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It’S Not All Sunflowers And Roses At Home: A Narrative Inquiry Of At-Risk Girls And Their Perceptions Of Their Educational Experiences, Jessica Aggeles Curtis

USF Tampa Graduate Theses and Dissertations

The population of girls being incarcerated continues to grow amid the decline of boy offenders. While society has seen an increase in violent offenses perpetrated by these girls, the majority are still detained on status offenses or for non-violent crimes. For many girls, school is a place to seek solace and safety. Yet, for a growing population of girls, the bond they once shared with school is disintegrating. This disconnect has proven to be a critical turning point in their lives. The purpose of this study is to give girls who have been removed from the general education setting a …

Chemical Investigations Of Fungal Natural Products For Drug Discovery, Danielle H. Demers

USF Tampa Graduate Theses and Dissertations

Natural products have, historically, played an important role in drug discovery. Nevertheless, drug resistance, pathogen evolution, and global climate change threaten human health and nearly all current anti-infective treatments on the market today. It is undeniable that new drug discovery efforts are needed with increasing urgency.

Bolstered by a rich history of discovering treatments in the world around us, natural products chemists continue to look to the environment with increasing understanding and emerging technologies that allow efficient, effective isolation of new chemical entities. This thesis will describe one such endeavor.

Focusing on fungal natural products, herein is described the isolation …

Traumatic Brain Injury In Adolescence: The Relationship Between High School Exiting And Future Productivity, Jeffrey S. Garofano

USF Tampa Graduate Theses and Dissertations

Traumatic brain injury (TBI) is the leading cause of death and disability among children and adolescents. Brain injury survivors are often left with persistent impairments that have the potential to impede daily functioning, delay or prevent the attainment of developmental milestones, and subsequently limit future productivity in adulthood. A shared goal of both neurorehabilitation and the educational system is to prepare youth for a productive adulthood with both systems of care having substantial, yet independent, literature bases regarding factors associated with productivity (e.g., engagement in employment or post-secondary education). It is currently assumed that because type of high school exiting …

Rational Drug Design Directed At Blocking The Initial Signaling Events In Lipopolysaccharide-Induced Sepsis., Christopher A. Tipton

Theses

Systemic Inflammatory Response Syndrome (SIRS) is classified as an immune system response to an infectious state. If left untreated, SIRS leads to sepsis, septic shock, end-organ dysfunction, and death. As a patient progresses through these stages, associations of acute respiratory distress, disseminated intravascular coagulation, and acute renal failure persist, resulting in millions of deaths annually. Lipopolysaccharide (LPS), a bacterial endotoxin, is released into the blood stream, triggering SIRS. LPS is found in the outer cell-wall of Gram-negative bacteria and is responsible for initiation of a devastating cytokine storm. One of the regions of LPS, lipid A, is a polyacylated glucosamine …

Effects On Campostoma Oligolepis Digestive Morphology And Gut Microbiota Composition Across A Gradient Of Urbanization, Hannah Grice

Master of Science in Integrative Biology Theses

Campostoma oligolepis, the Largescale Stoneroller, is a species of minnow native to northwest Georgia. This study investigated the impacts of urbanization on gut length and gut microbiota community composition in C. oligolepis from four small watersheds within the Etowah River drainage basin with different levels of impervious surface coverage (ISC). Individuals were collected from each sample site in the summer of 2016 between late July and early September. A second round of sampling was conducted in the fall between mid-October and mid-November. The gut length to total length ratio was calculated for each individual to allow for an unbiased …

Systematic Elucidation Of Factors That Influence The Strength Of Tetrel Bonds, Steve Scheiner

Chemistry and Biochemistry Faculty Publications

Quantum calculations are used to examine the properties of heterodimers formed by a series of tetrel-containing molecules with NH₃ as universal Lewis base. TH₄ was taken as a starting point, with T= C, Si, Ge, and Sn. The H atoms were replaced by various numbers of F atoms: TH₃F, TF₃H, and TF₄ so as to monitor the effects of adding electron-withdrawing substituents. Unsubstituted TH₄ molecules form the weakest tetrel bonds, only up to about 2 kcal/mol. The bond is strengthened when the H opposite NH₃ is replaced by F, rising up …

Psychosocial Mechanisms Of Outcome In Pediatric Psychiatry, Alessandro S. De Nadai

