Digital Commons Network^™

Low-Temperature Fabrication Process For Integrated High-Aspect Ratio Metal Oxide Nanostructure Semiconductor Gas Sensors, William Paul Clavijo

Theses and Dissertations

This work presents a new low-temperature fabrication process of metal oxide nanostructures that allows high-aspect ratio zinc oxide (ZnO) and titanium dioxide (TiO₂) nanowires and nanotubes to be readily integrated with microelectronic devices for sensor applications. This process relies on a new method of forming a close-packed array of self-assembled high-aspect-ratio nanopores in an anodized aluminum oxide (AAO) template in a thin (2.5 µm) aluminum film deposited on a silicon and lithium niobate substrate (LiNbO₃). This technique is in sharp contrast to traditional free-standing thick film methods and the use of an integrated thin aluminum film …

Functional Study Of Cmya5, A Candidate Gene For Schizophrenia, Anting Hsiung

Theses and Dissertations

CMYA5 is a candidate gene for schizophrenia because of the association of variant rs10043986 (Pro4063Leu). Studies of CMYA5 and its gene product, myospryn, in brain and neuronal cells have not been previously reported. We examined the neuronal expression of myospryn and its binding partner, desmin intermediate filament (IF), and investigated the difference in binding and colocalization of the two alleles of myospryn to IFs. Myospryn and desmin are expressed in brain regions. Using yeast two-hybrid and surface plasmon resonance, the T allele (Leu) is found to have higher binding affinity to desmin than the C allele (Pro). Myospryn localizes to …

Ethanol Reversal Of Oxycodone Tolerances, Joanna C. Jacob

Theses and Dissertations

Oxycodone is a semi-synthetic opioid originally developed as a safer alternative to morphine. It is commonly prescribed for its pain-relieving effects, but has recently been implicated as a major underlying cause of the current opioid epidemic due to its clinical limitations that include tolerance, dependence and a high abuse liability. Simultaneous consumption of opioids and ethanol has been shown to increase the risk of overdose and death from opioids in opioid-tolerant individuals. We hypothesized that ethanol reversed opioid tolerance and previous studies showed that ethanol reversed morphine tolerance. This dissertation investigated whether ethanol reversed tolerance to other opioids in mice, …

Community Gardens: Exploring Race, Racial Diversity And Social Capital In Urban Food Deserts, Jennifer F. Jettner

Theses and Dissertations

Study purpose. The study examined race and racial diversity in community gardens located in Southern urban food deserts, as well as the capacity of community gardens to generate social capital and promote social justice. Methods. A mixed-methods approach was used to describe characteristics of gardeners and community gardens located in urban food deserts, and test Social Capital Theory hypotheses. A convenience sample of 60 gardeners from 10 community gardens was obtained. Data was collected using surveys and semi-structured interviews. Analyses. Univariate and bivariate statistics were used to describe gardeners and gardens. Leader rationales for garden characteristics were analyzed using thematic …

Lung Disposition Model-Based Analyses Of Clinical Pharmacokinetic Profiles For Inhaled Drugs, Anuja Raut

Theses and Dissertations

There has been a desire to accurately interpret the inhaled pharmacokinetic (PK) profiles of drugs in humans to aid successful inhaled drug and product developments. However, challenges are layered, as 1) the drug dose delivered to the lung (DTL) from inhalers is a portion of the formulated dose but rarely determined; 2) lung delivery and regional deposition differ, depending on drug, formulation and inhaler; 3) drugs are not only absorbed from the lung but may also be from the gastrointestinal (GI) tract; and 4) in addition to absorption into the systemic circulation, multiple non-absorptive processes also eliminate drugs from the …

Interleukin-18 As A Therapeutic Target In Western-Diet Induced Cardiomyopathy, Pratyush Narayan

Theses and Dissertations

Background: Heart Failure (HF) is characterized by impaired cardiac function with symptoms of dyspnea, fatigue and exercise intolerance. Western diet (WD), a diet high in saturated fats and sugars, causes systemic increase in IL-18, a cytokine elevated in HF, which induces abnormal myocardial structure and diastolic dysfunction. IL-18 binding protein(IL-18BP) binds IL-18, preventing the binding to the IL-18-receptor. We investigated a therapeutic intervention using recombinant-murine IL-18BP to improve the WD-induced cardiomyopathy in C57BL/6J mice.

