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Front Matter And Faculty Notes, Transactions: The Tennessee Journal Of Business Law

Transactions: The Tennessee Journal of Business Law

No abstract provided.

2018-2019 Faculty Handbook, St Norbert College

Faculty Handbooks

No abstract provided.

Demonstrating Feminist Metic Intelligence Through The Embodied Rhetorical Practices Of Julia Child, Lindy E. Briggette

Open Access Dissertations

The concept of metis reinserts the body and its intelligences into the ways in which rhetoric is understood, harnessed, and performed. Originating from the wisdom of Greek goddess Metis, the concept of metis is commonly understood as cunning intelligence that is deployed in order to escape an adversary, trick an opponent, or dupe its victim. When metic intelligence is read through the helping acts of Metis and her daughter, goddess Athena, however, an expanded version of its ways of operating begins to emerge. Through her efforts to debunk French cuisine using rule-based approaches meant to empower home chefs in their …

Integrated Clinical Experiences (Ices) In Physical Therapy: Impact On Communication Skills And Professionalism Prior To First Full-Time Clinical Internship, John Mclinden

Open Access Dissertations

The purpose of this study was to investigate student and programmatic factors that may influence doctor of physical therapy (DPT) students’ communication skills and professionalism before and after participating in a first time integrated clinical experience (ICE). Clinical education is an important component in healthcare education, including physical therapy (PT) education. It can take many forms including internships, co-ops, clerkships, and integrated clinical experiences (ICEs). The ICEs have been given specific attention in physical therapy because the Commission on Accreditation in Physical Therapy Education (CAPTE) has mandated their inclusion in DPT curricula. Best practices for ICEs, however, have not been …

Analysis Of Band Pair Formation In Elasmobranch Vertebrae With Implications For Fisheries Management, Kelsey James

Open Access Dissertations

Sharks, skates, and rays are particularly sensitive to over-exploitation due to their life history traits (slow growth, late age at maturity, small litter size, and extended longevity). It is important to know the age of sharks, skates, and rays because it has implications for our ability to assess the status of populations and to manage fisheries. They are aged most often using the concentric bands that alternate in appearance: opaque and translucent in their vertebral centra. An opaque and translucent band together (a band pair) is assumed to represent one year of growth and is counted to estimate an individual’s …

Collective Synchrony In Team Sports, Daniel Martin Smith

Open Access Dissertations

Collective synchrony is the simultaneous occurrence of behavior, cognition, emotion, and/or physiology within a group of three or more people. In this dissertation, I draw from various literatures to inform exploratory empirical and methodological investigation of collective synchrony in team sports. These include physiological synchrony, which has been examined primarily in dyads, and collective behavior in sports teams.

In Manuscript 1, I present a conceptual framework of collective synchrony in team sports. I argue that three possible antecedents (copresence, shared task, and coordination) underlie the interindividual matching of emotion, behavior, and cognition. This matching contributes to collective behavioral synchrony and/or …

Evaluation Of New Antimalarial Drug Combinations, Robert Tyrone Higginbotham

Honors Theses

Malaria is a disease that has affected people throughout the world for centuries and is still responsible for over 200 million clinical cases per year. While a number of developed countries have eradicated the disease, its prevalence in tropical regions poses a significant global health challenge. The disease is caused by the Plasmodium genus, an obligate, intracellular parasite that is carried by the female Anopheles mosquito. While there are effective antimalarial drugs in clinical use, Plasmodium's resilient nature has allowed it to develop resistance to multiple drugs. This fact makes it imperative to seek out novel drugs to combat resistant …

Towards An Innovative Approach For Teacher Education: Training Teacher To Train (Ttt) Model, Ferial Malaeb-Khaddage, Helen Crompton

