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2017

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Functional Characterization Of Natural Sunscreen Compound Mycosporine-2-Glycine From Extremophilic Cyanobacterium Halothece Sp. Pcc 7418 In Macrophage Cell Line And Fresh Water Cyanobacterium, Supamate Tarasuntisuk Jan 2017

Functional Characterization Of Natural Sunscreen Compound Mycosporine-2-Glycine From Extremophilic Cyanobacterium Halothece Sp. Pcc 7418 In Macrophage Cell Line And Fresh Water Cyanobacterium, Supamate Tarasuntisuk

Chulalongkorn University Theses and Dissertations (Chula ETD)

Mycosporine-2-glycine (M2G) is a rare UV-screening compound in a group of mycosporine-like amino acids (MAAs). This molecule is found in only two cyanobacteria; Euhalothece sp. LK-1 and Aphanothece halophytica (Halothece sp. PCC 7418). The structure of M2G composed of 4-deoxygadusol as a core structure, attached by 2 molecules of glycine at C1 and C3 positions. M2G has a maximal adsorption at 331 nm and a better antioxidative activity than other MAAs. Thus, it is interesting in determination of other activities for further cosmeceutical and pharmaceutical applications. In this study, a high purity M2G was successfully extracted and purified from Halothece …

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Predicting Factors Of Recovery Among Persons With Major Depressive Disorder, Nusra Vorapatratorn Jan 2017

Predicting Factors Of Recovery Among Persons With Major Depressive Disorder, Nusra Vorapatratorn

Chulalongkorn University Theses and Dissertations (Chula ETD)

The purposes of this descriptive research was to examine the causal relationship between strength self-efficacy, resourcefulness, purpose in life, social support, alcohol abuse, and recovery among persons with major depressive disorder (MDD). The conceptual framework was guided by Schlotfeldt's Health Seeking Model. 444 participants with MDD. who attended outpatient department, mental health and psychiatric clinics, and mental health and psychiatric division in eight hospitals from all part of Thailand participated in this study. The participants were obtained by simple random sampling. The research instruments included a personal data sheet, the Strength Self-Efficacy Scale, the Resourcefulness Scale, the Purpose in Life …

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Prevalence Of Chronic Temporomandibular Disorder Pain And Comorbidities In A Group Of Thai Patient: A Cross Sectional Study, Tra Thu Nguyen Jan 2017

Prevalence Of Chronic Temporomandibular Disorder Pain And Comorbidities In A Group Of Thai Patient: A Cross Sectional Study, Tra Thu Nguyen

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objectives: 1. to investigate the prevalence of chronic temporomandibular disorder (TMD) and its comorbidities in a group of Thai patients; 2. to evaluate the relationship between pain parameters (pain duration, pain intensity, and pain frequency) with the number of comorbidities and widespread pain index (WPI); 3. to assess the relationship between the presence of chronic pain with familial history in TMD pain patients. Methods: A cross-sectional study was undertaken of 351 outpatients. Patients were given an interviewer-administered questionnaire which contained four parts (demographic data, pain parameters, WPI and comorbidities diagnosis). Diagnosis was made in accordance with Diagnostic Criteria for Temporomandibular …

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Patient's Perception And Satisfaction On Dental Implant Therapy By Postgraduate Dental Students And Experienced Dentists, Pat Vipattanaporn Jan 2017

Patient's Perception And Satisfaction On Dental Implant Therapy By Postgraduate Dental Students And Experienced Dentists, Pat Vipattanaporn

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objective: To evaluate and compare patient's perception and satisfaction between patients who received dental treatment from postgraduate dental students and experienced dentists. Material and methods: This descriptive cross-sectional study was performed in patients who received the dental implant from Faculty of dentistry Chulalongkorn University. A data collection of patient's perception and satisfaction was done by questionnaire which was sent by mail. The questionnaire contained 23 statements including 7 statements of demographic data, 7 statements of perception, and 9 statements of satisfaction. The patient had to answer through the one-best-answer multiple choices and visual analog scale (VAS). Results: The 382 participants …

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Comparison Of The Accuracy Of Surgical Guided Template Produced From Intraoral Scan Technique And Model Scan Technique For Implantation Using Computer Assisted Implant Surgery, Prudsaporn Kiatkroekkrai Jan 2017

