Digital Commons Network^™

A Novel Mechanism Of Non- Feminizing Estrogens In Neuroprotection, Elizabeth B. Engler-Chiurazzi, Douglas F. Covey, James W. Simpkins

Clinical and Translational Science Institute

Estrogens are potent and efficacious neuroprotectants both in vitro and in vivo in a variety of models of neurotoxicity. We determined the structural requirements for neuroprotection in an in vitro assay using a panel of more than 70 novel estratrienes, synthesized to reduce or eliminate estrogen receptor (ER) binding. We observed that neuroprotection could be enhanced by as much as 200-fold through modifications that positioned a large bulky group at the C2 or C4 position of the phenolic A ring of the estratriene. Further, substitutions on the B, C or D rings either reduced or did not markedly change neuroprotection. …

Acute Myeloid Leukemia, Adrianna Wayble

Nursing Student Class Projects (Formerly MSN)

The purpose of this research project is to explore the disease process of Acute Myeloid Leukemia, or AML. AML is a disease that is estimated to affect 21,380 people in the U.S., killing 10,590 this year alone according to the National Institute of Cancer (NIC, 2017). The goal of treatment for AML is complete remission, using either a combination of chemotherapy, and/or radiation, followed by stem cell transplant (Wang & Bailey, 2016). The disease is multi-faceted with many factors believed to contribute to AML, from environmental exposures to genetics (Wang & Bailey, 2016). This project discusses the treatment choices for …

2017 Diversity Conference Program, Lawrence University

Diversity Conference 2017

Lawrence University’s inaugural diversity conference focused on inclusive pedagogy.

Strategies For Increasing Female Navy Officer Retention: Deploying Mothers’ Perspectives, Angela Holcombe Walker

Dissertations

The complexity of the global environment, driven by rapid and profound change, requires a globally dominant fighting force. To adequately protect and defend the security of the United States, the Department of Defense must maintain warfighting superiority through innovation and diversity of thought (SECNAV, 2016; Scoppio, 2012). More than five years have passed since the 2011 Military Leadership Diversity Commission reported to President Obama and members of Congress that “top military leaders are representative neither of the population they serve nor of the forces they lead” (p. xvi). Females are underrepresented among senior military leadership. Increasing the number of female …

Taxonomy And Systematics Of Plagioporus (Trematoda), With Descriptions Of 10 New Species From Freshwater Fishes Of The Nearctic, Thomas John Fayton

Dissertations

The Opecoelidae Ozaki, 1925 is one of the largest families of digenetic trematodes of fishes. While the family is mostly marine/estuarine, invasion of freshwater hosts has occurred at least two times. The only representative freshwater plagioporine sequenced to date is Plagiocirrus loboides Curran, Overstreet, & Tkach, 2007, which previous phylogenetic analyses resolved as being related to deep water marine opecoelids. The taxonomy of the freshwater plagioporines, particularly Plagioporus, has long been confused; homoplasy is rife within the family and has complicated the delineation of species and genera, and the freshwater species from marine forms. Here, I hypothesize that the …

Traumatic Induced Coagulopathy, Paul Devore

Nursing Student Class Projects (Formerly MSN)

Trauma is a leading cause of mortality and morbidity in the United States. For years patients have been resuscitated in a similar method without improvement in survival of the most severely injured cohort. While acidemia, hypoxia, and hypothermia have long been recognized as complicating factors in the care of trauma patients, it is only recently that research has led to a greater understanding of the pathophysiology of this deadly trio. Coagulopathy of trauma is a multi factorial process which is now being recognized as the proximate cause of death in many patients. This poster examines the pathophysiology and nursing interventions …

Finding The Theory And Method For The Pedagogy Of Teaching Legal Research: A Response To Callister's “Time To Blossom”, Paul Mclaughlin

Law Library Faculty Scholarship

In his article “Time to Blossom,” Callister invites legal research experts to begin a discussion as to what theory and methodology would be most effective for teaching legal research. This article suggests that utilizing a tailored form of systems theory in conjunction with active learning methods would allow legal educators not only to teach students in an effective and understandable manner but also to adapt their teaching methods to correspond to changes in the legal research field.

