Digital Commons Network^™

The Microfluidic Intravital Window : A Tool For Manipulation And Imaging Of The Tumor Microenvironment, Logan William Butt

Legacy Theses & Dissertations (2009 - 2024)

The tumor microenvironment (TME) is a heterogeneous collection of both healthy and pathological cells, whose complex interactions hold the key for understanding and overcoming cancer. Metastasis leverages these complex interactions into a sophisticated process by which single cells from the tumor disseminate into the blood and form new colonies in other organ systems. Subsequent formation of tumors throughout the body, as a direct result of metastatic events, is responsible for most deaths related to cancer, making metastasis a necessary target for cancer therapy.

Cravings And Gestational Weight Gain : Predictors Of Weight-Related Health In Pregnancy And The Postpartum, Natalia Christine Orloff

Legacy Theses & Dissertations (2009 - 2024)

More than half of all pregnancies result in excess gestational weight gain (GWG), which is one of the most common high-risk obstetric conditions and is associated with health complications in the mother and the fetus. We have conceptualized excess GWG within the Elaboration Intrusion framework and developed studies to test this theory and identify predictors of excess GWG. These studies sought to 1) establish the appropriateness of existing measures related to the constructs of the EI Theory, 2) establish a causal effect of food craving on excess GWG, 3) examine the role of knowledge as a predictor in excess GWG, …

Cell Biological Analyses Of The Role Of The Vrk1 Protein Kinase In Mammary Epithelial Cells, Aye M. Mon

MUSC Theses and Dissertations

Vaccinia-related kinase 1 (VRK1) is a pro-proliferative nuclear serine/threonine kinase. Mice engrafted with VRK1-depleted MDA-MB-231 cells develop fewer distal metastases than mice engrafted with control cells, suggesting a potential role for VRK1 in cell migration, invasion, and/or colonization. In work described herein, we investigated the impact of VRK1 overexpression on human mammary epithelial cells. We demonstrated that VRK1 overexpression in MCF10A cells (normal mammary epithelial cells) diminishes cell invasion and impairs both single-cell and sheet migration, as well as the migration-associated processes of cell spreading and cytoskeletal rearrangement. Interestingly, VRK1-overexpressing cells show reduced accumulation of the mesenchymal marker vimentin and …

Dis/Inheritance : Love, Grief, And Genealogy In Faulkner, Daisuke Kiriyama

Legacy Theses & Dissertations (2009 - 2024)

This dissertation is devoted to the close examination of two novels of William Faulkner, Absalom, Absalom! and Go Down, Moses. I find in them the repression and return of prohibited emotions and a consistent pattern of “the race between the pursuing white man and the fleeing black man.” I explore how these are related to the Faulknerian conception of time and the establishment and disruption of the conventional Southern notions of race, class, gender, and sexuality. The white man’s pursuit, performed in various forms, ultimately aims to prove his mastery and masculinity, racial superiority, or everything that whiteness means to …

"True Principles Of Liberty And Natural Right" : The Vermont State Constitution And The American Revolution, Kevin R. Ingraham

Legacy Theses & Dissertations (2009 - 2024)

The Vermont state constitution was the most revolutionary and democratic plan of government established in America during the late eighteenth century. It abolished adult slavery, eliminated property qualifications for holding office, and established universal male suffrage. It invested broad power in a unicameral legislature, through which citizens might directly express their will through their elected representatives. It created a weak executive with limited power to veto legislation. It mandated annual elections for all state offices, by which the people might frequently accept, or reject, their leaders. It thus established a participatory democracy in which ordinary citizens enjoyed broad access to …

Nutrition Transition, Trace Elements In Nails, And Blood Pressure Along The Interoceanic Highway, Madre De Dios, Peru, Stacy M. Pettigrew

Legacy Theses & Dissertations (2009 - 2024)

The paving of the Interoceanic Highway (IOH) brought rapid development to the Madre de Dios (MDD) region in the Peruvian Amazon. Development brings concerns of toxic trace element exposures, and road development has been a major driver of the transition from traditional to calorie-dense processed ‘Western’ diets in lower and middle-income countries. Investigacion de Migracion, Ambiente, y Salud (IMAS) (Investigation of Migration, the Environment, and Health) is the first analysis of health, diet, and integrated toxic trace elements in nails in the region. In 2014 we collected household surveys from 310 households in 46 communities along the IOH and nails …

Fusing Satellite Data To Monitor The Urban Area's Effect On Plant Phenology, Norman Gervais

Legacy Theses & Dissertations (2009 - 2024)

