Digital Commons Network^™

Librarians Dream Of Electric Cats: A Tech Team’S Journey Into The World Of Emerging Technologies, Jason Lilly, Kellie Kaneshiro

Against the Grain

No abstract provided.

Table Of Contents

Against the Grain

No abstract provided.

Don's Conference Notes-Scholarly Publishing At The Crossroads: The 40th Ssp Meeting, Donald T. Hawkins

Against the Grain

No abstract provided.

Cases Of Note- Copyright - Sea Divers Implied-In-Fact Contract, Bruce Strauch, Bryan M. Carson, Jack Montgomery

Against the Grain

No abstract provided.

Atg Profiles Encouraged

Against the Grain

No abstract provided.

Characterization Of Cdk(5) Inhibitor, 20-223 (Aka Cp668863) For Colorectal Cancer Therapy, Caroline M. Robb, Smit Kour, Jacob I. Contreras, Ekta Agarwal, Carter J. Barger, Sandeep Rana, Yogesh Sonawane, Beth K. Neilsen, Margaret Taylor, Smitha Kizhake, Rhishikesh N. Thakare, Sanjib Chowdhury, Jing Wang, Jennifer D. Black, Michael A. Hollingsworth, Michael G. Brattain, Amarnath Natarajan

Journal Articles: Biochemistry & Molecular Biology

Colorectal cancer (CRC) remains one of the leading causes of cancer related deaths in the United States. Currently, there are limited therapeutic options for patients suffering from CRC, none of which focus on the cell signaling mechanisms controlled by the popular kinase family, cyclin dependent kinases (CDKs). Here we evaluate a Pfizer developed compound, CP668863, that inhibits cyclin-dependent kinase 5 (CDK5) in neurodegenerative disorders. CDK5 has been implicated in a number of cancers, most recently as an oncogene in colorectal cancers. Our lab synthesized and characterized CP668863 – now called 20-223. In our established colorectal cancer xenograft model, 20-223 reduced …

Pancreatic Cancer Associated With Obesity And Diabetes: An Alternative Approach For Its Targeting, Ramesh Pothuraju, Satyanarayana Rachagani, Wade M. Junker, Sanjib Chaudhary, Saraswathi Viswanathan, Sukhwinder Kaur, Surinder K. Batra

Journal Articles: Biochemistry & Molecular Biology

BACKGROUND: Pancreatic cancer (PC) is among foremost causes of cancer related deaths worldwide due to generic symptoms, lack of effective screening strategies and resistance to chemo- and radiotherapies. The risk factors associated with PC include several metabolic disorders such as obesity, insulin resistance and type 2 diabetes mellitus (T2DM). Studies have shown that obesity and T2DM are associated with PC pathogenesis; however, their role in PC initiation and development remains obscure.

MAIN BODY: Several biochemical and physiological factors associated with obesity and/or T2DM including adipokines, inflammatory mediators, and altered microbiome are involved in PC progression and metastasis albeit by different …

The Bi-Directional Relationship Between Gut Microbiota And Autoimmunity, Trevor O. Kirby

EWU Masters Thesis Collection

Humans serve as a major reservoir for a vast number of microbiota. These microbes have evolved symbiotic relationships with humans due to their close proximity with their host. As a result, the immune system adapts to the microbiota thus modulating immunological function. Autoimmunity is a state in which there are aberrant immune responses produced against host tissue. Intestinal bacteria are directly impacted by instances of inflammation brought on by autoimmunity. The complicated nature between autoimmunity and bacterial modulation demonstrates a bi-directional relationship. Here, we utilize experimental autoimmune encephalomyelitis, a model for multiple sclerosis, to explore the bi-directional relationship that disease …

The Source Of Excess Nutrients To Pine Draw, Turnbull National Wildlife Refuge, Henry Price

