Digital Commons Network^™

Comparing Groups' Affective Sentiments To Group Perceptions, Daniel Burton Shank, Alexander Burns

Psychological Science Faculty Research & Creative Works

Affect control theory focuses on interaction among individuals, not groups. Groups, like individual identities, vary in affective sentiments across the dimensions of evaluation, potency, and activity, but a separate literature shows the importance of the group perceptions of entitativity, homogeneity, essentialism, and agency. Therefore, to consider affect control theory's applicability to groups, we compare these principal group perceptions to affective sentiments for 64 group concepts. The results reveal that affective sentiments correlate with all four group perceptions in meaningful ways.

Therapeutic Effect Of Rho Kinase Inhibitor Fsd-C10 In A Mouse Model Of Alzheimer's Disease., Qing-Fang Gu, Jie-Zhong Yu, Hao Wu, Yan-Hua Li, Chun-Yun Liu, Ling Feng, Guang-Xian Zhang, Bao-Guo Xiao, Cun-Gen Ma

Department of Neurology Faculty Papers

Fasudil, a Rho kinase (ROCK) inhibitor, effectively inhibits disease severity in a mouse model of Alzheimer's disease (AD). However, given its significant limitations, including a relatively narrow safety window and poor oral bioavailability, Fasudil is not suitable for long-term use. Thus, screening for ROCK inhibitor(s) that are more efficient, safer, can be used orally and suitable for long-term use in the treatment of neurodegenerative disorders is required. The main purpose of the present study is to explore whether FSD-C10, a novel ROCK inhibitor, has therapeutic potential in amyloid precursor protein/presenilin-1 transgenic (APP/PS1 Tg) mice, and to determine possible mechanisms of …

Studies On The Physicochemical Characterization Of Flours And Protein Hydrolysates From Common Beans, Hollman Andres Motta Romero

Department of Food Science and Technology: Dissertations, Theses, and Student Research

Pulses represent a rich source of nutrition and have several potential health benefits such as the reduction of the risk of developing cardiovascular diseases, obesity, and diabetes. Beans from the species Phaseolus vulgaris and Cicer arietinum are important crops raised in some regions of the United States, including Western Nebraska. Nevertheless, the traditional preparation procedures involved in the cooking of these beans are tedious and time-consuming, thus leading to the underutilization of these resources. Therefore, the present work focused on evaluating alternative utilizations of these beans in order to improve their economic value.

One alternative to improve the consumption of …

Ohio University Study Aims To Help Military Regain Full Strength (November 1, 2018), University Communications And Marketing

OHIO News Articles Archive

No abstract provided.

Isobavachalcone Sensitizes Cells To E2-Induced Paclitaxel Resistance By Down-Regulating Cd44 Expression In Er+ Breast Cancer Cells, Junfeng Shi, Yi Chen, Wenxing Chen, Cuiju Tang, Honghong Zhang, Yuetong Chen, Xiuwei H. Yang, Zhi Xu, Jingsun Wei, Jinfei Chen

Pharmacology and Nutritional Sciences Faculty Publications

Oestrogen receptor (ER) is expressed in approximately 60%‐70% of human breast cancer. Clinical trials and retrospective analyses have shown that ER‐positive (ER+) tumours are more tolerant to chemotherapeutic drug resistance than ER‐negative (ER−) tumours. In addition, isobavachalcone (IBC) is known as a kind of phytoestrogen with antitumour effect. However, the underlying mechanism of IBC in ER+ breast cancer needs to be elucidated further. Our in vitro experiments showed that IBC could attenuate 17β‐estradiol (E₂)‐induced paclitaxel resistance and that E₂ could stimulate CD44 expression in ER+ breast cancer cells but not in ER− cells. Meanwhile, E₂ could …

Formerly Known As Nasty: From Womanhood To Enlightenment, Michelle Riofrio Bravo

Graduate Student Dissertations, Theses, Capstones, and Portfolios

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The Press And The Expectation Of Executive Counterspeech, Ronnell Andersen Jones