USF Tampa Graduate Theses and Dissertations

Nearly half of all youths experience a mental health disorder at some point during childhood (Merikangas et al., 2010). Pediatric psychopathology is associated with a substantial amount of impairment in the school, social, and home domains, and such symptoms can have adverse impacts on subsequent development (Beauchaine & Hinshaw, 2013; Patel, Flisher, Hetrick, & McGorry, 2007). Fortunately, a number of medications have demonstrated efficacy in treating a number of mental health conditions (Martin, Scahill, & Kratochvil, 2010). Despite these demonstrated effects, treatment response is often incomplete, and the mechanisms by which pharmacotherapy lead to behavior change are not well understood. …

Beyond Age And Stage: Consequences Of Individual Variation In Demographic Traits, Erin Elizabeth Feichtinger

USF Tampa Graduate Theses and Dissertations

Within natural populations, individuals vary in their propensity to grow, survive and produce offspring. Additionally, fates of individuals are often correlated and non-independent as a result of shared genes, rearing environment or both. Variation in demographic traits can change population dynamics over time. The effects of variation in individual growth rate on population growth rate, net reproductive rate and generation time are examined, along with quantifying the sources of variation in survival of a long-lived cooperatively breeding bird, the Florida Scrub-Jay (Aphelocoma coerulescens). I built a 2 stage population model with two growth phenotypes, fast and slow, and …

Performing Narrative Medicine: Understanding Familial Chronic Illness Through Performance, Alyse Keller

USF Tampa Graduate Theses and Dissertations

This study presents the process of creating a performance ethnography of my family’s narratives about familial chronic illness and disability. I label this process performing narrative medicine. By documenting and granularly analyzing the process of my performance ethnography, the following chapters provide a step-by-step discussion of how families communicate about chronic illness/disability through storytelling and humor, and how/what performance does as a method, metaphor and object of study to further our current communicative practices and understandings of chronic illness and disability in families. I argue that performing narrative medicine is a heuristic for families living with chronic illness and …

Dwivedi To Chair Nih Study Section, Linda Gunter

Browse All News

No abstract provided.

Study Of Polysulfide Speciation In Lithium Sulfur Batteries Using In Situ Confocal Raman Microscopy, Josefine Mcbrayer

Nanoscience and Microsystems ETDs

Secondary lithium sulfur (Li-S) batteries have been heavily studied in the battery community since the start of the 21^st century due to their high theoretical capacity and specific energy density. The ground-breaking lithium ion battery has revolutionized society and its ability to store energy, however the lithium ion battery is reaching its limit with a theoretical capacity almost five times lower than that of lithium sulfur. With the improvement and commercialization of Li-S batteries, electric vehicles and personal electronics will have extended performance on a single charge. The viability of this promising chemistry relies on overcoming several key difficulties, …

One-Step Protein Purification Achieves High Yields, Purity And Activity, Jeff Hansen

Browse All News

No abstract provided.

Water Quality's Influence On The Occupancy Of Two Jeopardized Fishes: The Blackside Dace (Chrosomus Cumberlandensis) And The Cumberland Arrow Darter (Etheostoma Sagitta) In Northeast Tennessee, Brandon L. Yates

Morehead State Theses and Dissertations

A thesis presented to the faculty of the College of Science, Morehead State University, in partial fulfillment of the requirements for the Degree Master of Science by Brandon L. Yates July 5, 2017.

The Sulfoquinovosyltransferaselike Enzyme Sqd2.2 Is Involved In Flavonoid Glycosylation, Regulating Sugar Metabolism And Seed Setting In Rice, Xuemin Wang, Qingwen Shen, Xinqiao Zhan, Yueyun Hong

Biology Department Faculty Works

Seed setting is an important trait that contributes to seed yield and relies greatly on starchaccumulation. In this study, a sulfoquinovosyl transferase-like protein, designated as SQD2.2involved in seed setting and flavonoid accumulation, was identified and characterized in rice.Rice SQD2.2 is localized to the cytoplasm, and the SQD2.2 transcript was highest in leaves. RiceSQD2.2-overexpressing (OE) plants exhibited a decreased seed setting rate and diminished tillernumber simultaneously with an increased glycosidic flavonoid level compared with wild-type(WT) plants. SQD2.2 catalyzes the glycosylation of apigenin to produce apigenin 7-O-glucosideusing uridine diphosphate-glucose (UDPG) as a sugar donor, but it failed to compensate forsulfoquinovosyldiacylglycerol (SQDG) synthesis …

The Sixth Estate – The Rule Of Algorithms, Roman Batko, Jan Kreft

European Management Studies

On the basis of the analysis of numerous texts and social phenomena in which the hermeneutical method is applied, we would like to present the following article on a phenomenon that can be observed in new media. We have referred to the phenomenon as the Sixth Estate, the rule of algorithms. Nowadays, digital mechanisms applied for selecting contents, controlling consumer and political behaviour reach far beyond the limit of a marginal phenomenon, and they readily join the mainstream. With the appearance of the Sixth Estate, some other phenomena can be observed, such as mythologisation of abstruse digital mechanisms which interact …

