Digital Commons Network^™

A Continued Musical And Personal Dialogue With The Waves Of Epilepsy., Alan Douglas Miles

Other Faculty of Arts, Humanities and Business Theses

A Continued Musical and Personal Dialogue with the Waves of Epilepsy. In the early hours of the morning several years ago I awoke with paramedics leaning over me. In a state of confusion, my first conscious decision was to enter my music production studio while they attempted to lead me to the ambulance. Music was important to me even in a disorientated post-ictal state (an altered state of consciousness following a seizure). Two weeks later I awoke with paramedics standing over me again. I had started to experience multiple seizures. During the previous weeks, I also experienced numerous incidents of …

‘University Must Be Saved’ Genealogy As A Knowledge Approach., Patrizia Moschella

School of Art, Design and Architecture Theses

The research offers an elaboration of genealogy as an approach to knowledge from Friedrich Nietzsche's original work on method (1887) processed by Michel Foucault (1971). It provides an interdisciplinary version that integrates theoretical and analytical contributions from the philosophy of knowledge, from exact and social sciences to artistic research. This work also takes into account those who have most explicitly enhanced the potentialities of geneaalogy such as Gilles Deleuze (1962) and, more recently, Carlo Sini (2007) and Giorgio Agamben (2010), but also embraces the reflections of researchers, from the past or present, whom I dare associate with the genealogy approach …

Turbo Film As Artistic Apparatus And As Manifesto For The Uncertain Future Of Moving Images, Paololuca Barbieri Marchi

School of Art, Design and Architecture Theses

The following research is a practice-based Ph.D. in filmmaking that proposes to define an unclassified film genre and its specific artistic practice. This practice, at the intersection of experimental films, art-cinema and Youtube user- generated videos, I refer to as “Turbo Films.” Beginning with a critical perspective on video art and experimental film history, as it relates to today’s public approach towards the production of moving images, the concept of “Turbo Films” is proposed as an opportunity to understand new trajectories in the production of image-culture, and as holistic modus operandi for the current cross-media environment. Turbo Films have been …

A Framework For The Consideration Of Narrative In Creative Arts Practice, Paul Green

School of Art, Design and Architecture Theses

This research project is aimed at creative practitioners in art and design who choose to engage in postgraduate research and who recognise narrative to be an important aspect of their work. While the goal of narratology has been explicitly declared as an interest in understanding narrative in all its forms, this project responded to a perceived absence of art and design centred perspectives in the general literature on narrative. A general attitude has developed throughout the course of the twentieth century resulting in a view that narrative has become a dead issue for contemporary practitioners. Findings from the investigations conducted …

An Investigation Of Computer Vision Syndrome With Smart Devices, Muhammad Afzam Shah Bin Abdul Rahim

School of Health Professions Theses

The overarching theme of the thesis was to investigate the association between smart device use and computer vision syndrome. The initial study designed and developed the Open Field Tear film Analyser (OFTA) enabling a continuous, real-time assessment of the tear film and blink characteristics during smart device use. The monocular OFTA prototype was validated and showed good intra- and inter-observer repeatability relative to the Oculus Keratograph 5M and Bausch and Lomb one position keratometer. Subsequently, tear osmolarity following engagement with reading and gaming tasks on smart device and paper platforms was investigated. Discrete measures of osmolarity pre- and post-engagement with …

Developing An Artificial Colour-Sound Association For Musical Composition, Richard Abbott

Other Faculty of Arts, Humanities and Business Theses

Some great composers - Messiaen, Scriabin, Liszt in exemplum - have been found to have an internal colour world that responds to music and characterises the way they experience and express music. Many of these artists, it could be strongly argued, had the neurological trait synaesthesia. The author, a non-synaesthete, creates a logical correspondence between colour and sound and uses it to explore the tonality of aesthetic colour combinations in nature and modern life. He argues that if the colour-sound practitioner is consistent in their colour-sound association, they can benefit in harmonic discoveries as the synaesthete does. It was found …

The Development And Application Of Computational Multi-Agent Models For Investigating The Cultural Transmission And Cultural Evolution Of Humpback Whale Song, Michael Mcloughlin