Missouri Law Review

This Article explores the wider constitutional and democratic consequences of a president’s refusal to engage in counterspeech on matters of public concern. It argues that both fundamental principles of First Amendment theory and watershed cases from the United States Supreme Court presuppose a constitutional system of dialogue between the press and the executive in which the president offers verifiable, supported, fact-based counterspeech to press coverage with which he disagrees. Part II of this Article describes how marketplace-of-ideas, self-governance, and checking-function principles—although more often invoked to protect private speech from governmental restriction—also manifest a longstanding assumption of executive counterspeech. It explores …

Synthesis And Biological Evaluation Of Phaeosphaeride A Derivatives As Antitumor Agents, Victoria Abzianidze, Petr Beltyukov, Sofya Zakharenkova, Natalia Moiseeva, Jennifer Mejia, Alvin Holder, Yuri Trishin, Alexander Berestetskiy, Victor Kuznetsov

Chemistry & Biochemistry Faculty Publications

New derivatives of phaeosphaeride A (PPA) were synthesized and characterized. Anti-tumor activity studies were carried out on the HCT-116, PC3, MCF-7, A549, К562, NCI-Н929, Jurkat, THP-1, RPMI8228 tumor cell lines, and on the HEF cell line. All of the compounds synthesized were found to have better efficacy than PPA towards the tumor cell lines mentioned. Compound 6 was potent against six cancer cell lines, HCT-116, PC-3, K562, NCI-H929, Jurkat, and RPMI8226, showing a 47, 13.5, 16, 4, 1.5, and 7-fold increase in anticancer activity comparative to those of etoposide, respectively. Compound 1 possessed selectivity toward the NCI-H929 cell line (IC …

Gaspar Octavio Hernández, Un Poeta Modernista, Karina Ayodele Clarke Murrain

Department of Modern Languages and Literatures: Dissertations, Theses, and Student Research

Panama is known empirically for its geography, climate and natural environment, so it is not surprising that the Afro-Panamanian writer and journalist, Gaspar Octavio Hernández (1893-1918) uses climate and natural conditions as inspirations for his writing. As a modernista, it is entirely plausible that Hernández was attracted to and compelled by both the process and the production of writing poetry. As we approach his work critically, it is evident that Hernández explores nature in his work and his acknowledgment thereof is the principal motivation of his poetry. From this point, Hernández establishes not only a framework for exploring themes …

Examining Patterns In Nest Predation Using Artificial Nests, Victoria L. Simonsen

School of Natural Resources: Dissertations, Theses, and Student Research

The use of artificial nests to study the predation of avian nests has faced disregard by ecologists due to inconsistencies found between the survival rates of real and artificial nests across studies and reviews. The negative perception of artificial nests providing an inconsistent assessment of survival has thus fostered the perception that artificial nests are a secondary option to be used to overcome logistical hurdles associated with achieving sufficient sample sizes in systems where study species are rare or elusive, or as merely a preliminary method to study predation across gradients. We argue that the greatest mistake ecologists have made …

Can State Constitutional Development Make A Difference In Illinois?, John Christopher Anderson

Northern Illinois University Law Review

For over a decade, Illinois has faced perilous financial and political crises. Many commentators believe that state constitutional development in the context of pensions, term limits, and legislative redistricting are a necessary key to placing Illinois on a path toward prosperity. This article considers whether state constitutional reform (by way of judicial interpretation or amendment) in these areas is possible and whether it would likely bring about the change some observers seek.

Postseismic Restoration Of The Ecological Environment In The Wenchuan Region Using Satellite Data, Zhibin Huang, Min Xu, Wei Chen, Xiaojuan Lin, Chunxiang Cao, Ramesh Singh

Mathematics, Physics, and Computer Science Faculty Articles and Research

Using Landsat remote-sensing data combined with geological information extracted from ALOS and Sentinel-1A radar data, the ecological environment was evaluated in the years 2007, 2008, 2013, and 2017 through gray correlation analysis on the basis of the construction of the pressure-state-response model. The main objective of this research was to assess the ecological environment changes in Wenchuan County before and after the earthquake, and to provide reference for future social development and policy implementation. The grading map of the ecological environment was obtained for every year, and the ecological restoration status of Wenchuan County after the earthquake was evaluated. The …

Leveling The Playing Field: Supporting Neurodiversity Via Virtual Realities, Louanne E. Boyd, Kendra Day, Natalia Stewart, Kaitlyn Abdo, Kathleen Lamkin, Erik J. Linstead