Teaching & Learning Faculty Publications

The world is now connected virtual and mobile, it is currently going through a fundamental transformation in the way we humans work, perform tasks and activities. Automation and ‘thinking machines’ are replacing basic human tasks and jobs, and changing the skills that organizations are looking for in their people. In this paper, the authors discuss current technological innovations and how our world is changing rapidly in all aspects. New set of skills is needed; hence the authors focus on crucial practices and skills that are needed to be taught to harness our children for the future. The authors emphasis on …

Child Reader's Process Of Selecting Picture Books Based On Gender: Focused On 2nd Grade Elementary Student, Seongryeong Yu, Haeju Cheon

Teaching & Learning Faculty Publications

This study explores process of selecting picture books influenced by child reader’s identity. 44 second-grade students’ responses about picture book selection were collected by sign response gathering test and focused student interviews. The child readers showed diverse preferences on components of picture book’s cover. The perspectives of participants were largely derived from their identity formed by gender-separated peer groups, especially for boys: the boys selected books on the basis of their gender-biased beliefs compared with girls. The excessive self-centeredness lead children to misguided judgments regarding the contents of books, and avoiding certain books. It shows even child readers are needed …

The Big Crowd And The Small Enterprise: Intracorporate Disputes In The Close-But-Crowdfunded Firm, Martin Edwards

Penn State Law Review (2003 - Present)

No abstract provided.

Improving Security Message Adherence Through Improved Comprehension: Neural And Behavioral Insights, Bonnie Brinton Anderson, Daniel Bjornn, Jeffrey Jenkins, C. Brock Kirwan, Anthony Vance

Faculty Publications

Security warnings are critical to help users make contextual security decisions. Unfortunately, users find these warnings hard to understand, and they routinely expose themselves to unintended risks as a result. Although it is straightforward to determine when users fail to understand a warning, it is more difficult to pinpoint why this happens. The goal of this research is to use eye tracking to step through the building blocks of comprehension—attention, semantics, syntax, and pragmatics—for SSL and other common security warnings. Through this process, we will identify ways to design security warnings to be more easily understood.

Neuropeptide Y Cells Regulate Anxiety Behavior, Katelynn Corder

All ETDs from UAB

Dysregulation of the GABAergic system has long been implicated in anxiety disorders. Classic anxiolytic drugs, such as benzodiazepines, increase GABAergic transmission by modulating GABA¬A receptors, relieving anxiety symptoms. However, these treatments are not always effective and are often accompanied by negative side effects. Glutamate decarboxylase (GAD) is the enzyme responsible for producing GABA. Recent studies have shown that when the isoform GAD67 is reduced in specific brain regions or GABAergic subtypes, differential anxiety effects were found. These studies suggest that targeting specific GABAergic cell subtypes may provide a more effective treatment for anxiety disorders. Neuropeptide Y (NPY) is an abundant …

Tutoring Video Compositions: A Model Of Adaptation, Teresa Mckinney Davis

All ETDs from UAB

With the availability and ease-of-use of recording software on mobile phones, video essays are more accessible for composition classrooms. As these assignments are increasingly used, writ-ing centers are addressing the need for the ability to tutor video compositions. This article and conference presentation explore the foundational practices of directive and non-directive tutor-ing, examining how they can be adapted to working with video. More specifically, I argue that tutors can adapt existing theory and training to maintain a collaborative method when working with digital writing, without the need for specialized technology or technical training.

Immune Modulation Of Pain And Recovery Via Diet, Stacie Totsch

All ETDs from UAB

Chronic pain is the most common disability in the United States. Additionally, one out of three adults in America are obese and obesity and pain are often comorbid. Obesity is an inflammatory state due to the release of pro-inflammatory mediators from adipose tissue. Generally, obesity is a result of a poor-quality diet. Specific dietary components and patterns are independent activators of the immune system and can exacerbate the obesity-induced inflammatory state. It is known that immune system activation is a critical aspect in the development and progression of many chronic pain conditions. To address a general lack of preclinical investigations …

Reaching Consensus On Global Health Nursing Competencies For Baccalaureate Nursing Education In The United States: A Delphi Method Study, Herica Maria Torres-Alzate

