Digital Commons Network^™

Hernia Of Morgagni Presenting As Constipation In A 65-Year-Old Male, Hamza A Khan, Adeel Samad, Omar A Khan, Farida K Chagan, Jamal K Khan, Saulat H. Fatimi

Department of Surgery Docs

Hernia of Morgagni is congenital defects in the diaphragm. They are mostly asymptomatic and present with vague symptoms when they do so. A high index of suspicion is required for timely diagnose of this condition. Here we present the case of a 65-year-old male patient presented to our institute with constipation for the past six months. Chest radiology raised the suspicion of a hernia which was further confirmed by contrast studies. Laparotomy was done and the hernia sac identified, colon and greater omentum reduced and defect repaired. He was discharged in stable condition and was doing well on follow-up.

Defining The Food Movement In Sacramento, California: Branding America’S Farm-To-Fork Capital, Dawnie Marie Andrak

University of the Pacific Theses and Dissertations

In October 2012, then-Mayor Kevin Johnson, surrounded by the region’s chefs, restaurateurs, and others working in the food arena, proclaimed the City of Sacramento “America’s Farm-to-Fork Capital.” The basis for the designation, in part, was Sacramento’s geographic proximity to agricultural production. With more than 50 farmers markets and between 7,000 – 8,000 acres of “boutique farms” in the region, the Mayor stated the designation would be more than “simply a marketing campaign.” Based on interviews with a wide variety of people working in “local food” (including a non-profit organization with a mission to get kids to eat their vegetables, large …

Autonomous Driving With A Simulation Trained Convolutional Neural Network, Cameron Franke

University of the Pacific Theses and Dissertations

Autonomous vehicles will help society if they can easily support a broad range of driving environments, conditions, and vehicles.

Achieving this requires reducing the complexity of the algorithmic system, easing the collection of training data, and verifying operation using real-world experiments. Our work addresses these issues by utilizing a reflexive neural network that translates images into steering and throttle commands. This network is trained using simulation data from Grand Theft Auto V~\cite{gtav}, which we augment to reduce the number of simulation hours driven. We then validate our work using a RC car system through numerous tests. Our system successfully drive …

Isolating The Targets Of Six Transcription Factor In Ephydatia Muelleri And Identifying The Role Of The Superoxide Dismutase 6 In Host Immune Response To Trichomonas Vaginalis, Gurbir Kaur Gudial

University of the Pacific Theses and Dissertations

Sponges are the descendants of the oldest members of the metazoan phylogenetic lineage and their genome contains animal specific genes but lack true tissues, organ systems, and neurons. Thus, the sponge model system can be used to elucidate origin of developmental processes. The PSED (RDGN) network (Pax/Six/Eya/Dac) is important in development of eyes, muscles, and other structures in Bilaterians. Similarly, sponges contain a precursor Pax-Six gene network. The Ephydatia muelleri (Em) PaxB protein binds to a

Pax2/5/8 consensus sequence site and two cis-regulatory elements upstream and one intron sequence of EmSix1/2 (Rivera et al., 2013).

This study aimed to determine …

Examining The Relationship Between Exercise Induced Fatigue And Postural Stability Among Geriatric Patients With Vestibular Disorders, Alexis Christine King

University of the Pacific Theses and Dissertations

Purpose: This study examined: (1) the relationship between exercise induced fatigue and postural balance amongst geriatric patients with vestibular disorders. (2) Assessed the duration for postural stability to return to baseline measurements upon induced fatigue.

Methods: A controlled pre-post test experimental design method was used during this study. This study incorporated a quantitative analysis to explore the relationship between exercise induced fatigue and postural balance with a sample of 24 subjects. The subjects were randomly assigned to either an experimental or control group. Baseline postural stability measurements were conducted prior to all subject testing and were accounted for again once …

Studies On Development In Euphilomedes Ostracods: Embryology, Nervous System Development, And The Genetics Of Sexually Dimorphic Eye Development, Kristina Koyama

University of the Pacific Theses and Dissertations

Model organism studies have been fundamental in understanding evolutionary and developmental biology. However, non-model organisms present opportunities to study unique characteristics and as comparisons to model organisms, leading us toward broader and more relevant perspectives on diversity. The Euphilomedes genus of ostracods is an example of a non-model group with potential for evolutionary and developmental studies.