Mathematics, Physics, and Computer Science Faculty Articles and Research

Neurodiversity is a term that encapsulates the diverse expression of human neurology. By thinking in broad terms about neurological development, we can become focused on delivering a diverse set of design features to meet the needs of the human condition. In this work, we move toward developing virtual environments that support variations in sensory processing. If we understand that people have differences in sensory perception that result in their own unique sensory traits, many of which are clustered by diagnostic labels such as Autism Spectrum Disorder (ASD), Sensory Processing Disorder, Attention-Deficit/Hyperactivity Disorder, Rett syndrome, dyslexia, and so on, then we …

Let Them Eat Cake: Why Public Proprietors Of Wedding Goods And Services Must Equally Serve All People, Labdhi Sheth, Molly Christ

Loyola of Los Angeles Law Review

No abstract provided.

Development And Utilization Of 3d Printed Material For Thoracotomy Simulation, Evan Yates, Roger Chirurgi, Frosso Adamakos, Rania Habal, Rajnish Jaiswal, Hossein Kalantari, Getaw W. Hassen

NYMC Faculty Publications

Medical simulation is a widely used training modality that is particularly useful for procedures that are technically difficult or rare. The use of simulations for educational purposes has increased dramatically over the years, with most emergency medicine (EM) programs primarily using mannequin-based simulations to teach medical students and residents. As an alternative to using mannequin, we built a 3D printed models for practicing invasive procedures. Repeated simulations may help further increase comfort levels in performing an emergency department (ED) thoracotomy in particular, and perhaps this can be extrapolated to all invasive procedures. Using this model, a simulation training conducted with …

Emerging Roles Of The Membrane Potential: Action Beyond The Action Potential, Lina Abdul Kadir, Michael Stacey, Richard Barrett-Jolley

Bioelectrics Publications

Whilst the phenomenon of an electrical resting membrane potential (RMP) is a central tenet of biology, it is nearly always discussed as a phenomenon that facilitates the propagation of action potentials in excitable tissue, muscle, and nerve. However, as ion channel research shifts beyond these tissues, it became clear that the RMP is a feature of virtually all cells studied. The RMP is maintained by the cell's compliment of ion channels. Transcriptome sequencing is increasingly revealing that equally rich compliments of ion channels exist in both excitable and non-excitable tissue. In this review, we discuss a range of critical roles …

A Dollar For Your Thoughts: Determining Whether Nominal Damages Prevent An Otherwise Moot Case From Being An Advisory Opinion, Maura B. Grealish

Fordham Law Review

This Note examines whether nominal damages should sustain an otherwise moot constitutional claim. A majority of circuit courts have held that a lone claim for nominal damages is sufficient. A minority of circuit courts have determined that nominal damages are insufficient because there is no practical effect in determining such a case. The courts in the minority analogize nominal damages to declaratory judgments and justify their rulings on the basis of judicial economy. This Note proposes that the minority rule is impermissible under current precedent from the U.S. Supreme Court. However, this Note also proposes that the majority rule be …

Case Review: Food Pattern Effects On Milk Lipid Profiles, Darby Dickton, Jimi Francis

Health & Kinesiology Faculty Publications and Presentations

It has been shown that maternal food intake determines the levels of unsaturated fatty acids that are present in human milk. This case study compares the human milk lipid profiles the first two weeks of lactation from women consuming three food patterns: vegan, standard American diet, and Asian. Participants were matched for demographics. The milk samples were analyzed using gas chromatography to determine the lipid profile for each participant. The lipid profiles differed by food pattern (p<0.007). Linoleic acid and alpha-linolenic acid levels were highest for the vegan food pattern. The ratios of omega-6 to omega-3 fatty acids were well above the suggested ratio considered to be optimal with the vegan pattern had the lowest omega-6 to omega-3 ratio and the highest level of docosahexaenoic acid, possibly indicating conversion of alpha-linoleic acid to docosahexaenoic acid. Further research is needed to determine the impact this may have on long-term infant health.

