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Mutations In The Transmembrane Domain And Cytoplasmic Tail Of Hendra Virus Fusion Protein Disrupt Virus-Like-Particle Assembly, Nicolás P. Cifuentes-Muñoz, Weina Sun, Greeshma Ray, Phuong Tieu Schmitt, Stacy Webb, Kathleen Gibson, Rebecca Ellis Dutch, Anthony P. Schmitt

Molecular and Cellular Biochemistry Faculty Publications

Hendra virus (HeV) is a zoonotic paramyxovirus that causes deadly illness in horses and humans. An intriguing feature of HeV is the utilization of endosomal protease for activation of the viral fusion protein (F). Here we investigated how endosomal F trafficking affects HeV assembly. We found that the HeV matrix (M) and F proteins each induced particle release when they were expressed alone but that their coexpression led to coordinated assembly of virus-like particles (VLPs) that were morphologically and physically distinct from M-only or F-only VLPs. Mutations to the F protein transmembrane domain or cytoplasmic tail that disrupted endocytic trafficking …

Is Biological Repair Of Heart On The Horizon?, H R. Ahmad, Satwat Hashmi

Department of Biological & Biomedical Sciences

The stem cells keep us young by endogenously repairing us upon need. They do so bysmartly one step forward towards differentiation while another step backward to nurturethe undifferentiated stem cells. They are building blocks for every organ witha differential rate of repair of worn out tissues. Since stem cells can be cultured with a normal karyo type, they could be the ideal source for heart repair after myocardial infarction. As opposed to lower vertebrates and neonatal mice, cardiac regeneration in adult mammalian heart seems to be difficult to assess with a solid evidence of cytokinesis. It becomes more difficult to …

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COSM Newsletter

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Sexual Isolation Between Two Sympatric Desmognathus In The Gulf Coastal Plain, Jennifer Y. Lamb

Faculty Publications

A substantial body of work exists examining courtship in lungless salamanders (family Plethodontidae), but there are many species and population pairs that have not been tested for sexual isolation. Spotted (Desmognathus conanti sensu lato [SL]) and Southern Dusky Salamanders (D. aff. auriculatus) occur sympatrically within drainages in South Mississippi. I crossed individuals from three populations of D. aff. auriculatus (n = 6 individuals) and seven populations of D. conanti (SL) (n = 10) occurring in the Pascagoula and Pearl River basins. I alternated homospecific (n = 23) and heterospecific (n = 23) trials …

Southward Flow On The Western Flank Of The Florida Current, Alexander Soloviev, Amy Hirons, Christopher Maingot, Cayla Whitney Dean, Richard E. Dodge, Alexander E. Yankovsky, Jon Wood, Robert H. Weisberg, Mark E. Luther, Julian P. Mccreary

Marine & Environmental Sciences Faculty Articles

A suite of long-term in situ measurements in the Straits of Florida, including the ADCP bottom moorings at an 11-m isobath and 244-m isobath (Miami Terrace) and several ADCP ship transects, have revealed a remarkable feature of the ocean circulation - southward flow on the western, coastal flank of the Florida Current. We have observed three forms of the southward flow - a seasonally varying coastal countercurrent, an undercurrent jet attached to the Florida shelf, and an intermittent undercurrent on the Miami Terrace. According to a 13-year monthly climatology obtained from the near-shore mooring, the coastal countercurrent is a persistent …

Ideology As Individuation, Individuating Ideology, Jason Read Phd

Faculty Publications

No abstract provided.

Caring For Orphans And Vulnerable Children In Institutional Care Facilities In Sub-Saharan Africa: A Social Development Intervention., Reuben Addo Phd

School of Social Work

No abstract provided.