Ostracoda is an ancient, basally branching lineage of Crustaceans with a complete and prodigious fossil record. Despite the group’s promise for evolutionary studies, much remains unknown about the basic biology of this clade. There are a limited number of embryogenesis studies in Ostracoda; here, …

Fragment-Based Excitonic Coupled-Cluster Theory For Large Chemical Systems, Yuhong Liu

University of the Pacific Theses and Dissertations

Accurate energetic modeling of large molecular systems is always desired by chemists. For example, ligand-protein binding simulations and enzymatic catalysis studies all involve with a small energy difference. The energetic accuracy depends largely on a proper handling of electronic correlations. Molecular mechanics (MM) methods deliver a parameterized Newtonian treatment to these problems. They show great capability in handling large calculations but give only qualitatively good results. Quantum mechanics (QM) methods solve Schrödinger equations and exhibit much better energy accuracy, though the computational cost can be prohibitive if directly applied to very large systems.

Fragment-based methods have been developed to decompose …

Using The Medication Cabinet To Predict Fall Risk In Elderly Adults, Jessica Lopez

University of the Pacific Theses and Dissertations

Background: In the United States, 30-60% of older adults fall each year; 10-20% of these falls result in injury, hospitalization, or even death. Better prevention of falls in this population may be facilitated by broader identification of risk factors. The use of statins has emerged as a potential risk factor, but the data provide conflicted results.

Purpose: To examine the relationship between statin use and falls among community-dwelling older adults.

Methods: We evaluated the patient registry of a Level 1 trauma center. All patients aged > 50 years who were admitted for falls in 2015 were included (n=615). Many of these …

Investigating Secondary Structure Features Of Yap1 Protein Fragments Using Molecular Dynamics (Md) And Steered Molecular Dynamics (Smd) Simulations, Ferdiemar Cardenas Guinto Jr.

University of the Pacific Theses and Dissertations

Molecular dynamics (MD) is a powerful tool that can be applied to protein folding and protein structure. MD allows for the calculation of movement, and final position, of atoms in a biomolecule. These movements can be used to investigate the pathways that allow proteins to fold into energetically favorable structures. While MD is very useful, it still has its limitations. Most notable, computing power and time are of constant concern.

Protein structure is inherently important due to the direct link between the structure of a protein and its function. One of the four levels of protein structure, the secondary structure, …

The Effect Of Token Reinforcement On Moderate-To-Vigorous Physical Activity Exhibited By Young Children, Rutvi R. Patel

University of the Pacific Theses and Dissertations

We used a multiple-baseline across participants and combined reversal and multielement design to assess the effects of contingent-token-reinforcement, compared to noncontingent-token-reinforcement, on moderate-to-vigorous physical activity (MVPA) exhibited by four preschool-aged children. Three children engaged in higher levels of MVPA when tokens were delivered contingent on MVPA compared to baseline (no token) and noncontingent-token conditions. Although MVPA was differentiated across contingent-token sessions and corresponding baseline (no token) control probes for three of the four participants, some variability was apparent. The present study demonstrated that the delivery of tokens contingent on MVPA can increase and maintain MVPA exhibited by preschool-aged children, resulting …

Solubility Enhancement Of Model Compounds, Lavanya Pitani

University of the Pacific Theses and Dissertations

Solubility is the amount of solute in the solvent system at phase equilibrium with certain temperature and pressure. Many of the new chemical entities are lipophilic molecules that require techniques to enhance solubility. Solubility enhancement can be achieved by either physical and/or chemical modification of the drug. Various techniques are available for solubility enhancement of poorly soluble drugs include particle size reduction, salt formation, solid dispersions, use of surfactants, prodrug, crystal modification, etc.

In this study, the three model drugs belong to BCS class II and IV having low solubility with a certain range of physicochemical properties were studies in …

The Rational Investigation Of Anti-Cancer Peptide Specificity Using The Knob-Socket Model, Shivarni Patel

University of the Pacific Theses and Dissertations

Cancer has been a pervasive and deadly problem for many years. No treatments have been developed that effectively destroy cancer cells while also keeping healthy cells safe. In this work, the knob-socket construct is used to analyze two systems involved in cancer pathways, the PDZ domain and the Bcl-BH3 complex. Application of the knob-socket model in mapping the packing surface topology (PST) allows a direct analysis of the residue groups important for peptide specificity and affinity in both of these systems. PDZ domains are regulatory proteins that bind the C-terminus of peptides involved in the signaling pathway of cancer progression. …

Clinical Factors Associated With Hepatitis C Treatment Selection In A Veterans Affairs Population, Carly Anne Ranson

University of the Pacific Theses and Dissertations

Background: Hepatitis C virus is currently the most common chronic blood borne pathogen in the United States, with only half of those infected aware of their condition. The cost for treatment is higher with Harvoni® (ledipasvir/sofosbuvir) than Viekira Pak® (ombitasvir/paritaprevir/ritonavir and dasabuvir). With finite resources available to treat patients, it is important to understand which clinical factors may influence treatment selection decisions.