Myotis Rufoniger Genome Sequence And Analyses: M. Rufoniger’S Genomic Feature And The Decreasing Effective Population Size Of Myotis Bats, Youngjune Bhak, Yeonsu Jeon, Sungwon Jeon, Oksung Chung, Sungwoong Jho, Jehoon Jun, Hak-Min Kim, Yongsoo Cho, Changhan Yoon, Seungwoo Lee, Jung-Hoon Kang, Jong-Deock Lim, Junghwa An, Yun Sung Cho, Doug-Young Ryu, Jong Bhak

KIP Articles

No abstract provided.

One-Step Protein Purification Achieves High Yields, Purity And Activity, Jeff Hansen

Browse All News

No abstract provided.

Hormonal Changes During Early Development Limit Lifespan In Mice, Staff

Browse All News

No abstract provided.

Mechanism-Informed Refinement Reveals Altered Substrate-Binding Mode For Catalytically Competent Nitroreductase, Warintra Pitsawong, Chad A. Haynes, Ronald L. Koder, David W. Rodgers, Anne-Frances Miller

Chemistry Faculty Publications

Nitroreductase from Enterobacter cloacae (NR) reduces diverse nitroaromatics including herbicides, explosives and prodrugs, and holds promise for bioremediation, prodrug activation and enzyme-assisted synthesis. We solved crystal structures of NR complexes with bound substrate or analog for each of its two half-reactions. We complemented these with kinetic isotope effect (KIE) measurements elucidating H-transfer steps essential to each half-reaction. KIEs indicate hydride transfer from NADH to the flavin consistent with our structure of NR with the NADH analog nicotinic acid adenine dinucleotide (NAAD). The KIE on reduction of p-nitrobenzoic acid (p-NBA) also indicates hydride transfer, and requires revision of …

Physiological Responses To Ocean Acidification And Warming Synergistically Reduce Condition Of The Common Cockle Cerastoderma Edule, E. Z. Ong, M. Briffa, T. Moens, Colen C Van

School of Biological and Marine Sciences

No abstract provided.

Osteopontin Facilitates West Nile Nirus Neuroinvasion Via Neutrophil "Trojan Horse" Transport, Amber M. Paul, Dhiraj Acharya, Laurel Duty, E. Ashley Thompson, Linda Le, Dobrivoje S. Stokic, A. Arturo Leis, Fengwei Bai

Faculty Publications

West Nile virus (WNV) can cause severe human neurological diseases including encephalitis and meningitis. The mechanisms by which WNV enters the central nervous system (CNS) and host-factors that are involved in WNV neuroinvasion are not completely understood. The proinflammatory chemokine osteopontin (OPN) is induced in multiple neuroinflammatory diseases and is responsible for leukocyte recruitment to sites of its expression. In this study, we found that WNV infection induced OPN expression in both human and mouse cells. Interestingly, WNV-infected OPN deficient (Opn −/−) mice exhibited a higher survival rate (70%) than wild type (WT) control mice (30%), suggesting OPN plays a …

The Role Of Elevated Hyaluronan-Mediated Motility Receptor (Rhamm/Hmmr) In Ovarian Cancer, Stephanie T. Buttermore

USF Tampa Graduate Theses and Dissertations

Ovarian cancer (OC) has the highest mortality among gynecological cancers. The high mortality is associated with the lack of an accurate screening tool to detect disease in early stage. As a result the majority of OCs are diagnosed in late stage. Further, the molecular events responsible for malignant transformation in the ovary remain poorly understood. Consequently, delineating key molecular players driving OC could help elucidate potential diagnostic, prognostic and therapeutic targets.

