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Plant-Expressed Cocaine Hydrolase Variants Of Butyrylcholinesterase Exhibit Altered Allosteric Effects Of Cholinesterase Activity And Increased Inhibitor Sensitivity, Katherine E. Larrimore, I. Can Kazan, Latha Kannan, R. Player Kendle, Tameem Jamal, Matthew Barcus, Ashini Bolia, Stephen Brimijoin, Chang-Guo Zhan, S. Banu Ozkan, Tsafrir S. Mor

Molecular Modeling and Biopharmaceutical Center Faculty Publications

Butyrylcholinesterase (BChE) is an enzyme with broad substrate and ligand specificities and may function as a generalized bioscavenger by binding and/or hydrolyzing various xenobiotic agents and toxicants, many of which target the central and peripheral nervous systems. Variants of BChE were rationally designed to increase the enzyme’s ability to hydrolyze the psychoactive enantiomer of cocaine. These variants were cloned, and then expressed using the magnICON transient expression system in plants and their enzymatic properties were investigated. In particular, we explored the effects that these site-directed mutations have over the enzyme kinetics with various substrates of BChE. We further compared the …

Garden Of Plenty, University Of Dayton

College of Arts and Sciences Newsroom

Inspired by environmental biology and sustainability, energy and the environment students, and led by the Hanley Sustainability Institute and facilities management, the University of Dayton Kennedy Union rooftop garden will provide a campus hub for sustainability education, improved aesthetics and a cooler roof that can lower the building's energy costs, and send cleaner water into storm sewers.

Silver Rating Shows Major Progress For Campus Sustainability, September 5, 2017, University Of South Florida St. Petersburg Office Of University Advancement.

USF St. Petersburg Campus News and Press Releases

No abstract provided.

Barr Peer Advisers Helping Science Students Thrive, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

C. Elegans Avoids Toxin-Producing Streptomyces Using A Seven Transmembrane Domain Chemosensory Receptor, Alan Tran, Angelina Tang, Colleen O’Loughlin, Anthony Balistreri, Eric Chang, Doris Coto Villa, Joy Li, Aruna Varshney, Vanessa Jimenez, Jacqueline Pyle, Bryan Tsujimoto, Christopher Wellbrook, Christopher Vargas, Alex Duong, Nebat Ali, Sarah Matthews, Samantha Levinson, Sarah Woldemariam, Sami Khuri, Martina Bremer, Daryl Eggers, Noelle L’Etoile, Laura Miller Conrad, Miri Vanhoven

Faculty Publications, Chemistry

Predators and prey co-evolve, each maximizing their own fitness, but the effects of predator–prey interactions on cellular and molecular machinery are poorly understood. Here, we study this process using the predator Caenorhabditis elegans and the bacterial prey Streptomyces, which have evolved a powerful defense: the production of nematicides. We demonstrate that upon exposure to Streptomyces at their head or tail, nematodes display an escape response that is mediated by bacterially produced cues. Avoidance requires a predicted G-protein-coupled receptor, SRB-6, which is expressed in five types of amphid and phasmid chemosensory neurons. We establish that species of Streptomyces secrete dodecanoic acid, …

Carroll Presents Microbiology Research At Gordon Research Conference, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Biological Sciences Graduates Two Grad Students Over Summer, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Evaluating Multiple Causes Of Persistent Low Microwave Backscatter From Amazon Forests After The 2005 Drought, Stephen E. Frolking, Stephen Hagen, Bobby H. Braswell, Thomas E. Milliman, Christina Herrick, Seth Peterson, Dar Roberts, Michael Keller, Michael W. Palace

All Materials

Amazonia has experienced large-scale regional droughts that affect forest productivity and biomass stocks. Space-borne remote sensing provides basin-wide data on impacts of meteorological anomalies, an important complement to relatively limited ground observations across the Amazon’s vast and remote humid tropical forests. Morning overpass QuikScat Ku-band microwave backscatter from the forest canopy was anomalously low during the 2005 drought, relative to the full instrument record of 1999–2009, and low morning backscatter persisted for 2006–2009, after which the instrument failed. The persistent low backscatter has been suggested to be indicative of increased forest vulnerability to future drought. To better ascribe the cause …

Key Factor Identified In Gene Silencing, Jeff Hansen

Browse All News

No abstract provided.

