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2018

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Making Babies With Cows, Scout Calvert Jan 2018

Making Babies With Cows, Scout Calvert

University of Nebraska-Lincoln Libraries: Faculty Publications

The conceit of section one of this essay is partial role reversal. How would a doctor who was a cow explain to yearling interns how to breed humans? This is what a cow might sound like if she thought about humans the ways that human purebred livestock breeders think about cows. Section two switches back to a human perspective and treats the extensive interventions into cattle reproduction as the mundane options that they have become for many farmers. This essay highlights the traffic of reproductive technologies across the porous human-bovine species boundary.

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Gene Expression Profiles Of The Small Intestinal Mucosa Of Dogs Repeatedly Infected With The Cestode Echinococcus Multilocularis, Hirokazu Kouguchi, Takao Irie, Jun Matsumoto, Hidefumi Furuoka, Kenji Ishiwata, Ryo Nakao, Kinpei Yagi Jan 2018

Gene Expression Profiles Of The Small Intestinal Mucosa Of Dogs Repeatedly Infected With The Cestode Echinococcus Multilocularis, Hirokazu Kouguchi, Takao Irie, Jun Matsumoto, Hidefumi Furuoka, Kenji Ishiwata, Ryo Nakao, Kinpei Yagi

Harold W. Manter Laboratory of Parasitology: Library Materials

The data set presented in this article is related to a previous research article entitled, The timing of worm exclusion in dogs repeatedly infected with the cestode Echinococcus multilocularis (Kouguchi et al., 2016). This article describes the genes >2 fold up- or down-regulated in the first- and repeated-infection groups compared to the healthy controls group. The gene expression profiles were generated using the Agilent-021193 Canine (V2) Gene Expression Microarray (GPL15379). The raw and normalized microarray data have been deposited with the Gene Expression Omnibus (GEO) database under accession number GSE105098.

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The Interface Between Wheat And The Wheat Curl Mite, Aceria Tosichella, The Primary Vector Of Globally Important Viral Diseases, Anna Skoracka, Brian G. Rector, Gary L. Hein Jan 2018

The Interface Between Wheat And The Wheat Curl Mite, Aceria Tosichella, The Primary Vector Of Globally Important Viral Diseases, Anna Skoracka, Brian G. Rector, Gary L. Hein

Department of Entomology: Faculty Publications

Wheat production and sustainability are steadily threatened by pests and pathogens in both wealthy and developing countries. This review is focused on the wheat curl mite (WCM), Aceria tosichella, and its relationship with wheat. WCM is a major pest of wheat and other cereals and a vector of at least four damaging plant viruses (Wheat streak mosaic virus, High plains wheat mosaic virus, Brome streak mosaic virus, and Triticum mosaic virus). The WCM–virus pathosystem causes considerable yield losses worldwide and its severity increases significantly when mixed-virus infections occur. Chemical control strategies are largely ineffective because WCM occupies …

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The Influence Of Spatiotemporally Decoupled Land Use On Honey Bee Colony Health And Pollination Service Delivery, Matthew D. Smart, Clint R. V. Otto, Benjamin L. Carlson, Cali L. Roth Jan 2018

The Influence Of Spatiotemporally Decoupled Land Use On Honey Bee Colony Health And Pollination Service Delivery, Matthew D. Smart, Clint R. V. Otto, Benjamin L. Carlson, Cali L. Roth

Department of Entomology: Faculty Publications

Societal dependence on insects for pollination of agricultural crops has risen amidst concerns over pollinator declines. Habitat loss and lack of forage have been implicated in the decline of both managed and native pollinators. Land use changes in the Northern Great Plains of the US, a region supporting over 1 million honey bee colonies annually, have shifted away from historical grassland ecosystems bees rely on for forage toward landscapes dominated by corn, soybeans, and other row crops. We investigated how land use impacts honey bee colony population size during the growing season and subsequent colony population size for almond pollination …

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Parental Rnai Suppression Of Chromatin Remodeling Genes To Control Coleopteran Pests, Blair D. Siegfried, Kenneth E. Narva, Kanika Arora, Sarah E. Worden, Chitvan Khajuria, Elane Fishilevich, Nicholas P. Storer, Meghan Frey, Ronda L. Hamm, Ana Maria Velez Jan 2018

Parental Rnai Suppression Of Chromatin Remodeling Genes To Control Coleopteran Pests, Blair D. Siegfried, Kenneth E. Narva, Kanika Arora, Sarah E. Worden, Chitvan Khajuria, Elane Fishilevich, Nicholas P. Storer, Meghan Frey, Ronda L. Hamm, Ana Maria Velez

Department of Entomology: Faculty Publications

This disclosure concerns nucleic acid molecules and meth ods of use thereof for control of hemipteran pests through RNA interference - mediated inhibition of target coding and transcribed non - coding sequences in hemipteran pests. The disclosure also concerns methods for making transgenic plants that express nucleic acid molecules useful for the control of hemipteran pests, and the plant cells and plants obtained thereby.

