Digital Commons Network^™

Long Days Enhance Recognition Memory And Increase Insulin-Like Growth Factor 2 In The Hippocampus, Adriano Dellapolla, Ian Kloehn, Harshida Pancholi, Ben L. Callif, David Wertz, Kayla Rohr, Matthew M. Hurley, Kimberly Baker, Samer Hattar, Marieke R. Gilmartin, Jennifer A. Evans

Biomedical Sciences Faculty Research and Publications

Light improves cognitive function in humans; however, the neurobiological mechanisms underlying positive effects of light remain unclear. One obstacle is that most rodent models have employed lighting conditions that cause cognitive deficits rather than improvements. Here we have developed a mouse model where light improves cognitive function, which provides insight into mechanisms underlying positive effects of light. To increase light exposure without eliminating daily rhythms, we exposed mice to either a standard photoperiod or a long day photoperiod. Long days enhanced long-term recognition memory, and this effect was abolished by loss of the photopigment melanopsin. Further, long days markedly altered …

The "Eyes" Have It?-Intra- And Inter-Observer Reproducibility Of The Pd-L1 Companion Diagnostic Assay, Steven G. Gray, Mark Wright, Stephen Finn

Articles

No abstract available.

Impact Of Supplemental Home Enteral Feeding Postesophagectomy On Nutrition, Body Composition, Quality Of Life, And Patient Satisfaction, C.L. Donohoe, L.A. Healy, M. Fanning, Suzanne Doyle, A. Mchugh, J. Moore, N. Ravi, J.V. Reynolds

Articles

The aim of this prospective cohort study is to analyze the impact of supplemental home enteral nutrition (HEN) post-esophageal cancer surgery on nutritional parameters, quality of life (QL), and patient satisfaction. A systematic review reported that over 60% of patients lose >10% of both body weight and BMI by 6 months after esophagectomy. Enteral feeding (EF) is increasingly a modern standard postoperatively; however, the impact of extended HEN postdischarge has not been systematically studied. One hundred forty-nine consecutive patients [mean age 62 ± 9, 80% male,76% adenocarcinoma, 66% on multimodal protocols, and 69% with BMI ≥ 25 kg/m2] were studied. …

Cancer Incidence In Ireland—The Possible Role Of Diet, Nutrition And Lifestyle, Daniel Mccartney, Declan Byrne, Marie Cantwell, Michael Turner

Articles

Aim This observational ecological study aims to compare Ireland’s age-specific cancer incidence rates (ASRs) with equivalent European and global data and to highlight possible dietary, nutritional and lifestyle contributors to cancer in Ireland.

Subjects and methods Using the International Agency for Research on Cancer’s (IARC) GLOBOCAN database, Irish ASRs for all-site cancer and for "lifestyle-related" cancers such as those of the colo-rectum, oesophagus, breast, lung and prostate were compared with European and global incidence data. Irish dietary and nutrient intake data were reviewed and evaluated in the context of these cancer incidence data and in relation to the established dietary, …

Pcr-Ribotype Distribution Of Clostridium Difficile In Irish Pigs, Katharina Stein, Sarah Egan, Helen Lynch, Celine Harmanus, Lorraine Kyne, Celine Herra, Sinead Mcdermott, Ed Kuijper, Fidelma Fitzpatrick, Susan Fitzgerald, Lynda Fenelon, Denise Drudy

Articles

Clostridium difficile is an important enteric pathogen in humans causing infections in the healthcare environment and the community. Carriage of C. difficile and C. difficile-related enterocolitis has been reported in piglets worldwide. The aim of this study was to investigate the rates of C. difficile isolation from pigs in Ireland. Faecal samples from piglet litters and sows were collected from six farms in 2015. The sows were non-diarrhoeal at the time of sampling. The diarrhoeal status of the piglets was unknown. C. difficile was isolated from 34/44 (77%) of piglet litter samples and from 33/156 (21%) of sow samples. The …

Adolescents' Self-Described Transformations And Their Alignment With Transformative Learning Theory, Katie Titus Larson

Antioch University Dissertations & Theses

This phenomenological, collaborative inquiry explored the depth of two adolescent girls’ lived experiences during their high school years and the degree to which their self-described transformative incidents aligned with transformative learning theory.Traditionally this theory has been reserved for adults, yet the current paradigm may have overlooked the capabilities of modern adolescents to not only experience, but to describe and interpret transformative learning in ways both similar to and unique from adults.My two 19-year-old co-researchers and I examined four years of their self-identified transformative incidents by breaking them into components, analyzing the language within, and seeking evidence of critical self-reflection throughout; …

The Effects Of Gender And Perception Of Community Safety On Happiness, Jennifer K. Daffon