Preventing Neurodegenerative Memory Loss In Hopfield Neuronal Networks Using Cerebral Organoids Or External Microelectronics, M. Morrison, P. D. Maia, J. N. Kutz

Mathematics Faculty Publications - Archive

Developing technologies have made significant progress towards linking the brain with brain-machine interfaces (BMIs) which have the potential to aid damaged brains to perform their original motor and cognitive functions. We consider the viability of such devices for mitigating the deleterious effects of memory loss that is induced by neurodegenerative diseases and/or traumatic brain injury (TBI). Our computational study considers the widely used Hopfield network, an autoassociative memory model in which neurons converge to a stable state pattern after receiving an input resembling the given memory. In this study, we connect an auxiliary network of neurons, which models the BMI …

Enrichment Of Beneficial Bacteria In The Skin Microbiota Of Bats Persisting With White-Nose Syndrome, Virginie Lemieux-Labonté, Anouk Simard, Craig K. R. Willis

KIP Articles

Background Infectious diseases of wildlife are increasing worldwide with implications for conservation and human public health. The microbiota (i.e. microbial community living on or in a host) could influence wildlife disease resistance or tolerance. White-nose syndrome (WNS), caused by the fungus Pseudogymnoascus destructans (Pd), has killed millions of hibernating North American bats since 2007. We characterized the skin microbiota of naïve, pre-WNS little brown bats (Myotis lucifugus) from three WNS-negative hibernation sites and persisting, previously exposed bats from three WNS-positive sites to test the hypothesis that the skin microbiota of bats shifts following WNS invasion. Results Using high-throughput 16S rRNA …

Conjugated Linoleic Acid Rich Vegetable Oil Production Using Heterogeneous Catalysis, Andrew Proctor, Chuanmin Ruan

Patents Granted

The invention is directed to CLA-rich vegetable oil production from linoleic rich oils by heterogeneous catalysis. The process produces conjugated PUFA in triglyceride form, preferably at least 20% CLA-rich, by isomerization of a non-conjugated PUFA in vegetable oils using a heterogeneous transition metal catalyst promoted by an organic acid and/or thiol-containing compound. The heterogeneous catalysis isomerization process can use steam/vacuum distillation, hydrogenation unit and/or deodorization to produce CLA-rich soy oil. After processing, any catalyst residue may be removed by filtration, beaching, deodorizing, adsorbents or centrifugation to obtain high quality, CLA-rich oils.

Garden Of Plenty, University Of Dayton

News Releases

Inspired by environmental biology and sustainability, energy and the environment students, and led by the Hanley Sustainability Institute and facilities management, the University of Dayton Kennedy Union rooftop garden will provide a campus hub for sustainability education, improved aesthetics and a cooler roof that can lower the building's energy costs, and send cleaner water into storm sewers.

Categorized, Indexed, And Tagged, Alexander Bourque

Honors Theses

No abstract provided.

Sheaf Theoretic Formulation For Consciousness And Qualia And Relationship To The Idealism Of Non-Dual Philosophies, Menas Kafatos, Goro Kato

Mathematics, Physics, and Computer Science Faculty Articles and Research

Questions about the nature of reality, whether Consciousness is the fundamental reality in the universe, and what is Consciousness itself, have no answer in systems that assume an external reality independent of Consciousness. Ultimately, the ontological foundation of such systems is the absolute division of subject and object. We advocate instead what we consider to be an approach that is in agreement with the foundation of quantum reality, which is based on Rāmānuja’s version of Vedanta philosophy and non-dual Kashmir Śaivism. Quantum mechanics opened the door to consciousness, but it cannot account for consciousness. However, the quantum measurement problem implies …

Um Cancer Institute Researchers Receive International Recognition, Cynthia Wall

University of Mississippi News

Team honored for work revealing bacterial role in echinacea's immune-boosting power

The Bg News September 05, 2017, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. September 05, 2017. Volume 97-Issue 6.

Week Of September 5, 2017, New York Medical College

InTouch

• NYMC Mourns the Death of Former President and Chief Executive Officer Harry C. Barrett, D.Min., M.P.H.
• Ph.D. Candidate Awarded Prestigious NIH Fellowship
• M.P.H. Student Brings Passion for Medicine, Public Health and Sports Together in Guyana
• Join NYMC for the Founder's Dinner

September 5, 2017: Welcome From The Provost, Saint Mary's College Of California

SMC Bulletin 2013-2020

No abstract provided.

Southern Annular Mode Drives Multicentury Wildfire Activity In Southern South America, Andrés Holz, Juan Paritsis, Ignacio A. Mundo, Thomas T. Veblen, Thomas Kitzberger, Grant J. Williamson, Ezequiel Aráoz, Carlos Bustos-Schindler, Mauro E. González, H. Ricardo Grau, Juan M. Quezada

Geography Faculty Publications and Presentations

The Southern Annular Mode (SAM) is the main driver of climate variability at mid to high latitudes in the Southern Hemisphere, affecting wildfire activity, which in turn pollutes the air and contributes to human health problems and mortality, and potentially provides strong feedback to the climate system through emissions and land cover changes. Here we report the largest Southern Hemisphere network of annually resolved tree ring fire histories, consisting of 1,767 fire-scarred trees from 97 sites (from 22 °S to 54 °S) in southern South America (SAS), to quantify the coupling of SAM and regional wildfire variability using recently created …

The Prospector, September 5, 2017, Utep Student Publications

The Prospector

Headline: UTEP Football is Celebrating 100 Years

Newsroom, Georgia Southern University

Newsroom (2006-2023)

• Area educators invited to attend Georgia International Conference on Information Literacy Sept. 15-16
• Georgia Southern University College of Business named a Key Institution in Business and Management Education Research
• Georgia Southern College of Business launches mobile App
• Man on a mission: Chad Asplund helps athletes reach their goals

Connect Oer Annual Report, 2016-2017, Brady Yano

Copyright, Fair Use, Scholarly Communication, etc.