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Mirdis: A Web Tool For Endogenous And Exogenous Microrna Discovery Based On Deep-Sequencing Data Analysis, Hanyuan Zhang, Bruno Vieira Resende E Silva, Juan Cui Jan 2018

Mirdis: A Web Tool For Endogenous And Exogenous Microrna Discovery Based On Deep-Sequencing Data Analysis, Hanyuan Zhang, Bruno Vieira Resende E Silva, Juan Cui

School of Computing: Faculty Publications

Small RNA sequencing is the most widely used tool for microRNA (miRNA) discovery, and shows great potential for the efficient study of miRNA cross-species transport, i.e., by detecting the presence of exogenous miRNA sequences in the host species. Because of the increased appreciation of dietary miRNAs and their far-reaching implication in human health, research interests are currently growing with regard to exogenous miRNAs bioavailability, mechanisms of cross-species transport and miRNA function in cellular biological processes. In this article, we present microRNA Discovery (miRDis), a new small RNA sequencing data analysis pipeline for both endogenous and exogenous miRNA detection. Specifically, we …

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The Rhetoric Of Science Education And Technology, Iwasan D. Kejawa Jan 2018

The Rhetoric Of Science Education And Technology, Iwasan D. Kejawa

School of Computing: Faculty Publications

Nearly thousands of science experiments are performed both on humans and animals every year in the United States (Gregory, 1999). Does Science enormously play a role in the well-beings of individual in the society? Research has found that science education is through motivation and satisfying the needs of humans. The scientific world is part of an elongated human development. This can be substantiated with the use and evolution of TECHNOLOGY and SCIENCE (Minton, 2004). Education of the entities that comprise the need to achieve the goal of TECHNOLOGY and SCIENCE which are important issues of today. Research has shown that …

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First U-Pb Zircon Ages For Late Miocene Ashfall Konservat-Lagerstatte And Grove Lake Ashes From Eastern Great Plains, Usa, Jon J. Smith, Elijah Turner, Andreas Moller, Robert M. Joeckel, Rick E. Otto Jan 2018

First U-Pb Zircon Ages For Late Miocene Ashfall Konservat-Lagerstatte And Grove Lake Ashes From Eastern Great Plains, Usa, Jon J. Smith, Elijah Turner, Andreas Moller, Robert M. Joeckel, Rick E. Otto

Department of Earth and Atmospheric Sciences: Faculty Publications

This paper documents the first U-Pb zircon ages for Ashfall Fossil Beds (Nebraska, USA), a terrestrial Konservat-Lagerstatte mass-death assemblage that is arguably the most diverse of its type and age. The Ashfall tephra was correlated with ignimbrites from the Bruneau-Jarbidge volcanic field (12.7–10.5 Ma) in southwest Idaho based on geochemical analysis. The methods and geochemical data supporting the original age assessment of the ash bed, however, were never published, and there has been a persistent misconception that dateable heavy minerals (e.g., zircon) are absent. Notwithstanding, we recovered abundant zircons from Ashfall Fossil Beds, and from an ash bed ~6 km …

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Recent Ecological Change In Ancient Lakes, Stephanie E. Hampton, Suzanne Mcgowan, Ted Ozersky, Salvatore G. P. Virdis, Tuong Thuy Vu, Trisha L. Spanbauer, Benjamin M. Kraemer, George Swann, Anson W. Mackay, Stephen M. Powers, Michael F. Meyer, Stephanie G. Labou, Catherine M. O'Reilly, Morgan Dicarlo, Aaron W. E. Galloway, Sherilyn C. Fritz Jan 2018