This dissertation centrally focuses on developing and validating the use of fused satellite imagery to monitor the effects of the urban area on plant phenology, specifically the timing of the start and end of the growing season (SOS and EOS, respectively). In the first paper, Chapter 2, data from the Moderate Resolution Imaging Spectroradiometer (MODIS) and Landsat were fused together using the Spatial and Temporal Adaptive Reflectance Fusion Model (STARFM) to produce a time series of a high spatial and high temporal resolution vegetation index. From this time series, the SOS and EOS were extracted and compared between the urban …

Zno Nanowires For Advanced X-Ray Source Applications, Vance Scott Robinson

Legacy Theses & Dissertations (2009 - 2024)

X-ray system technology trends tend towards simpler, smaller and more efficient devices. A broad range of applications are driving contemporary efforts in X-ray source miniaturization: Portable and/or remote nondestructive evaluation; High throughput protein crystallography, invasive radiotherapy; monitoring fluid flow and particulate generation in situ; and portable radiography devices for battle-front or large scale disaster triage scenarios. Most of the x-ray sources for these applications follow a top-down approach focused on improving portability, and reducing mass and/or size.

Retinoic Acid Receptor Isoform-Specific Control Of Mouse Salivary Gland Development And Regeneration, Kara Desantis

Legacy Theses & Dissertations (2009 - 2024)

Controlled expansion and differentiation of progenitor cell populations is essential for organogenesis followed by continued maintenance of the population into and through adulthood. As the K5+ basal cell population is regulated by retinoic acid signaling, we interrogated the contribution of specific RAR isoforms to the regulation of these cells during submandibular salivary gland (SMG) organogenesis and regeneration. Retinoic acid has previously been shown to be involved in the development of the salivary gland, and recently, lack of retinoid signaling has been shown to impact the K5+ population of basal progenitor cells. Since retinoic acid is known to exert stimulatory effects …

A Practitioner Research Study Exploring Critical Literacy In A Secondary English Classroom, Dilnavaz F. Hushmendy

Legacy Theses & Dissertations (2009 - 2024)

ABSTRACT

Carborane Functionalized Cysteine : Synthesis, Structural Characterization, And Biological Evaluation For Boron Neutron Capture Therapy, Tianyu He

Legacy Theses & Dissertations (2009 - 2024)

Carbon-containing boranes, also known as carboranes, have attracted immense interest since their discovery in the 1950’s. Characterization of carboranes revealed their highly symmetrical polyhedral structures, which make them chemically and thermally stable. Their unique chemical properties, hydrophobicity and aromaticity also make them ideal candidates for a variety of applications. Prominent among these are the applications in materials and medicinal chemistry. On the materials chemistry front, carboranes have been investigated as self-assembly building blocks, liquid crystals and gas storage and separation materials. In the medicinal chemistry field, carborane derivatives have been extensively investigated as potential drugs, with a lot of attention …

Maritime Archaic Spearpoints : A New Examination Of Their Context And Chronology, John Michael Garbellano

Legacy Theses & Dissertations (2009 - 2024)

This research focuses on the morphology, chronology and provenience of nipple-based spearpoints found in Newfoundland and Labrador and their relationship to larger-scale cultural processes during the Archaic period of that Province. Nipple-based points are primarily thought to date between 7500-6000 B.P. and are associated with the early Maritime Archaic tradition, the earliest inhabitants of Newfoundland and Labrador. A recent find of a nipple-based point at the Stock Cove site (CkA1-3) in eastern Newfoundland could mean that part of the island was colonized earlier than previously thought. Lithic analysis of the Stock Cove artifact will be discussed, and the results will …

Inhibition Of Apoptosis Exacerbates Fatigue-Damage Tendon Injuries In An In Vivo Rat Model, R. Bell, M. A. Robles-Harris, M. Anderson, D. Laudier, M. B. Schaffler, E. L. Flatow, N. Andarawis-Puri

Publications and Research

Tendinopathy is a common and progressive musculoskeletal disease. Increased apoptosis is an end-stage tendinopathy manifestation, but its contribution to the pathology of the disease is unknown. A previously established in vivo model of fatigue-damage accumulation shows that increased apoptosis is correlated with the severity of induced tendon damage, even in early onset of the disease, supporting its implication in the pathogenesis of the disease. Consequently, this study aimed to determine: (1) whether apoptosis could be inhibited after fatigue damage and (2) whether its inhibition could lead to remodeling of the extracellular matrix (ECM) and pericellular matrix (PCM), to ultimately improve …

Role Of Oxidized Extracellular Vesicles As Early Biomarkers And Inflammatory Mediators In Chemotherapy-Induced Normal Tissue Injury, Chontida Yarana

Theses and Dissertations--Toxicology and Cancer Biology

Significant advances in the efficacy of cancer therapy have been accompanied by an escalation of side effects that result from therapy-induced injury to normal tissues. Patients with high grade cancer or metastasis are often treated with chemotherapy, 50% of which are associated with reactive oxygen species generation and cellular oxidative stress. Heart is the normal tissue most susceptible to chemotherapy-induced oxidative stress and heart disease is the most common leading cause of death in cancer survivors. However, early and sensitive biomarkers to identify heart disease are still lacking. Extracellular vesicles (EVs) are released from cells during oxidative stress and send …