Cache Valley Resident Exposure To Pm2.5, Kristina Krepinski

Undergraduate Honors Capstone Projects

Air pollution poses one of the largest environmental risks to human health, and greatly contributes to increased mortality within populations. Of the different types of pollutants, fine particulate matter (PM_2.5) has the most adverse health effects. Long-term exposure to PM_2.5 is known to have serious health outcomes; however, evidence has indicated that even short-term exposure to moderate concentrations of PM_2.5 is detrimental to human health. While PM_2.5 does contribute to various respiratory conditions by affecting lung function, it also significantly affects the cardiovascular system. Elevated PM_2.5 exposure increases risk for cardiovascular disease, congestive heart …

The Possibility Of Determining The Level Of Performance In The Faculty Of Education At Kuwait University Using The ‘Balanced Scorecard’ From The Perspective Of Faculty Members, Sultan Aldaihani

Journal of Educational and Psychological Studies

This study aimed to identify the possibility of determining the level of performance in the Faculty of Education at Kuwait University using the ‘Balanced Scorecard’ from the point of view of faculty members. The study used the descriptive methodology through a tool which was applied to (98) faculty members in the College of Education at Kuwait University. The results showed that the ‘vision and action strategies’ have obtained an average performance, while the rest of the dimensions were of poor performance. There were statistically significant differences due to educational degree in favor of professors, and years of experience in favor …

Age And Sex Normalization Of Intestinal Permeability Measures For The Improved Assessment Of Enteropathy In Infancy And Early Childhood: Results From The Mal-Ed Study, Margaret N. Kosek, Gwenyth O. Lee, Richard L. Guerrant, Rashidul Haque, Gagandeep Kang, Tahmeed Ahmed, Pascal Bessong, Syed Asad Ali, Shahida Qureshi, Anita K. M. Zaidi

Department of Paediatrics and Child Health

Objectives: The aim of the study was to describe changes in intestinal permeability in early childhood in diverse epidemiologic settings.
Methods: In a birth cohort study, the lactulose:mannitol (L:M) test was administered to 1980 children at 4 time points in the first 24 months of life in 8 countries. Data from the Brazil site with an incidence of diarrhea similar to that seen in the United States and no growth faltering was used as an internal study reference to derive age- and sex-specific z scores for mannitol and lactulose recoveries and the L:M ratio.
Results: A total of 6602 tests …

Barriers To Empowerment: How Can Gender Equality Training Reduce The Barriers That Women Farmers Face In Nicaragua?, Krista Pelletier

Capstone Collection

Women farmers worldwide face difficulties, unrelated to men, in their control over and access to resources and participation within farming systems. In Nicaragua, women are legally allowed to own land and participate in cooperatives, however, due to social, political, and economic factors they face barriers in their equitable access to resources and participation. Feminist political ecology theorizes that gender plays a key role and determines access to knowledge and resources, additionally, gender motivates people to social and political activism differently, which in effect shapes human-environment interactions. Can women, women’s groups, and NGO’s find ways to reduce the barriers women face …

Using The Uganda National Panel Survey To Analyze The Effect Of Staple Food Consumption On Undernourishment In Ugandan Children, William E. Herrin, Michelle M. Amaral, Graze Bulenzi Gulere

School of International Studies Faculty Articles

Background: The United Nations’ Millennium Development Goals Report, 2015, documents that, since 1990, the number of stunted children in sub-Saharan Africa has increased by 33% even though it has fallen in all other world regions. Recognizing this, in 2011 the Government of Uganda implemented a 5-year Nutrition Action Plan. One important tenet of the Plan is to lessen malnutrition in young children by discouraging over-consumption of nutritionally deficient, but plentiful, staple foods, which it defines as a type of food insecurity.

Methods: We use a sample of 6101 observations on 3427 children age five or less compiled from three annual …

Geographic Strain Differentiation Of Schistosoma Japonicum In The Philippines Using Microsatellite Markers, Kharleezelle J. Moendeg

Biology Faculty Publications

Background

Microsatellites have been found to be useful in determining genetic diversities of various medically-important parasites which can be used as basis for an effective disease management and control program. In Asia and Africa, the identification of different geographical strains of Schistosoma japonicum, S. haematobium and S. mansoni as determined through microsatellites could pave the way for a better understanding of the transmission epidemiology of the parasite. Thus, the present study aims to apply microsatellite markers in analyzing the populations of S. japonicum from different endemic areas in the Philippines for possible strain differentiation.