Comparison Of The Accuracy Of Surgical Guided Template Produced From Intraoral Scan Technique And Model Scan Technique For Implantation Using Computer Assisted Implant Surgery, Prudsaporn Kiatkroekkrai

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objectives: To compare the accuracy of implant position placed by CAIS technique using surgical guided template produced by intraoral scan and model scan. Materials and methods: Patients who needed single tooth implant restoration were enrolled in this study and devided into two groups randomly according to the surface scan technique (n=30 each group). Intraoral scans were done using the Trios Scanner (3shape). While, diagnostic casts were scanned by D900L lab scanner (3shape). The templates were design by the clinician using coDiagnostiX software (Dental Wings Inc.). Implant surgery were performed according to fully CAIS protocol. CoDiagnostiX software was used to compare …

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In Vitro Effect Of L-Ascorbic Acid On Gingival Fibroblast To Regulate Wound Healing., Tatcha Chaitrakoonthong Jan 2017

In Vitro Effect Of L-Ascorbic Acid On Gingival Fibroblast To Regulate Wound Healing., Tatcha Chaitrakoonthong

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background and Objective: Besides closing the wound by intrinsic properties like migration and proliferation, gingival fibroblasts produce a major source of extracellular matrix especially collagen and play a major role in oral wound healing. Vitamin C or L-ascorbic acid has diverse functions in the body, including an essential role in hydroxylation reactions which is necessary for collagen formation. Whether L-ascorbic acid can promote gingival wound healing through inducing proliferation of fibroblasts is of our interest. The aim of this study is to evaluate the effect of L-ascorbic acid on gingival fibroblasts behaviors to promote wound healing in vitro. Materials and …

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Comparative Study Of In Vivo Bone Regeneration Using Chitosan/Dicarboxylic Acid Scaffold Implanted With Human Periodontal Ligament Cells, Teerawat Sukpaita Jan 2017

Comparative Study Of In Vivo Bone Regeneration Using Chitosan/Dicarboxylic Acid Scaffold Implanted With Human Periodontal Ligament Cells, Teerawat Sukpaita

Chulalongkorn University Theses and Dissertations (Chula ETD)

After tooth loss, a consequent atrophy of the alveolar process always takes place and adversely affect the reconstruction process especially by dental implant. A novel chitosan/dicarboxylic acid scaffold (CS/DA scaffold) has been developed and proven to be an excellent candidate material in bone tissue engineering. This study aimed to evaluate the effects of a CS/DA scaffold with and without seeded primary human periodontal ligament cells (hPDLCs) in mouse calvarial defect model. Eighteen mice were divided into 3 groups of 6 each. Four-millimeter calvarial defects were created on both side of parietal bone and implanted with either CS/DA scaffold or CS/DA …

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Induction Of S100a7 Expression From Mechanical Stress-Induced Human Dental Pulp Cells And Its Effect On Osteoclastogenesis, Hataichanok Charoenpong Jan 2017

Induction Of S100a7 Expression From Mechanical Stress-Induced Human Dental Pulp Cells And Its Effect On Osteoclastogenesis, Hataichanok Charoenpong

Chulalongkorn University Theses and Dissertations (Chula ETD)

Mechanical injuries of dental pulp tissues could lead to root resorption by osteoclast/odontoclast. S100A7 has been demonstrated to involve in inflammatory processes and potentially involved in bone destruction. However, the roles of S100A7 in dental pulp have not been reported. Therefore, this this study aimed to investigate the effect of mechanical stress on S100A7 expression in human dental pulp cells (hDPCs) and to investigate the effect of S100A7 protein on osteoclast differentiation. HDPCs were stimulated with in vitro compressive loading. Cell viability was determined using MTT assay. Real-time PCR (qPCR) and ELISA were utilized to determine the mRNA and protein …

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The Application Of Prostacyclin In Promoting Angiogenesis Of Dental Pulp Tissue In A Three Dimensional Organ Culture System, Sonntana Seang Jan 2017

The Application Of Prostacyclin In Promoting Angiogenesis Of Dental Pulp Tissue In A Three Dimensional Organ Culture System, Sonntana Seang