All ETDs from UAB

The purpose of this study was to reach consensus among experts on global health competencies for baccalaureate nursing students in the United States. A Nursing Global Health Competencies Framework (NGHCF) was created to guide identification of the domains and competencies for BSN nursing education. A three-round modified Delphi study intersected with a mixed methods research approach to reach consensus from experts in global health on essential global health competencies in nursing. The first phase revised the original list of competencies based on: (a) qualitative responses to the surveys conducted by Wilson et al. (2012), Ventura et al. (2014), and Warren …

Novel Insights Into Neurofibromin Function And Human Neurofibromatosis Type 1 Mutations Using Genetically Engineered Mouse Models, Ashley Nicole Turner

All ETDs from UAB

Loss of NF1 in different developmental and cellular contexts leads to unique physiological outcomes due to loss of neurofibromin function, including embryonic lethality, sporadic cancers, and the genetic disorder NF1. Neurofibromin acts as a tumor suppressor by modulation of RAS signaling, with other functions of this multi-domain protein being less clear. Even within the monogenic disorder of NF1, the clinical heterogeneity and mutational spectrum are immense, revealing the complexity underlying this disorder. There is a huge urgency and need for NF1 therapeutic treatments, and the same urgency to develop in vivo models to better understand NF1 that can be utilized …

Synaptic Mechanisms Underlying The Integration Of Adult-Generated Neurons In The Dentate Gyrus, Ryan Vaden

All ETDs from UAB

The dentate gyrus is a region in the adult brain where new neurons continue to be generated throughout life. While most adult-generated neurons undergo apoptosis within the first few weeks of maturation, a fraction survives and integrates into the existing circuit. It is well established that γ-aminobutyric acid (GABA) receptor-mediated mechanisms contribute to the activity-dependent regulation of adult-neurogenesis. GABAergic interneurons regulate stem cell quiescence, progenitor proliferation, and the synaptic integration of newborn neurons, however the synaptic interactions underlying integration are not fully understood. Furthermore, the impact of adult-generated neurons integrating into the existing circuit is not completely known. The collective …

Clinical And Histomorphometric Outcomes Following The Use Of Small Versus Large Particle Sized Bone Allografts In Ridge Preservation Procedures: A Randomized Clinical Trial, Gentiane Valiquette

All ETDs from UAB

Alveolar ridge preservation at the time of tooth extraction is a commonly performed procedure as it significantly minimizes ridge resorption and allows for more optimal implant placement. The amount of new vital bone has been shown to vary with the use of different types of bone replacement grafts, however, the effect of bone graft particle size on the outcomes following ridge preservation has not been elucidated in the scientific literature. The present randomized clinical trial compared clinically, radiographically and histomorphometrically the use of small- (0.25-1.0mm) versus large- (1.0- 2.0mm) sized particle mineralized cortico-cancellous bone freeze-dried bone allografts (FDBAs) in ridge …

Endothelialization Of Microchannels In A Three Dimensional Breast Cancer Tumor Surrogate Model, Derek Van Vessem

All ETDs from UAB

Drug discovery and testing commonly employs two dimensional (2D) human cell line monolayers for lead compound identification before becoming a candidate therapy to be studied in animal models. Culturing cells in 2D produces a homogenous disbursement of nutrients and anticancer-therapeutics resulting in a response specific to 2D that does not necessarily translate to a three dimensional (3D) response. This method unfortunately distorts the in vivo human drug response. The lack of physiologic dimensionality in 2D cell monolayers distort cellular responses relative to 3D systems that can be attributed to minimal drug approvals. Oncology drugs are the least successful with only …