Recent Ecological Change In Ancient Lakes, Stephanie E. Hampton, Suzanne Mcgowan, Ted Ozersky, Salvatore G. P. Virdis, Tuong Thuy Vu, Trisha L. Spanbauer, Benjamin M. Kraemer, George Swann, Anson W. Mackay, Stephen M. Powers, Michael F. Meyer, Stephanie G. Labou, Catherine M. O'Reilly, Morgan Dicarlo, Aaron W. E. Galloway, Sherilyn C. Fritz

Department of Earth and Atmospheric Sciences: Faculty Publications

Ancient lakes are among the best archivists of past environmental change, having experienced more than one full glacial cycle, a wide range of climatic conditions, tectonic events, and long association with human settlements. These lakes not only record long histories of environmental variation and human activity in their sediments, but also harbor very high levels of biodiversity and endemism. Yet, ancient lakes are faced with a familiar suite of anthropogenic threats, which may degrade the unusual properties that make them especially valuable to science and society. In all ancient lakes for which data exist, significant warming of surface waters has …

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An Observational And Modeling Study Of Mesoscale Air Masses With High Theta-E, Wolfgang Hanft, Adam L. Houston Jan 2018

An Observational And Modeling Study Of Mesoscale Air Masses With High Theta-E, Wolfgang Hanft, Adam L. Houston

Department of Earth and Atmospheric Sciences: Faculty Publications

Typically, the cool side of an airmass boundary is stable to vertical motions due to its associated negative buoyancy. However, under certain conditions, the air on the cool side of the boundary can undergo a transition wherein it assumes an equivalent potential temperature and surface-based convective available potential energy that are higher than those of the air mass on the warm side of the boundary. The resultant air mass is herein referred to as a mesoscale air mass with high theta-e (MAHTE). Results are presented from an observational and mesoscale modeling study designed to examine MAHTE characteristics and the processes …

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Relational Uncertainty Management In Adult Children Of Divorce, Sylvia L. Mikucki-Enyart, Sarah R. Petitte, Sarah E. Wilder Jan 2018

Relational Uncertainty Management In Adult Children Of Divorce, Sylvia L. Mikucki-Enyart, Sarah R. Petitte, Sarah E. Wilder

Department of Communication Studies: Faculty Publications

Utilizing uncertainty management theory (UMT) and a multiple goals theory of personal relationships (MGPR) the present study examined how adult children of divorce (ACOD) manage relational uncertainty following parental divorce. In-depth, semistructured interviews with 25 adult children who had experienced parental divorce when they were 18 years of age or older revealed two broad types of information acquisition strategies: deliberate (i.e., information-seeking and information-avoiding) and incidental (i.e., incidental information acquisition). Deliberate information acquisition strategies were animated by several goals, including reducing and maintaining uncertainty, avoiding feeling caught, and protection. Alongside goals, various constraints (e.g., target efficacy, coping efficacy) played a …

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Resistance In Rice To Tibraca Limbativentris (Hemiptera: Pentatomidae) Influenced By Plant Silicon Content, Lincoln Luis França, Cássio Antonio Dierings, André Cirilo De Sousa Almeida, Marcio Da Silva Araújo, Elvis Arden Heinrichs, Anderson Rodrigo Da Silva, José Alexandre Freitas Barrigossi, Flávio Gonçalves De Jesus Jan 2018

Resistance In Rice To Tibraca Limbativentris (Hemiptera: Pentatomidae) Influenced By Plant Silicon Content, Lincoln Luis França, Cássio Antonio Dierings, André Cirilo De Sousa Almeida, Marcio Da Silva Araújo, Elvis Arden Heinrichs, Anderson Rodrigo Da Silva, José Alexandre Freitas Barrigossi, Flávio Gonçalves De Jesus

Department of Entomology: Faculty Publications

Tibraca limbativentris Stål (Hemiptera: Pentatomidae) is a major pest causing economic losses to rice cultivation in Brazil. The objectives of this work were to assess different sources of silicon in the induction of plant resistance, to examine the interaction of rice varieties with silicon-based resistance, and to determine the effects of varieties and silicon on stink bug biology. The interaction of rice cultivars BRS Esmeralda, IRGA 429 (widely cultivated in Brazil), and Canela de Ferro (a resistant cultivar), and 2 sources of silicon (K silicate, and Ca + Mg silicate) were studied. Plant parameters measured were percentage of damaged stems, …

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Symposium Paper Building Bridges Between Disciplines For Sustainable Crop Protection, Rangaswamy Muniappan, E. A. Heinrichs Jan 2018