Other Faculty of Arts, Humanities and Business Theses

Three different multi-agent models are presented in this thesis, each with a different goal. The first model investigates the possible role migratory routes may have on song evolution and revolution. The second model investigates what social networks could theoretically facilitate song sharing in a population of whales. The third model implements a formal grammar algorithm in order to investigate how the hierarchal structure of the song may affect song evolution. Finally, the thesis attempts to reconnect the models with their origins and discusses how these models could potentially be adapted for composing music. Through the development of these different models, …

Revue De La Littérature Sur Les Liens Entre La Surdité Professionnelle Et La Presbyacousie, Tony Leroux, Alexis Pinsonnault-Skvarenina

États de la question, rapports d’expertise et revues de littérature

À la demande de la Présidence-direction générale de l’Institut de recherche Robert-Sauvé en santé et en sécurité du travail (IRSST), une revue de la littérature a été réalisée pour répondre à une série de questions concernant le processus d’acquisition de la surdité professionnelle. L'objectif général du projet visait à documenter comment s'acquiert la surdité professionnelle en relation, plus particulièrement, avec la presbyacousie.

Cette revue de la littérature visait plus spécifiquement à 1) déterminer si l'exposition au bruit peut accélérer le processus de la presbyacousie; 2) établir si l'utilisation de facteurs de correction peut permettre de discriminer la surdité professionnelle …

Review Of The Literature On The Links Between Occupational Hearing Loss And Presbycusis, Tony Leroux, Alexis Pinsonnault-Skvarenina

États de la question, rapports d’expertise et revues de littérature

À la demande de la Présidence-direction générale de l’Institut de recherche Robert-Sauvé en santé et en sécurité du travail (IRSST), une revue de la littérature a été réalisée pour répondre à une série de questions concernant le processus d’acquisition de la surdité professionnelle. L'objectif général du projet visait à documenter comment s'acquiert la surdité professionnelle en relation, plus particulièrement, avec la presbyacousie.

Cette revue de la littérature visait plus spécifiquement à 1) déterminer si l'exposition au bruit peut accélérer le processus de la presbyacousie; 2) établir si l'utilisation de facteurs de correction peut permettre de discriminer la surdité professionnelle …

Milkfish, Emylisa Warrick

Theses and Dissertations

Milkfish is a collection of poems that explores familial and generational trauma in a Filipino-American family. Primarily written in first person narrative, it gives voice to a Filipina-American who has experienced controlling behavior, verbal abuse, silencing, and colorist attitudes and behaviors from her father and mother. The collection seeks to understand why the speaker’s parents raised her this way by investigating how the parents were raised in the Philippines. These poems were constructed with the help of interviews between the author and her parents. Additionally, it explores the patriarchal structure of Filipino families and shines a light on “women’s work,” …

Cognitive Remediation Of Working Memory Deficits In Children With Chronic Health Conditions: Tailoring Cogmed Training To Address Barriers To Adherence, Kelsey Smith

Theses and Dissertations

Objective: Children with sickle cell disease (SCD) and cancer are at risk for working memory impairment due to the disease and treatment. However, inconsistency in adherence to cognitive training programs conducted with this population suggests that adaptations are necessary in order to improve the effectiveness of this intervention. In addition, it is unclear whether gains in working memory translate to improvement in classroom functioning.

Methods: Children engaged in cognitive training exclusively over the summer in order to improve adherence to Cogmed Working Memory Training. A total of 17 children ages 7- 17 with a diagnosis of SCD (n = 14) …

Phenotypic Response Of Marine Cryptophytes To Varying Spectral Irradiance, Kristin M. Heidenreich

Theses and Dissertations

Cryptophytes are eukaryotic algae found in a variety of aquatic ecosystems, that vary in the color of light available for photosynthesis. This algal division displays a diversity in necessary photosynthetic pigments, possessing either phycoerythrin (Cr-PE; “pink”) phycocyanin (Cr-PC; “green”). According to the theory of complementary chromatic adaptation, this diversity should help maximize absorption of light within natural environments. The objective of this study was to determine if pigmentation related to growth performance in environments of differing spectral irradiance. Eight species of marine cryptophytes (5 Cr-PE and 3 Cr-PC species) were grown under four different spectral light environments. Growth rates, cellular …