Cardiovascular Disease Risk Among Breast Cancer Survivors, Jacqueline B. Vo

All ETDs from UAB

Background: There are nearly 3.5 million breast cancer survivors in the U.S., and approximately 10% are diagnosed prior to age 45 and considered “young.” The overall five-year survival rate for breast cancer survivors is approaching 90%. Living longer, many breast cancer survivors are at risk for developing cardiovascular disease due to cancer treatment, such as anthracyclines and/or trastuzumab. This study’s purpose was to examine cardiovascular disease risk, measured using excess heart age, among young breast cancer survivors. Methods: A retrospective, two-year longitudinal design was used to review electronic medical records of breast cancer survivors diagnosed between 30 and 44 years …

Nf-Κb And Methyl-Lysine Signaling In The Epigenetic Regulation Of Memory, William Mitchell Webb

All ETDs from UAB

Epigenetic mechanisms such as DNA methylation and histone methylation are critical regulators of gene transcription during memory consolidation and retrieval. However, the means by which these mechanisms are themselves initiated and directed to specific gene regions, and the extent to which these marks coordinate control of gene expression, remain poorly understood. In this dissertation, we explore the role of methyl-lysine signaling in the epigenetic regulation of gene expression in two contexts. First, we investigated the role of histone H3 lysine 4 tri-methylation (H3K4me3) and DNA 5-hydroxymethylation (5hmC) during memory retrieval, finding that these marks increased globally and at CpG-enriched coding …

Identification Of Molecular Regulators Of Morphogenesis During Early Development Of Xenopus, Ivan Popov

All ETDs from UAB

During embryonic development of all animal species, dramatic changes in morphology occur to transform a single-celled zygote into a well-organized adult body that contains different organs positioned in stereotypical ways for the species. The processes that shape tissues and organs are called morphogenesis, and gastrulation is the first morphogenetic process in embryogenesis. During gastrulation, three germ layers are specified and a set of regionally specific cell movements act in concert to position these germ layers for proper establishment of future body plan of the developing animal. Although factors regulating cell lineage specification have been studied extensively, the molecular machinery controlling …

Calcium Signaling And Regulation Of Ecdysteroid Molting Hormone Production In Y-Organs Of The Blue Crab (Callinectes Sapidus), Megan Elizabeth Roegner

All ETDs from UAB

In the blue crab (Callinectes sapidus), molting, and subsequent incremental growth, is triggered by the release of molting hormones, or ecdysteroids, from paired endocrine glands termed Y-organs. The method that triggers the increase in ecdysteroid release before molting is not fully resolved, but previous evidence suggests a calcium (Ca2+) signal may be involved. The goal of this research is to better understand the role Ca2+ signaling plays in blue crab molt hormone production. The first part of my dissertation focused on the Ca2+ regulatory protein sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), which removes Ca2+ to the ER after a Ca2+ influx. …

Effects Of Stored Red Blood Cells On The Components Of The Lung-Capillary Membrane, Kaitlyn S. Ryan

All ETDs from UAB

Trauma is the leading cause of death for Americans between the ages of 1 and 44. Implementation of massive transfusion protocols has improved early mortality due to traumatic hemorrhage; however, long-term complication rates associated with hemorrhagic shock remain high due to the development of multiple organ failure. In particular, resuscitation with large volumes of stored red blood cells (RBC) introduces high concentrations of free heme, which contributes to the development of acute lung injury (ALI) after trauma. Angiopoietin-2 (Agpt-2) is a mediator of trauma-related lung injury, but the effect of RBC storage-derived free heme on Agpt-2 regulation is unknown. The …

The Contribution Of Mitochondrial Genetic Background To Glucose Metabolism And Insulin Sensitivity In Vivo, Melissa June Sammy

All ETDs from UAB

It has been observed that the risk of developing diabetes increases with age as well as among certain races, most notably African Americans and Hispanic Americans who are almost two times as likely to develop perturbed glucose metabolism compared to Caucasian Americans. Interestingly, there are distinct mitochondrial DNA polymorphisms that distinguish people of different races and thus may contribute to differential susceptibility to diseases of glucose metabolism. To test the hypothesis that the mitochondrial DNA (mtDNA) contributes to glucose metabolism and insulin sensitivity, two strains of mice were used with distinct mtDNA sequences namely, C57BL6/J and C3H/HeN as well as …