Methods: The study is a 12-month medical record review within the Veterans Affairs (VA) system to evaluate significant relationships between selected clinical and sociodemographic factors and HCV treatment selection with either Harvoni® or Viekira Pak®. Clinical and demographic …

Liposome-Coated Magnesium Phosphate Nanoparticle For Delivery Of Cytochrome C Into Lung Cancer Cells A549, Weizhou Yue

University of the Pacific Theses and Dissertations

Proteins are large biomolecules that have great therapeutic potential in treating many human diseases. However, chemical/enzymatic degradation, denaturation, and poor penetration into cells are some of the challenges for clinical use of intracellular proteins.

Previously, our group has developed cationic lipid-coated magnesium phosphate nanoparticle (LP MgP NP-CAT) formulations to enhance the intracellular delivery of the negatively charged protein catalase. The goal of the current research is to develop a formulation to deliver cytochrome c (CytC), a positively charged protein into lung cancer cells A549. Specifically, this thesis research prepares and tests liposome-coated magnesium phosphate nanoparticle for delivery of cytochrome c …

Preclinical Evaluation Of Ag10 For Therapeutic Use Against Familial Amyloid Cardiomyopathy And Its Application In Various Other Technologies, Mark Russell Miller

University of the Pacific Theses and Dissertations

Transthyretin (TTR) amyloidosis is a progressive, fatal disease in which deposition of amyloid derived from either mutant or wild-type TTR causes severe organ damage and dysfunction. TTR cardiomyopathy is an infiltrative, restrictive cardiomyopathy characterized by progressive left and right heart failure. Familial amyloid cardiomyopathy (FAC) is driven by pathogenic point mutations in the TTR gene that destabilize the TTR tetramer, prompting its dissociation into dimers and monomers, with subsequent misfolding, aggregation and deposition of toxic TTR amyloid aggregates in the myocardium. The most prevalent mutation that causes FAC is the V122I variant, carried by 3.4% of African Americans, that increases …

Spirit Determinism In The Christian Anthropology Of Yorù̀Bá Indigenous Churches, Bernard T. Ayọ̀Ọlá

CTS PhD Doctoral Dissertations

There are people who think everything in life is an accident. Then, there are the Yorùbá of Southwestern Nigeria who believe that life outcomes are prearranged by the Supreme Being but may also be altered, for better or for worse, by the spirit beings in the universe. Yorùbá Christians, like their non-Christian kin, believe that many experiences in life are manifestations of the activities of the superhuman spirit beings in the community. While the good spirits (such as ancestors and angels) ordinarily have positive impacts on society, the evil spirits (such as witches, wizards, and demons) often work in collaboration …

Comparative Liquid Chromatographic Study For Concurrent Determination Of Canagliflozin And Metformin In Combined Tablets, Wafaa A. Zaghary, Shereen Mowaka, Moataz S. Hendy

Pharmacy

© Copyright 2017 Wafaa A. Zaghary et al. New HPLC-UV method (method A), for simultaneous determination of metformin (MET) and canagliflozin (CANA), was developed and compared to another novel UPLC-UV method (method B) in their tablet combination. Concerning method A, isocratic separation was done by C18 column (100mm × 2.1 mm, 3 μm) using methanol and 0.03M phosphate buffer (75: 25, V/V) at pH 3.2 as a mobile phase. Meanwhile, chromatographic separation in method B was achieved via Hypersil® gold (50mm × 2.1 mm, 1.9 μm). Mobile phase was methanol and 0.03M phosphate buffer at ratio of 80: 20 V/V. …

The Political Personality Of Russian Federation President Vladimir Putin, Aubrey Immelman, Joseph V. Trenzeluk

Psychology Faculty Publications

This paper presents the results of an indirect assessment of the personality of Vladimir Putin, president of the Russian Federation, from the conceptual perspective of personologist Theodore Millon.

Psychodiagnostically relevant data regarding President Putin were extracted from open-source intelligence and synthesized into a personality profile using the Millon Inventory of Diagnostic Criteria (MIDC), which yields 34 normal and maladaptive personality classifications congruent with Axis II of DSM-IV.