Constructing Scientific Knowledge: The Understanding Of The Slow Virus, 1898-1976, Burke Hood Dial

Theses and Dissertations

Scrapie is the ovine form of the transmissible spongiform encephalopathies. The understanding of scrapie as a slow viral disease was developed through an international scientific dialogue during the first half of the twentieth century. British investigators used epidemiological and experimental observations to define its very long incubation period before the appearance of symptoms. This enabled French researchers to prove scrapie could be transmitted from sick to healthy animals and allowed them to define the etiological agent as an ultramicroscopic, filterable virus. Following this, an Icelandic scientist, Björn Sigurdsson, investigated two other ovine diseases characterized by unusually long periods between contracting …

Association Between Mechanics And Biology In Vascular Graft Remodeling, David Andrew Prim

Theses and Dissertations

Coronary artery bypass grafting (CABG) restores myocardial perfusion in patients with severe coronary artery disease by utilizing autografts – usually at least one of the internal thoracic artery (ITA), radial artery (RA), and great saphenous vein (GSV) – to bypass stenosed regions of coronary arteries. While decades of research and clinical improvements have made CABG an indispensable procedure, tens of thousands of grafts fail each year, which is due, at least in part, to an inability of the source vessels to adapt to the altered stimuli of the coronary circulation. In this dissertation, we first quantify and compare the mechanical …

Attitudes And Thoughts On Tone Quality In Historic Piano Teaching Treatises, Jeongsun Lim

Theses and Dissertations

Various approaches to the perception and production of tone quality on the piano have been suggested throughout the history of piano pedagogy. Tone quality differences are controversial among physicists, acoustic scientists, pianists, and piano pedagogues. Studies and research began to investigate tone quality with scientific experiments, and physicists and scientists asserted that differences in tone quality are differences in pitch, intensity, duration, and in combinations of tone and noise. They asserted that tone quality does not change with different physical touches and the pianist cannot control the quality of the tone. However, pianists and pedagogues believed that pianists have control …

Immunobiology Of Adenovirus-Vector Vaccines For Mrsa, Emily Orvis

Master's Theses

Staphylococcus aureus is a gram-positive, extracellular bacterium that has emerged as an

important human pathogen. This bacterium is a leading cause of skin and soft tissue infections

(SSTIs) in humans, often leading to invasive and life-threatening infections. Treatment of S.

aureus infections is becoming more complicated due to the rise of methicillin-resistant S. aureus

(MRSA) strains, which are becoming increasingly resistant to a number of antibiotics. In the

United States, invasive MRSA infections result in more deaths annually than any other infectious

agent.

Despite a dire need, there is currently no vaccine against S. aureus infections. The failure

of past …

Surveying Host Innate Immune Responses To Interferon Antagonist-Deficient Murine Coronaviruses, Aaron Brian Volk

Master's Theses

Two coronaviruses (CoVs)—severe acute respiratory syndrome (SARS) virus and Middle East respiratory syndrome (MERS) virus—have emerged in the 21st century from animal reservoirs into the human population, each causing an epidemic associated with significant disease and mortality. CoV epidemics are currently only controllable by rigorous public health measures; no targeted therapeutics or vaccines exist to treat or prevent any human CoV infection. One method of generating attenuated CoV strains to be studied as vaccine candidates involves specifically disrupting CoV-encoded interferon (IFN) antagonists, thereby rendering the virus vulnerable to host innate antiviral immunity. Deubiquitinating (DUB) activity encoded within CoV nonstructural protein …

Induction Of Zika Virus-Specific Cd8+ T Cells By Means Of Dna Vaccine, Frank Gambino Jr.

Master's Theses

Zika virus (ZIKV) is a member of the virus family flaviviridae and is transmitted via Aedes aegypti mosquitos. Monoclonal antibodies against dengue virus have been found to cross-react with ZIKV but show no ability to neutralize it. Further studies have shown that Stat2-/- mice given plasma from dengue positive donors exhibit a heightened disease phenotype when challenged with ZIKV. Antibody dependent enhancement is theorized to cause such effect. The goal of this study was to design a plasmid which, when encoded, creates an antigen that will be used to stimulate exclusively CD8+ T cells. The gene sequence of NS3 was …

Understanding The Dynamics Of Protein Lipoylation In Staphylococcus Aureus, Sarah C. Flury

Master's Theses

Staphylococcus aureus is a commensal bacterium that also acts as an opportunistic pathogen. The pathogenicity of S. aureus has often been attributed to the wide range of virulence factors that the bacterium produces. While virulence factors do contribute a great deal, there is a growing field of research that aims to investigate the role of metabolism in bacterial virulence.