Antioch University Dissertations & Theses

Income-based indicators of happiness have been shown to be limited in their ability to predict happiness. Alternative measures of happiness have been gaining prominence in happiness research, and two predictors of happiness were investigated in the current study. The extent to which happiness (measured by affect, life satisfaction, and psychological well-being) could be predicted by gender and perception of community safety was investigated with 19,644 participant responses to The Happiness Alliance Survey. Multiple linear regression models indicated that gender and community safety are significant predictors of affect, life satisfaction, and psychological well-being. The effect of the predictor variables was similar …

Leading Change In Complex Systems: A Paradigm Shift, Cheryl Lemaster

Antioch University Dissertations & Theses

This qualitative study is an in-depth exploration of the experiences of 20 executive-level leaders from American corporations, government agencies, hospitals, and universities.At the heart of this investigation are stories that reveal the challenge of leading change in complex systems from the leader perspective, creating an opportunity to explore sense-making and sense-giving as guided by individual values and organizational contexts.Complexity Science, the framework for this research, is the study of relationships within and among systems.The aim of approaching this research from a complexity perspective is to gain a more realistic view of the issues and challenges that leaders face during change, …

Elements Of Effective Interorganizational Collaboration: A Mixed Methods Study, Patricia A. Greer

Antioch University Dissertations & Theses

Interorganizational collaboration is a process used by committed stakeholders within a problem domain to solve 'messy’ or complex issues. Joint identification and resolution of complex problems is achieved through an iterative process, using elements for success: committed members, resources, time, communication, trust, shared goal, defined process, and collective identity. This study utilized an exploratory sequential mixed methods process as a practical approach, resulting in richer data and increased understanding of the phenomenon of collaboration. The guiding research problem explored which elements influence successful collaborations and, specifically, how collective identity is developed, sustained, and related to the perception of success. The …

Rhizomatic Learning And Adapting: A Case Study Exploring An Interprofessional Team's Lived Experiences, Renee Charney

Antioch University Dissertations & Theses

The purpose of this theoretical case study was to explore the lived experiences of members within an inter-professional team about how they learn and adapt while dedicating their lives toward the well-being of students residing in and attending a rehabilitation home school. Although there is broad literature that addresses legacy learning theories and frameworks, as well as complex-adaptive organizations, very little shows how the application of rhizome philosophy principles address learning and adapting within an organizational context. This study is a step toward addressing that gap. Using interviews, thematic analysis, and storyline networking, the study explored in depth the lived …

Transracial Adoptees’ Thoughts On Culturally Competent Parenting, Molly Conley

Antioch University Dissertations & Theses

Transracial adoption, the adoption of a child of a different race than those of the adoptive parents, occurs in approximately 40% of all adoptions. While transracial adoption alone is not sufficient to cause mental health concerns, it does pose a series of unique challenges that can impact self-esteem, racial identity, and sense of belonging in adoptees. Much of the research on adoption focuses on adoptive parents, collecting quantitative data from adoptees, and mental health professionals’ views of adoptees’ experiences. This study elicited feedback from adult transracial adoptees on Vonk’s 2001 model of culturally competent parenting. Data were interpreted using Interpretive …

Design Thinker Profile: Creating And Validating A Scale For Measuring Design Thinking Capabilities, Dani Chesson

Antioch University Dissertations & Theses

This study developed a scale for assessing design thinking capabilities in individuals. Many organizations today are turning to design thinking to tackle the complex challenges they face. As organizations move toward adopting this way of working the need to develop design thinking capabilities in individuals becomes imperative. The capabilities needed for engaging in design thinking are skills that we all have to some varying degree, but we do not all use them to their full potential when solving problems. The scale developed in this study measures the degree to which an individual uses design thinking capabilities when engaged in problem …

Spring/Summer 2017

University of Richmond Magazine

No abstract provided.

"Through A Glass, Darkly" Technical, Policy, And Financial Actions To Avert The Coming Digital Dark Ages, Richard S. Whitt

Santa Clara High Technology Law Journal

"Through A Glass, Darkly" Technical, Policy, and Financial Actions to Avert the Coming Digital Dark Ages

The Frontier In Paris: Artists From The American West In The French Capital, 1890–1900, James R. Swensen

Faculty Publications

From 1890 to 1900 several artists traveled from the American West to Paris to advance their studies. Coming from the “wild West,” the French capital represented for them the most sophisticated city on earth. Interestingly, they found Paris to be a place of danger and adventure, a frontier of its own right. They also discovered that their European peers longed for images of a frontier West that included Native Americans, cowboys, and wild animals. Through their experiences in this new and exotic land, artists from Robert Henri to Cyrus Dallin learned that the frontier was more of a state of …

Attitudes And Beliefs Of North Dakota Early Childhood Educators Toward Gender Constructs, Janelle Jean Ferderer

Theses and Dissertations

The purpose of this qualitative study was to examine the attitudes and beliefs about gender and gender diversity held by certified practicing early childhood teachers in North Dakota Department of Public Instruction approved preschool programs. Selected children’s books were used to elicit qualitative responses that provided insight into teachers’ beliefs, attitudes, and practices regarding gender.

