Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Social and Behavioral Sciences (5885)
- Law (4835)
- Physical Sciences and Mathematics (4080)
- Medicine and Health Sciences (4018)
- Education (3920)
-
- Arts and Humanities (3527)
- Engineering (3077)
- Life Sciences (2813)
- Psychology (1498)
- Business (1463)
- Computer Sciences (1317)
- Sociology (902)
- Higher Education (823)
- Medical Specialties (813)
- Communication (788)
- Religion (758)
- History (682)
- Nursing (644)
- Public Health (633)
- Electrical and Computer Engineering (632)
- Physics (623)
- Biology (578)
- Computer Engineering (545)
- Mechanical Engineering (544)
- Public Affairs, Public Policy and Public Administration (540)
- Economics (524)
- Curriculum and Instruction (493)
- Constitutional Law (492)
- Library and Information Science (492)
- Teacher Education and Professional Development (483)
- Institution
-
- UIdaho Law (1283)
- University of Nebraska - Lincoln (972)
- University of South Florida (690)
- Utah State University (684)
- Brigham Young University (675)
-
- Purdue University (675)
- City University of New York (CUNY) (656)
- Walden University (654)
- Villanova University Charles Widger School of Law (575)
- Louisiana State University (567)
- University of Kentucky (566)
- University of Montana (514)
- University of Mississippi (507)
- University of Plymouth (497)
- Singapore Management University (464)
- U.S. Naval War College (422)
- Portland State University (421)
- University of South Carolina (410)
- West Virginia University (373)
- California Polytechnic State University, San Luis Obispo (359)
- Washington University School of Medicine (357)
- San Jose State University (354)
- Collin College (349)
- University of Central Florida (327)
- University of Arkansas, Fayetteville (326)
- Nova Southeastern University (320)
- University of Rhode Island (318)
- Liberty University (314)
- University of New Hampshire (310)
- University of New Mexico (301)
- Keyword
-
- Education (339)
- The U.S. Naval War College (175)
- EIU (170)
- Physics (169)
- Humans (166)
-
- Leadership (160)
- Gender (151)
- Eastern Illinois University (149)
- Daily Eastern News (148)
- Machine learning (145)
- Female (129)
- Technology (128)
- Communication (126)
- Newspaper (123)
- Assessment (114)
- United States (111)
- Male (110)
- Climate change (109)
- Particle physics (108)
- Psychology (107)
- Syllabus, syllabi, journalism, communication, media, strategic media (104)
- Nuclear physics (102)
- Student newspaper (102)
- Undergraduate (102)
- Race (101)
- Higher education (99)
- History (97)
- Children (96)
- Autism (92)
- Culture (90)
- Publication
-
- Theses and Dissertations (1488)
- Not Reported (838)
- Faculty Publications (733)
- Electronic Theses and Dissertations (644)
- Walden Dissertations and Doctoral Studies (635)
-
- 2018 Decisions (547)
- Naval War College Review (411)
- Idaho Supreme Court Records & Briefs, All (398)
- Faculty Scholarship (397)
- Dissertations (369)
- Fall 2018 (331)
- Open Access Publications (331)
- Open Access Dissertations (330)
- University of Montana Course Syllabi (310)
- Master's Theses (291)
- Articles (271)
- Honors Theses (264)
- Chulalongkorn University Theses and Dissertations (Chula ETD) (245)
- USF Tampa Graduate Theses and Dissertations (245)
- Theses (237)
- Publications and Research (231)
- Masters Theses (225)
- Research Collection School Of Computing and Information Systems (216)
- Dissertations, Theses, and Capstone Projects (211)
- Doctoral Dissertations (202)
- Faculty and Student Publications (Open Access) (189)
- Graduate Theses and Dissertations (183)
- Journal Articles (180)
- Graduate Theses, Dissertations, and Problem Reports (ETD) (176)
- Doctoral Dissertations and Projects (147)
- Publication Type
Articles 1351 - 1380 of 41108
Full-Text Articles in Entire DC Network
Prosecutorial Misconduct: Typologies And Need For Policy Reform, Rylee Broyles, Tamara J. Lynn
Prosecutorial Misconduct: Typologies And Need For Policy Reform, Rylee Broyles, Tamara J. Lynn
Academic Leadership Journal in Student Research
A gross manifestation of injustice within the criminal justice system, warranting policy development to correct, is the issue of prosecutorial misconduct. There are numerous reasons why misconduct occurs and oftentimes overlooked within the courts. Action must be taken to both prevent and rectify such wrongdoings committed by those whom are presumed to be the most virtuous of our justice system. Future policy action is paramount to the constitutionality of criminal proceedings and the abatement of prosecutorial misconduct in every capacity. The implementation of austere policies would positively impact all criminal defendants whom cross the threshold of a courthouse.