Methodology/ Principal …

Music Appreciation (Georgia Gwinnett College), Todd Mueller, Elizabeth Whittenburg Ozment, Irina Escalante-Chernova, Marc Gilley, Catherine Kilroe-Smith, Rachael Fischer

Fine Arts Open Textbooks

This Music Appreciation textbook was created under an ALG Round Five Textbook Transformation Grant. The original copy was presented in five modules, which are provided as separate files.

Authors' Description:

"The author of this text has intentionally kept it general in nature in order to create a platform for those who want to expand content into more in depth studies of the mentioned concepts and traditions. I believe that appreciation of any subject comes from open-minded exposure to that topic. With the arts this generally must happen at a moment when the message and meaning of the work resonates …

Cyclin D1 Restrains Oncogene-Induced Autophagy By Regulating The Ampk-Lkb1 Signaling Axis., Mathew C. Casimiro, Gabriele Disante, Agnese Di Rocco, Emanuele Loro, Claudia Pupo, Timothy G. Pestell, Sara Bisetto, Marco A. Velasco-Velázquez, Xuanmao Jiao, Zhiping Li, Christine M. Kusminski, Erin L. Seifert, Chenguang Wang, Daniel Ly, Bin Zheng, Che-Hung Shen, Philipp E. Scherer, Richard Pestell

Department of Cancer Biology Faculty Papers

Autophagy activated after DNA damage or other stresses mitigates cellular damage by removing damaged proteins, lipids, and organelles. Activation of the master metabolic kinase AMPK enhances autophagy. Here we report that cyclin D1 restrains autophagy by modulating the activation of AMPK. In cell models of human breast cancer or in a cyclin D1-deficient model, we observed a cyclin D1-mediated reduction in AMPK activation. Mechanistic investigations showed that cyclin D1 inhibited mitochondrial function, promoted glycolysis, and reduced activation of AMPK (pT172), possibly through a mechanism that involves cyclin D1-Cdk4/Cdk6 phosphorylation of LKB1. Our findings suggest how AMPK activation by cyclin D1 …

Mining Non-Lattice Subgraphs For Detecting Missing Hierarchical Relations And Concepts In Snomed Ct, Licong Cui, Wei Zhu, Shiqiang Tao, James T. Case, Olivier Bodenreider, Guo-Qiang Zhang

Computer Science Faculty Publications

Objective: Quality assurance of large ontological systems such as SNOMED CT is an indispensable part of the terminology management lifecycle. We introduce a hybrid structural-lexical method for scalable and systematic discovery of missing hierarchical relations and concepts in SNOMED CT.

Material and Methods: All non-lattice subgraphs (the structural part) in SNOMED CT are exhaustively extracted using a scalable MapReduce algorithm. Four lexical patterns (the lexical part) are identified among the extracted non-lattice subgraphs. Non-lattice subgraphs exhibiting such lexical patterns are often indicative of missing hierarchical relations or concepts. Each lexical pattern is associated with a potential specific type of error. …

Sexual Selection And Sex Ratios In Anolis Lizards, Pavitra Muralidhar, Michele A. Johnson

Biology Faculty Research

Biased sex ratios, or unequal numbers of males and females in a population, can alter the intensity of sexual selection by enhancing competition for mates, and thus may affect the evolution of reproductive strategies. Studies of sex ratio variation across a clade provide an opportunity to examine the morphological or behavioral consequences of different levels of sexual selection. We examined sex ratio variation, using phylogenetic comparative methods, across a diverse clade of terrestrial vertebrates, the Anolis lizards. Across a sample of 14 species in 21 localities, we found remarkable bidirectional variation in sex ratios across the Anolis clade: males are …

Addressing The Pitfalls Of Exclusive Flag State Jurisdiction: Improving The Legal Regime For The Protection Of Submarine Cables, Zoe Scanlon

Journal of Maritime Law and Commerce

No abstract provided.

Who Teaches Science To Nurses?, Naghma Rizvi

School of Nursing & Midwifery

OBJECTIVE:

To explore the demographics of individuals teaching basic science courses in private nursing schools.