Symposium Paper Building Bridges Between Disciplines For Sustainable Crop Protection, Rangaswamy Muniappan, E. A. Heinrichs

Department of Entomology: Faculty Publications

Plant protection is an interdisciplinary area that historically involved agronomy, plant breeding, entomology, plant pathology, statistics, and weed science. After World War II, pesticide development took precedence and chemistry, physics, and engineering were favored. This led to excessive use of synthetic pesticides, causing pest resistance to insecticides, contamination of ecosystems and undesirable health effects. As a result, the integrated pest management concept was developed in the 1960s. This expanded into new disciplines, such as mathematics, computer science, meteorology, and aeronautics to forecast pest occurrence and dispersal. It also included molecular biology and microbiology to produce biological control agents and GMOs …

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Shared Mechanisms Among Probiotic Taxa: Implications For General Probiotic Claims, Mary Ellen Sanders, Andrew K. Benson, Sarah Lebeer, Daniel J. Merenstein, Todd R. Klaenhammer Jan 2018

Shared Mechanisms Among Probiotic Taxa: Implications For General Probiotic Claims, Mary Ellen Sanders, Andrew K. Benson, Sarah Lebeer, Daniel J. Merenstein, Todd R. Klaenhammer

Department of Food Science and Technology: Faculty Publications

Strain-specificity of probiotic effects has been a cornerstone principle of probiotic science for decades. Certainly, some important mechanisms are present in only a few probiotic strains. But scientific advances now reveal commonalities among members of certain taxonomic groups of probiotic microbes. Some clinical benefits likely derive from these shared mechanisms, suggesting that sub-species-specific, species specific or genus-specific probiotic effects exist. Human trials are necessary to confirm specific health benefits. However, a strain that has not been tested in human efficacy trials may meet the minimum definition of the term ‘probiotic’ if it is a member of a well-studied probiotic species …

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Modification Of Wheat Gluten For Improvement Of Binding Capacity With Keratin In Hair, Shukun Wang, Danyang Meng, Sisi Wang, Zhong Zhang, Ruijin Yang, Wei Zhao Jan 2018

Modification Of Wheat Gluten For Improvement Of Binding Capacity With Keratin In Hair, Shukun Wang, Danyang Meng, Sisi Wang, Zhong Zhang, Ruijin Yang, Wei Zhao

Department of Food Science and Technology: Faculty Publications

In this study, enzymatic hydrolysis and cationization with epoxypropyldodecyldimethylammonium chloride of wheat protein, an economic protein complex containing great amount of disulfide bonds, were conducted to improve properties such as solubility and disassociation behaviour for recovery of damaged hair when used in shampoo. The optimal conditions for enzymatic hydrolysis were pH 8.2, 55°C with Alcalase for 60min. After the selected hydrolysis, the degree of hydrolysis, nitrogen solubility index, foaming capacity index, foam stability index, emulsifying activity index and emulsion stability index of hydrolysate with 58.71% of shortchain peptides (less than 1000 Da) were 8.81%, 39.07%, 225%, 56.67%, 9.62m2 g …

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Shared Mechanisms Among Probiotic Taxa: Implications For General Probiotic Claims, Mary Ellen Sanders, Andrew K. Benson, Sarah Lebeer, Daniel J. Merenstein, Todd R. Klaenhammer Jan 2018

Shared Mechanisms Among Probiotic Taxa: Implications For General Probiotic Claims, Mary Ellen Sanders, Andrew K. Benson, Sarah Lebeer, Daniel J. Merenstein, Todd R. Klaenhammer

Department of Food Science and Technology: Faculty Publications

Strain-specificity of probiotic effects has been a cornerstone principle of probiotic science for decades. Certainly, some important mechanisms are present in only a few probiotic strains. But scientific advances now reveal commonalities among members of certain taxonomic groups of probiotic microbes. Some clinical benefits likely derive from these shared mechanisms, suggesting that sub-species-specific, speciesspecific or genus-specific probiotic effects exist. Human trials are necessary to confirm specific health benefits. However, a strain that has not been tested in human efficacy trials may meet the minimum definition of the term ‘probiotic’ if it is a member of a well-studied probiotic species expressing …