The Effects Of Sample Storage Conditions On The Microbial Community Composition In Hydraulic Fracturing Produced Water, Daniel Lipus, Amit Vikram, Richard Hammack, Kyle Bibby, Djuna Gulliver
The Effects Of Sample Storage Conditions On The Microbial Community Composition In Hydraulic Fracturing Produced Water, Daniel Lipus, Amit Vikram, Richard Hammack, Kyle Bibby, Djuna Gulliver
Roman L. Hruska U.S. Meat Animal Research Center: Reports
The petroleum industry has an increasing interest in understanding the microbial communities driving biofouling and biocorrosion in reservoirs, wells, and infrastructure. However, sampling of the relevant produced fluids from subsurface environments for microbiological analyses is often challenged by high liquid pressures, workplace regulations, operator liability concerns, and remote sampling locations. These challenges result in infrequent sampling opportunities and the need to store and preserve the collected samples for several days or weeks. Maintaining a representative microbial community structure from produced fluid samples throughout storage and handling is essential for accurate results of downstream microbial analyses. Currently, no sample handling or …
2018-19 Faculty Senate Xxiii - December 10, 2018 Minutes Summary, Faculty Senate
2018-19 Faculty Senate Xxiii - December 10, 2018 Minutes Summary, Faculty Senate
Faculty Senate Agendas & Minutes
No abstract provided.
Pervasive Iron Limitation At Subsurface Chlorophyll Maxima Of The California Current, Shane L. Hogle, Christopher L. Dupont, Brian M. Hopkinson, Andrew L. King, Kristen N. Buck, Kelly L. Roe, Rhona K. Stuart, Andrew E. Allen, Elizabeth L. Mann, Zackary I. Johnson, Katherine A. Barbeau
Pervasive Iron Limitation At Subsurface Chlorophyll Maxima Of The California Current, Shane L. Hogle, Christopher L. Dupont, Brian M. Hopkinson, Andrew L. King, Kristen N. Buck, Kelly L. Roe, Rhona K. Stuart, Andrew E. Allen, Elizabeth L. Mann, Zackary I. Johnson, Katherine A. Barbeau
Marine Science Faculty Publications
Subsurface chlorophyll maximum layers (SCMLs) are nearly ubiquitous in stratified water columns and exist at horizontal scales ranging from the submesoscale to the extent of oligotrophic gyres. These layers of heightened chlorophyll and/or phytoplankton concentrations are generally thought to be a consequence of a balance between light energy from above and a limiting nutrient flux from below, typically nitrate (NO3). Here we present multiple lines of evidence demonstrating that iron (Fe) limits or with light colimits phytoplankton communities in SCMLs along a primary productivity gradient from coastal to oligotrophic offshore waters in the southern California Current ecosystem. SCML …
The Bg News December 10, 2018, Bowling Green State University
The Bg News December 10, 2018, Bowling Green State University
BG News (Student Newspaper)
The BGSU campus student newspaper. December 10, 2018. Volume 98-Issue 29.
Daily Eastern News: December 10, 2018, Eastern Illinois University
Daily Eastern News: December 10, 2018, Eastern Illinois University
December
No abstract provided.