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Dental pulp vitality can be threatened by carious or iatrogenic exposure that can lead to pulp tissue loss. The formation of a vascular network is crucial to provide a suitable environment for tissue regeneration. Thus, promoting angiogenesis is essential for successful pulpal repair in regenerative endodontics therapy. Iloprost, a prostacyclin analog, promotes vascularization in several organs such as, heart, lung, and corneal. Previously, it has been demonstrated that, iloprost induced pulpal blood flow and enhanced dentin formation in a rat mechanical pulp exposure model. However, the angiogenic effect of iloprost on the human dental pulp vasculature remains unknown. Objective: …

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Differential Dendritic Cell Responses To Candida Species, Thu Nguyen Ngoc Jan 2017

Differential Dendritic Cell Responses To Candida Species, Thu Nguyen Ngoc

Chulalongkorn University Theses and Dissertations (Chula ETD)

Mannan in the outermost layer of Candida cell wall may be the first molecules that interact with host dendritic cells (DCs) and activate immune responses that determine disease outcomes. However, little is known how different mannan structures of common Candida species affect DC activation and T cell responses. Thus, this work compared the effects of mannans of Candida albicans, Candida tropicalis, Candida glabrata, Candida krusei, Candida parapsilosis and Candida dubliniensis on bone marrow-derived DC (BMDC) responses in mice. C. albicans and C. tropicalis mannan could not activate DC maturation, however, they induced IFN-gamma production which consequently provoked Th1 responses. C. …

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Expression Of Inflammatory Mediators In Cd103+ And Cd103- T Cells Isolated From Periodontitis Tissue, Benjarat Isaraphithakkul Jan 2017

Expression Of Inflammatory Mediators In Cd103+ And Cd103- T Cells Isolated From Periodontitis Tissue, Benjarat Isaraphithakkul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Despite the important role of tissue - resident memory T (TRM) cells in immunity and pathology of mucosal tissues, the study of tissue-resident memory T cells in periodontitis tissues is limited. Previous investigation in our laboratory identified the localization of TRM (CD103+ T cells) in periodontitis tissue. However, their function is not known. The aim of this study is to investigate the production of inflammatory mediators by CD103+ and CD103- T cells in periodontitis tissue. Human periodontal tissues were obtained from patients with severe chronic periodontitis. Intracellular cytokine staining was performed and expression of CD103, interferon gamma (IFN-γ), interleukin-17 (IL-17) …

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Microbial Conversion Of Cellulose To Sugars By Bacterial Enzyme, Kessara Seneesrisakul Jan 2017

Microbial Conversion Of Cellulose To Sugars By Bacterial Enzyme, Kessara Seneesrisakul

Chulalongkorn University Theses and Dissertations (Chula ETD)

This work studied the conversion of lignocellulosic materials to sugars, the intermediates for bioethanol production, by a bacterial enzyme. Due to the complex structure of lignocellulose, a cellulase enzyme cannot effectively access and hydrolyse cellulose fibers. Various pretreatment processes of lignocellulose have been studied to enhance enzymatic hydrolysis to date. In this work, corncob was firstly studied for microbial pretreatment using three microorganisms including two bacterial strains of Bacillus subtilis A 002 and Cellulomonas sp. TISTR 784 and a fungal strain of Phanerochaete sordida SK7. The results showed that the microbial pretreatment with P. sordida SK7 was the most effective …

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Metal-Salen Derivatives For Electro-Reduction Of Carbon Dioxide, Kantima Chitchak Jan 2017

Metal-Salen Derivatives For Electro-Reduction Of Carbon Dioxide, Kantima Chitchak

Chulalongkorn University Theses and Dissertations (Chula ETD)

Copper(II) salen, salophen-based ligands, and their corresponding copper complexes were prepared and utilized for the electrocatalytic reduction of carbon dioxide. Controlled-potential electrolysis of copper(II) salen electrocatalyst with carbon dioxide in non-aqueous solution was investigated to obtain the optimized electrolysis condition including the applied potential and proton donor quantity. With the applied potential of –2.10 V, carbon monoxide (3.50-16.30%) was obtained as the only product in gas phase. Methane was additionally found with the addition of proton donor and its maximum percentage (0.39 ± 0.00%) were obtained from the electrolysis with 25.00 mM proton donor and 2.00 mM copper(II) salen. Moreover, …

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Electrochemical Sensors For Human Papillomavirus Dna, C-Reactive Protein And Food Colorants Detections, Sakda Jampasa Jan 2017

Electrochemical Sensors For Human Papillomavirus Dna, C-Reactive Protein And Food Colorants Detections, Sakda Jampasa