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Who/Iuis Allergen Nomenclature: Providing A Common Language, Anna Pomes, Janet M. Davies, Gabriele Gadermaier, Christiane Hilger, Thomas Holzhauser, Jonas Lidholm, Andreas L. Lopata, Geoffrey A. Mueller, Andreas Nandy, Christian Radauer, Sanny K. Chan, Uta Jappe, Jorg Kleine-Tebbe, Wayne R. Thomas, Martin D. Chapman, Marianne Van Hage, Ronald Van Ree, Stefan Vieths, Monika Raulf, Richard E. Goodman Jan 2018

Who/Iuis Allergen Nomenclature: Providing A Common Language, Anna Pomes, Janet M. Davies, Gabriele Gadermaier, Christiane Hilger, Thomas Holzhauser, Jonas Lidholm, Andreas L. Lopata, Geoffrey A. Mueller, Andreas Nandy, Christian Radauer, Sanny K. Chan, Uta Jappe, Jorg Kleine-Tebbe, Wayne R. Thomas, Martin D. Chapman, Marianne Van Hage, Ronald Van Ree, Stefan Vieths, Monika Raulf, Richard E. Goodman

Department of Food Science and Technology: Faculty Publications

A systematic nomenclature for allergens originated in the early 1980s, when few protein allergens had been described. A group of scientists led by Dr. David G. Marsh developed a nomenclature based on the Linnaean taxonomy, and further established the World Health Organization/International Union of Immunological Societies (WHO/IUIS) Allergen Nomenclature Sub-Committee in 1986. Its stated aim was to standardize the names given to the antigens (allergens) that caused IgE-mediated allergies in humans. The Sub-Committee first published a revised list of allergen names in 1986, which continued to grow with rare publications until 1994. Between 1994 and 2007 the database was a …

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Algal Bloom Expansion Increases Cyanotoxin Risk In Food, Niam M. Abeysiriwardena, Samuel J. L. Gascoigne, Angela Anandappa Jan 2018

Algal Bloom Expansion Increases Cyanotoxin Risk In Food, Niam M. Abeysiriwardena, Samuel J. L. Gascoigne, Angela Anandappa

Department of Food Science and Technology: Faculty Publications

As advances in global transportation infrastructure make it possible for out of season foods to be available year-round, the need for assessing the risks associated with the food production and expanded distribution are even more important. Risks for foodborne illness are associated with contamination by bacteria, viruses, mold, parasites, natural and synthetic toxins, chemical residues, and conditions that lead to contamination. An increase in the popularity of natural alternatives to pharmaceuticals, herbal remedies and the desire for consuming “super foods” is leading to a change in the dietary patterns of consumers. Similarly, dietary trends are plentiful, with more consumers adopting …

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Probiotic Bifidobacterium Strains And Galactooligosaccharides Improve Intestinal Barrier Function In Obese Adults But Show No Synergism When Used Together As Synbiotics, Janina A. Krumbeck, Heather E. Rasmussen, Robert W. Hutkins, Jennifer L. Clarke, Krista Shawron, Ali Keshavarzian, Jens Walter Jan 2018

Probiotic Bifidobacterium Strains And Galactooligosaccharides Improve Intestinal Barrier Function In Obese Adults But Show No Synergism When Used Together As Synbiotics, Janina A. Krumbeck, Heather E. Rasmussen, Robert W. Hutkins, Jennifer L. Clarke, Krista Shawron, Ali Keshavarzian, Jens Walter

Department of Food Science and Technology: Faculty Publications

Background: One way to improve both the ecological performance and functionality of probiotic bacteria is by combining them with a prebiotic in the form of a synbiotic. However, the degree to which such synbiotic formulations improve probiotic strain functionality in humans has not been tested systematically. Our goal was to use a randomized, double-blind, placebo-controlled, parallel-arm clinical trial in obese humans to compare the ecological and physiological impact of the prebiotic galactooligosaccharides (GOS) and the probiotic strains Bifidobacterium adolescentis IVS-1 (autochthonous and selected via in vivo selection) and Bifidobacterium lactis BB-12 (commercial probiotic allochthonous to the human gut) when used …

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Stability Of The Phenolic Compounds And Antioxidant Capacity Of Five Fruit (Apple, Orange, Grape, Pomelo And Kiwi) Juices During In Vitro-Simulated Gastrointestinal Digestion, Wei Quan, Yadan Tao, Mei Lu, Bo Yuan, Jie Chen, Maomao Zeng, Fang Qin, Fengxian Guo, Zhiyoung He Jan 2018