Citation: Paul Jerome Mclaughlin, Jr. (2017) Finding the Theory and Method for the Pedagogy of Teaching Legal Research: A Response to Callister's “Time …

The New Mechanical Philosophy, Stuart Glennan

Philosophy, Religion, and Classics

The New Mechanical Philosophy argues for a new image of nature and of science--one that understands both natural and social phenomena to be the product of mechanisms, and that casts the work of science as an effort to discover and understand those mechanisms. Drawing on an expanding literature on mechanisms in physical, life, and social sciences, Stuart Glennan offers an account of the nature of mechanisms and of the models used to represent them. A key quality of mechanisms is that they are particulars - located at different places and times, with no one just like another. The crux of …

Two Novel Susceptibility Loci For Prostate Cancer In Men Of African Ancestry, David V Conti, Bettina F Drake, Adam S Kibel, Et Al.

2010-2019 OA Pubs

Prostate cancer incidence is 1.6-fold higher in African Americans than in other populations. The risk factors that drive this disparity are unknown and potentially consist of social, environmental, and genetic influences. To investigate the genetic basis of prostate cancer in men of African ancestry, we performed a genome-wide association meta-analysis using two-sided statistical tests in 10 202 case subjects and 10 810 control subjects. We identified novel signals on chromosomes 13q34 and 22q12, with the risk-associated alleles found only in men of African ancestry (13q34: rs75823044, risk allele frequency = 2.2%, odds ratio [OR] = 1.55, 95% confidence interval [CI] …

Molecular Mechanisms Of Dna Replication Initiation In Hpvs With Genetic Variations Leading To Cellular Carcinogenesis, Gulden Yilmaz

Graduate School of Biomedical Sciences Theses and Dissertations

Human papillomaviruses are a vast family of double-stranded DNA viruses containing non-carcinogenic and carcinogenic types, whose crucial differences remain unknown, except for the difference in the frequency of DNA replication. The human papillomavirus (HPV) E2 protein regulates the initiation of viral DNA replication and transcription. Its recognition and binding to four 12 bp palindromic sequences in the viral origin is essential for its function. Little is known about the DNA binding mechanism of the E2 protein found in HPV types that have low risk for oncogenicity (low-risk) as well as the roles of various elements of the individual binding sites. …

Trident - August 2017, Dugoni School Of Dentistry

Trident

The newsletter of the Pacific Orthodontic Alumni Chapter at University of the Pacific, Arthur A. Dugoni School of Dentistry

Nietzsche’S Posthuman Imperative: On The Human, All Too Human Dream Of Transhumanism, Babette Babich

Articles and Chapters in Academic Book Collections

No abstract provided.

Utilization And Transferability Of Technical Skills In A Choice Based Art Unit, Sarah George

Action Research Projects

The study explores differences between a class who was taught technical skills prior to expressing their ideas and a class who expressed their ideas prior to learning technical skills in a TAB-Choice classroom. Two third grade art classes from a school in Ann Arbor, Michigan participated in the study where four students from each class were chosen to participate in a focus study. Students filled out pre and post surveys. The teacher as researcher used a rubric to evaluate each work of art, photographed the art for documentation, and then compared the rubrics, surveys, and responses. Collected data demonstrated how …

How Can The Art Making Process Foster A Stronger Sense Of Self?, Claire Christine Kniveton

Action Research Projects

This thesis considered how the art making process can help foster a stronger sense of self in an individual. This investigation was carried out as an action research study with high school students at a therapeutic boarding school. The purpose of this study was to explore ways to help the troubled teenager, who struggles in finding their identity, to foster a better sense of self. It is through the art making process, with a positive work environment, a medium of exploration, and introspective questions, that a student can begin to have insight on themselves and who/what they identity with in …

Geographic Variation In Low Frequency Narrow-Band Sounds Produced By Amazon River Dolphins (Inia Geoffrensis) In Brazil And Peru, Grace Olson

Graduate Theses

Relatively few studies have investigated the sound production of Amazon River dolphins (Inia geoffrensis), and many questions remain regarding their social sounds. In this study, we document the presence of “low frequency narrow-band” (LFN) sounds in Amazon River dolphins. Amazon River dolphin LFN sounds were recorded in the Mamirauá Sustainable Development Reserve (Brazil), and 1,512 km away in the Área de Conservación Regional Comunal Tamshiyacu Tahuayo reserve (Peru). A quantitative comparison of LFN sounds produced by these two populations demonstrates evidence of geographic variation. The variation found in the social sounds produced by geographically separated Amazon River dolphin populations provides …

Neasc Fifth-Year Interim Report, Bridgewater State University

University Accreditation

This is the interim report Bridgewater State University created in preparation for the accreditation review from the Commission on Institutions of Higher Education, New England Association of Schools and Colleges.

