Learning Environment, Elizabeth Oviawe

CCAC Theses and Dissertations

Policymakers and electronic health records (EHR) experts agree that healthcare professionals lack proficiency in meaningful use of EHRs. This competency gap can result in increased medical errors. It is essential for health professions graduates to acquire skill sets that are adaptable to any electronic health information technologies including the EHRs to facilitate work process and information access. Simulation as an instructional method to create transformative learning experiences has shown promise in the medical profession. In simulations, learners are able to engage in real-life scenarios and practice their cognitive, affective, and psychomotor skills in a safe environment.

The goal was to …

Preparing For The Future: 2017–2018 Annual Report

University of Nebraska's National Strategic Research Institute: Publications

3 Letter from the Executive Director Robert Hinson

4 About NSRI-- Combatting WMD. Focusing on Deterrence.

6 Key Accomplishments/ Highlights of Business Operations Research Focus Areas

8 Nuclear Detection and Forensics

10 Active and Passive Defense Against Weapons of Mass Destruction

12 Detection of Chemical and Biological Weapons

14 Consequence Management

16 Mission-Related Research

18 Education & Training

20 Student & Faculty Engagement

22 NSRI/NU Key Journal Articles, 2017–2018

23 NSRI Board of Directors

Differentiating Human Populations Based On K-Mer Classification Of Hand Bacteria, Thrisha Doppala

Graduate Theses, Dissertations, and Problem Reports (ETD)

Bacterial communities found in and on the human body are not only used in studying human health conditions but are also effective in differentiating individuals due to their distinct profiles. Human palm regions harbor relatively more diverse bacterial communities and are indicative of population groups, life styles, geographic locations, age groups and health conditions. Sequences extracted from hypervariable region V3 of the 16S rRNA bacterial gene of hand bacterial samples from 9 different population groups were classified into Operational Taxonomic Units (OTU) with GreenGenes reference taxonomy using RDP (Ribosomal Database Project) classifier. Frequencies of identified OTUs were used to study …

Bio 2292 : Anatomy And Physiology Ii, Honors, Biological Sciences

Approved Course Proposals

No abstract provided.

Bio 2291 : Anatomy And Physiology I, Honors, Biological Sciences

Approved Course Proposals

No abstract provided.

Development And Validation Of A Scale To Measure Misconceptions About Educational Psychology Among Pre-Service Teachers, Morgan Mcafee

Electronic Theses and Dissertations

Misconceptions are widespread or commonly held beliefs explicitly contradicted by empirical evidence. When teachers harbor misconceptions or unjustified beliefs about teaching, learning, and human motivation, the potential pedagogical consequences are profound, and these inaccurate beliefs may be instilled into future students through ineffective teaching strategies and gross misinterpretations of learning science. While existing research has examined misconceptions about general psychology and neuroscience among various populations, no prior work has evaluated pre-service teachers' misconceptions about topics of educational psychology, comprising inaccurate beliefs about teaching, learning, and human motivation. The purpose of this research is to describe the development and validation of …

Development Of A Non-Human Primate Model For Staphylococcus Aureus Nasal Carriage, Amanda Lasseter

Electronic Theses and Dissertations

Staphylococcus aureus nasal carriage (SANC) is largely asymptomatic, but presents a risk of autoinfection and dissemination to new immunocompromised hosts. SA disease states range from mild cutaneous infections to life-threatening bacteremia. Historically utilized rodent models do not naturally carry SA in the nose, are insufficient in longitudinal SANC experimentation, and lack immune factors that are vital in human clearance of SA. The nasal passages of non-human primates are similar anatomically and histologically, and reproductive mucosal studies have shown similar immune responses to pathogens and human-relevant microbial profiles. Seventeen captive pigtailed macaques (Macaca nemestrina) were found to naturally carry SA in …

Bulletin Of Yale University School Of Nursing 2018-2019, Yale School Of Nursing

Yale School of Nursing Bulletins and Catalogues

Series 114, Number 15

September 5, 2018

Quantifying Extravehicular Activity Performance Degradation Due To Sustenance Deprivation, Eryn Beisner

Theses and Dissertations

Modern EVAs (spacewalks) performed onboard the International Space Station require astronauts to endure up to twelve hours of intense mental and physical exertion without food, as they do not stop to eat nor do they currently have the capabilities to consume sustenance in their spacesuits. With the future of space exploration taking aim at the Moon, Mars, and beyond, EVAs are expected to become more demanding than ever. This is a pilot study to attempt to quantify astronaut performance during an EVA to determine if there is significant performance degradation because of acute starvation. Astronauts conducting EVA training at NASA’s …

Arterial And Venous Impacts Of Transdermally Administered Vasodilators On The Local Microvasculature, George Guo

Yale Medicine Thesis Digital Library

Microcirculatory function is an important component of cardiovascular pharmacology as related to cardiovascular dysfunction. We used photoplethysmography (PPG) to compare the microcirculatory effects of transdermal patches of rivastigmine (Exelon, Novartis), nicotine, nitroglycerin (NTG) and topically applied EMLA (eutectic mixture of lidocaine/prilocaine). We anticipate that this initial pilot comparison of single doses of each medication will catalyze future multi-dose comparisons of the various vasodilatory features of these and other drugs.

