Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2017

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 30331 - 30350 of 30350

Full-Text Articles in Entire DC Network

Global Proteome And Phosphoproteome Analysis Of Meningiomas., J Dunn, S Ferluga, E Lasonder, O Hanemann Jan 2017

Global Proteome And Phosphoproteome Analysis Of Meningiomas., J Dunn, S Ferluga, E Lasonder, O Hanemann

Peninsula Medical School

INTRODUCTION Meningiomas are common brain tumours arising from meningeal tissue. Despite the majority of them displaying benign features, they can cause mild to severe morbidity. The current main therapeutic approach is complete tumour resection commonly with adjunct radiation therapy. However, tumour location can hamper complete resection and chemotherapies are ineffective. In this study we aim to elucidate dysregulated pathways in meningioma pathogenesis and identify novel molecular targets by deciphering the proteome and phosphoproteome of different grades of meningiomas. METHODS Tumour lysates were collected from grade I, II and III frozen meningioma specimens and three normal healthy human meninges. Phosphoprotein purification …

Go to article

Risk Factors And Functional Abnormalities Associated With Adult Onset Secondary Nocturnal Enuresis In Women, C Madhu, H Hashim, Dg Enki, M Yaasin, M Drake Jan 2017

Risk Factors And Functional Abnormalities Associated With Adult Onset Secondary Nocturnal Enuresis In Women, C Madhu, H Hashim, Dg Enki, M Yaasin, M Drake

Peninsula Medical School

Aims The study aims to evaluate bothersome lower urinary tract symptoms (LUTS), risk factors, and associated functional abnormalities in women reporting adult onset secondary nocturnal enuresis (SNE), to help understand factors associated with SNE. Methods 12,795 women (age >18) attending a tertiary referral centre underwent a comprehensive standardized evaluation including urodynamic testing in accordance with the International Continence Society recommendations. Records of all patients reporting bedwetting while asleep were evaluated under various categories. Multiple logistic regression was used to identify statistically significant risk factors and urodynamic findings associated with SNE. Results The prevalence of SNE in women undergoing urodynamic testing …

Go to article

Realising The Full Potential Of Primary Care: Uniting The ‘Two Faces’ Of Generalism, Joanne Reeve, Richard Byng Jan 2017

Realising The Full Potential Of Primary Care: Uniting The ‘Two Faces’ Of Generalism, Joanne Reeve, Richard Byng

Peninsula Medical School

Faced with an unprecedented mismatch between presented health needs and resources available, we must rethink both how we deliver healthcare and what care we deliver. Work has already started on the ‘how’: notably with efforts to strengthen access and integration — improved coordination of the comprehensive care needed to meet a diverse range of needs.2 It is defining ‘what’ to deliver that is proving more challenging. To address emerging problems of over- and under-treatment associated with the undue specialisation of healthcare,3 we need to strengthen delivery of generalist medical care.4 This means that we need to bolster the capacity to …

Go to article

Suppression Of Mapk11 Or Hipk3 Reduces Mutant Huntingtin Levels In Huntington's Disease Models, Meng Yu, Yuhua Fu, Yijiang Liang, Haikun Song, Y Yao, Peng Wu, Y Yao, Yuyin Pan, Xue Wen, Lixiang Ma, Saiyin Hexige, Yu Ding, Shouqing Luo, Boxun Lu Jan 2017

Suppression Of Mapk11 Or Hipk3 Reduces Mutant Huntingtin Levels In Huntington's Disease Models, Meng Yu, Yuhua Fu, Yijiang Liang, Haikun Song, Y Yao, Peng Wu, Y Yao, Yuyin Pan, Xue Wen, Lixiang Ma, Saiyin Hexige, Yu Ding, Shouqing Luo, Boxun Lu

Peninsula Medical School

No abstract provided.

Go to article

Examining Primary Prevention Methods And Pharmacological Interventions In Identifying Lower Risk Of Coronary Heart Diease, Melissa Stewart Jan 2017

Examining Primary Prevention Methods And Pharmacological Interventions In Identifying Lower Risk Of Coronary Heart Diease, Melissa Stewart

Undergraduate Theses and Senior Projects

No abstract provided.

Go to article

Antigen Challenge Alters Innate Behavior And Expression Of Brain Histaminergic Autoreceptor In Mouse Model Of Milk Allergy, Lane Vendsel Jan 2017

Antigen Challenge Alters Innate Behavior And Expression Of Brain Histaminergic Autoreceptor In Mouse Model Of Milk Allergy, Lane Vendsel

Undergraduate Theses and Senior Projects

No abstract provided.