Chulalongkorn University Theses and Dissertations (Chula ETD)

In this dissertation, electrochemical sensors for determination of medical biomolecular markers and food colorants were developed. The research can be divided into two parts. In the first part, electrochemical sensors for determination of clinically important biomarkers were studied. There was two subprojects based on the target markers. The first subproject was the development of electrochemical sensor for the simultaneous detection of high-risk human papillomaviruses (HPV) DNA type 16 and 18 as biomarkers for cervical cancer. In this work, a highly specific pyrrolidinyl peptide nucleic acid was employed as DNA capture probe for both target DNAs. A second PNA probe labeled …

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Microencapsulation Of Eugenol In Polyelectrolyte Complexes Of Chitosan And Alginate, Chamaiporn Supachettapun Jan 2017

Microencapsulation Of Eugenol In Polyelectrolyte Complexes Of Chitosan And Alginate, Chamaiporn Supachettapun

Chulalongkorn University Theses and Dissertations (Chula ETD)

Eugenol is widely used in several applications such as food activity packaging to prolong shelf life of fruits and vegetables because of its antimicrobial activity. However, eugenol is easy to decompose, leading to reduce its activity. In this work, we prepared eugenol loaded alginate-chitosan microparticles in order to solve this problem and controlled release essential oil using ionic gelation technique. The effect of concentration of eugenol (0.1-0.5 g), calcium chloride (0.5 – 8 %W/V) and surfactant (2-10% W/V) was investigated. The results showed that the optimum condition was eugenol 0.1 g, calcium chloride 2% W/V and surfactant 4% W/V. The …

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Synthesis Of Puerarin-Gold Nanoparticles For Transdermal Delivery, Kwanruen Chanpeng Jan 2017

Synthesis Of Puerarin-Gold Nanoparticles For Transdermal Delivery, Kwanruen Chanpeng

Chulalongkorn University Theses and Dissertations (Chula ETD)

Puerarin (Pur) is herbal medicine that its inflammatory response but low solubility to reduce activity. Thus, the aim of this study was to synthesize q188-kappa-carrageenan@Pur@gold nanoparticles (q188-κ-c@Pur@AuNPs) for enhancing solubility and transdermal delivery. The κ-c was synthesized by quaternization of κ-c with 25% (v/v) q188, and the q188-κ-c @AuNPs was prepared by reducing HAuCl4 into AuNPs by using 25% (v/v) q188-κ-c as reducing and stabilizing agents. The highest degree of quaternization (%DQ) at 21.12% was found q188 addition, which was calculated from 1H NMR. The solubility of the q188-κ-c derivatives was 43.7±0.01%, which higher than κ-c. The size of synthesized …

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Hydrodeoxygenation Of Oleic Acid On Unsupported Co-Mo And Ni-Mo Sulfide Catalysts, Paphawee Sanggam Jan 2017

Hydrodeoxygenation Of Oleic Acid On Unsupported Co-Mo And Ni-Mo Sulfide Catalysts, Paphawee Sanggam

Chulalongkorn University Theses and Dissertations (Chula ETD)

In this research, hydrodeoxygenation (HDO) of oleic acid (model compound of palm oil) over unsupported Co-Mo and Ni-Mo sulfide catalysts was carried out in Parr reactor to produce bio-hydrogenated diesel (BHD). The effects of reaction parameters: temperature, hydrogen pressure and the mole ratio of catalysts (Ni/(Ni+Mo) or Co/(Co+Mo)) on the conversion and product yields (mainly n-C17 and n-C18 hydrocarbons) were investigated to find the optimal conditions. The results showed that high pressure favored a HDO pathway, while high temperature strongly affected to decarboxylation and decarbonylation pathways. At optimal condition as temperature of 280oC, reaction times of 6 h and hydrogen …

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Molecular Dynamics Of Single-Wall Carbon Nanotube Wrapped With Polypropylene, Wanwisa Panman Jan 2017

Molecular Dynamics Of Single-Wall Carbon Nanotube Wrapped With Polypropylene, Wanwisa Panman

Chulalongkorn University Theses and Dissertations (Chula ETD)