My project focuses on the necessity of a metabolic cofactor, lipoic acid. To ensure sufficient amounts of lipoic acid are available for enzyme activity, S. aureus has evolved two pathways to obtain the important nutrient. The lipoic acid salvage pathway is …

Cell Intrinsic Characteristics Of Cord Blood Naive Cd4 T Cells, Taylor Keller

Master's Theses

The neonatal immune system is functionally distinct from the adult immune system. Neonatal immune responses are less reactive than their adult counterparts, and as such, have an increased susceptibility to infection, resulting in increased duration and severity of disease. There is evidence that T-cells are partially responsible for the observed immunological differences between neonates and adults. Murine studies on neonatal immunity suggest that Th2 like responses predominate the neonatal immune system, an observation not found in the adult immune system. However, studies on human cord blood revealed that human neonates do not exhibit elevated Th2 like cytokines (with the exception …

Inhibition Of Mutant Egfr In Nsclc Promotes Endothelin-1-Mediated Nsclc Disease Progression, Stephen Ollosi

Master's Theses

Angiogenesis in NSCLC has been identified as important therapeutic target in combination with EGFR TKIs. However, only small incremental advancements have been made for the use of angiogenesis inhibitors in NSCLC and it remains elusive why the inhibition of VEGF-mediated neovascularization is not therapeutically efficacious. I present experimental evidence that a subpopulation of NSCLC cells with EGFR TKI-induced EMT contributes toward the attenuation of the response to EGFR TKI therapy. One of the hallmarks of cancer is heterogeneity and I have previously demonstrated that tumor heterogeneity within NSCLC cells lines harboring EGFR kinase domain mutations gives rise to divergent resistance …

Cryptic Diversification Of Two Widespread Species In Madagascar, Lynika Sharlice Strozier

Master's Theses

Using phylogenetic and phylogeographic tools to uncover hidden diversity within the genus Newtonia in Madagascar

Madagascar is known for its rich biodiversity and high level of endemic species that are found nowhere else. Cryptic diversification, defined as genetically and evolutionarily distinct species that are hard to detect because they are morphologically indistinguishable from their closest relatives, has been hypothesized to occur in many groups on Madagascar. Currently it is unclear to what extent this phenomenon occurs in birds because only a few studies have been conducted. My study examined the phylogenetic and phylogeographic patterns within a songbird genus, Newtonia, that …

Lidocaine Attenuates An Induced Inflammatory Response, Stephanie Zack

Master's Theses

Inflammation is common to the pathogenesis of a variety of diseases. Therapeutics which can regulate and reduce damaging inflammation are therefore valuable in the treatment of inflammation and inflammatory diseases.

One commonly used analgesic, recently identified as limiting inflammation, is lidocaine. Additionally, alternative, less toxic therapeutics like the snake venom peptides, Zep 3 and Zep 4, are thought to have anti-inflammatory effects. Yet a well-defined mechanism or cellular target for lidocaine or Zep peptides' anti-inflammatory effects has not been proposed.

We aimed to determine whether lidocaine and Zep peptides reduce the release of the proinflammatory cytokine, IL-1β, from activated human …

Galateia In The Land Of The Amazons: The Silver Plate Of Yenikend (Azerbaijan) And Cultural Transfers Between The Greco-Roman World And The Caucasus, Anca Dan

Khazar Journal of Humanities and Social Sciences

No abstract provided.