METHODS:

The study was conducted in Karachi, and comprised teachers teaching basic science courses in 16 registered private nursing schools. A demographic questionnaire was used to collect data. The study was conducted in the year 2013.

RESULTS:

Teachers holding academic/professional degrees in different science disciplines were involved in teaching science to nurses. In most of the schools, all the basic science courses were taught by one subject specialist science teacher. These subject specialist science teachers held degrees in different disciplines, which included Doctor of Philosophy, …

Public Health Research Priorities To Address Us Human Trafficking, Emily F. Rothman, Hanni Stoklosa, Susie B. Baldwin, Makini Chisolm-Straker, Rumi Kato Price, Holly G. Atkinson

Publications and Research

In this Perspective, HEAL Trafficking, the nation's leading public health anti-trafficking organization maps out a national research agenda to tackle the problem of human trafficking. Given the paucity of research on trafficking, HEAL Trafficking engaged its membership in a consensus development process throughout 2016 to develop its national research agenda. HEAL Trafficking proposes five priorities that public health researchers should focus on in the decade ahead to make meaningful progress on preventing and responding to human trafficking in the Unites States.

Proteogenomic Analysis Of The Total And Surface-Exposed Proteomes Of Plasmodium Vivax Salivary Gland Sporozoites., Kristian E Swearingen, Scott E Lindner, Erika L Flannery, Ashley M Vaughan, Robert D Morrison, Rapatbhorn Patrapuvich, Cristian Koepfli, Ivo Muller, Aaron Jex, Robert L Moritz, Stefan H I Kappe, Jetsumon Sattabongkot, Sebastian A Mikolajczak

Articles, Abstracts, and Reports

Plasmodium falciparum and Plasmodium vivax cause the majority of human malaria cases. Research efforts predominantly focus on P. falciparum because of the clinical severity of infection and associated mortality rates. However, P. vivax malaria affects more people in a wider global range. Furthermore, unlike P. falciparum, P. vivax can persist in the liver as dormant hypnozoites that can be activated weeks to years after primary infection, causing relapse of symptomatic blood stages. This feature makes P. vivax unique and difficult to eliminate with the standard tools of vector control and treatment of symptomatic blood stage infection with antimalarial drugs. Infection …

Introduction To Psychology (College Of Coastal Georgia), Brian Pope, Lisa Mcneal

Psychology, Sociology, Anthropology, and Social Work Grants Collections

This Grants Collection for Introduction to Psychology was created under a Round Six ALG Textbook Transformation Grant.

Affordable Learning Georgia Grants Collections are intended to provide faculty with the frameworks to quickly implement or revise the same materials as a Textbook Transformation Grants team, along with the aims and lessons learned from project teams during the implementation process.

Documents are in .pdf format, with a separate .docx (Word) version available for download. Each collection contains the following materials:

• Linked Syllabus
• Initial Proposal
• Final Report

Introduction To General Psychology (Augusta), Georgina Hammock, Quentin Hartmann, Lauren Verlaque, Stephanie Northington, Li Ma

Psychology, Sociology, Anthropology, and Social Work Grants Collections

This Grants Collection for Introduction to General Psychology was created under a Round Five ALG Textbook Transformation Grant.

Affordable Learning Georgia Grants Collections are intended to provide faculty with the frameworks to quickly implement or revise the same materials as a Textbook Transformation Grants team, along with the aims and lessons learned from project teams during the implementation process.

Documents are in .pdf format, with a separate .docx (Word) version available for download. Each collection contains the following materials:

• Linked Syllabus
• Initial Proposal
• Final Report

Technical Communication, Tamara Powell, Jonathan Arnett, Monique Logan, Cassandra Race, Tiffani Reardon, Lance Linimon, James Monroe

Communication Grants Collections

This Grants Collection for Technical Communication was created under a Round Three ALG Textbook Transformation Grant.

Affordable Learning Georgia Grants Collections are intended to provide faculty with the frameworks to quickly implement or revise the same materials as a Textbook Transformation Grants team, along with the aims and lessons learned from project teams during the implementation process.