Nowadays, the nanocomposite materials have been widely used in various applications due to their unique properties such as thermal and electrical properties. Polymer/carbon nanotube (CNT) nanocomposite is one the important nanocomposite materials that are manufactured for improving thermal conductivity and electrical properties of polymers. Unfortunately, polypropylene (PP)/CNT preparation is difficult because of CNT dispersion and aggregation. Accordingly, amylose (AMY) and chitosan (CS) are selected in the present study in order to demonstrate how AMY and CS could diminish such problems by non-covalent modification on outer surface of single-walled CNT using molecular dynamics (MD) simulations. The MD results reveal that AMY …

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Probiotic Properties And Anti-Helicobacter Pylori Activity Of Lactic Acid Bacteria From Plant And Fermented Food Products, Sujitra Techo Jan 2017

Probiotic Properties And Anti-Helicobacter Pylori Activity Of Lactic Acid Bacteria From Plant And Fermented Food Products, Sujitra Techo

Chulalongkorn University Theses and Dissertations (Chula ETD)

Two hundred and thirty-eight strains of lactic acid bacteria (LAB) isolated from several plant-materials and fermented food products collected in Thailand were screening for antibacterial activity. Fifty-three strains which exhibited antimicrobial activity against Helicobacter pylori clinical strains, were selected and identified based on the phenotypic, chemotaxonomic characteristics and 16S rRNA gene sequence analysis. They were identified as Lactobacillus (Lb.) plantarum subsp. plantarum (3 strains), Lb. pentosus (10 starins), Pediococcus (P.) pentosaceus (2 strains), Lb. paracasei subsp. tolerans (1 strain), Lb. fermentum (5 strains), Enterococcus (En.) faecium (2 strains), En. casseliflavus (1 strain), Lactococcus (Lc.) garvieae subsp. garvieae (1 strain), Lc. …

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Clinical Efficacy Of Biocellulose Wound Dressing Containing Silk Sericin And Polyhexamethylene Biguanide For Split-Thickness Skin Graft Donor Sites, Supamas Napavichayanun Jan 2017

Clinical Efficacy Of Biocellulose Wound Dressing Containing Silk Sericin And Polyhexamethylene Biguanide For Split-Thickness Skin Graft Donor Sites, Supamas Napavichayanun

Chulalongkorn University Theses and Dissertations (Chula ETD)

A biocellulose wound dressing composed of silk sericin as an accelerative wound healing component and polyhexamethylene biguanide (PHMB) as an antimicrobial agent which showed effective and safe wound treatment. A prospective, single-blinded, randomized controlled matched-pair study was designed to evaluate the safety and the clinical efficacy of the biocellulose wound dressing containing silk sericin and PHMB compared with Bactigras® in healthy volunteers (phase I clinical study) and in split-thickness skin graft (STSG) donor site wound treatment (phase II clinical study). There were 105 healthy volunteers in phase I clinical study. The results showed that the erythema and melanin levels of …

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Anti-Aging Activity Evaluation Of Grammatophyllum Speciosum Extract For Development Into An Anti-Wrinkle Serum, Verisa Chowjarean Jan 2017

Anti-Aging Activity Evaluation Of Grammatophyllum Speciosum Extract For Development Into An Anti-Wrinkle Serum, Verisa Chowjarean

Chulalongkorn University Theses and Dissertations (Chula ETD)

Grammatophyllum speciosum Blume (Orchidaceae) is a large-sized orchid in Southeast Asia. The aim of this study was to evaluate G. speciosum pseudobulb extract for anti-aging activities, both in vitro and in vivo. In vitro anti-aging activity was performed using non-cell and cell-based assays. In vitro study, G. speciosum pseudobulb extract exhibited a high content of gastrodin, which was used as an active analytical marker. The total content of the antioxidant polyphenols in G. speciosum ethanolic extract was 48.19 ± 0.39 mg epigallocatechin gallate (EGCG) equivalent / g extract. The anti-collagenase enzyme activity of the ethanolic extract of the pseudobulb of …

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Free Radical Scavengers From Dendrobium Palpebrae, Napat Kyokong Jan 2017

Free Radical Scavengers From Dendrobium Palpebrae, Napat Kyokong

Chulalongkorn University Theses and Dissertations (Chula ETD)