EWU Masters Thesis Collection

Nitrogen and phosphorus are the most common limiting nutrients for biological activity in freshwater ecosystems. Applying inorganic nitrogen fertilizer has increased crop productivity but caused excess nitrogen inputs to the hydrosphere. Nitrate contamination is a worldwide environmental problem. The fate of nitrogen in ecosystems is variable based on land type and hydrogeological interactions. Excess nitrogen can be retained in soils, sequestered in stream organisms, denitrified or transported downstream. The goals of this study were to monitor nitrogen concentrations in Pine Draw, Turnbull National Wildlife Refuge (TNWR), Washington, U.S.A., and to determine the source of nitrogen loading. Pine Draw is unique …

Informal Science In The Classroom: How Informal And Formal Educational Institutions Support Science Instruction, Kellie Michelle Crawford

EWU Masters Thesis Collection

Science education has seen a major overhaul with the implementation of ideas from the NRC’s (2012) report, A Framework for K-12 Science Education: Practices, Crosscutting Concepts, and Core Ideas. At the same time, we have seen a rise in the number of formal educational facilities partnering with informal facilities to bring these practices to students. This study explored the effect these blended approaches had on both student attitudes and their achievement in science content areas. To do this, surveys were designed to assess these areas in upper elementary students participating in a one-year blended science program. First, the literature was …

Anima, Tessa N. Bryant

EWU Masters Thesis Collection

No abstract provided.

Some Things I Left In Denver, Jenny Catlin

EWU Masters Thesis Collection

No abstract provided.

Optimisation Of Ion Exchange Chromatography Purification Protocols For A Staphylococcal Peptidoglycan Degrading Hydrolase Enzyme, Fiona Maher

Theses

Bacteriophage (phage) are the most abundant biological entities on earth and were first discovered by d’Herelle in 1917. They are found wherever their hosts live and, like all viruses they do not have the ability to make their own protein. Therefore, in order to reproduce, phage must invade and infect bacterial cells. This project focused on the optimisation of Ion Exchange Chromatography purification protocols for a staphylococcal peptidoglycan degrading hydrolase enzyme (CHAPk). The project objective was to obtain the greatest yield of enzyme from the growth of the E.coU XL 1-Blue expression system into which the vector pQE60 was previously …

Predicting Energy And Water Consumption On Dairy Farms Through Statistical Analysis And Machine-Learning Methods, Philip Shine

Theses

With the abolishment of milking quotas across all European Union member states in April 2015, dairy farmers must adjust their farming practises to minimise milk production costs to adequately prepare for potential periods of reduced revenue. Milk production is an intense energy and water consuming process. Coupled with challenging European greenhouse gas reduction targets and legislation regarding the prevention of groundwater pollution and deterioration, increasing the production of milk in Ireland must be met with the sustainable consumption of on-farm energy and direct water resources, to ensure the future monetary and environmental sustainability of Ireland’s dairy industry. Thus, this body …

Development Of Multi-Class Analytical Methods For Agrochemical Contaminants, Sarah Tuck

Theses

In this project, cost-effective multi-class analytical methods were developed to detect a range of antiparasitic, feed additive and pesticide substances in foodstuffs of animal origin. These substances have the potential to enter the food chain through their occurrence as residues either through the animals themselves or other routes e.g. contamination. To ensure the continued safety of food destined for human consumption regulatory control limits have been established for permitted levels of these residues in foods of animal origin. Despite these controls the continued monitoring of foodstuffs is necessary to ensure these limits are not breached and that substances are not …

Development Of Chitosan/Gelatin/Keratin Composite Containing Hydrocortisone Sodium Succinate As A Buccal Mucoadhesive Patch To Treat Desquamative Gingivitis, Zahra Davoudi, Mohammad Rabiee, Behzad Houshmand, Niloofar Eslahi, Kimia Khoshroo, Morteza Rasoulianboroujeni, Mohammadreza Tahriri, Lobat Tayebi