Practice And Lived Experience Of Menstrual Exiles (Chhaupadi) Among Adolescent Girls In Far Western Nepal. December 2018, Prabisha Amatya, Saruna Ghimire, Karen E. Callahan, Binaya Kumar Baral, Krishna C. Poudel
Practice And Lived Experience Of Menstrual Exiles (Chhaupadi) Among Adolescent Girls In Far Western Nepal. December 2018, Prabisha Amatya, Saruna Ghimire, Karen E. Callahan, Binaya Kumar Baral, Krishna C. Poudel
School of Public Health Faculty Research
Background: Menstrual exile, also known as Chhaupadi, is a tradition of “untouchability” in far-western Nepal. Forbidden from touching other people and objects, women and girls are required to live away from the community, typically in a livestock shed, during menstruation. We assessed the lived experiences of Chhaupadi among Nepalese adolescent girls in the far-western Achham district of Nepal, observed the safety and sanitation of their living spaces during Chhaupadi, and assessed the perceptions of local adult stakeholders towards the practice of Chhaupadi. Methods: We collected data from 107 adolescent girls using a self-administered survey in two local schools in Achham. …
Quantum Transfiguration Of Kruskal Black Holes, Abhay Ashtekar, Javier Olmedo, Parampreet Singh
Quantum Transfiguration Of Kruskal Black Holes, Abhay Ashtekar, Javier Olmedo, Parampreet Singh
Faculty Publications
We present a new effective description of macroscopic Kruskal black holes that incorporates corrections due to quantum geometry effects of loop quantum gravity. It encompasses both the "interior" region that contains classical singularities and the "exterior" asymptotic region. Singularities are naturally resolved by the quantum geometry effects of loop quantum gravity, and the resulting quantum extension of the full Kruskal space-time is free of all the known limitations of previous investigations of the Schwarzschild interior. We compare and contrast our results with these investigations and also with the expectations based on the AdS/CFT duality.
Initial Summary Of Far Survey, Faculty Senate
Initial Summary Of Far Survey, Faculty Senate
Faculty Senate Agendas & Minutes
No abstract provided.
The Inner Mind Of A Fashion Designer, Olivia Martinez
The Inner Mind Of A Fashion Designer, Olivia Martinez
Honors Theses
The Inner Mind of the Fashion Designer
After speaking with Laurie from the University Honors Program, I have decided to provide an inside look, into the mind of a fashion designer. So many people have no real understanding of what my industry is about. They seem to think it is all fun and games, that it is easy and that I always have a bunch of free time. They are so incredibly wrong! I want this thesis to open eyes of the readers and provide a better understanding of the plethora of intensive and difficult steps taken to create the …
Scheduling Autonomy For Nursing Staff Retention, Gina Fungcharoen, Gina Fungcharoen
Scheduling Autonomy For Nursing Staff Retention, Gina Fungcharoen, Gina Fungcharoen
Master's Projects and Capstones
It is the obligation of the Clinical Nurse Leader to place their skills up against the pulse of the microsystem they work within. This nursing leader is in a position to observe and react to flaws that affect their specific workforce. This microsystem project will provide an evidence-based perspective on how to improve monthly scheduling within the unit of 4 South, Surgical Intensive Care. The intent is to increase nurse retention as a function of improved scheduling efforts, allowing staff the ability to manage their own exchange of shifts while addressing the daily staffing needs of the unit. Despite efforts …
Change In Brain Volume And Cortical Thickness After Behavioral And Surgical Weight Loss Intervention, Cara Bohon, Allan Geliebter
Change In Brain Volume And Cortical Thickness After Behavioral And Surgical Weight Loss Intervention, Cara Bohon, Allan Geliebter
Lander College of Arts and Sciences Publications and Research
Obesity is associated with reduced cortical thickness and brain volume, which may be related to poor nutrition. Given that brain atrophy in anorexia nervosa recovers with nutritional improvements and weight gain, it is worth examining how brain structure changes at the other end of the weight spectrum with weight loss. Thus, this study aimed to examine change in cortical thickness and brain volume in 47 patients with severe obesity who participated in no treatment, behavioral weight loss, or bariatric surgery. T1-weighted MRI scans were conducted pre-treatment and approximately four months later. Measures of cortical thickness, gray matter volume, and white …
State V. Bybee Appellant's Brief Dckt. 46204
State V. Ramirez Appellant's Brief Dckt. 46256
Conscious Consumerism: A Design Process For Stylish Sustainable Apparel, Luz Becerra
Conscious Consumerism: A Design Process For Stylish Sustainable Apparel, Luz Becerra