Can Windbreaks Benefit Your Soil Health Management System?

Working Trees (USDA-NAC)

Yes, windbreaks can benefit your soil health management system.

Simple Method For Markerless Gene Deletion In Multidrug Resistant Acinetobacter Baumannii, Bindu Subhadra, Man Hwan Oh, Chul Hee Choi

Faculty Publications - Biological Sciences

No abstract provided.

Chaperoning Ef Hands That Shape Calcium Response: Ncald, Hpca And S100b, Jingyi Zhang

Graduate School of Biomedical Sciences Theses and Dissertations

All organisms have an internal clock with a defined period between repetitions of activities. The period for circadian clock in human is 24.5 hours, while in mouse and rat, it is 23.5 hours. However, all organisms are forced to be in synchronization with their environment. A major environmental force that resets the internal clock to 24 hours is light. This phenomenon is defined as “light entrainment” or “phase-setting”. It is unclear how this entrainment process occurs. Studies from this laboratory indicate a role for two neuronal calcium sensor proteins: Neurocalcin  (NCALD) and S100B. For these two genes, mRNA as …

People -- Marine Mammal Interactions, Andrew Butterworth, Mark P. Simmonds

Our relationships with marine mammals are complex. We have used them as resources, and in some places this remains the case; viewed them as competitors and culled them (again ongoing in some localities); been so captivated and intrigued by them that we have taken them into captivity for our entertainment; and developed a lucrative eco-tourism activity focused on them in many nations. When we first envisaged this special topic, we had two overarching aims:

Firstly, we hoped to generate critical evaluation of some of our relationships with these animals.

Secondly, we hoped to attract knowledgeable commentators and experts who might …

International Consensus Principles For Ethical Wildlife Control, Sara Dubois, Nicole Fenwick, Erin A. Ryan, Liv Baker, Sandra E. Baker, Ngaio J. Beausoleil, Scott Carter, Barbara Cartwright, Federico Costa, Chris Draper, John Griffin, Adam Grogan, Gregg Howald, Bidda Jones, Kate E. Littin, Amanda T. Lombard, David J. Mellor, Daniel Ramp, Catherine A. Schuppli, David Fraser

Ethics and Conservation Biology Collection

Human–wildlife conflicts are commonly addressed by excluding, relocating, or lethally controlling animals with the goal of preserving public health and safety, protecting property, or conserving other valued wildlife. However, declining wildlife populations, a lack of efficacy of control methods in achieving desired outcomes, and changes in how people value animals have triggered widespread acknowledgment of the need for ethical and evidence-based approaches to managing such conflicts. We explored international perspectives on and experiences with human–wildlife conflicts to develop principles for ethical wildlife control. A diverse panel of 20 experts convened at a 2-day workshop and developed the principles through a …

Report On Owned Dog Population Survey In Lapu-Lapu City, Philippines, Kazami Joanne Amano, Tamara Kartal, Amit Chaudhari

Demography and Statistics for Companion Animal Populations Collection

The Philippines has consistently been one of the top countries with an existing rabies problem. There is an average of 200 human rabies deaths reported annually, the majority of which are caused by dog bites (Deray, 2015). Globally, more than 95% of human rabies cases have been reported to have domestic dogs as their sources of infection (Cleaveland, et al., 2006). Therefore, it is paramount to address the rabies problem by focusing on the source. It has been established that communities achieve at least 70% vaccination coverage of the dog population to eliminate canine rabies (WHO, 2015) and maintain the …

Macalester Today Fall 2017, Macalester College

Macalester Today

No abstract provided.

Isu Today- August 25, 2017, Indiana State University, Communications And Marketing

University Announcements - ISU Today

No abstract provided.

Assessing The Primary Drivers Of The Abundance And Diversity Of Elasmobranchs On Caribbean Coral Reefs, Gina Marie Clementi

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

In response to the decline of reef-associated sharks in the greater-Caribbean due to overexploitation, several nations have enacted fisheries legislation to minimize and/or prohibit shark fishing. Despite the establishment of shark sanctuaries (e.g. The Bahamas), most nations have minimal shark fishery management outside of well-established marine reserves (e.g. Belize). I hypothesized that the diversity and abundance of exploited elasmobranchs (Caribbean reef shark Carcharhinus perezi, blacknose shark Carcharhinus acronotus, Atlantic sharpnose shark Rhizoprionodon terraenovae, Caribbean sharpnose shark Rhizoprionodon porosus, tiger shark Galeocerdo cuvier, great hammerhead shark Sphyrna mokarran, lemon shark Negaprion brevirostris) would be primarily driven by direct fishing pressure while …