Go to article

Extending Data Curation Service Models For Academic Library And Institutional Repositories, Jon Wheeler Jan 2017

Extending Data Curation Service Models For Academic Library And Institutional Repositories, Jon Wheeler

University Libraries & Learning Sciences Faculty and Staff Publications

Many academic libraries have implemented institutional repositories (IR), which offer some potential for publishing and archiving data but can fall short of usability expectations and requirements. As general purpose repositories, IR's may lack the metadata and service capabilities to dynamically represent data and to effectively capitalize on complex, domain oriented metadata schema such as the Ecological Metadata Language (EML) or the ISO 19115-2014 Geographic information metadata standards. For libraries interested in providing data publishing services, one alternative to the domain agnostic nature of IR content and metadata models is to maintain the IR for traditional document types and in addition …

Go to article

Region Of Smooth Functions For Positive Solutions To An Elliptic Biological Model, Joon Hyuk Kang, Timothy Robertson Jan 2017

Region Of Smooth Functions For Positive Solutions To An Elliptic Biological Model, Joon Hyuk Kang, Timothy Robertson

Faculty Publications

The non-existence and existence of the positive solution to the generalized elliptic model ∆u+g(u v) = 0 in Ω, ∆v+h(u, v) = 0 in Ω, u=v= 0 on∂Ω, were investigated.

Go to article

Designing New Zealand’S Emissions Trading Scheme, Tor Håkon Jackson Inderberg, Ian Bailey, Nichola Harmer Jan 2017

Designing New Zealand’S Emissions Trading Scheme, Tor Håkon Jackson Inderberg, Ian Bailey, Nichola Harmer

School of Geography, Earth and Environmental Sciences

No abstract provided.

Go to article

Academic Capitalism In Architecture Schools: A Feminist Critique Of Employability, 24/7 Work And Entrepreneurship, I Troiani Jan 2017

Academic Capitalism In Architecture Schools: A Feminist Critique Of Employability, 24/7 Work And Entrepreneurship, I Troiani

School of Art, Design and Architecture

This chapter examines the current situation that many universities worldwide are facing due to globalisation, which is of transitioning from institutions for education (Foucault’s ‘premodern or medieval university’) toentrepreneurial businesses (the ‘modern university’). The modern university is governed by a neoliberal system of production and consumption of students, staff, knowledge and research for the purpose of improving nation economies. Looking particularly at schools of architecture, it discusses employability, 24-hour work and entrepreneurship in relation to marketisation and economisation. It tracks the inequalities that arise from the neoliberalisation of public universities on teaching content, an administrative-directed work, workloads, wellbeing and gender. …

Go to article

Playing In The Dark With Online Games For Girls, Rebecca Sinker, Mike Phillips, Victoria De Rijke Jan 2017

Playing In The Dark With Online Games For Girls, Rebecca Sinker, Mike Phillips, Victoria De Rijke

School of Art, Design and Architecture

Pregnant Rapunzel Emergency is part of a series of online free games aimed at young girls ( forhergames.com or babygirlgames.com ), where dozens of characters from fairy tales, children’s toys and media feature in recovery settings, such as ‘Barbie flu’. The range of games available to choose from includes not only dressing, varnishing nails or tidying messy rooms, but also rather more troubling options such as extreme makeovers, losing weight, or a plethora of baby showers, cravings, hospital pregnancy checks, births (including caesarean), postnatal ironing, washing and baby care. Taking the online game Pregnant Rapunzel Emergency as an exemplar of …

Go to article

Innovative Tidal Notch Detection Using Tls And Fuzzy Logic: Implications For Palaeo-Shorelines From Compressional (Crete) And Extensional (Gulf Of Corinth) Tectonic Settings, S. Schneiderwind, S. J. Boulton, I. Papanikolaou, K. Reicherter Jan 2017

Innovative Tidal Notch Detection Using Tls And Fuzzy Logic: Implications For Palaeo-Shorelines From Compressional (Crete) And Extensional (Gulf Of Corinth) Tectonic Settings, S. Schneiderwind, S. J. Boulton, I. Papanikolaou, K. Reicherter

School of Geography, Earth and Environmental Sciences

No abstract provided.