"Ask Me No Questions": The Struggle For Disclosure Of Cultural And Genetic Resource Utilization In Design, Margo A. Bagley

Vanderbilt Journal of Entertainment & Technology Law

New issues relating to the intersection of design protection and cultural and genetic resource utilization are arising from the confluence of an increased interest in design protection, the sustained allure of exotic cultural expressions, and novel uses of biological and genetic resources in crafting the appearance of articles protected by industrial design rights. As awareness of the many ways in which cultural and genetic resource use and misappropriation can occur is evolving, some developing countries have begun exploring the appropriateness of--and in some cases even instituting--a requirement that a designer disclose the origin of traditional cultural expressions, traditional knowledge, and …

The Bridge, Volume 15, 2018, Bridgewater State University

the bridge

Editor-in-Chief: Mialise Carney

Managing Editor: Alex Everette

Lead Designer: Cady Parker

Editors:
Sydney Cabral
Jake Camara
Christina Carter
Care DeSouza
Gabriel Hazeldine
Parker Jones
Karina Lagstrom
Alexandria Machado
Emily Melo-Coppinger
Katie McPherson
Joe Near
Harrison Ryan
Soraya Santos
Treina Santos
John Wilson

Faculty Advisor: Evan Dardano

Graduate Assistant: Jill Boger

Consultant: Cheryl Sirois, Design

Critical Thinking And Buddhism, Ruihan Zhang

Outstanding Gateway Papers

Many people believe that religions and science cannot coexist logically because science is evidence-based, whereas religion belief is supported by spiritual, personal, or subjective experiences. When a scientific theory is presented, many immediately ask for proof or hard evidence. When people speak of religious revelations, many ask what it was and how it was experienced. Hence, people make connections between science and critical thinking much more readily than they make such connections between religion and critical thinking. Critical thinking is conventionally related more to the scientific method, logic, deductive/inductive reasoning, etc. However, a sincere Buddhist, born into a Buddhist family, …

When Popular Culture And The Nfl Collide: Fan Responsibility In Ending The Concussion Crisis, Taylor Simpson-Wood, Robert H. Wood

Marquette Sports Law Review

None

The Impacts Of Honey Bee Queen Stress On Worker Behavior And Health, Sarah R. Preston

Theses and Dissertations--Entomology

Pesticides, poor nutrition, parasites and diseases work synergistically to contribute to the decline of the honey bee. Heritable sub-lethal behavior/immune effects may also contribute to the decline. Maternal stress is a common source of heritable immune/behavior deficits in many species. A stressed honey bee queen has the potential to pass such deficits on to worker bees. Using a repeated measures design, this study will determine whether the health of worker bee is reduced by a cold stress on the queen by analyzing egg hatch rate and protein content, emergence rate, and adult aggression and immune function for offspring laid before …

Frankenstein’S Migratory Subject : Under The Dome And Formosa Vs. Formosa, Chia-Ju Chang

Journal of Modern Literature in Chinese 現代中文文學學報

No abstract provided.

Where The Desert Fathers And Mothers Meet Permaculture, Brenda Nagunst

Doctor of Ministry

This dissertation claims that a retreat center with an eco-spiritual focus is one way to introduce Christians to the connection between stewardship of God’s creation and relationship with God. For the purposes of this paper the word “creation” is used to identify the natural world: earth, soil, plants, animals, birds, fish, and humans. Many Christians do not steward the earth as God commanded in Genesis, thus missing a spiritual connection with God that can uniquely happen through creation. This dissertation addresses the question, “In what way is care of creation a critical part of a modern Christian’s relationship with God?” …

Prochoicelife: Asking Who Protects Life And How -- And Why It Matters In Law And Politics, Reva Siegel

Indiana Law Journal

In this Essay I reason from a “prochoicelife” perspective that asks whether government protects new life by means that respect women’s reproductive decisions. I develop a framework that allows us to compare the policies for protecting new life that governments choose and the values they demonstrate. This Essay’s critical framework connects policies on sexual education, contraception, abortion, health care, income assistance, and the accommodation of pregnancy and parenting in the workplace. It shows that some jurisdictions protect new life selectively, favoring policies for protecting new life that restrict women’s reproductive decisions over policies that respect women’s reproductive decisions.

This Essay …

Rethinking Behavior - Winter 2018, Midwest Symposium For Leadership In Behavior Disorders

ReThinking Behavior Magazine

A magazine for professionals serving children and youth with behavioral needs.