Receptor for hyaluronan-mediated motility (RHAMM) belongs to a group of hyaladherins, which share a common ability to bind to hyaluronan (HA). Intracellularly, RHAMM is involved in microtubule spindle assembly …

Health Literacy, Depression, Anxiety, And Posttraumatic Stress Disorder As Predictors Of Biological Markers Of Immune Functioning In Youth And Young Adults With Hiv, Courtney A. Lynn

USF Tampa Graduate Theses and Dissertations

Human immunodeficiency virus (HIV) is a virus that affects the body’s immune system (Centers for Disease Control [CDC], 2016a). HIV is a worldwide epidemic and disproportionately impacts youth in the United States. Youth living with HIV (YLWH) face significant mental health problems, namely depression, anxiety, and posttraumatic stress disorder (PTSD) with rates of these disorders discrepant from those in the general population. In addition to psychological difficulties, health literacy is another factor that influences individuals with HIV and is a priority of research with adolescents (Kalichman et al., 2000; Manganello, 2008). The National HIV/AIDS Strategy: Update 2020 (White House Office …

Role Of Amylase In Ovarian Cancer, Mai Mohamed

USF Tampa Graduate Theses and Dissertations

Ovarian cancer (OC) accounts for 4% of all cancer cases and 4.2% of all cancer deaths worldwide. OC is the most lethal gynecological cancer because it lacks early disease symptoms and does not have a specific diagnostic marker. As a result, more than 70% of OC patients are diagnosed in later stages when the disease has already metastasized and the 5-year survival rate has decreased to less than 20% compared with approximately 90% survival for women diagnosed with early stage disease. Therefore, I initiated my studies with a computational analysis of the 27 most commonly reported literature-derived ovarian cancer (LDOC) …

Osteopontin Facilitates West Nile Virus Neuroinvasion Via Neutrophil “Trojan Horse” Transport, Amber M. Paul, Dhiraj Acharya, Laurel Duty, E. Ashley Thompson, Linda Le, Dobrivoje S. Stokic, A. Arturo Leis, Fengwei Bai

Publications

West Nile virus (WNV) can cause severe human neurological diseases including encephalitis and meningitis. The mechanisms by which WNV enters the central nervous system (CNS) and host factors that are involved in WNV neuroinvasion are not completely understood. The proinflammatory chemokine osteopontin (OPN) is induced in multiple neuroinflammatory diseases and is responsible for leukocyte recruitment to sites of its expression. In this study, we found that WNV infection induced OPN expression in both human and mouse cells. Interestingly, WNV-infected OPN deficient (Opn−/−) mice exhibited a higher survival rate (70%) than wild type (WT) control mice (30%), suggesting OPN plays a …

State V. Blair Appellant's Brief Dckt. 44637

Not Reported

No abstract provided.

Bisphosphonate Functionalized Gold Nanoparticles For The Study And Treatment Of Osteoporotic Disease, Christopher Conners

USF Tampa Graduate Theses and Dissertations

The use of nanoparticles for disease treatment is an increasingly popular area of research. The potential for multi-functionality allows nanoparticles to be used as transport and delivery vehicles for drugs and as diagnostic aides, among other applications, to address the unmet needs of many disease treatments. One such class of disease is osteoporosis including severe disorders, like Paget’s disease, Osteogenesis Imperfecta and Legg Calve Perthes disease. In this dissertation, we discuss a nanoparticle system consisting of gold nanoparticles surface functionalized with primary amine bisphosphonates, which is a classification of pharmaceuticals that is common in the treatment of osteoporosis. Functionalized nanoparticles …

A Motivational Interviewing Intervention To Increase Utilization Of Smoking Cessation Services Among Veterans Undergoing Substance Use Treatment, Nicole S. Menzie

USF Tampa Graduate Theses and Dissertations

Smoking remains the single most preventable cause of death worldwide and primary cause of several types of cancer, cardiovascular disease, and respiratory illness (USDHHS, 2014). Although the prevalence of smoking among the general population continues to decline, the prevalence of smoking among the veteran population remains high. In addition, the prevalence of smoking among veterans with substance and alcohol use disorders is 2 to 3 times higher than in the general population. Over the years, the VA has implemented empirically-based treatments for smoking cessation to address the cigarette smoking epidemic. These services, however, are greatly underutilized. Motivational interviewing (MI) has …

Research News. Publications, 2017. Volume 1, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar

Publications (2015-)

Publications that appeared during the period January 1 through June 30, 2017

A Novel Application Of Machine Learning Methods To Model Microcontroller Upset Due To Intentional Electromagnetic Interference, Rusmir Bilalic

Electrical and Computer Engineering ETDs

A novel application of support vector machines (SVMs), artificial neural networks (ANNs), and Gaussian processes (GPs) for machine learning (GPML) to model microcontroller unit (MCU) upset due to intentional electromagnetic interference (IEMI) is presented. In this approach, an MCU performs a counting operation (0-7) while electromagnetic interference in the form of a radio frequency (RF) pulse is direct-injected into the MCU clock line. Injection times with respect to the clock signal are the clock low, clock rising edge, clock high, and the clock falling edge periods in the clock window during which the MCU is performing initialization and executing the …