Methods: Echocardiography with pulse-wave Doppler and tissue imaging was performed to assess cardiac function. Oral glucose tolerance test was performed to assess metabolic parameters and IL-18 …

Gomds - Grumpy Old Men Doing Shakespeare; The Comedy Of Errors As Metaphor For Life, Aging, And Building Community, Elizabeth B. Pedersen

Theses and Dissertations

This thesis explores the process of building community over time, through collaboration, to rehearse and produce a portable production of Shakespeare's The Comedy of Errors, looking at the elements of time, trust and age with an ensemble of ten men, all actors over the age of 55. The building of trust over time was vital to the production process and the actors had the time to embody their roles and the language of the play. We look at the questions “why this play,” “why all men?” and “why theatre?” and investigate the physical nature of the play and its …

Application Of The Fisher Dimer Model To Dna Condensation, John C. Baker Iii

Theses and Dissertations

This paper considers the statistical mechanics occupation of the edge of a single helix of DNA by simple polymers. Using Fisher's exact closed form solution for dimers on a two-dimensional lattice, a one-dimensional lattice is created mathematically that is occupied by dimers, monomers, and holes. The free energy, entropy, average occupation, and total charge on the lattice are found through the usual statistical methods. The results demonstrate the charge inversion required for a DNA helix to undergo DNA condensation.

Effects Of Hydraulic Dredging And Vessel Operation On Atlantic Sturgeon Behavior In A Large Coastal River, Michael R. Barber

Theses and Dissertations

The tidal James River, a focus of VCU's Atlantic Sturgeon program, supports both commercial shipping and hydraulic dredging. These anthropogenic threats present documented but preventable sources of mortality to the endangered species. Using three separate VEMCO Positioning System (VPS) receiver arrays, spatial data of previously-tagged fish were collected. ArcGIS and Programita software were used to analyze fish spatial distributions in the presence and absence of potential threats, using additional data including automatic identification system (AIS) vessel locations, vessel passages compiled using camera footage, and dredge records provided by the US Army Corps of Engineers. The data showed a change in …

Short And Long Chain Free Fatty Acids Differentially Regulate Glucagon-Like Peptide-1 And Peptide Yy Transcript Levels In Enteroendocrine Cells (Stc-1), Colin M. Catherman

Theses and Dissertations

The regulation of glucagon-like peptide-1 and peptide YY hormone levels are regulated based on different influential factors, but primarily levels are dependent upon ingested food content. As meals today become more fat-enriched, there is greater requirement for evaluation of these hormones that regulate insulin and satiety levels within the body. We have shown that the gene expression transcript production of glucagon-like peptide-1 and peptide YY are modulated by different concentrations, and times of short-chain fatty acids and long-chain fatty acids. Although the peptide hormone levels have the influential physiological role on effector tissue, the regulation of these hormones begins at …

(Re)Mediating The Spirit: Evangelical Christian Young Adult Media, Tamara Watkins

Theses and Dissertations

"We are in the world, but not of the world," a maxim frequently spoken in evangelical Christian culture, provides insight into how these individuals view their relationship with secular culture. They presume to share the same temporal plane with secular culture, but do not participate in it. In this dissertation, I explore whether the division between evangelical Christian culture and secular culture is as clear as this aphorism implies. To facilitate this investigation, I examine media Christian content creators created for an American evangelical Christian young adult audience in the early twenty-first century, specifically focusing on novel-length fiction, comics and …

A Targeted Approach To Increasing The African American Blood Donor Pool, Arnethea L. Sutton

Theses and Dissertations

A continuous need for blood products, specifically for those who require frequent transfusions, such as individuals with sickle cell disease, warrants the need for targeted interventions to increase blood donations from underrepresented populations. One population in particular, African Americans, only account for 1% of blood donors in the United States. Literature indicates numerous reasons why this population is underrepresented amongst donors, including fear, lack of knowledge about the blood donation, and specific to this population, lack of trust in the medical community. This study involves the development, implementation, and assessment of a targeted educational approach, incorporating the Theory of Planned …

An Integrated Behavioral Model Of Healthcare Utilization Among Transgender And Gender-Nonconforming Adults, Megan Elizabeth Sutter

Theses and Dissertations

Transgender and gender-nonconforming (TGNC) individuals in the United States experience significant marginalization due to stigma enacted at the structural, interpersonal, and individual levels. As a result, this population has reported increased behavioral and physical health needs, as well as unique barriers to healthcare. Moreover, TGNC individuals have reported greater experiences of childhood abuse compared to cisgender individuals. The cumulative experiences of stigma-related stressors and adverse childhood experiences put this population at risk for the development of mental and physical health problems, increasing need for health services. However, TGNC individuals have reported being denied medical care and postponing seeking care due …

Conflicted Commons: A Local Makerspace In The Neoliberal City, Caitlin Cunningham