Physiological And Pathological Regulation Of Bioenergetic Homeostasis And Oncogenesis By Pi3k P110?, Jennifer Leigh Deleon

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

In multicellular organisms, nutrient uptake and metabolism are tightly regulated in response to growth factor availability through the trafficking of nutrient transporters. Oncogenic transformation is often associated with abnormal nutrient uptake and metabolism. Previous work demonstrated that Phosphoinositide 3-kinase (PI3K) p110? regulates intracellular membrane trafficking by modulating the small GTPase, Rab5. In this study, we used a SILAC mass spectrometry approach to identify plasma membrane proteins and novel endocytic cargos whose abundance is regulated by p110?. Among the peptides identified, the plasma membrane-associated glucose transporter, GLUT1, was increased in p110?-deficient cells, which correlated with increased uptake and metabolic processing of …

Juvenile Radiation Dose Comparison And Analysis Of Traditional Radiographs And Cone Beam Computed Tomography Volumetric Images In The Assessment Of Root Resorption Associated With Maxillary Impacted Canines, Hee Gi An

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Ectopic eruption and impaction of the permanent maxillary canines represent a significant problem of dental development, occurring in 1% to 3% of the population. Careful observation of the development and eruption of maxillary canines is necessary in growing patients as canine impaction can result in serious sequelae to the dentition. A major sequela associated with impaction of maxillary canines is external root resorption of neighboring teeth. Root resorption is often clinically asymptomatic and mainly discovered during radiographic examination. Accurate diagnosis of canine position and detection of possible root resorption of adjacent teeth can significantly impact the orthodontic-surgical treatment planning. The …

Interactive Effects Of Thermal Stress, Acidification, And Hypoxia On Growth And Survival Of Juvenile Bivalves, Alexandra Marie Stevens

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Historically, coastal regions have supported large populations of biologically and commercially important shellfish species. However, in recent decades, the sustainability of these populations has been threatened by climate change processes that are contributing toward rising temperatures, hypoxic conditions, and acidified waters. Additionally, coastal zones receive river water, groundwater, and other sources of nutrient loading that further promote hypoxia and acidification. While previous studies have examined the individual effects of thermal stress, acidification, and hypoxia on bivalves, the interactions of these climate change stressors on these shellfish are poorly understood. My thesis was designed to investigate the interactive effects of thermal …

Developing A Novel Method To Explore The Ubiquitin Substrate Spectrum Of The Ubiquitin Conjugating Enzyme Ubc4, Grace Ai Peng Tan

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The ubiquitin-proteasome system (UPS) regulates a myriad of signaling pathways to maintain cellular homeostasis. UPS function hinges on the conjugation of a small, highly conserved protein called ubiquitin (Ub) to target proteins. Ubiquitinated proteins can be targeted to many downstream processes such as degradation, cellular trafficking, and DNA repair. It is unsurprising, then, that aberrations in the UPS are implicated in diseases such as cancer and neurodegenerative disorders. Ub is conjugated to substrates via the sequential action of three enzymes – E1, E2, and E3. The E2 and E3 enzymes dictate the substrate specificity of the UPS. Thus, elucidating the …

Sulfur Cycling In The Cariaco Basin And The Meromictic Green Lake In Fayetteville, New York, Kristen Ann Butler

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

An imbalance in the flux of oxidants and reductants to the suboxic zone (which lies between layers containing oxygen (O2) and hydrogen sulfide (H2S)) has been observed in many anoxic basins. These basins also have high levels of chemoautotrophy and elemental sulfur in the suboxic zone, which is defined here as the region where oxygen levels are < 2µM and sulfide levels are < 2µM. It has been hypothesized that there is a ‘cryptic sulfur cycle’ in the suboxic zone that is mediated by sulfate (SO42–) reducers and sulfide oxidizers. This study examines elemental sulfur in the Cariaco Basin and a meromictic lake using HPLC and Raman microspectroscopy techniques to evaluate if the elemental sulfur is produced by biological or chemical oxidation. Concentrations of particulate sulfur (> 0.2µm) and total zerovalent sulfur (TZVS made up of particulate sulfur, colloidal sulfur, and polysulfides) were determined in the suboxic zone of the Cariaco Basin in November 2014 and 2015. Analysis of samples from November 2015 with Raman microspectroscopy found sulfur inside cells …