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2017

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Halophilic Bacteria From Salty Fermented Foods And Its Bacteriocin Encoding Gene Expression To Use As Biocontrol Agent Against Staphylococcus Aureus In Salt Added Foods, Vishal Chhetri Jan 2017

Halophilic Bacteria From Salty Fermented Foods And Its Bacteriocin Encoding Gene Expression To Use As Biocontrol Agent Against Staphylococcus Aureus In Salt Added Foods, Vishal Chhetri

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research was aimed to isolate, select and apply bacteriocin producing halophilic bacteria from salty fermented foods, Plara (Thai traditional salty fermented fish) and soya sauce as bio-control agent in foods. The isolates having inhibitory activity against different strains of Staphylococcus aureus were selected, identified and characterized prior to application as protective starter in food models. Bacterial communities of Plara and soya sauce samples were studied by two methods, a cultural dependent and cultural independent method (Reverse Transcriptase PCR DGGE (Rev-T PCR-DGGE)), and subsequently sequenced by 16s rDNA analysis. Halanaerobium spp. in Plara and Staphylococcus gallinarum in soya sauce were …

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Effects Of Processing Methods On Quality Of Green Coffee, Fareeya Kulapichitr Jan 2017

Effects Of Processing Methods On Quality Of Green Coffee, Fareeya Kulapichitr

Chulalongkorn University Theses and Dissertations (Chula ETD)

To study the impact of processing on quality of Arabica green coffee, the research was divided into two parts: I) the study of the effects of postharvest processing practices on the quality of coffee, and II) the study of the effects of heat pump drying conditions on physicochemical properties of coffee with focus on the determination of the key volatile compounds affected by drying treatments. In part 1, the subtopics of the study were: 1.1) the study of the effects of the selection of coffee cherries differing in maturity (ripe vs unripe) on the quality of green coffee based on …

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The Effect Of Edta-Application To Heavy Metals Phytoremediation By Vetiver, Ramida Wasino Jan 2017

The Effect Of Edta-Application To Heavy Metals Phytoremediation By Vetiver, Ramida Wasino

Chulalongkorn University Theses and Dissertations (Chula ETD)

Contaminated soil with heavy metals includes Pb, Zn, and Cd were remediated by phytoremediation with vetiver to solved the problem in Thailand. This study compared the ability of two species of vetiver (i.e., Songkhla 3 and Prachuap Khiri Khan) in absorbing Pb, Zn, and Cd in contaminated soils and study the effect of EDTA application. After the experiment, Toxicity Characteristic Leaching Procedure (TCLP) test, Allium test, and seed germination were used to determined the toxicity of remediated soil. In this study, 5 mmol of ethylenediaminetetraacetic acid (EDTA) was used to improve the solubility of heavy metals in soil which leads …

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Pretreatment Prognostic Factors To Predict Survival Outcome In Advanced Non-Small Cell Lung Cancer With First Line Treatment In Thailand: A Retrospective Cohort Study, Sureerat Jaruhathai Jan 2017

Pretreatment Prognostic Factors To Predict Survival Outcome In Advanced Non-Small Cell Lung Cancer With First Line Treatment In Thailand: A Retrospective Cohort Study, Sureerat Jaruhathai

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Tumor genetic information and biologic markers are often used as prognostic factors. However, these have limited applicable in real daily practice due to their high cost . Objective: To evaluate which inexpensive, convenient simple prognostic factors are associated with survival outcome with first line treatment among patients with advanced non-small cell lung cancer (NSCLC). Methods: Retrospectively reviewed the charts of patients diagnosed with having advanced NSCLC with no previous treatment seen at King Chulalongkorn Memorial Hospital and Police General Hospital during 1 January 2008-31 Dec 2013. Results: A total of 301 patients were included in the study; 68.1% males. …

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Factors Affecting Health Seeking Behavior Of People In Ejin Horo County, China, Yuan Yuan Jan 2017

Factors Affecting Health Seeking Behavior Of People In Ejin Horo County, China, Yuan Yuan

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study aims to explore health seeking behavior in Ejin Horo county, China, specifically it tries to assess how socioeconomic-demographic factors and health literacy affect the decision to use formal outpatient care and conditioning on use the choice among the three-tiered health care facilities visited by people in Ejin Horo county, China during the period of 2016. Our attention is placed on the demand side because Ejin Horo county is the most powerful county in Inner Mongolia and the supply of health services in this county is quite comprehensive. In essence, the study on health seeking behavior will be able …

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Application Of Radio Frequency Identification (Rfid) Technology For Tracking The Manufacture Of Narcotic Drugs And Psychotropic Substances: A Case Study Of Phenobarbital Tablets Production, Jesdaporn Rachivong Jan 2017