The theoretical framework for the study was based on Vygotsky’s theories on the Zones of Proximal Development (ZPD) and the More Knowledgeable Other (MKO), which focus on the importance of the role of educators’ influence in the social development of young children. The methodology for …

Using The Expectancy-Value Theory To Understand Why Women Persist Or Leave Collegiate Stem Programs: A Mixed Methods Study, Joseph Appianing

Theses and Dissertations

Concerns have been raised about the ability of the U.S. to maintain its global technological competitive advantage in the future because of American college students’ attitudes—particularly women—toward STEM programs and careers (Chen, 2013; Ehrenberg, 2010; Palmer & Wood, 2013). Many female students graduate from high school academically well-prepared to pursue STEM majors, and many choose to pursue STEM majors in college, yet many also leave those majors (Chen, 2015; Hill, Corbett, & Rose, 2010). Theories such as perceived value and expectations for success (Eccles et al., 1983), self-efficacy (Bandura, 1977, 1986), and self-determination (Deci & Ryan, 1985) have been advanced …

Feminism And Economic Inequality, Katharine T. Bartlett

Faculty Scholarship

No abstract provided.

Pharmaceutical M&A Activity: Effects On Prices, Innovation, And Competition, Barak D. Richman, Will Mitchell, Elena Vidal, Kevin Schulman

Faculty Scholarship

The rise of blockbuster pharmaceutical acquisitions has prompted fears that unprecedented market concentration will weaken competition. Two of the most prominent concerns focus on the upstream and downstream ends of the pharmaceutical industry: (1) the concern that these mergers will concentrate the market for discovery and will therefore lead to fewer discoveries; and (2) the concern that merging large marketing, sales, and distribution forces will strengthen the hands of select pharmaceutical manufacturers and weaken downstream competition. Having considered potential dynamic effects in the industry and conducted a series of preliminary interviews with knowledgeable observers, though, this Article argues that neither …

The U.S. Culture Collection Network Responding To The Requirements Of The Nagoya Protocol On Access And Benefit Sharing, Kevin Mccluskey, Katharine B. Barker, Hazel A. Barton, Kyria Boundy-Mills, Daniel R. Brown, Jonathan A. Coddington, Kevin Cook, Philippe Desmeth, David Geiser, Jessie A. Glaeser, Stephanie Greene, Seogchan Kang, Michael W. Lomas, Ulrich Melcher, Scott E. Miller, David R. Nobles Jr., Kristina J. Owens, Jerome H. Reichman, Manuela Da Silva, John Wertz, Cale Whitworth, David Smith

Faculty Scholarship

The U.S. Culture Collection Network held a meeting to share information about how culture collections are responding to the requirements of the recently enacted Nagoya Protocol on Access to Genetic Resources and the Fair and Equitable Sharing of Benefits Arising from their Utilization to the Convention on Biological Diversity (CBD). The meeting included representatives of many culture collections and other biological collections, the U.S. Department of State, U.S. Department of Agriculture, Secretariat of the CBD, interested scientific societies, and collection groups, including Scientific Collections International and the Global Genome Biodiversity Network. The participants learned about the policies of the United …

Gvsu Undergraduate And Graduate Catalog, 2017-2018, Grand Valley State University

Course Catalogs, 1963 - Current

Grand Valley State University 2017-2018 undergraduate and/or graduate course catalog published annually to provide students with information and guidance for enrollment.

Regulating Cumulative Risk, Sanne H. Knudsen

Articles

This Article proceeds in four parts. Part I describes how cumulative risk assessments tackle the real-world exposure problems that lie at the heart of public health. It shows how risk science has evolved and why policy, not science, lags behind. Part II then examines why key public health concerns cannot be answered through information disclosure or consumer choice models alone.

Having established that regulatory drivers are needed, Part III begins to examine how to move forward. It does so by looking backward and examining how TSCA and FIFRA have failed historically to provide this critical public health focus despite room …

Lake Kanasatka, Cooperative Extension

UNH Cooperative Extension

No abstract provided.