Stability Of The Phenolic Compounds And Antioxidant Capacity Of Five Fruit (Apple, Orange, Grape, Pomelo And Kiwi) Juices During In Vitro-Simulated Gastrointestinal Digestion, Wei Quan, Yadan Tao, Mei Lu, Bo Yuan, Jie Chen, Maomao Zeng, Fang Qin, Fengxian Guo, Zhiyoung He

Department of Food Science and Technology: Faculty Publications

The in vitro digestive stability of phenolic compounds and the antioxidant capacity of five kinds of commonly consumed fruit juices in the daily diet, including apple juice (AJ), orange juice (OJ), grape juice (GJ), pomelo juice (PJ) and kiwifruit juice (KJ), were studied. Following in vitro digestion, the total phenolic (TP) content of fruit juices decreased to different extents by 35%, 25.3%, 23.5%, 22.2% and 7.8% for KJ, OJ, PJ, GJ and AJ, respectively. The individual phenolic content showed similar changes to the TP content, showing reductions of naringenin-trisaccharide in OJ and PJ, epicatechin in GJ, and chlorogenic acid in …

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Metabolic Syndrome, Gut Microbiome And Dietary Bioactive Peptides, An Unexplored Triad, Rohita Sinha, Jennifer Clarke, Jean-Jack Riethoven Jan 2018

Metabolic Syndrome, Gut Microbiome And Dietary Bioactive Peptides, An Unexplored Triad, Rohita Sinha, Jennifer Clarke, Jean-Jack Riethoven

Department of Food Science and Technology: Faculty Publications

The gut microbiome is a complex, biochemically rich and essential component of the human metabolic system. It has been our understanding for very long that the gut microbes are primarily there to digest the undigested food (mainly fibers), get nourishment, and in return release metabolites helping host cells — short-chain fatty acids produced by gut microbes are a great source of energy for the colonocytes. It is only in the last decade, with advancements of DNA sequencing platforms, that we are lettered about the association between the gut microbial composition and metabolic disorders such as obesity, dysglycemia, dyslipidemia, and cardiovascular …

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Commensal Escherichia Coli Strains Can Promote Intestinal Inflammation Via Differential Interleukin-6 Production, Hatem Kittana, Joao Carlos Gomes-Neto, Kari Heck, Abby L. Geis, Rafael R. Segura Munoz, Liz A. Cody, Robert J. Schmaltz, Laure B. Bindels, Rohita Sinha, Jesse M. Hostetter, Andrew K. Benson, Amanda E. Ramer-Tait Jan 2018

Commensal Escherichia Coli Strains Can Promote Intestinal Inflammation Via Differential Interleukin-6 Production, Hatem Kittana, Joao Carlos Gomes-Neto, Kari Heck, Abby L. Geis, Rafael R. Segura Munoz, Liz A. Cody, Robert J. Schmaltz, Laure B. Bindels, Rohita Sinha, Jesse M. Hostetter, Andrew K. Benson, Amanda E. Ramer-Tait

Department of Food Science and Technology: Faculty Publications

Escherichia coli is a facultative anaerobic symbiont found widely among mammalian gastrointestinal tracts. Several human studies have reported increased commensal E. coli abundance in the intestine during inflammation; however, host immunological responses toward commensal E. coli during inflammation are not well-defined. Here, we show that colonization of gnotobiotic mice with different genotypes of commensal E. coli isolated from healthy conventional microbiota mice and representing distinct populations of E. coli elicited strain-specific disease phenotypes and immunopathological changes following treatment with the inflammatory stimulus, dextran sulfate sodium (DSS). Production of the inflammatory cytokines GM-CSF, IL-6, and IFN-y was a hallmark of the …

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Analysis Of Genetic And Nongenetic Factors Influencing Triglycerides-Lowering Drug Effects Based On Paired Observations, Zheng Xu, Qing Duan, Juan Cui, Yumou Qiu, Qidong Jia, Cong Wu, Jennifer Clarke Jan 2018

Analysis Of Genetic And Nongenetic Factors Influencing Triglycerides-Lowering Drug Effects Based On Paired Observations, Zheng Xu, Qing Duan, Juan Cui, Yumou Qiu, Qidong Jia, Cong Wu, Jennifer Clarke