School of Dentistry Faculty Research and Publications

The aim of this research was to develop chitosan/gelatin/keratin composite containing hydrocortisone sodium succinate as a buccal mucoadhesive patch to treat desquamative gingivitis, which was fabricated through an environmental friendly process. Mucoadhesive films increase the advantage of higher efficiency and drug localization in the affected region. In this research, mucoadhesive films, for the release of hydrocortisone sodium succinate, were prepared using different ratios of chitosan, gelatin and keratin. In the first step, chitosan and gelatin proportions were optimized after evaluating the mechanical properties, swelling capacity, water uptake, stability, and biodegradation of the films. Then, keratin was added at different percentages …

Notices, Editorial Office

Contemporary Aesthetics (Journal Archive)

No abstract provided.

Recent Publications, Editorial Office

Contemporary Aesthetics (Journal Archive)

No abstract provided.

On Dust: Memory As Performance And Materiality, Natasha Lushetich

Contemporary Aesthetics (Journal Archive)

The world's "worldliness" is, to a large extent, perceptually constructed through touch, kinaesthetics, and proprioception. Gesture, too, is embedded in sedimentations of the body's prior sensory exchanges with the environment. Materiality is transitive; it triggers sensory landscapes through performance. Consisting of particles of pollen, human and animal skin, hairs, minerals, soil, and burnt meteorites, dust is usually seen as the antithesis of the performative-material nexus. In this paper, I propose a different view: that dust is and acts as a connective tissue. Borrowing from Hélène Cixous's écriture blanche, Quentin Smith's degree presentism, and theorizing nostalgia as a structuring absence, …

The Art Scenes, Jozef Kovalčik, Max Ryynänen

Contemporary Aesthetics (Journal Archive)

"The art scene in Berlin is political." "The Atlanta hip hop scene is red hot!" These are remarks we have heard lately about scenes. Scenes are a commonplace in art talk. But what are scenes, and what is their role in arts? Aestheticians, art theorists, and art historians often pay attention to different scenes. Although many classics in the field are based on comments regarding only one scene, which is, for example, the case with Arthur C. Danto's "The Artworld" (1964) and Susan Sontag's "Notes on Camp" (1964), which both focus on New York, there is still no discussion about …

The Aesthetics Of Silence: A Matter Of Spatial Critique In The Works Of Marcel Broodthaers, Elsbeth Dekker

Contemporary Aesthetics (Journal Archive)

In 1967 Susan Sontag published her essay, "The Aesthetics of Silence,” on the craving towards silence in artistic movements of the nineteenth and twentieth centuries. Even though it appears that notions of silence are still influential within the visual arts, theoretical writings on silence are nearly absent. This article explores how notions of silence emerged in the early works of Marcel Broodthaers, by scrutinizing his works, related to Pense-Bête, together with the writings of Susan Sontag and related ideas from Stéphane Mallarmé and Theodor Adorno. Through a vivisection of these early works of Broodthaers, this article argues how silence …

Essential Evidence-Based Introductory Bioterrorism Content For Practicing Nurses, Manu Sharma

Yale School of Nursing Digital Theses

Bioterrorism content is too often absent from nursing education post-licensure. According to the Centers for Disease Control and Prevention (CDC), bioterrorism is defined as “the deliberate release of viruses, bacteria, or other germs (agents) used to cause illness or death in people, animals, or plants.” A literature search and a review of available resources elucidated pertinent content items on bioterrorism and its associated precautions for nurses. Next, two rounds of expert panel consisting of five members rated the identified content and proffered comments to validate the curriculum. Finally, a four-hour in-person pilot educational session was implemented based on the results. …

Threadable Curves, Joseph O’Rourke, Emmely Rogers

Computer Science: Faculty Publications

We define a plane curve to be threadable if it can rigidly pass through a point-hole in a line L without otherwise touching L. Threadable curves are in a sense generalizations of monotone curves. We have two main results. The first is a linear-time algorithm for deciding whether a polygonal curve is threadable—O(n) for a curve of n vertices—and if threadable, finding a sequence of rigid motions to thread it through a hole. We also sketch an argument that shows that the threadability of algebraic curves can be decided in time polynomial in the degree of the curve. The second …

The Einar Nelson And Guri Paalsdatter Family Of Lærdal Township, Sogn Og Fjordane County, Norway, Perry Township, Dane County, Wisconsin, Greenwood Township, Vernon County, Wisconsin, And Juneau County, Wisconsin, Lawrence W. Onsager

All Books

No abstract provided.