Documents are in .pdf format, with a separate .docx (Word) version available for download. Each collection contains the following materials:

• Linked Syllabus
• Initial Proposal
• Final Report

2017-July-01-Abeer Chaudhary, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

Dynamics Of Rna Polymerase In E. Coli Determined By Raster Image Correlation Spectroscopy And Number And Brightness Analysis, Daniel Bugas, Matthew Ferguson (Mentor), Abigail Figueroa, Steven Burden, Eric Hayden

Idaho Conference on Undergraduate Research

RNA Polymerase (RNAP) is fundamental in all living organisms, as it transcribes DNA into RNA molecules. Visualizing the molecular copy number and dynamics of RNAP in single living cells is difficult using conventional fluorescence microscopy. We use two techniques based on Fluorescence Correlation Spectroscopy (FCS) to determine the molecular copy number and mobility of RNAP in single living cells of Escheri coli. Raster Image Correlation Spectroscopy (RICS) is an image based FCS technique that measures the average molecular diffusion at every point in an image. This is useful in living cells for characterizing molecular diffusivity in addition to DNA, membrane …

Bidirectional Relations Between Prosocial Behavior And Self-Regulation Across Adolescence, Madison Kate Memmott

Theses and Dissertations

The purpose of this study was to take a multidimensional perspective to prosocial behavior and self-regulation by analyzing longitudinal, bidirectional relations between prosocial behavior toward strangers, friends, and family members and behavioral, cognitive, and emotional dimensions of self-regulation across adolescence. Participants included reports from 500 adolescents (age Time 1 = 12, Time 2 = 14, Time 3 = 16, Time 4 = 18; 52% female, 77% European American) taking part in the Flourishing Families Project. Nine cross-lagged panel models were conducted analyzing longitudinal associations between each target of prosocial behavior and each dimension of self-regulation. Results revealed that in early …

Response To Drought Of A Stream Fish Assemblage In A High Elevation Stream In The Intermountain West, Richard M. Simkins

Theses and Dissertations

One of the most influential disturbances for stream fish assemblages is large-scale declines in flow caused by periods of drought. Although stream characteristics are known to influence the response of stream fishes to drought, we asked if ecological traits of stream fishes determine, in part, their population level response to drought. To test for ecological trait-based responses to drought in a stream fish assemblage, we quantified species abundances over a period of 5 years that represented a wet to dry period. We sampled stream fishes in Yellow Creek, Wyoming, USA, a high elevation stream dependent on snow-storage for most of …

Biogeochemical Interactions In Flooded Underground Mines, Renee Schmidt

Graduate Theses & Non-Theses

This study presents a biogeochemical analysis of microbial communities in flooded underground mines in Butte, Montana, USA. Samples were collected from nine mineshafts representing three distinct geochemical zones. These zones consist of the East, West, and Outer Camp mines. The East Camp mines, bordering the Berkeley Pit Superfund site, have the highest concentrations of dissolved metals and the most acidic pH values. Dissolved metal concentrations in the West Camp are one to three orders of magnitude lower than in the East Camp and have nearly neutral pH values. The Outer Camp mines have similar metal concentrations to the West Camp …

Evaluation Of The Fertilization Properties Of Algal Biomass And Assessment Of Koh-Induced Flocculation Of Pw95 Algal Cells, Olakunle Ogunsakin

Graduate Theses & Non-Theses

Microalgae from the Coal Bed Methane (CBM) ponds of the Powder River Basin (PRB) in Southeastern Montana have the potential to be utilized as fertilizer for use on the economically important plants of Montana. Three very important economic field crops of Montana (winter wheat - Triticum aestivum, potato - Solanum tuberosum, and flax - Linum usitatissimum) were used for the fertilization experiments. Isolates of unicellular green algae - PW95 (sequenced as Neospongiococcum sp.) from the CBM ponds, and blue-green microalgae – Cyanobacteria (Anabaena Cylindrica) were cultured in the laboratory and the cells were concentrated using gravity sedimentation. Nutrient analysis of …