Phytochemical study of Dendrobium palpebrae Lindl. (Orchidaceae) afforded ten pure compounds. One of them was characterized as a new phenanthrene-phenanthraquinone derivative named dendropalpebrone, and nine known compounds were identified as gigantol, lusianthridin, nobilone, 3,7-dihydroxy-2,4,8-trimethoxyphenanthrene, 2,5-dihydroxy-4,9-dimethoxyphenanthrene, moscatilin, scoparone, 4,5,4'-trihydroxy-3,3'-dimethoxybibenzyl and dendroflorin. All of the isolated compounds were initially screened for their free radical scavenging activity via oxygen radical absorbance capacity assay, DPPH radical scavenging assay, deoxyribose degradation assay, and assay for intracellular antioxidant activity in H2O2-induced RAW 264.7 murine macrophage cells. Dendroflorin showed the most potent activity in all assays, especially in the deoxyribose degradation assay. It manifested an IC50 value …

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Bioactive Compounds From Dendrobium Infundibulum, Salinee Na Ranong Jan 2017

Bioactive Compounds From Dendrobium Infundibulum, Salinee Na Ranong

Chulalongkorn University Theses and Dissertations (Chula ETD)

Phytochemical study of the methanol extract from Dendrobium infundibulum (Orchidaceae) led to isolation of nine pure compounds including two new compounds (dendroinfundin A and dendroinfundin B) and seven known compounds (ephemeranthol A, moscatilin, aloifol I, batatasin III, 3,3'-dihydroxy-4,5-dimethoxybibenzyl, 3,4'-dihydroxy-3',4,5-trimethoxybibenzyl and dendrosinen B). Their structures were determined from their spectroscopic data. All compounds were then examined for their lipase and alpha-glucosidase inhibitory activities. Dendrosinen B (IC50 = 295.0±37.9 µM) showed moderate inhibitory activity against lipase when compared with orlistat (IC50 = 31.4±0.6 nM). Strong anti alpha-glucosidase agents were batatasin III (IC50 = 148.8±8.4 µM) and dendrosinen B (IC50 = 213.9±2.4 µM), …

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Free Radical Scavenging Compounds From Dendrobium Parishii, Virunh Kongkatitham Jan 2017

Free Radical Scavenging Compounds From Dendrobium Parishii, Virunh Kongkatitham

Chulalongkorn University Theses and Dissertations (Chula ETD)

In this study, the EtOAc extract of Dendrobium parishii Rchb. f. was separated to obtain two new compounds including a bibenzyl derivative, 4,3′,4′-trihydroxy-3,5-dimethoxybibenzyl, and a bibenzyl-dihydrophenanthrene derivative, (−)-dendroparishiol, and five known compounds including flavanthrinin, moscatilin, 4,5,4′-trihydroxy-3,3′-dimethoxybibenzyl, dendrocandin E and asiatic acid. The structures of all of the isolated compounds were determined by analysis of spectroscopic data (NMR and HR-ESI-MS). They were then evaluated for antioxidant activities using DPPH free radical scavenging activity, deoxyribose degradation and oxygen radical absorbance capacity assays. Among the tested compounds, (−)-dendroparishiol showed the strongest free radicals reduction and was further investigated for antioxidant activity in H2O2-induced …

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Chemical Constituents And Bioactivities Of The Leaves And Stems Of Pseuduvaria Fragrans, Wongvarit Panidthananon Jan 2017

Chemical Constituents And Bioactivities Of The Leaves And Stems Of Pseuduvaria Fragrans, Wongvarit Panidthananon

Chulalongkorn University Theses and Dissertations (Chula ETD)

Chemical investigation of the leaves and stems of Pseuduvaria fragrans resulted in the isolation of seven pure compounds, including a new benzophenone C-glycoside named pseuduvarioside and six known compounds comprising (-)-guaiol, (+)-isocorydine, cyathocaline, isoursuline, N-trans-feruloyltyramine and N-trans-coumaroyltyramine. The structure determination of the isolated compounds was carried out by analysis of their UV, HRS-ESI-MS and NMR data in comparison with previously reported values. All the isolates were evaluated for their α-glucosidase inhibitory activity. Only N-trans-feruloyltyramine and N-trans-coumaroyltyramine exhibited strong activity with IC50 values of 3.58 µM and 0.58 µM, respectively, as compared with the drug acarbose (IC50 985.6 µM). Kinetic studies …

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The Effects Of Trehalose On Osmotic Tolerance, Membrane Integrity And Quality Of Equine Sperm During Cold Storage And Cryopreservation, Dissaya Srinutiyakorn Jan 2017