The Jacobson Family From Laerdal Parish, Sogn Og Fjordane County, Norway: Pioneer Norwegian Settlers In Greenwood Township, Vernon County, Wisconsin, Lawrence W. Onsager

All Books

The Jacobson family emigrated from Laerdal in Sogn og Fjordane County, Norway to Greenwood Township, Vernon County, Wisconsin between 1857 and 1882. They were members of the Greenwood Norwegian Lutheran Church and were part of the Greenwood Norwegian-American Settlement in Vernon County.

This genealogy is part of a prosopographical study of the Greenwood settlement. Prosopographical research has the goal of learning about patterns of relationships and activities through the study of collective biography. Prosopography is interested in the details of individuals' lives and relationships not only with family but also with in-laws, friends, clients, business contacts and so forth. Even …

The Waldenses: Historical Perspectives From The Writings Of Ellen G. White, Kathleen Demsky

All Books

Excerpts from: White, Ellen G. The Great Controversy. Mountain View: Pacific Press Publishing Association, 1911. Chapter 4. White, Ellen G. Historical Sketches of the Foreign Missions of the Seventh-day Adventists. Basle: Imprimerie Polyglotte, 1885. Chapter 57.

Appreciating Nature And Art: Recent Western And Chinese Perspectives, Glenn Parsons, Xin Zhang

Contemporary Aesthetics (Journal Archive)

Landscape painting has played a significant role in shaping practices of nature appreciation in Western and Chinese cultures. Both cultures have also seen the recent emergence of philosophical views of nature appreciation that stress the importance of ecological understanding. However, these philosophical views differ in their response to the influence of the landscape painting tradition: whereas Western approaches have largely been critical, Chinese ecoaestheticians have embraced it. In this paper, we explore this difference and argue that it is not explained by differences between Western and Chinese art but by differences in Western and Chinese philosophers’ conceptions of ecology. We …

Global Water Crisis And Human Rights: A Glass Half Empty, Julian Montoya

Intercultural Human Rights Law Review

Water is Earth's most precious resource as it holds the fate of all living things. Throughout human history, civilizations have depended on a reliable supply of freshwater. From rain-water harvesting and irrigation canals to fracking and groundwater pumping, humans have continually developed ways to control and use water resources. Whether for industry or agriculture, all aspects of human life need water. As a result, societies always faced pressure from various competing interests. Today, however, the demand for water has surpassed sustainability levels overflowing into potentially irreversible paths. Using the New Haven School of Jurisprudence, this paper aims to diagnose the …

Health Promotion Behavior Among Hypertensive And Normotensive Armenian Americans, Zoya Minasyan, Leslie C. Hussey, Kathleen Brewer

Journal of Social, Behavioral, and Health Sciences

Hypertension presents a significant health risk to both developed and developing countries, affecting approximately 78 million Americans of various ethnic backgrounds. Though a great deal of research about hypertension and minority groups has been published, no studies were located about hypertension in the Armenian American population, despite evidence of health disparities in this population. The purpose of the present study was to examine the differences in health promotion behavior between hypertensive and normotensive Armenian Americans. A quantitative approach was used to examine the relationship between hypertensive status and health promotion behavior. With a sample size of n = 204, this …

Layperson Scoping Study Report For Production Of Biodiesel From Crop Oil, Ellen M. Walstad

Undergraduate Theses and Senior Projects

No abstract provided.