Honors Theses
The main objective of this paper is to explore current consumer behavior and perspective on sustainable apparel as well as future trends in the market place such as willingness to buy. I investigated the market for organic apparel brands, and identified potential areas of growth. My findings concluded that young consumers lack interest in sustainable apparel because they are not sufficiently educated in the topic and are not willing to sacrifice their style identity, consequently purchasing trendy fast-fashion items. The fashion industry is famously claimed to be the second most polluting industry in the world, so I designed a line …
Predictive Models In Brain Connectivity Analysis, Guenadie Nibbs
Predictive Models In Brain Connectivity Analysis, Guenadie Nibbs
Theses
Neuroscience have been the field with most significant contributions to the study of the human brain. The development of new techniques for image acquisition has made possible the improvement of extracting quality information of brain activity. Utilizing functional MRIs, is possible to measure brain activity based on changes of the oxygen level in the blood at certain period of time. This imaging data is transformed into numerical values using a software that maps all the information into a data object. Taking advantage of the availability of functional connectivity information of the human brain, the present study shows a widespread process …
Collaborative Innovation In Global Teams: A Case Study Of The Startup Grind Inc. Global Community Team, Camey L. Andersen
Collaborative Innovation In Global Teams: A Case Study Of The Startup Grind Inc. Global Community Team, Camey L. Andersen
Student Works
The Startup Grind Inc. Global Community Team was studied to show how creativity and innovation occur in a global virtual team. Innovation occurred by choosing team members who were committed to a creative team environment. Team creativity online was strengthened by providing opportunities for the global virtual team to meet in person. Alternative brainstorming methods outside the scheduled team meetings also added to the overall innovation of the team. Flexibility with the virtual office and meetings provided a platform for the team to think outside the box. Team members achieved a unity of ideas as they used innovation and creativity …
State V. Hayes Appellant's Reply Brief Dckt. 45601
State V. Chambers Appellant's Reply Brief Dckt. 45608
State V. Chambers Appellant's Reply Brief Dckt. 45608
Not Reported
No abstract provided.
Designing Cybersecurity Competitions In The Cloud: A Framework And Feasibility Study, Chandler Ryan Newby
Designing Cybersecurity Competitions In The Cloud: A Framework And Feasibility Study, Chandler Ryan Newby
Theses and Dissertations
Cybersecurity is an ever-expanding field. In order to stay current, training, development, and constant learning are necessary. One of these training methods has historically been competitions. Cybersecurity competitions provide a method for competitors to experience firsthand cybersecurity concepts and situations. These experiences can help build interest in, and improve skills in, cybersecurity.
While there are diverse types of cybersecurity competitions, most are run with on-premise hardware, often centralized at a specific location, and are usually limited in scope by available hardware. This research focuses on the possibility of running cybersecurity competitions, specifically CCDC style competitions, in a public cloud environment. …
Rediscovery Of Red Wolf Ghost Alleles In Canid Population Along The American Gulf Coast, Elizabeth Heppenheimer, Kristin Brzeski, Ron Wooten, William Waddell, Linda Y. Rutledge, Michael J. Chamberlain, Et. Al.
Rediscovery Of Red Wolf Ghost Alleles In Canid Population Along The American Gulf Coast, Elizabeth Heppenheimer, Kristin Brzeski, Ron Wooten, William Waddell, Linda Y. Rutledge, Michael J. Chamberlain, Et. Al.
College of Forest Resources and Environmental Science Publications
Rediscovering species once thought to be extinct or on the edge of extinction is rare. Red wolves have been extinct along the American Gulf Coast since 1980, with their last populations found in coastal Louisiana and Texas. We report the rediscovery of red wolf ghost alleles in a canid population on Galveston Island, Texas. We analyzed over 7000 single nucleotide polymorphisms (SNPs) in 60 canid representatives from all legally recognized North American Canis species and two phenotypically ambiguous canids from Galveston Island. We found notably high Bayesian cluster assignments of the Galveston canids to captive red wolves with extensive sharing …
The Ninth Circuit’S Asylum Ban Ruling Is A Message To Trump, Peter Margulies
The Ninth Circuit’S Asylum Ban Ruling Is A Message To Trump, Peter Margulies
Law Faculty Scholarship
No abstract provided.