Earlier this year, SPARC launched Connect OER—a platform to share and discover information about Open Educational Resources (OER) activities at campuses across North America. Through Connect OER, academic libraries create and manage profiles about their institution’s efforts on OER, producing valuable data that we use to populate a searchable directory and produce an annual report.

As the first Connect OER Annual Report, this document summarizes insights from the Connect OER pilot, which ran from May - July 2017. The data encompass 65 SPARC member libraries spanning 31 U.S. states and five Canadian provinces who participated in the pilot. Our analysis …

On Sequential Estimation Of Multivariate Associations, Aditya Mishra

Doctoral Dissertations

In multivariate analysis, one of the major problems of interest is to model multivariate responses using observed predictors. We often encounter responses of either continuous, binary or count types, or may be of mixed types. Multivariate linear regression (MLR) models the relationship in case of Gaussian outcomes. When outcomes are non-Gaussian or mixed types, i.e., generalized, a possible modeling approach proceeds via maximization of likelihood obtained after assuming conditionally independent observed outcomes are from exponential dispersion family. In high-dimensional setting, responses maybe interrelated and predictors maybe correlated or unimportant. Such dependency can be induced through a low-rank and sparse coefficient …

The George-Anne, Georgia Southern University

The George-Anne

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Interest Exceeds Understanding In Public Support Of Bee Conservation, Joseph S. Wilson, Matthew L. Forister, Olivia Messinger Carril

Biology Faculty Publications

Recent analyses suggesting that certain populations of bees may be declining have led to a variety of conservation efforts, many of which rely on public support and participation. However, little is known about the public's knowledge of bee diversity. We carried out a survey to measure public understanding of bee diversity and found that although 99% of respondents believed that bees are critical or important, only 14% were able to guess within 1000 the actual number of bee species in the US. Furthermore, when reviewing a selection of photographs depicting various insects, many respondents were unable to discern bees from …

Mainstreaming Marine Biodiversity Into The Sdgs: The Role Of Other Effective Area-Based Conservation Measures (Sdg 14.5), Daniela Diz, David Johnson, Michael Riddell, Sian Rees, Jessica Battle, Kristina Gjerde, Sebastian Hennige, J. Murray Roberts

School of Biological and Marine Sciences

No abstract provided.

Student Movement - Issue 1, Andrews University

Student Movement v. 102 (2017-2018)

Issue 1

Riparian Plant Litter Quality Increases With Latitude, Luz Boyero, Manuel A. S. Graça, Alan M. Tonin, Javier Pérez, Andrew J. Swafford, Verónica Ferreira, Andrea Landeira-Dabarca, Markos A. Alexandrou, Mark O. Gessner, Brendan G. Mckie, Ricardo J. Albariño, Leon A. Barmuta, Marcos Castillo, Julián Chará, Eric Chauvet, Jose Checo Colón-Gaud, David Dudgeon, Andrea C. Encalada, Ridcardo Figueroa, Alexander S. Flecker, Tadeusz Fleituch, André Frainer, José F. Gonçalves Jr., Julie E. Helson, Tomoya Iwata, Jude Mathooko, Charles M'Erimba, Catherine M. Pringle, Alonso Ramírez, Christopher M. Swan, Catherine M. Yule, Richard G. Pearson

Biology: Faculty Publications

Plant litter represents a major basal resource in streams, where its decomposition is partly regulated by litter traits. Litter-trait variation may determine the latitudinal gradient in decomposition in streams, which is mainly microbial in the tropics and detritivore-mediated at high latitudes. However, this hypothesis remains untested, as we lack information on large-scale trait variation for riparian litter. Variation cannot easily be inferred from existing leaf-trait databases, since nutrient resorption can cause traits of litter and green leaves to diverge. Here we present the first global-scale assessment of riparian litter quality by determining latitudinal variation (spanning 107°) in litter traits (nutrient …

Clean Water, Clean Life: Promoting Healthier, Accessible Water In Rural Appalachia, Erin Arcipowski, John Schwartz, Lisa Davenport, Meghan Hayes, Tracy Nolan

Journal of Contemporary Water Research and Education

In the rural Appalachian region of the United States, thousands of residents struggle with issues of water quality and accessibility. Vulnerabilities of poverty, isolation, and rough geographical terrain complicate life for Appalachians who need access to adequate water supply and septic systems. In 2013, an inter-professional team of nursing, architecture, engineering, and law enforcement faculty and students developed a water-focused collaboration with community members in southeastern Kentucky. Greater accessibility to clean drinking water is a critical need in the area. Collaborative community engagement yielded effective and sustainable interventions. Inter-professional teams completed N=30 comprehensive home assessments examining factors such as water …