Endothelin-1 And The Diurnal Regulation Of Sodium Excretion, Jermaine Gajrae Johnston

All ETDs from UAB

Healthy individuals typically have a diurnal rhythm in sodium (Na+) excretion, with levels higher during the daytime and lower at nighttime. While the mechanism behind this rhythm is not yet fully understood, molecular clock genes such as Bmal1 may contribute to the diurnal variation in urinary Na+ excretion (UNaV). Endothelin-1 (ET-1) is a peptide that aids in the regulation of Na+ balance through activation of the endothelin B (ETB) receptor. Although the ETB receptor has been shown to play an important role in promoting natriuresis, whether this varies according to time of day is unknown. This dissertation examines the role …

Risk Factors Associated With Multiple Myeloma, Stephen Gragg

All ETDs from UAB

Multiple myeloma (MM) is a hematologic malignancy in which clonal plasma cells accumulate in the bone marrow, leading to the formation of lytic bone lesions, hypercalcemia, anemia, renal insufficiency, and immunosuppression. It develops from a pre-malignant condition known as monoclonal gammopathy of undetermined significance (MGUS), which is prevalent in up to 3% of White populations over the age of 50 years, and twice that in Black populations. Although much progress has been made toward understanding the large scale genomic aberrations that facilitate the formation of MGUS clones and the various copy-number variations and mutations that trigger the development of MM, …

Role Of Diminished Pulsatility From Continous Flow Ventricular Assist Devices On Small Vessel Endothelial Dysfunction, Thomas Haglund

All ETDs from UAB

Ventricular assist devices (VADs) are standard therapy for patients with advanced heart failure that is refractory to medical therapy. VADs can be categorized as pulsatile flow VADs (PF-VADs) and continuous flow VADs (CF-VADs). Both PF-VADs and CF-VADs are similarly effective in providing hemodynamic benefit and improving the quality of life and functional capacity of patients. CF-VADs are preferred over the PF-VADs due to advantages such as compact size, reliability, energy efficiency, installation and operation. However, CF-VAD support results in non-physiological diminished arterial pressure and flow pulsatility. Using the endothelial cell culture model (ECCM), we previously established that diminished pulsatility resulted …

Mechanisms Of Leucine-Rich Repeat Kinase 2 And Alphα-Synuclein In Pathogenesis Of Parkinson Disease, Hisham Abdelmotilib

All ETDs from UAB

Two pathological hallmarks define Parkinson disease (PD) including dopaminergic neurodegeneration in substantia nigra pars compacta (SNpc) and accumulation of α-synuclein insoluble inclusions, called Lewy pathology, in surviving neurons. LRRK2 (encoding Leucine-rich repeat kinase 2) and SNCA (encoding α-synuclein (α-syn)) are two major genes linked to PD. Pathogenic mutations in these two genes cause autosomal dominant (AD) PD. Additionally, genetic variations in LRRK2 and SNCA are associated with increased risk of sporadic PD. Cellular and animal studies using preformed α-syn fibrils (PFF) demonstrate that the fibrils can be internalized by neurons and act as seeds that can recruit and corrupt endogenously …

Prohealing Multifunctional Endothelium Nanomatrix Coated Stents, Grant Alexander

All ETDs from UAB

Cardiovascular disease is currently the number one cause of death in the United States, and indeed, worldwide. Stents are the most commonly implanted devices used to treat cardiovascular disease. Bare metal stent use remains limited by relatively high rates of in-stent restenosis, a re-narrowing of the artery after stent deployment. Restenosis within stents is a result of neointimal proliferation of smooth muscle cells and the accom-panying extracellular matrix deposition in response to vessel injury. To address this, drug-eluting stents have been developed to reduce restenosis; however, difficulties with late stent thrombosis, inflammation, and poor re-endothelialization remained. Thus, alt-hough numerous approaches …