Theses and Dissertations

The commodification of culture, space, and resources is incentivized by neoliberal urbanism. In response, we have seen an attempt to develop collectively organized, oppositional spaces within urban places. The tensions that arise when considering the production of commons in the development of the neoliberal city are the central focus of this paper. As I will observe, these spaces are subjected to commodification as they become increasingly de-politicized through neoliberal ideologies. In order to theorize about these contradictory elements, I observe a makerspace in Richmond, Virginia called HackRVA. Specifically, I consider HackRVA as an urban commons. Through in-depth interviews and participant …

Synthesis And Characterization Of Metallic Nanoparticles For Catalytic Applications, Sarah Smith

Theses and Dissertations

In recent years, research has focused on reducing the cost of catalysts in a variety of ways including using less expensive materials, improving the synthetic method, and increasing the catalytic activity, recovery, and recyclability. Typically with nanoparticles, the size, shape, composition, and surface coating have an effect on catalytic activity.^1-2 In this work, we focused on reducing the cost of precious metal based catalysts by altering the synthetic methods.

One way to lower the cost of synthesizing precious metal nanoparticles is by debasing the precious metal with a second cheaper more abundant metal. CuPd nanoparticles were synthesized in oleylamine …

A Roadmap For Development Of Novel Antipsychotic Agents Based On A Risperidone Scaffold, Urjita H. Shah

Theses and Dissertations

Schizophrenia is a chronic psychotic illness affecting ~21 million people globally. Currently available antipsychotic agents act through a dopamine D₂ receptor mechanism, and produce extrapyramidal or metabolic side effects. Hence, there is a need for novel targets and agents. The mGlu₂/5-HT_2A receptor heteromer has been implicated in the action of antipsychotic agents, and represents a novel and attractive therapeutic target for the treatment of schizophrenia. A long-term goal of this project is to synthesize bivalent ligands where a 5-HT_2A receptor antagonist is tethered to an mGlu₂ PAM via a linker.

The goals of the …

Socioecological Aspects Of Tobacco Use In College Populations, Michael D. Sawdey

Theses and Dissertations

Background: Although cigarette smoking is decreasing in the US and among college students, tobacco use remains a major public health problem. Specific socioecological gaps in the literature related to college tobacco use exist including: trends of tobacco use, combinations of polysubstance use, and availability of tobacco products around college campuses.

Objectives: The main goal of this research was the understand interrelationships that exist within a socioecological framework of college tobacco use. Specifically, this project aims to: 1) examine trends of tobacco and polytobacco use by gender and associations of polytobacco use and perceived peer tobacco use, 2) examine …

Art For Recovery, Lucy Dabney

Theses and Dissertations

This thesis explores the design of a space for opioid addicts in recovery that combines an art therapy studio with a gallery space. It would provide a new type of therapy available to the area, engage and educate the Richmond community and spread awareness of the disease of opiate addiction. It will also enable addicts to express themselves in a non-verbal, creative format that allows for them to create a legacy and leave an imprint on the community.

Electronic And Structural Study Of The Reactivity Of Cu+ With Co, H2o, O2, N2 And Their Mixture, Cara M. Frame

Theses and Dissertations

A detailed theoretical study of the gas phase reactivity of copper cation (Cu⁺) with CO, H₂O, O₂, N₂ and their mixture was performed and compared to experimental results to determine the ability of Cu⁺ to act as a low-temperature catalyst for CO oxidation. It was found that Cu⁺ binds strongest to CO, followed by H₂O, N₂, and O₂, strongly interacting with each species until reaching saturation at a maximum of four ligands. It was also found that a single Cu …

The Dual Faces Of Misery, Arden Moscati

Theses and Dissertations

Major Depression (MD) and Generalized Anxiety Disorder (GAD) are psychiatric disorders that arise from dysfunction of the core human capacities for emotion. Sapience is inextricably bound up with the potential for feelings of regret, worry and concern. When these emotions lead to clinically significant impairment or distress, they may result in one or both of the disorders of MD and GAD. The occurrence of MD and GAD in the same person, known as comorbidity, is remarkably high; substantially higher than would be expected by chance.

MD and GAD have been studied since the mid-20^th century, resulting in a substantial …

Zebrafish (Danio Rerio) As A Model For Orofacial Research, Kevin A. Ghaffari

Theses and Dissertations

Across species, the face and more specifically the mouth, serves as an essential facet of everyday life. Amongst humans the mouth serves as a tool for the ingestion of food, a marker for facial recognition and a medium for communication. In order for the mouth to properly form, a series of precise growth and fusion events are needed. In order to insure that these events are orchestrated properly is a wide array of signals, transcription factors and epigenetic regulators. Due to the needed precision of these events, congenital birth defects of the face such as cleft lip and cleft palate …

The Monstrous Self: Negotiating The Boundary Of The Abject, Katya Yakubov

Theses and Dissertations

Through the lens of the horror film and the fairy tale, this thesis explores the notion of the grotesque as a boundary phenomenon—a negotiation of what is self and what is other. As such, it locates the function that the monstrous and the grotesque have in the formation of a personal and social identity. In asking why we take pleasure in the perverse, I explore how permutations of guilt, victimhood, and desire can be actively rewritten, in order to construct a stable sense of self.