Charting The Middle Course: An Argument For Robust But Well-Tailored Health Care Discrimination Protection For The Transgender Community, John E. Farmer

Georgia Law Review

Section 1557 of the Patient Protection and Affordable
Care Act offers sweeping discriminationprotections for
patients, applicable to both health insurers and health
care providers who receive federal funding or are
subject to federal administration. Placing itself in the
canon of federal antidiscriminationlaws, Section 1557
incorporates Title IX of the Education Amendments of
1972 to prohibit discrimination on the basis of sex.
Just how sweeping this aspect of Section 1557s
prohibitions is has been the subject of controversy
exemplified in litigation in the federal courts, as well as
in the starkly contrasting views of two presidential
administrations. The Department of Health …

Amphetamine Exposure During Embryogenesis Leads To Long-Term And Transgenerational Increase In Behavioral Response And Decrease In Dopamine Uptake, Talus J. Mccowan

Theses and Dissertations

Amphetamine (AMPH) is widely prescribed for the treatment of ADHD and a highly abused substance in society, yet little is known about the long-term effects of the drug. Here, we used Caenorhabditis elegans (C. elegans) to establish a model for the long-term and transgenerational effects of AMPH exposure on behavior. Furthermore, experiments were conducted to explore the molecular mechanisms of AMPH that were altered by embryonic AMPH exposure.

C. elegans have a well characterized behavioral response to AMPH known as Swimming Induced Paralysis (SWIP). For the SWIP test, animals are placed in fluid, which normally induces a thrashing behavior. However, …

Novel Approaches In Lignomics Employing Liquid Chromatography And Mass Spectrometry, Anastasia Alekseyevna Andrianova

Theses and Dissertations

Characterization of lignin and its degradation products, more specifically determination of their molecular weight (MW) distribution, is essential for assessment and applications of these potentially renewable phenolics. In this dissertation a suite of lignomics approaches allowing for comprehensive and accurate characterization of lignin focusing on the low and high MW species was developed. These methods may be used either in combination or independently. The methods were validated and applied to characterizing lignin and the products of its transformation.

Several size exclusion chromatography (SEC) systems were previously deemed to be suitable for MW-based separations and thus are frequently used for lignin …

Examining Deer Hunter Demographics, Perceptions, And Factors Influencing Satisfaction And Success During A Time Of Statewide Deer Population Decline, Kristen Elizabeth Black

Theses and Dissertations

North Dakota’s white-tailed deer (Odocoileus virginianus) and mule deer (O. hemionus) populations have declined significantly since their peak in 2008-2009. This may be due to heavy harvest pressure in an effort to reduce deer depredation on agricultural crops, a series of harsh winters, habitat fragmentation or loss, predation, and disease. In 2009, about 144,400 deer gun hunting licenses were allocated through a lottery system by the North Dakota Game and Fish Department (NDGF). Interest in deer hunting in North Dakota is high, with more than 69,700 resident and non-resident hunters applying for the 43,275 licenses available for the 2015 deer-gun …

Intergenerational Effects Of Embryonic Cocaine Exposure In Zebrafish, Cody Adam Boyle

Theses and Dissertations

Cocaine addiction has both genetic and environmentally driven components. Relatively recently several groups have suggested that epigenetic regulation of gene expression might be the mechanism linking environmental influence and inheritance in drug addiction. We have shown previously that embryonic cocaine exposure increases physiological and behavioral sensitivity to the drug in longitudinal adults. In this study, we provide evidence that the effects of embryonic pre-exposure to cocaine are intergenerational in zebrafish. In addition, we show how gene expression in the zebrafish telencephalon, which includes the teleost equivalent of the nucleus accumbens, changes during acute cocaine treatment during behavioral testing. These experiments …

A Comparison Study Of American Indian And Caucasian Sex Offenders On Trauma And Selected Trauma Effects, Regina Sioux Ertz

Theses and Dissertations

American Indian/Alaskan Natives (AI/AN) have a long history of documented trauma experiences. In addition, AI/AN individuals are likely to have fewer economic resources and are faced with increased traumatic experiences in comparison to the general population. Further, the American Indian population is also affected by overrepresentation with incarceration rates in federal and state government detention centers. These data support the need to address non-sexual recidivism issues in the American Indian population. Little research has examined trauma experiences, selected trauma effects, and unique differences for American Indian sex offenders. Treatment employed for American Indian sex offenders is conducted based on data …

Impact Of Wetlands Loss On The Long-Term Flood Risks Of Devils Lake In A Changing Climate, Sergey Gulbin

Theses and Dissertations

Endorheic (terminal) lakes with no water outlets are sensitive indicators of changes in climate and land cover in the watershed. Since 1990 Devils Lake watershed in North Dakota experienced a dramatic change of local climate: wet phase. This change yielded in a 10-m water level rise in just two decades. The Lake’s water level increase caused flooding of adjacent areas, including towns, agriculture fields and houses of Native Americans, costing over $1 billion in mitigation.

While the climate change contribution to flooding has been established, the role of large scale land conversion to agriculture has not been researched. The purpose …