Go to article

Numerical Modeling Of Tidal Notch Sequences On Rocky Coasts Of The Mediterranean Basin, S. Schneiderwind, S. J. Boulton, I. Papanikolaou, M. Kázmér, K. Reicherter Jan 2017

Numerical Modeling Of Tidal Notch Sequences On Rocky Coasts Of The Mediterranean Basin, S. Schneiderwind, S. J. Boulton, I. Papanikolaou, M. Kázmér, K. Reicherter

School of Geography, Earth and Environmental Sciences

AbstractTidal notches have had the potential to form at sea level from ~6.5 kyr B.P. in the Mediterranean Basin and preserve a symmetrical shape comparable to a quadric polynomial. Continuous erosion, predominantly by biological agents, affects a limestone cliff face from low‐ to high‐tide level at <1 mm/yr. Statically determined, the roots of a quadric polynomial are defined by the tidal range representing the limits of effective erosion. However, gradual variations of eustatic sea level rise (slow) and coseismic uplift/subsidence (fast) in tectonically active regions contribute to vertical shifts in the erosional base at coastlines. As a consequence, the cliff morphology gets modified through time resulting in widening, deepening, and separation of notches and possible overprinting of older features. In order to investigate successive modifications of coastal cliff morphology, we developed a numerical model that considers the erosion rate, the erosion zone relative to sea level, the regional sea level curve, and tectonic motion. The results show how slow and rapid sea level changes bias the modern cliff face and highlight that the present‐day notch sequence from top descending to sea level is not inevitably of decreasing age. Furthermore, the initiation of notch formation is not necessarily linked to the date of a certain seismic event. Especially in extensional tectonic settings where coseismic uplift is low and coastal morphological marks are not as distinct, knowledge about coastal evolution is beneficial for paleoseismological research.

Go to article

Coupled Changes Between The H-Print Biomarker And Delta N-15 Indicates A Variable Sea Ice Carbon Contribution To The Diet Of Cumberland Sound Beluga Whales, T. A. Brown, E. Chrystal, S. H. Ferguson, D. J. Yurkowski, C. Watt, N. E. Hussey, T. C. Kelley, S. T. Belt Jan 2017

Coupled Changes Between The H-Print Biomarker And Delta N-15 Indicates A Variable Sea Ice Carbon Contribution To The Diet Of Cumberland Sound Beluga Whales, T. A. Brown, E. Chrystal, S. H. Ferguson, D. J. Yurkowski, C. Watt, N. E. Hussey, T. C. Kelley, S. T. Belt

School of Geography, Earth and Environmental Sciences

No abstract provided.

Go to article

Resolving Discrepancies Between Field And Modelled Relative Sea-Level Data: Lessons From Western Ireland, Robin Edwards, W. Roland Gehrels, Anthony Brooks, Ralph Fyfe, Katie Pullen, Joseph Kuchar, Kieran Craven Jan 2017

Resolving Discrepancies Between Field And Modelled Relative Sea-Level Data: Lessons From Western Ireland, Robin Edwards, W. Roland Gehrels, Anthony Brooks, Ralph Fyfe, Katie Pullen, Joseph Kuchar, Kieran Craven

School of Geography, Earth and Environmental Sciences

No abstract provided.

Go to article

This Is Where We Are - Collectively Living, Working And Being, With And Through Predictive Algorithms., B Aga, M Phillips Jan 2017

This Is Where We Are - Collectively Living, Working And Being, With And Through Predictive Algorithms., B Aga, M Phillips

School of Art, Design and Architecture

‘This Is Where We Are’ (TIWWA) was an immersive and interactive algorithmic sculpture fuelled by the data we collectively generate. This collaborative work was created for the opening of the new Tate Modern Switch house in London in June 2016 by the i-DAT Research and Design Collective, Tate Collective London and Intercity. This technological fusion of interactive light and sound asked audiences to consider the data they generate and the algorithmic systems that increasingly mediate their reality and influence their behaviour. The creation of the sculptural artefacts and the digital systems driving them, were forged through interplay between data, algorithms …

Go to article

Development And Validation Of An Oecd Reproductive Toxicity Test Guideline With The Mudsnail Potamopyrgus Antipodarum (Mollusca, Gastropoda), K Ruppert, C Geiß, C Askem, R Benstead, R Brown, M Coke, V Ducrot, P Egeler, H Holbech, Th Hutchinson, Kl Kinnberg, L Lagadic, Page G Le, A Macken, P Matthiessen, S Ostermann, A Schimera, C Schmitt, A Seeland-Fremer, Aj Smith, L Weltje, J Oehlmann Jan 2017