Testing The Structural Invariance Of Affective Commitment On Unethical Pro-Organizational Behavior Across Clan And Hierarchy Organizational Culture Types, Julia A. Fulmore
Testing The Structural Invariance Of Affective Commitment On Unethical Pro-Organizational Behavior Across Clan And Hierarchy Organizational Culture Types, Julia A. Fulmore
Human Resource Development Theses and Dissertations
Unethical pro-organizational behavior (UPB) is concerned with employees’ engagement in unethical conduct for the benefit of the organization that is immoral and/or illegal. Research findings on motivators of UPB show some contradictory findings that need to be resolved. Considering the empirical findings that clan culture discourages unethical behavior while hierarchy culture encourages unethical behavior along with the contradicting empirical findings between affective commitment and UPB based on samples with different cultures, this study sought to empirically assess the contradictory findings in the literature by testing the structural invariance of affective organizational commitment on UPB based on the two organizational of …
Feeding And Oral Care Guidelines For Certified Nursing Assistants Working With Patients With Head And Neck Cancer, Emma Eisert
Feeding And Oral Care Guidelines For Certified Nursing Assistants Working With Patients With Head And Neck Cancer, Emma Eisert
Graduate Independent Studies - Communication Sciences and Disorders
No abstract provided.
Augmentative And Alternative Communication In The Intensive Care Unit: A Service Delivery Model, Beverly Lloyd, Ann R. Beck, Amy L. Yacucci
Augmentative And Alternative Communication In The Intensive Care Unit: A Service Delivery Model, Beverly Lloyd, Ann R. Beck, Amy L. Yacucci
Graduate Independent Studies - Communication Sciences and Disorders
Patients in the intensive care unit (ICU) often find it difficult or impossible to verbally communicate due to mechanical ventilation, tracheostomy tubes or increased fatigue and delirium. Augmentative and alternative communication (AAC) can provide ICU patients with a way to communicate during their ICU admittance. However, few hospitals currently have a systematic service delivery model in place for providing AAC tools and supports to ICU patients. This resource manual provides an outline for creating and implementing an AAC service delivery model along with AAC materials and resources appropriate for an ICU. Explanations of how each material is used, who they …
Feeding And Oral Care Guidelines For Certified Nursing Assistants Working With Patients With Head And Neck Cancer, Emma Eisert
Feeding And Oral Care Guidelines For Certified Nursing Assistants Working With Patients With Head And Neck Cancer, Emma Eisert
Graduate Independent Studies - Communication Sciences and Disorders
No abstract provided.
Accumulation And Transmission Dynamics Of A Naturally-Occurring Mtdna Deletion In Caenorhabditis Briggsae, Jennifer Anne Sullins
Accumulation And Transmission Dynamics Of A Naturally-Occurring Mtdna Deletion In Caenorhabditis Briggsae, Jennifer Anne Sullins
Dissertations and Theses
Maintaining mitochondrial genome sequence integrity is essential for preserving normal mitochondrial function. Several human diseases have been associated with heteroplasmic mitochondrial genome mutations, but few genetic systems can simultaneously represent pathogenic mitochondrial genome evolution and inheritance. The nematode Caenorhabditis briggsae is one such model. Natural C. briggsae isolates are globally-distributed and phylogenetically grouped into three distinct clades, with isolates exhibiting varying levels of a large-scale mtDNA deletion, nad5∆. Furthermore, a small subset of clade II isolates exhibits putative compensatory mutations that may reduce the risk of deletion formation and accumulation in those populations. In this thesis, the author characterizes the …