The Effects Of Trehalose On Osmotic Tolerance, Membrane Integrity And Quality Of Equine Sperm During Cold Storage And Cryopreservation, Dissaya Srinutiyakorn

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study aimed to investigate the protective effects of trehalose on osmotic tolerance and the quality of equine sperm before and after freezing and thawing. Equine ejaculated semen was collected from six stallions (3 ejaculates per stallion; >50% motility and >70% normal morphology). In the present study, the osmotic tolerance limit of equine sperm to osmotic changes was firstly verified, and followed with the protective effects of trehalose on osmotic tolerance of equine sperm. In the study, sperm was exposed to Tyrode's albumin lactate pyruvate (TALP) medium at different osmolalities: isosmolality (300 mOsm/kg; control) and anisosmolality (150, 450, 600 and …

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The Inflammatory Response Of Epithelial Cell To Corrosion Products From Recast Palladium -Silver Alloy, Verapol Singkarlsiri Jan 2017

The Inflammatory Response Of Epithelial Cell To Corrosion Products From Recast Palladium -Silver Alloy, Verapol Singkarlsiri

Chulalongkorn University Theses and Dissertations (Chula ETD)

In dentistry, there is an increase in alternative metals such as palladium or silver to add into noble metal alloys in order to improve properties and reduce cost. Apart from using other metals to replace gold or platinum, reuse is another way to save the cost. There are many studies on the recast dental alloys on mechanical properties and how many percentages of new alloys needed to add in the recasting process. It has been well accepted that amount of new and used alloys would affect the mechanical and physical properties. The biocompatibility of the alloys, however, has not been …

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Assessment Of Alcohol Consumption And Quality Of Life Amongchronic Liver Disease Patients In Mandalay, Myanmar, Chan Hein Tun Jan 2017

Assessment Of Alcohol Consumption And Quality Of Life Amongchronic Liver Disease Patients In Mandalay, Myanmar, Chan Hein Tun

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Alcohol drinking is one of the common addictive hazardous behaviours nowadays that would definitely cause consequent health system deteriorations, especially the hepatobiliary system - chronic liver diseases. This study was to find out the patterns of alcohol consumption, levels of alcohol screening, quality of life according to gender and age groups and associations between variables among the chronic liver disease patients in Mandalay, Myanmar. Methodology: A cross-sectional study, data collection was completed by face to face interviews and secondary data from medical records from total 280 chronic liver disease patients. The questionnaires consisted of structured parts, Alcohol Use Disorder …

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Prevalence And Factors Associated With Sexual Activites Among High School Students In Kendal Regency, Indonesia, Ekha Rifki Fauzi Jan 2017

Prevalence And Factors Associated With Sexual Activites Among High School Students In Kendal Regency, Indonesia, Ekha Rifki Fauzi

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: The risk of sexual activities among adolescents is high in globally. Unwanted pregnancy, sexual transmitted infections, and HIV are still the big problem in adolescents. This study was involved to exam the prevalence and factor associated with sexual activities among high school students. Methods: A cross-sectional study was conducted around 145 male students and 315 female students. The total populations was 460 students with multistage random sampling technique. A self-reported questionnaire was used including Illustrative Questionnaire for Interview-Surveys with Young People, Sexual Activity Scale and Sex Education Inventory. Descriptive statistics, Chi-square test, and multivariate logistic regression were used to …

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Knowledge Attitude And Practice (Kap) Of Long Term Care Services For The Elderly Among Trained Caregivers In Sisaket Province Thailand, Kamonthip Doungjan Jan 2017

Knowledge Attitude And Practice (Kap) Of Long Term Care Services For The Elderly Among Trained Caregivers In Sisaket Province Thailand, Kamonthip Doungjan

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study aimed to assess knowledge, attitudes, and practices of long term care for the elderly among caregivers and to identify association between socio-demographic factors, knowledge, attitudes, and practices of long term care for the elderly among caregivers in Sisaket province.
A cross sectional descriptive study with a self-administered questionnaire was conducted among 209 caregivers in Sisaket province from March to July 2018. Analysis of the variables was done using univariate and bivariate at 95% confident interval by SPSS Version 16.
The result founded out of 209 caregivers, majority of them (93.8%) were female, whereas 6.2% were male. Twenty-three percent …

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