Methods: With IRB approval, 10 healthy volunteers were monitored with PPG at the time each transdermal patch was applied and every 8 minutes afterwards for a total of 40 minutes. 1x1 …

The Role Of Pro-Inflammatory Mediators Ifnβ And Prostaglandin E2 In Suppression Of Innate Immunity To Listeria Monocytogenes, Michelle G. Pitts

Theses and Dissertations--Microbiology, Immunology, and Molecular Genetics

As a foodborne pathogen, Listeria monocytogenes (Lm) encounters many barriers to invasion and dissemination in the host that may change the nature of host response. Lm has been most commonly studied using intravenous (i.v.) inoculation, however, a method that delivers a bolus of bacteria directly to the bloodstream. Thus, little is known about what systemic and local mediators are triggered during the natural course of infection and how these may impact susceptibility. Our laboratory used foodborne transmission of Lm in mice to assess whether the method of transmission and the specific organ microenvironment could affect infection-induced secretion of …

Psychophysiology Meets Computer Science: Predicting The Magnitude Of Participant Physiological Response With Machine Learning, Avonie Parchment

Electronic Theses and Dissertations

The present inquiry uses methods from psychophysiology and machine learning to reduce overall error in classification models. The field of psychophysiology, though rooted in decades of experimentation, has never reached the same level of precision as some aspects of medical inquiry. In fact, while some medical regression models, when determining some way to classify a patient's illness based on certain symptoms, can result in highly significant results with large effect sizes, equal levels are virtually unheard of in psychophysiology. The present investigation attempts to unravel some part of this mystery and determines some possible reasons for the difficulty in finding …

Centrifugal Microfluidics For Label-Free Isolation Of Leukocytes Subpopulations From Whole Blood, Yuxi Sun

All ETDs from UAB

Leukocytes carry critical information regarding the immediate immune and inflammation status of the patients. Analysis of leukocytes requires isolation from blood since the leukocytes only consist <1% of all blood cells. Commonly used isolation processes exploit physical or biochemical differences between different cell types to enable separations. Current isolation methods inevitably subject cells to physical or biochemical stress that can activate leukocytes and change their natural state. Thus, information contained within isolated leukocytes is a combination of the natural state of the cell and an artifact of the isolation process. Microfluidics which takes advantage of scaling effects within microscale structures can ensure rapid and gentle alternatives to conventional isolation methods and is ideal for sorting, and analysis of cells and particles. The precise control of flow/particles and scaling effects of microfluidics have been applied for blood cells sorting and isolation. However, the limited processing capability and throughput as well as complex fabrication and operations have hampered widespread adoption of these approaches for replacement of conventional methods. My goal was to develop a simple yet powerful microfluidic tool that enables rapid separation of leukocytes while ensuring sufficient throughput, and minimizing isolation process induced activation without the need any sample pre-processing. This project is divided into two specific aims: i) to miniaturize the conventional density gradient centrifugation using centrifugal microfluidics for PBMC isolation and evaluate separation efficiency and activation status of isolated cells in comparison to conventional techniques; ii) develop new approach for PBMC sorting using microfluidic phase partitioning to enable separation of cells based on differences in cell surface energy. For specific aim 1, PBMCs were isolated based on differences in densities using microfluidic density gradient centrifugation. We show that PBMCs can be isolated from 100µl whole blood within 5 minutes. Evaluation of leukocyte activation via profiling of expression of surface integrins and chemokine receptors shows that our microfluidic approach significantly reduced PBMC activation in comparison to conventional isolation approaches. In specific aim 2, we sought to isolate cells based on differenced in surface energy using two-phase partitioning of dextran (DEX) and polyethylene glycol (PEG). Proof of concept demonstrations was accomplished using with polystyrene and silicon dioxide microbeads which represent a mixture of white blood cells and red blood cells. The DEX and PEG mixtures were introduced into a circular channel and phase separated under centrifugal force into unique DEX and PEG phases. The bead mixture was isolated via differences in their affinity to the two phases.

Virtual Environments For The Induction Of Action, Brian Adrian Flowers

Open Access Dissertations

This dissertation is a study on the ways in which Virtual Reality can actively and reactively affect human physiology. The first manuscript describes the design of a highly generalized Virtual Reality biofeedback system. This system was developed such that, given proper design, it would be able to provide users with a highly responsive Virtual Environment to meet the criteria of embodiment, which will increase the user's responsiveness to stimuli. The system also functions as a biofeedback system that can be used for biomechanical as well as physiological feedback by using a generalized design paradigm.