Parking And Traffic Information Released For Camellia Bowl, Georgia Southern University
Parking And Traffic Information Released For Camellia Bowl, Georgia Southern University
Athletics: News & Publications
- Parking and Traffic Information Released For Camellia Bowl
Myrmekite And Strain Weakening In Granitoid Mylonites, A Ceccato, L Menegon, G Pennacchioni, Lfg Morales
Myrmekite And Strain Weakening In Granitoid Mylonites, A Ceccato, L Menegon, G Pennacchioni, Lfg Morales
School of Geography, Earth and Environmental Sciences
At mid-crustal conditions, deformation of feldspar is mainly accommodated by a combination of fracturing, dissolution–precipitation, and reaction-weakening mechanisms. In particular, K-feldspar is reaction-weakened by the formation of strain-induced myrmekite – a fine-grained symplectite of plagioclase and quartz. Here we use electron backscattered diffraction to (i) investigate the microstructure of a granodiorite mylonite, developed at ~ 450 °C during cooling of the Rieserferner pluton (Eastern Alps); and (ii) assess the microstructural processes and the weakening associated with myrmekite development. Our analysis shows that the crystallographic orientation of plagioclase in pristine myrmekite was controlled by that of the replaced K-feldspar. Myrmekite nucleation …
Genome-Wide Mega-Analysis Identifies 16 Loci And Highlights Diverse Biological Mechanisms In The Common Epilepsies., Bassel Abou-Khalil, Pauls Auce, Andreja Avbersek, Melanie Bahlo, David J. Balding, Thomas Bast, Larry Baum, Albert J. Becker, Felicitas Becker, Bianca Berghuis, Samuel F. Berkovic, Katja E. Boysen, Jonathan P. Bradfield, Lawrence C. Brody, Russell J. Buono, Ellen Campbell, Gregory D. Cascino, Claudia B. Catarino, Gianpiero L. Cavalleri, Stacey S. Cherny, Krishna Chinthapalli, Alison J. Coffey, Alastair Compston, Antonietta Coppola, Patrick Cossette, John J. Craig, Gerrit-Jan De Haan, Peter De Jonghe, Carolien G.F. De Kovel, Norman Delanty, Chantal Depondt, Orrin Devinsky, Dennis J. Dlugos, Colin P. Doherty, Christian E. Elger, Johan G. Eriksson, Thomas N. Ferraro, Martha Feuch, Ben Francis, Andre Franke, Jacqueline A. French, Saskia Freytag, Verena Gaus, Eric B. Geller, Christian Gieger, Tracy Glauser, Simon Glynn, David B. Goldstein, Hongsheng Gui, Youling Guo, Kevin F. Haas, Hakon Hakonarson, Kerstin Hallmann, Sheryl Haut, Erin L. Heinzen, Ingo Helbig, Christian Hengsbach, Helle Hjalgrim, Michele Iacomino, Andrés Ingason, Jennifer Jamnadas-Khoda, Michael R. Johnson, Reetta Kälviäinen, Anne-Mari Kantanen, Dalia Kasperavičiūte, Dorothee Kasteleijn-Nolst Trenite, Heidi E. Kirsch, Robert C. Knowlton, Bobby P.C. Koeleman, Roland Krause, Martin Krenn, Wolfram S. Kunz, Ruben Kuzniecky, Patrick Kwan, Dennis Lal, Yu-Lung Lau, Anna-Elina Lehesjoki, Holger Lerche, Costin Leu, Wolfgang Lieb, Dick Lindhout, Warren D. Lo, Iscia Lopes-Cendes, Daniel H. Lowenstein, Alberto Malovini, Anthony G. Marson, Thomas Mayer, Mark Mccormack, James L. Mills, Nasir Mirza, Martina Moerzinger, Rikke S. Møller, Anne M. Molloy, Hiltrud Muhle, Mark Newton, Ping-Wing Ng, Markus M. Nöthen, Peter Nürnberg, Terence J. O’Brien, Karen L. Oliver, Palotie Palotie, Faith Pangilinan, Sarah Peter, Slavé Petrovski, Annapurna Poduri, Michael Privitera, Rodney Radtke, Sarah Rau, Philipp S. Reif, Eva M. Reinthaler, Felix Rosenow, Josemir W. Sander, Thomas Sander, Theresa Scattergood, Steven C. Schachter, Christoph J. Schankin, Ingrid E. Scheffer, Bettina Schmitz, Susanne Schoch, Pak C. Sham, Jerry J. Shih, Graeme J. Sills, Sanjay M. Sisodiya, Lisa Slattery, Alexander Smith, David F. Smith, Michael C. Smith, Philip E. Smith, Anja C.M. Sonsma, Doug Speed, Michael R. Sperling, Bernhard J. Steinhoff, Ulrich Stephani, Remi Stevelink, Konstantin Strauch, Pasquale Striano, Hans Stroink, Rainer Surges, K. Meng Tan, Liu Lin Thio, G. Neil Thomas, Marian Todaro, Rossana Tozzi, Maria S. Vari, Ellen P.G. Vining, Frank Visscher, Sarah Von Spiczak, Nicole M. Walley, Yvonne G. Weber, Zhi Wei, Judith Weisenberg, Christopher D. Whelan, Peter Widdess-Walsh, Markus Wolff, Wolking Wolking, Wanling Yang, Federico Zara, Fritz Zimprich