Feeding And Refusal Of Expressed And Stored Human (Fresh) Milk Study - A Short Communication, Jimi Francis, Darby Dickton

Health & Kinesiology Faculty Publications and Presentations

Breastfeeding initiation has been increasing to meet Healthy People 2020 goals. As breastfeeding initiation has increased, milk expression has increased. Consequently, storage of human milk has become more common. While it is reported anecdotally, there is no data available on the prevalence of infants refusing expressed, stored human milk. To fill this knowledge gap, a survey of lactating women indicates 25% of infants offered expressed, stored human milk refused to consume it. Almost one-third of respondents (29%) reported that the stored milk had an “odd” color. For the women reporting the refusal, 95% of those described an “off” smell to …

The Gut Microbiome And Aquatic Toxicology: An Emerging Concept For Environmental Health, Ondrej Adamovsky, Amanda Buerger, Alexis M. Wormington, Naomi Ector, Robert J. Griffitt, Joseph H. Bisesi Jr., Christopher J. Martyniuk

Faculty Publications

The microbiome plays an essential role in the health and onset of diseases in all animals, including humans. The microbiome has emerged as a central theme in environmental toxicology, as microbes interact with the host immune system in addition to its role in chemical detoxification. Pathophysiological changes in the gastrointestinal tissue caused by ingested chemicals, and metabolites generated from microbial biodegradation, can lead to systemic adverse effects. This critical review dissects what we know about the impacts of environmental contaminants on the microbiome of aquatic species, with special emphasis on the gut microbiome. We highlight some of the known major …

Temporal Dynamics Of Lipid And Fatty Acid Characteristics Of Gulf Menhaden, Brevoortia Patronus In The Northern Gulf Of Mexico, Robert R. Leaf, Jesse Trushenski, Nancy Brown-Peterson, Michael J. Andres

Faculty Publications

Gulf Menhaden, Brevoortia patronus, in the northern Gulf of Mexico support a large commercial fishery and are thought to play an important trophic role in the coastal ecosystem. The temporal dynamics of both fatty acid and oil content have a direct impact on the value of Gulf Menhaden to predators and to the fishery. In this work, we describe how oil content of Gulf Menhaden varies with season, sex, age, condition, and tissue and investigate how fatty acid composition of mature (137.5 mm FL) female tissues varies with season, month, and tissue type. We found pronounced temporal (January to …

Gene Expression Changes By Neuroprotectant Novel Antidotes To Organophosphates, Meghan L. Brino

Honors Theses

Recent assassinations and terrorist attacks demonstrate the need for a more effective antidote against nerve agents and other organophosphate (OP) compounds which inhibit the nervous system enzyme acetylcholinesterase (AChE). This study explored the changes in gene expression induced by novel phenoxyalkyl pyridinium oximes (U.S. patent 9,277,937) that have demonstrated the ability to cross the blood-brain barrier and attenuate brain damage in a rat model. More specifically, this study determined whether rats treated with high levels of a surrogate for the nerve agent sarin (nitrophenyl isopropyl methylphosphonate; NIMP) and rats treated with NIMP followed by a novel oxime displayed significant differences …

When Daubert Is The Way: The Road Less Traveled By, Cynthia Ford

Faculty Journal Articles & Other Writings

No abstract provided.

Physiological Response Of The Giant Acorn Barnacle, Balanus Nubilus, To Air Exposure, Emily Jane Resner

Master's Theses

The giant acorn barnacle, Balanus nubilus, is a resident of the subtidal and low intertidal rocky shoreline on the Pacific Coast of North America (Alaska to Baja California). B. nubilusis notable for having the largest muscle fibers in the animal kingdom; fiber diameters that can exceed 3mm in adults! At such extreme sizes these muscle cells may be at risk for insufficient oxygen delivery to mitochondria owing to low SA:V ratios and long intracellular diffusion distances. Oxygen limitation to these muscles may be further exacerbated during low tide air exposure (emersion) or environmental hypoxia events, which are increasing …

Patriarchal Ecocide: An Ecofeminist Reading Of Rahul Varma's Bhopal And Henrik Ibsen's An Enemy Of The People, Rania M Rafik Khalil

English Language and Literature

Ecofeminism is a movement that sees a connection between the exploitation of the natural world and the subordination of women. This concept of ecology and feminism conceptualized by Simone de Beauvoir (1952) and later refined by Francoise d’Eaubonne in 1974 has greened artistic values across disciplines, it is however perceived to be found only sparsely in drama. Una Chaudhuri (1994) and Theresa J. May (2005) argue that theatre is both “immediate and communal” (May 85) with a wealth of productions that “awaken ecological sensibilities” (85) and contest “industrialisation’s animus against nature” (24). Within this context, Henrik Ibsen’s An Enemy of …