Winter 2018, Volume 1, Issue 2

Magnetic Assembly Of Soft Robots With Hard Components, Sen Wai Kwok, Stephen A. Morin, Bobak Mosadegh, Ju-Hee So, Robert F. Shepherd, George M. Whitesides

Department of Chemistry: Faculty Publications

Reconfigurable soft robotic actuators with hard components are described. Magnetic attraction is used to couple flexible molded bodies capable of actuation upon pressurization with other flexible molded bodies and/or with hard components (e.g., frames and connectors) to form a seal for fluidic communication and cooperative actuation. Pneumatic decoupling chambers built into the hard components to decouple the hard components from the magnetically-coupled soft molded bodies are described. The use of magnetic self- alignment coupling and pneumatic de-coupling allows for the remote assembly and disassembly of complex structures involving hard and soft components. The magnetic coupling allows for rapid, reversible reconfiguration …

Health Information Programming In Public Libraries: A Content Analysis, Lili Luo

Faculty Publications

Health information programs, defined as library programs focusing on health-related topics, are an essential way for public libraries to reach out to their user communities, raising awareness of and interest in healthy lifestyle, promoting access to quality health information, and ultimately enhancing health literacy of the citizenry. This study presents a content analysis of the health information programs provided by a large urban public library system in the past year, seeking to strengthen the professional understanding of how public libraries can contribute to health literacy improvement through effective programming, and help other libraries gain insights on health information program planning …

Flexible Thin Robotic Actuators, Aaron D. Mazzeo, Stephen A. Morin, Robert F. Shepherd, George M. Whitesides, William B. Kalb

Department of Chemistry: Faculty Publications

Some embodiments of the disclosed subject matter includes a laminated robotic actuator. The laminated robotic actuator includes a strain-limiting layer comprising a flexible, non extensible material in the form of a sheet or thin film, a flexible inflatable layer in the form of a thin film or sheet in facing relationship with the strain-limiting layer, wherein the inflatable layer is selectively adhered to the strain-limiting layer, and wherein a portion of an un-adhered region between the strain-limiting layer and the inflatable layer defines a pressurizable channel, and at least one fluid inlet in fluid communication with the pressurizable channel. The …

Typhoid Mario: Video Game Piracy As Viral Vector And National Security Threat, Andrew V. Moshirnia

Indiana Law Journal

Current academic and policy discussions regarding video game piracy focus on the economic losses inherent to copyright infringement. Unfortunately, this approach neglects the most significant implication of video game piracy: malware distribution. Copyright-motivated efforts to shut down file-sharing sites do little to reduce piracy and actually increase viral malware infection. Pirated video games are an ideal delivery device for malware, as users routinely launch unverified programs and forego virus detection. The illicit nature of the transaction forces users to rely almost entirely on the reputation of websites, uploaders, and other users to determine if a file is safe to download. …

Licenses And The Property/Contract Interface, Christina M. Mulligan

Indiana Law Journal

INTRODUCTION

I. THE ROLE OF FORMAL CATEGORIES

II. THE COMPOUND-PAUCITAL LICENSE

A. IDIOSYNCRASY AND INFORMATION ASYMMETRIES

B. REGULATING LICENSES

1. THE NOTICE STRATEGY

2. THE PROTECTION STRATEGY

III. RESTRAINTS ON ALIENATION AND USE

A. HARMS CAUSED BY RESTRAINTS ON ALIENATION AND USE

1. INCREASED INFORMATION COSTS

2.WASTE

B. LIMITING HARM WITH PROTECTIVE STANDARDIZATION

1. THE LICENSE V. SALE DISTINCTION IN PRACTICE

2.WHAT IS A DIGITAL SALE?

3. FAVORING SALES WITHOUT LOSING FLEXIBILITY

C. DISTINGUISHING BETWEEN IN REM AND IN PERSONAM LICENSE TERMS

IV. LICENSE REVOCATION

A. TIMING REVOCATION

B. BENEFITS AND CONCERNS

1.MANAGING SHARED RESOURCES VS. UPSET RELIANCE INTERESTS

2. …

Reducing Firearms-Related Domestic Violence Injuries: Legal Developments And Policy And Practice Implications, Marshall B. Kapp, Robin Hassler Thompson

Florida Public Health Review

The potential dangers posed by a combination of firearms availability and domestic violence are substantial in the United States today. The dangers posed and resulting harms must be addressed as a pressing public health matter. This article reports on a 2016 United States Supreme Court decision that, although fairly narrow in terms of the technical legal question answered, supports broad public health implications for future policy and practice concerning the intersection of firearms regulation and the prevention or mitigation of domestic violence. Following a brief summary of the legal case, we make recommendations for reducing the incidence and severity of …

Protection Spell / Apocalypse Mix, Jessica Murray

Birmingham Poetry Review

pp. 210-217