Department of Food Science and Technology: Faculty Publications

Obesity is a risk factor for heart disease, stroke, diabetes, high blood pressure, and other chronic diseases. Some drugs, including fenofibrate, are used to treat obesity or excessive weight by lowering the level of specific triglycerides. However, different groups have different drug sensitivities and, consequently, there are differences in drug effects. In this study, we assessed both genetic and nongenetic factors that influence drug responses and stratified patients into groups based on differential drug effect and sensitivity. Our methodology of investigating genetic factors and nongenetic factors is applicable to studying differential effects of other drugs, such as statins, and provides …

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Food-Derived Bioactive Peptides In Human Health: Challenges And Opportunities, Subhadeep Chakrabarti, Snigdha Guha, Kaustav Majumder Jan 2018

Food-Derived Bioactive Peptides In Human Health: Challenges And Opportunities, Subhadeep Chakrabarti, Snigdha Guha, Kaustav Majumder

Department of Food Science and Technology: Faculty Publications

Recent scientific evidence suggests that food proteins not only serve as nutrients, but can also modulate the body’s physiological functions. These physiological functions are primarily regulated by some peptides that are encrypted in the native protein sequences. These bioactive peptides can exert health beneficial properties and thus are considered as a lead compound for the development of nutraceuticals or functional foods. In the past fewdecades, awide range of food-derived bioactive peptide sequences have been identified, with multiple health beneficial activities. However, the commercial application of these bioactive peptides has been delayed because of the absence of appropriate and scalable production …

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Investigating Colonization Of The Healthy Adult Gastrointestinal Tract By Fungi, Thomas A. Auchtung, Tatiana Y. Fofanova, Christopher J. Stewart, Andrea K. Nash, Matthew C. Wong, Jonathan R. Gesell, Jennifer M. Auchtung, Nadim J. Ajami, Joseph F. Petrosino Jan 2018

Investigating Colonization Of The Healthy Adult Gastrointestinal Tract By Fungi, Thomas A. Auchtung, Tatiana Y. Fofanova, Christopher J. Stewart, Andrea K. Nash, Matthew C. Wong, Jonathan R. Gesell, Jennifer M. Auchtung, Nadim J. Ajami, Joseph F. Petrosino

Department of Food Science and Technology: Faculty Publications

A wide diversity of fungi have been detected in the human gastrointestinal (GI) tract with the potential to provide or influence important functions. However, many of the fungi most commonly detected in stool samples are also present in food or the oral cavity. Therefore, to recognize which gut fungi are likely to have a sustained influence on human health, there is a need to separate transient members of the GI tract from true colonizers. To identify colonizing fungi, the eukaryotic rRNA operon’s second internal transcribed spacer (ITS2) was sequenced from the stool, saliva, and food of healthy adults following consumption …

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Chemical Composition And Safety Of Unrecorded Grain Alcohol (Bai Jiu) Samples From Three Provinces In China, Ian M. Newman, Ling Qian, Niran Tamrakar, Bo-Bo Zhang Jan 2018

Chemical Composition And Safety Of Unrecorded Grain Alcohol (Bai Jiu) Samples From Three Provinces In China, Ian M. Newman, Ling Qian, Niran Tamrakar, Bo-Bo Zhang

Department of Educational Psychology: Faculty Publications

Abstract: About 20% of spirits consumed in China are “unrecorded”, where these spirits are produced in small-scale distilleries and sold outside the systems of taxation and quality control. Researchers visited small distilleries in rural Yunnan, Hubei and Anhui and purchased 56 samples of unrecorded bai jiu. Seven samples of the recorded bai jiu were purchased as reference samples. An independent laboratory conducted a blind analysis of the samples. Results were compared to the standards for unrecorded alcohol adopted by the European Commission’s Alcohol Measures for Public Health Research Alliance (AMPHORA). No samples exceeded the AMPHORA guidelines for methanol, ethyl acetate, …

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Plaque Burden Influences Accurate Classification Of Fibrous Cap Atheroma By In-Vivo Optical Coherence Tomography In A Porcine Model Of Advanced Coronary Atherosclerosis., Christian B. Poulsen, Ryan M. Pedrigi, Nilesh Pareek, Ismail D. Kilic, Niels R. Holm, Jacob F. Bentzon, Hans Erik Botker, Erling Falk, Rob Krams, Ranil De Silva Jan 2018