The second manuscript describes a biofeedback …

Effects Of Lighting And Noise On Performance And Situation Awareness In Air Traffic Control Tasks, Saralee Pruksaritanon

Student Works

Work environment influences an individual’s performance and situation awareness (SA). This study aims to investigate the effects of lighting and noise on the performance and SA in air traffic control (ATC) tasks. These two variables are important in the domain of ATC because the tasks require an individual to receive and process information both visually and auditorily. The results are useful for designing air traffic control rooms, which are set differently among different air navigation service providers. The subjects are 16 students majoring in Air Traffic Management (ATM) at Embry-Riddle Aeronautical University (ERAU) – Daytona Beach, FL. The research uses …

Outlook Magazine, Winter 2018

Outlook Magazine

No abstract provided.

The Effects Of Exercise Training On Cardiovascular-Related Circulating Micrornas, Jacob Luther Barber

Theses and Dissertations

PURPOSE: MicroRNAs (miRNAs) are small regulatory RNAs that post transcriptionally modify mRNAs and control gene expression. Circulating miRNAs are significantly altered following a single session of exercise, however the effects of exercise training on the circulating miRNA profile is unclear. Therefore, the purpose of the present study was to determine the effects of endurance exercise training on the abundance of targeted circulating miRNAs and the association of changes in miRNA levels with concomitant changes in cardiometabolic traits, in a subsample of adults from the HERITAGE Family Study.

METHODS: This exploratory analysis examined 20 previously sedentary adults from the HERITAGE Family …

Unwavering Gratitude: 2017-18 Report Of The President, Office Of The President, Gonzaga University

Office of the President Publications

Each year, Gonzaga University's Office of the President produces an annual Report of the President. This publication that highlights just a few of the many accomplishments over the previous academic year, and is intended to convey gratitude to our Trustees and Regents, benefactors, and many supporters.

Rocky Mountain High: An Investigation Of Downhill Snow Sports And Marijuana Use, Silas Phillips

Undergraduate Theses, Professional Papers, and Capstone Artifacts

What comes to mind when you imagine a ‘stoner?’ Most stereotype the term– some couch-bound, chip-munching slouch with a foggy gaze (and perhaps a goofy grin). Marijuana and its chemical effects hold an increasing presence in American minds. With full legalization of recreational use in 8 states and various degrees of medical legality in 18 others, the substance is caught up in a cultural shift. Our society is tackling the ethicality of marijuana, and the stigmas built around the drug are changing. What was once cited for ‘reefer madness’ is becoming (to some) a medical treatment, or just another way …

Acute Cardiovascular Responses To Novel Combinations Of Resistance And Aerobic Exercise, Travis Wakeham

Dissertations, Master's Theses and Master's Reports

Cardiovascular disease (CVD) is the leading cause of death globally. One of the most effective forms of prevention and treatment is physical activity. However, recent studies have suggested that resistance exercise can increase arterial stiffness. Maintaining adequate strength is critical for performing activities of daily living, occupational-related tasks, and sport movements. The purpose of this project was to determine if novel combinations of resistance and aerobic exercise could offer musculoskeletal benefits without adverse cardiovascular consequences. In Study 1, we examined the effect of order (i.e. aerobic before resistance, or resistance before aerobic) on arterial stiffness when combining these exercise …

A Combined High Salt Plus Fructose Diet Mediates Hypertension, Taija Marie Hahka

Dissertations, Master's Theses and Master's Reports

The sympathetic nervous system (SNS) is the main control center for the neurogenic regulation of blood pressure and is affected in fructose induced hypertension. The brain is by far the greatest consuming and energy demanding organ in the body which has the ability to metabolize and generate fructose but with consequences. Diets high in salt and fructose enter the body and eventually crosses the blood brain barrier where it exerts its effects on SNS signaling. The aim of this thesis is to determine the connection between fructose and hypertension along with the detrimental effects of fructose within the brain. Here …

Does Lavender Aromatherapy Or Tea Improve Quality Of Sleep In Women?, Meredith A. Mcnelis

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine whether or not “Does Lavender Aromatherapy or Tea Improve Quality of Sleep in Women?”

Study Design: Systematic review of three English language, primary, randomized controlled trials published between 2012 and 2015.

Data Sources: Three randomized controlled trials were obtained using PubMed and NCBI.

Outcomes Measured: The clinical outcome of sleep quality was measured in these studies via the Postpartum Sleep Quality Scale (PSQS), the Pittsburgh Sleep Quality Index and the Chinese Pittsburgh Sleep Quality Index (CPSQI).

Results: Statistical significance was determined for each randomized control trial (RCT) using pvalue …

Catalog Changes Rn Bs, Nursing

Program Revisions/Additions

No abstract provided.

Catalog Cover Sheet Rn To Bs In Nursing, Nursing

Program Revisions/Additions

No abstract provided.

Rn To Bs, Nursing

Program Revisions/Additions

No abstract provided.