Development And Validation Of An Oecd Reproductive Toxicity Test Guideline With The Mudsnail Potamopyrgus Antipodarum (Mollusca, Gastropoda), K Ruppert, C Geiß, C Askem, R Benstead, R Brown, M Coke, V Ducrot, P Egeler, H Holbech, Th Hutchinson, Kl Kinnberg, L Lagadic, Page G Le, A Macken, P Matthiessen, S Ostermann, A Schimera, C Schmitt, A Seeland-Fremer, Aj Smith, L Weltje, J Oehlmann

School of Geography, Earth and Environmental Sciences

Mollusks are known to be uniquely sensitive to a number of reproductive toxicants including some vertebrate endocrine disrupting chemicals. However, they have widely been ignored in environmental risk assessment procedures for chemicals. This study describes the validation of the Potamopyrgus antipodarum reproduction test within the OECD Conceptual Framework for Endocrine Disrupters Testing and Assessment. The number of embryos in the brood pouch and adult mortality serve as main endpoints. The experiments are conducted as static systems in beakers filled with artificial medium, which is aerated trough glass pipettes. The test chemical is dispersed into the medium, and adult snails are …

Go to article

Depth Related Brachiopod Faunas From The Lower Cambrian Forteau Formation Of Southern Labrador And Western Newfoundland, Canada, Cb Skovsted, I Knight, Ku Balthasar, Wd Boyce Jan 2017

Depth Related Brachiopod Faunas From The Lower Cambrian Forteau Formation Of Southern Labrador And Western Newfoundland, Canada, Cb Skovsted, I Knight, Ku Balthasar, Wd Boyce

School of Geography, Earth and Environmental Sciences

A diverse fauna of organophosphatic brachiopods is described from the late early Cambrian (Series 2, Stage 3-4) Forteau Formation of southern Labrador and western Newfoundland. The total fauna includes 11 species representing a wide selection of Cambrian brachiopod groups. Three distinct assemblages are recognized: Assemblages 1 and 2 are found in shallow water carbonates in association with archaeocyathans in southern Labrador and the western side of the Great Northern Peninsula of western Newfoundland. Assemblage 3 is found in a distal shelf setting of Gros Morne National Park. Assemblages 1 and 2 are found in stratigraphic continuity and define two brachiopod …

Go to article

Suitability Of Various Chromatographic And Spectroscopic Techniques For Analysis And Kinetic Degradation Study Of Trelagliptin, Wafaa A. Zaghary, Shereen Mowaka, Mostafa A. Hassan, Bassam M. Ayoub Jan 2017

Suitability Of Various Chromatographic And Spectroscopic Techniques For Analysis And Kinetic Degradation Study Of Trelagliptin, Wafaa A. Zaghary, Shereen Mowaka, Mostafa A. Hassan, Bassam M. Ayoub

Pharmacy

© The Author(s) 2017. Multifaceted comparative analytical methods for trelagliptin (TRL) were investigated, applied to ZAFATEK tablets and HPLC-UV was selected for a degradation kinetic study. UPLC-MS/MS (Method I), UPLC-UV (Method II), HPLC-UV (Method III), UHPLC-UV (Method IV) and direct UV (Method V) methods were developed. Methods (I-V) showed satisfactory results using TRL concentration ranges of 50–800 ng/mL, 2.5–80 μg/mL, 5–100 μg/mL, 5–100 μg/mL and 5–50 μg/mL, respectively. Multiple Reaction Monitoring (MRM) of the transition pairs of m/z 358.176 to 134.127 for TRL and m/z 340.18 to 116.08 for alogliptin (IS) were employed utilizing positive mode Electrospray Ionization (ESI). The …

Go to article

Synthesis Of New Pyridothienopyrimidinone And Pyridothieno -Triazolopyrimidine Derivatives As Pim-1 Inhibitors, Bassem Naguib, Hala B. El-Nassan, Engy A. Beshay Jan 2017

Synthesis Of New Pyridothienopyrimidinone And Pyridothieno -Triazolopyrimidine Derivatives As Pim-1 Inhibitors, Bassem Naguib, Hala B. El-Nassan, Engy A. Beshay

Pharmacy

No abstract provided.

Go to article

First Prev