The personality profile yielded by the MIDC was analyzed on the basis of interpretive guidelines provided in the MIDC and Millon Index of Personality Styles manuals. Putin’s primary personality patterns were found …

Comparison Of Two Bpt Models And Their Effects On Parental Skill Acquisition, Leah E. Ward

University of the Pacific Theses and Dissertations

This study examined the effectiveness of two behavioral parent-training teaching models on the acquisition of six parenting skills (play, praise, tangible rewards, effective commands, ignoring, and time-out). One method focused more on didactic instruction with video modeling using the Incredible Years manualized treatment, while the other method focused more exclusively on rehearsal and structured feedback. Participants were 32 parents with children aged between I month and 20 years from the Central Valley region of California that participated in a group parent-training program. Structured role-plays with corresponding task analyses were used to assess parent skill integrity. Baseline scores were compared to …

The Genesis: A Symphonic Work And Analysis, Max Keller

Faculty Publications

The biblical account of creation found in the Book of Genesis is known to billions around the world through its proclamation by multiple religions and numerous denominations. As such it is embedded in many cultures, especially that of the Western civilization and art. This article contains all but two of the movements, three and six, of Max Keller’s analysis of his multi-movement symphonic work The Genesis. The work sought to be a musical expression of the creation narrative found in the Book of Genesis, with direct correlations to the original Hebrew text. As such, the analysis takes an in-depth look …

Early Research: Becoming By Doing, Desmond H. Murray

Faculty Publications

"The overwhelming evidence from

different fields of study indicates that our high school students are not too young to research. One such study — “Scientific Thinking in Young Children: Theoretical Advances, Empirical Research, and Policy Implica - tions” — was reported by Science magazine in 2012 by Professor Alison Gopnik of the University of California, Berkeley. These studies all confirm the “ole folks tales” about the inquisitive, forever questioning and curious nature of young children. Indeed, about 400 years ago in 1620, the reputed father of the scientific method, Francis Bacon, wrote in Novum Organum that we “must become as …

Region Of Smooth Functions For Positive Solutions To An Elliptic Biological Model, Joon Hyuk Kang, Timothy Robertson

Faculty Publications

The non-existence and existence of the positive solution to the generalized elliptic model ∆u+g(u v) = 0 in Ω, ∆v+h(u, v) = 0 in Ω, u=v= 0 on∂Ω, were investigated.

Characterization Of Rectifying And Sphere Curves In R^3, Yun Myung Oh, Julie Logan

Faculty Publications

Studies of curves in 3D-space have been developed by many geometers and it is known that any regular curve in 3D space is completely determined by its curvature and torsion, up to position. Many results have been found to characterize various types of space curves in terms of conditions on the ratio of torsion to curvature. Under an extracondition on the constant curvature, Y.L. Seo and Y. M. Oh found the series solution when the ratio of torsion to curvature is a linear function. Furthermore, this solution is known to be a rectifying curve by B. Y. Chen’s work. This …

The Power Of Praying Parents, S. Joseph Kidder

Faculty Publications

No abstract provided.

Cultural Perspectives On Social Presence: Research And Practical Guidelines For Online Design, Charlotte Nirmalani Gunawardena

University Libraries & Learning Sciences Faculty and Staff Publications

No abstract provided.

Sonic Affects And The Production Of Space: ‘Music By Handle’ And The Politics Of Street Music In Victorian London, Paul Simpson

School of Geography, Earth and Environmental Sciences

This article examines the affective capacities of sound and its role in the on-going production of social spaces. More specifically, the article seeks to understand the situated nature of sound’s affectivity within particular social-political-material contexts or circumstances. This is developed through a discussion of an empirical case study related to the history of street music: the ‘street music debates’ of Victorian London. The interrelation here of the sounds street musicians made, the broader urban soundscape of the time, who played street music and who it was that found themselves listening to this music demonstrate clearly the situated affective capacities of …

A Sense Of The Cycling Environment: Felt Experiences Of Infrastructure And Atmospheres, Paul Simpson

School of Geography, Earth and Environmental Sciences

This paper explores how cyclists gain a sense of the environments they move through by considering their felt experiences of the affective atmospheres that emerge in and through their movements. More specifically, the focus falls upon how various forms of transport infrastructure choreograph bodies in their movements through the city and so contributes towards the co-production of various affective atmospheres between differently mobile bodies. Drawing on video interviews with 24 commuter cyclists in Plymouth, UK, the roles that such infrastructures and atmospheres play in shaping the experience of cycling through shared forms of transport space are considered. Based on this, …

The Effect Of Wastewater Effluent Derived Ligands On Copper And Zinc Complexation, C. Constantino, S. D.W. Comber, M. D. Scrimshaw

School of Geography, Earth and Environmental Sciences

No abstract provided.

River Terraces And Alluvial Fans: The Case For An Integrated Quaternary Fluvial Archive, A. E. Mather, M. Stokes, E. Whitfield

School of Geography, Earth and Environmental Sciences

No abstract provided.

Psychological Interventions For Coronary Heart Disease, Suzanne H. Richards, Lindsey Anderson, Caroline E. Jenkinson, Ben Whalley, Karen Rees, Philippa Davies, Paul Bennett, Zulian Liu, Robert West, David R. Thompson, Rod S. Taylor

School of Psychology

No abstract provided.