On The Verge Of Diagnosis: Detection, Reporting, And Investigation Of De Novo Variants In Novel Genes Identified By Clinical Sequencing., Isabelle Thiffault, Maxime Cadieux-Dion, Emily G. Farrow, Raymond Caylor, Neil A. Miller, Sarah E. Soden, Carol J. Saunders

Manuscripts, Articles, Book Chapters and Other Papers

The variable evidence supporting gene-disease associations contributes to the difficulty of accurate variant reporting in a clinical setting. An evidence-based scoring system for evaluating the clinical validity of gene-disease associations, proposed by ClinGen, considers experimental as well as genetic evidence. De novo variants are heavily weighted, given the overall rarity in the genome and their contribution to human disease, however they are reported as "genes of unknown significance" in our center when there is insufficient evidence for the gene-disease assertion. We report a collection of 21 de novo variants in genes of unknown clinical significance ascertained via clinical testing, of …

Childhood Kidney Disease: A Troubling Prognosis?, Darcy K. Weidemann, Bradley A. Warady, Susan L. Furth

Manuscripts, Articles, Book Chapters and Other Papers

No abstract provided.

Enteric Infection Coupled With Chronic Notch Pathway Inhibition Alters Colonic Mucus Composition Leading To Dysbiosis, Barrier Disruption And Colitis., Ishfaq Ahmed, Badal C. Roy, Rita-Marie T. Raach, Sarah M. Owens, Lijun Xia, Shrikant Anant, Venkatesh Sampath, Shahid Umar

Manuscripts, Articles, Book Chapters and Other Papers

Intestinal mucus layer disruption and gut microflora modification in conjunction with tight junction (TJ) changes can increase colonic permeability that allows bacterial dissemination and intestinal and systemic disease. We showed previously that Citrobacter rodentium (CR)-induced colonic crypt hyperplasia and/or colitis is regulated by a functional cross-talk between the Notch and Wnt/β-catenin pathways. In the current study, mucus analysis in the colons of CR-infected (108 CFUs) and Notch blocker Dibenzazepine (DBZ, i.p.; 10μmol/Kg b.w.)-treated mice revealed significant alterations in the composition of trace O-glycans and complex type and hybrid N-glycans, compared to CR-infected mice alone that preceded/accompanied alterations in 16S rDNA …

Molecular Level Interactions And Transformations Of Natural Organic Matter Within The Environment, Benjamin J. Haywood

LSU Doctoral Dissertations

This work was done in order to deepen the understanding of interactions occurring during sorption of anthropogenic organic compounds and dissolved organic matter (DOM) onto soil. As well as the transformation DOM undergoes during the sorption process and the overall transformation OM undergoes in the environment. This was achieved through the use of a “bottom-up” synthetic investigation, “top-down” natural system study, and a combination of these approaches.

The “bottom-up” approach, discussed in Chapter 2, involved the synthesis of a modular multi-tiered engineered soil surrogate (ESS) designed to mimic OM and general trends identified in the literature that impacts sorption behavior. …

Nrh:Quinone Oxidoreductase 2 (Nqo2) And Glutaminase (Gls) Both Play A Role In Large Extracellular Vesicles (Lev) Formation In Preclinical Lncap-C4-2b Prostate Cancer Model Of Progressive Metastasis, Thambi Dorai, Ankeeta Shah, Faith Summers, Rajamma Mathew, Jing Huang, Tze-Chen Hsieh, Joseph M. Wu

NYMC Faculty Publications

In the course of studies aimed at the role of oxidative stress in the development of metastatic potential in the LNCaP-C4-2B prostate cancer progression model system, we found a relative decrease in the level of expression of the cytoplasmic nicotinamide riboside: quinone oxidoreductase (NQO2) and an increase in the oxidative stress in C4-2B cells compared to that in LNCaP or its derivatives C4 and C4-2. It was also found that C4-2B cells specifically shed large extracellular vesicles (LEVs) suggesting that these LEVs and their cargo could participate in the establishment of the osseous metastases. The level of expression of caveolin-1 …