Genome-Wide Mega-Analysis Identifies 16 Loci And Highlights Diverse Biological Mechanisms In The Common Epilepsies., Bassel Abou-Khalil, Pauls Auce, Andreja Avbersek, Melanie Bahlo, David J. Balding, Thomas Bast, Larry Baum, Albert J. Becker, Felicitas Becker, Bianca Berghuis, Samuel F. Berkovic, Katja E. Boysen, Jonathan P. Bradfield, Lawrence C. Brody, Russell J. Buono, Ellen Campbell, Gregory D. Cascino, Claudia B. Catarino, Gianpiero L. Cavalleri, Stacey S. Cherny, Krishna Chinthapalli, Alison J. Coffey, Alastair Compston, Antonietta Coppola, Patrick Cossette, John J. Craig, Gerrit-Jan De Haan, Peter De Jonghe, Carolien G.F. De Kovel, Norman Delanty, Chantal Depondt, Orrin Devinsky, Dennis J. Dlugos, Colin P. Doherty, Christian E. Elger, Johan G. Eriksson, Thomas N. Ferraro, Martha Feuch, Ben Francis, Andre Franke, Jacqueline A. French, Saskia Freytag, Verena Gaus, Eric B. Geller, Christian Gieger, Tracy Glauser, Simon Glynn, David B. Goldstein, Hongsheng Gui, Youling Guo, Kevin F. Haas, Hakon Hakonarson, Kerstin Hallmann, Sheryl Haut, Erin L. Heinzen, Ingo Helbig, Christian Hengsbach, Helle Hjalgrim, Michele Iacomino, Andrés Ingason, Jennifer Jamnadas-Khoda, Michael R. Johnson, Reetta Kälviäinen, Anne-Mari Kantanen, Dalia Kasperavičiūte, Dorothee Kasteleijn-Nolst Trenite, Heidi E. Kirsch, Robert C. Knowlton, Bobby P.C. Koeleman, Roland Krause, Martin Krenn, Wolfram S. Kunz, Ruben Kuzniecky, Patrick Kwan, Dennis Lal, Yu-Lung Lau, Anna-Elina Lehesjoki, Holger Lerche, Costin Leu, Wolfgang Lieb, Dick Lindhout, Warren D. Lo, Iscia Lopes-Cendes, Daniel H. Lowenstein, Alberto Malovini, Anthony G. Marson, Thomas Mayer, Mark Mccormack, James L. Mills, Nasir Mirza, Martina Moerzinger, Rikke S. Møller, Anne M. Molloy, Hiltrud Muhle, Mark Newton, Ping-Wing Ng, Markus M. Nöthen, Peter Nürnberg, Terence J. O’Brien, Karen L. Oliver, Palotie Palotie, Faith Pangilinan, Sarah Peter, Slavé Petrovski, Annapurna Poduri, Michael Privitera, Rodney Radtke, Sarah Rau, Philipp S. Reif, Eva M. Reinthaler, Felix Rosenow, Josemir W. Sander, Thomas Sander, Theresa Scattergood, Steven C. Schachter, Christoph J. Schankin, Ingrid E. Scheffer, Bettina Schmitz, Susanne Schoch, Pak C. Sham, Jerry J. Shih, Graeme J. Sills, Sanjay M. Sisodiya, Lisa Slattery, Alexander Smith, David F. Smith, Michael C. Smith, Philip E. Smith, Anja C.M. Sonsma, Doug Speed, Michael R. Sperling, Bernhard J. Steinhoff, Ulrich Stephani, Remi Stevelink, Konstantin Strauch, Pasquale Striano, Hans Stroink, Rainer Surges, K. Meng Tan, Liu Lin Thio, G. Neil Thomas, Marian Todaro, Rossana Tozzi, Maria S. Vari, Ellen P.G. Vining, Frank Visscher, Sarah Von Spiczak, Nicole M. Walley, Yvonne G. Weber, Zhi Wei, Judith Weisenberg, Christopher D. Whelan, Peter Widdess-Walsh, Markus Wolff, Wolking Wolking, Wanling Yang, Federico Zara, Fritz Zimprich
Department of Neurology Faculty Papers
The epilepsies affect around 65 million people worldwide and have a substantial missing heritability component. We report a genome-wide mega-analysis involving 15,212 individuals with epilepsy and 29,677 controls, which reveals 16 genome-wide significant loci, of which 11 are novel. Using various prioritization criteria, we pinpoint the 21 most likely epilepsy genes at these loci, with the majority in genetic generalized epilepsies. These genes have diverse biological functions, including coding for ion-channel subunits, transcription factors and a vitamin-B6 metabolism enzyme. Converging evidence shows that the common variants associated with epilepsy play a role in epigenetic regulation of gene expression in the …