Plaque Burden Influences Accurate Classification Of Fibrous Cap Atheroma By In-Vivo Optical Coherence Tomography In A Porcine Model Of Advanced Coronary Atherosclerosis., Christian B. Poulsen, Ryan M. Pedrigi, Nilesh Pareek, Ismail D. Kilic, Niels R. Holm, Jacob F. Bentzon, Hans Erik Botker, Erling Falk, Rob Krams, Ranil De Silva

Department of Mechanical and Materials Engineering: Faculty Publications

Advanced coronary atherosclerosis assessed by in-vivo optical coherence tomography (OCT) has not been directly compared with histology. In a porcine model with human-like coronary atherosclerosis we compared in-vivo OCT images with histology in five animals. We found a high sensitivity but modest specificity of OCT in classifying fibrous cap atheroma (FCA). The modest specificity was caused by misclassification of FCA lesions as pathological intimal thickening. The misclassification most frequently occurred when plaque burden exceeded ~20%. Compared with histology, OCT has high sensitivity but modest specificity for identifying FCA. The study suggests that plaque burden should be considered when interpreting OCT …

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Scaffold Structural Microenvironmental Cues To Guide Tissue Regeneration In Bone Tissue Applications, Xuening Chen, Hongyuan Fan, Xiaowei Deng, Lina Wu, Tao Yi, Linxia Gu, Changchun Zhou, Yujiang Fan, Xingdong Zhang Jan 2018

Scaffold Structural Microenvironmental Cues To Guide Tissue Regeneration In Bone Tissue Applications, Xuening Chen, Hongyuan Fan, Xiaowei Deng, Lina Wu, Tao Yi, Linxia Gu, Changchun Zhou, Yujiang Fan, Xingdong Zhang

Department of Mechanical and Materials Engineering: Faculty Publications

In the process of bone regeneration, new bone formation is largely affected by physico-chemical cues in the surrounding microenvironment. Tissue cells reside in a complex scaffold physiological microenvironment. The scaffold should provide certain circumstance full of structural cues to enhance multipotent mesenchymal stem cell (MSC) differentiation, osteoblast growth, extracellular matrix (ECM) deposition, and subsequent new bone formation. This article reviewed advances in fabrication technology that enable the creation of biomaterials with well-defined pore structure and surface topography, which can be sensed by host tissue cells (esp., stem cells) and subsequently determine cell fates during differentiation. Three important cues, including scaffold …

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An Historical Overview And Update Of Wolf-Moose Interactions In Northeastern Minnesota, L. David Mech, John Fieberg, Shannon M. Barber-Meyer Jan 2018

An Historical Overview And Update Of Wolf-Moose Interactions In Northeastern Minnesota, L. David Mech, John Fieberg, Shannon M. Barber-Meyer

United States Geological Survey, Northern Prairie Wildlife Research Center: Publications

Wolf (Canis lupus) and moose (Alces americanus) populations in northeastern Minnesota, USA, have fluctuated for decades and, based on helicopter counts, moose numbers declined to a new low from 2006 to about 2012. Other steep declines were found in 1991 and 1998 during periods when moose counts were done with fixed-wing aircraft; these declines also appeared to be real. Winter wolf numbers, monitored in part of the moose range, had been increasing since about 2002 to the highest population in decades in 2009. However, from 2009 to 2016, wolves decreased precipitously, and the moose- population decline leveled …

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Conserving All The Pollinators: Variation In Probability Of Pollen Transport Among Insect Taxa, Diane L. Larson, Jennifer L. Larson, Deborah A. Buhl Jan 2018

Conserving All The Pollinators: Variation In Probability Of Pollen Transport Among Insect Taxa, Diane L. Larson, Jennifer L. Larson, Deborah A. Buhl

United States Geological Survey, Northern Prairie Wildlife Research Center: Publications

As concern about declining pollinator populations mounts, it is important to understand the range of insect taxa that provide pollination services. We use pollen transport information acquired over three years in two habitats at Badlands National Park, South Dakota, USA, to compare probabilities of pollen transport among insect taxa and between sexes of bees. Sampling was conducted on 1-ha plots, eight in sparse vegetation (May–October samples; N = 74 surveys) and 12 in wheatgrass prairie vegetation (June–July samples; N = 87 surveys). Insects contacting reproductive parts of flowers were netted, placed individually into tubes charged with ethyl acetate, then transferred …

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