The Fractured Memory Of A Mind’S Eye, Russell G. White

Theses and Dissertations

The work I create is informed by questioning reality/identity, the fractalizing planes

of existence our essence occupies, and the artifacts of memory experience navigating

through space time. While existing in this realm of oversaturated media and neon

glow, I question the effects of pervasive data systems overloading or programming the

mental software we possess. My work includes humor as a means of exploring these

conventions while also displaying psychedelic surrealist imagery to help break away

from the conscious prison this existence births our concept apparatuses within.

Construction Of An Album For Oneself, Maria Tinaut

Theses and Dissertations

My work focuses on the construction and validation of images assembled from fragments of found photographs, generating new narratives that hover between “reality” and fiction. Archive and Fiction: Construction of the past and the self is the result of two years of artwork exploring my family archives and my relationship to my family through them. I understand the family as a place of identity in continuous change, serving as a container of history and memory. Conceiving of my family albums as material allows me to approach my family history as a visitor. Mediated memory and constructed memory intertwine in the …

Adventures Close To Home, Ryan Syrell

Theses and Dissertations

My work articulates experiences of intimacy and porosity with regard to domestic space. I think of these paintings as fields of interrelatedness which work to dismantle the perceived thresholds between things. The following text brings together the research of my studio practice and a survey of artists, writers, and filmmakers who have charted related spaces of the ordinary, domestic, and porous.

Altering A Runner’S Foot Strike Using A Modified Elliptical Trainer, Daniel Shull

Theses and Dissertations

One possible solution to common running related injuries is to transition runners from a rearfoot strike during initial contact to a midfoot strike. Natural rearfoot strike runners were studied to see if a modified elliptical trainer could be used to alter their running pattern to that of a midfoot strike runner. Their results were compared to subjects who ran on a non-modified elliptical trainer. After training on the modified elliptical trainer, subjects demonstrated a decrease in foot angle at initial contact when attempting to run with a midfoot strike. Training did not affect all kinetic metrics or stride frequency. However, …

Positions Of Place: Converging Viewpoints In Visual Communication, Gregory J. Schmidt

Theses and Dissertations

This thesis includes a body of work that explores our visual relationship to the physical spaces and places we inhabit in our everyday lives. Today we live in a complex world where we are bombarded with fragments of information and inundated with distractions. As designers, we are equipped with tools and methods that allow us to experience and interpret our environment through multi-faceted perspectives and from different viewpoints. My approach to graphic design adopts techniques and practices from a mix of different disciplines. The work focuses on a design process that alternates between the parallel depiction of first-person and third-person …

A Dull Soldier And A Keen Guest: Stumbling Through The Falstaffiad One Drink At A Time, Emma Givens

Theses and Dissertations

Theatre history has long interwoven with the production, consumption, and peddling of alcohol. While the seedier aspects of our past generally go unremembered, we can find traces of them in the culture of the times. If we read Shakespeare through the lens of drinking culture, what can we discover about the play and what can that tell us about how to produce his works today? By looking at the rules and customs surrounding alehouses during the English Renaissance I have analyzed the three plays contained within the Falstaffiad (1 Henry IV, 2 Henry IV, and Merry Wives …

Spooky Action At A Distance, Jonathan A. Rehwoldt

Theses and Dissertations

The question posed is “Can I experience remote human intimacy?” This is only posed after a network of computer code, images and entities have worked through the studio apparatus. These objects only materialize after khaos, the gap, the chasm has been recognized and a remote position has been realized. The work is about examining this constellation of objects and processes in their aspiration to answer the stated question in the affirmative. The resulting presentation is an experience of the failures and illuminations of both the material and the work.

Nature Nurtures, Moriah Rhodes

Theses and Dissertations

Richmond, Virginia is defined by our connection to the James River. The James River Park system stretches over 550 acres of natural beauty. The park is broken into 14 different sections from the Huguenot Bridge in the west to a half mile beyond the I-95 Bridge in the east. The James River includes water features that appeal to the young and curious to the most experienced river-adventurer. The James River Park System boasts idyllic shorelines, peaceful meadows, and miles of challenging hiking and biking trails that appeal to the community and guests alike. Every year thousands of people come to …