Ancient And Medieval Ages Caucasian Albania: A Contact Zone Of Sedentary Population And Their States With Eurasian Nomadic People (V-Vii Centuries Ce), Farda Asadov

Khazar Journal of Humanities and Social Sciences

The paper addresses the issue of antagonistic relationship between sedentary population and movable cattle breeders as experienced in Caucasian Albania - the buffer zone between big empires and Eurasian nomadic people in the early Middle Ages. Evidence of mediaeval Arab sources is provided to justify that the interests of ruling elite and population at the boundary with nomadic people might differ from those of big empires. Nomads used to help the borderland state to struggle for their independence vis-a-vis the expansion of the great powers. Political contacts between elites, cooperation in international trade and border guarding policy of superpowers of …

Tuned In: An Investigation Of The Use Of Group Amplification Systems For Students, Including Those On The Autism Spectrum, In First Grade Mainstream Classrooms, Emily Velichka

Senior Independent Study Theses

The purpose of this study was to determine the academic benefits and challenges, if any, of utilizing a group amplification system in first-grade mainstream classrooms. More specifically, this study measured the influence of a group amplification system throughout language-based tasks, such as spelling accuracy. A total of 33 first-grade students, including two students reportedly diagnosed with an Autism Spectrum Disorder (ASD), participated in the study, with 17 students in Classroom A and 16 students in Classroom B. This study’s experimental procedures included a spelling pretest, two intervention activities, and a spelling posttest, administered over the course of four days. The …

The Influence Of Exposure To Unbalanced Sex Ratios On Perceived Vocal Attractiveness, Taylor N. Sikich

Senior Independent Study Theses

The population sex ratio greatly impacts human behavior, especially mating patterns. Recent research shows that visual exposure to unbalanced sex ratios influences perceived facial attractiveness for opposite-sex faces. When opposite-sex faces are scarce in exposure, subsequent opposite-sex faces are rated as more attractive than when they are plentiful during exposure. The current work examines an auditory analog of this effect by exposing listeners to unbalanced ratios of male and female voices and measuring the perceived attractiveness of subsequently presented opposite sex voices. A 2x2 ANOVA was conducted with participant sex and sex ratio exposure as the between-subject factors. Results showed …

Americanized Chinese Dishes As Heritage Food And Bridging Identities, Megu Itoh

Senior Independent Study Theses

Chinese food has become ingrained in the lives of everyday Americans. But while ordering Chinese takeout is now an ordinary occurrence, Chinese food culture still experiences the lasting consequences of discrimination in the United States. First viewed as the uncivilized other and later as the exotic other, the status of Chinese food has shifted overtime. Chinese food has also experienced changes in its actual form, adapting to the American palate by adjusting flavor and presentation. My research explores the ways in which this Americanized Chinese food has impacted the identities of Chinese restaurant workers, and continues to manifest change within …

Sports Analytics With Computer Vision, Colby T. Jeffries

Senior Independent Study Theses

Computer vision in sports analytics is a relatively new development. With multi-million dollar systems like STATS’s SportVu, professional basketball teams are able to collect extremely fine-detailed data better than ever before. This concept can be scaled down to provide similar statistics collection to college and high school basketball teams. Here we investigate the creation of such a system using open-source technologies and less expensive hardware. In addition, using a similar technology, we examine basketball free throws to see whether a shooter’s form has a specific relationship to a shot’s outcome. A system that learns this relationship could be used to …

Vitamin E Status Is Inversely Associated With Risk Of Incident Tuberculosis Disease Among Household Contacts, Omowunmi Aibana, Molly F Franke, Chuan-Chin Huang, Jerome T Galea, Roger Calderon, Zibiao Zhang, Mercedes C Becerra, Emily R Smith, Carmen Contreras, Rosa Yataco, Leonid Lecca, Megan B Murray

Faculty, Staff and Student Publications

BACKGROUND: Few studies have previously assessed how pre-existing vitamin E status is associated with risk of tuberculosis (TB) disease progression.

OBJECTIVE: We evaluated the association between baseline plasma concentrations of 3 vitamin E isomers (α-tocopherol, γ-tocopherol, and δ-tocopherol) and TB disease risk.

METHODS: We conducted a case-control study nested within a longitudinal cohort of household contacts (HHCs) of pulmonary TB cases in Lima, Peru. We defined cases as HHCs who developed active TB disease ≥15 d after the diagnosis of the index patient, and we matched each case to 4 control cases who did not develop active TB based on …