Application Of Radio Frequency Identification (Rfid) Technology For Tracking The Manufacture Of Narcotic Drugs And Psychotropic Substances: A Case Study Of Phenobarbital Tablets Production, Jesdaporn Rachivong

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study applied RFID tracking of the manufacturing process and tracing back of product for preventing API loss with phenobarbital tablets as a case study. GPO has produced narcotic drugs, and psychotropic substances complied with GMP, Narcotics Act, and Psychotropic Substances Act. It included designing RFID implementation, determining user requirement and functional specification, selecting suitable devices, evaluating significant parameters and verifying the designed system. The verified software was continuously tested in stages of site testing and was assessed the risk with FMEA tool, user's satisfaction and the impact on the manufacturing process. The risk priority class of a plant which …

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Adaptation Of South Korean Leading Music Companies' Marketing Strategy In Globalization Case Study In Thai Market, Anyarin Sereemanopat Jan 2017

Adaptation Of South Korean Leading Music Companies' Marketing Strategy In Globalization Case Study In Thai Market, Anyarin Sereemanopat

Chulalongkorn University Theses and Dissertations (Chula ETD)

Music industry in South Korea has developed the new marketing strategy focusing on the big market in China, Japan, and Thailand. To continue the success, G-L-G' K-Pop's Globalization Strategy is introduced as a new marketing strategy. From the past, K-POP has been well-known as a result of the co-operation between government and private sector in exporting the product of culture, especially K-POP music. The leading music company turns its focus to adjusting the Standardization Strategy, which is based on Korean members, to Localization Strategy, which is based on local members. The growing success of Super Junior M, f(x), EX-O M, …

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Strategic Fit For Outsourcing Of Pharmaceutical Manufacturing: A Scenario Study In Thailand, Sompong Apithamsoonthorn Jan 2017

Strategic Fit For Outsourcing Of Pharmaceutical Manufacturing: A Scenario Study In Thailand, Sompong Apithamsoonthorn

Chulalongkorn University Theses and Dissertations (Chula ETD)

Outsourcing is recognized as one of the critical factors for efficient execution of pharmaceutical supply chain management, many pharmaceutical companies engage in international outsourcing of services (IOS) to survive in global highly competitive business. Since the key success factors for both domestic & international alliances are partnership characteristics and strategic fit management, but there is no empirical research on this issue in Thai pharmaceutical partnership offshore outsourcing. Therefore, this survey of Thai and foreign companies, both contract providers (CPs) and contract manufacturers (CMs), seeks to indicate significant relationships among both outsourcing strategic fit type and partnership type, including outsourcing performance …

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Seasonal Variations Of Picophytoplankton, Nanophyto-Plankton And Microphytoplankton Communities At Sichang Island, Chonburi Province, Anassaya Deesuk Jan 2017

Seasonal Variations Of Picophytoplankton, Nanophyto-Plankton And Microphytoplankton Communities At Sichang Island, Chonburi Province, Anassaya Deesuk

Chulalongkorn University Theses and Dissertations (Chula ETD)

Sichang Island is in the eastern part of the Inner Gulf of Thailand where is primarily influenced by two monsoon winds, the northeast monsoon and the southwest monsoon. The effect of this factor lead to changes in phytoplankton community. However, most studies have been focused on microphytoplankton community not pico- and nanophytoplankton due to their small size and study methods. Therefore, seasonal variations of pico-, nano-, and microphytoplankton around Sichang Island were observed. The samplings were conducted at 10 stations around Sichang Island in two monsoon and two intermonsoon periods. Pico- and nanophytoplankton were analyzed by flow cytometry whereas microphytoplankton …

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Effects Of Food On Growth And Gonadal Development Of Seahorse Hippocampus Sp., Thatpon Kamnurdnin Jan 2017

Effects Of Food On Growth And Gonadal Development Of Seahorse Hippocampus Sp., Thatpon Kamnurdnin

Chulalongkorn University Theses and Dissertations (Chula ETD)

Hippocampus sp. has received attention as a source of aquarium and ornamental trade. Seahorses have been threatened from non-target fisheries, habitat loss and traditional Chinese medicine (TCM). In response to concern about a decrease of population in the wild, an aquaculture of this species may provide the seahorse numbers for the commercial demands. However, one of the critical problems in aquaculture is the proper dietary for growth and their development. Therefore, this study was conducted on different types of preys on survival rates, growth rates and gonadal development in Hippocampus sp. during the day of birth until the 31day after …

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Surface Modification Of Microcrystalline Cellulose From Parawood Sawdust Via Mechanochemical Process For Reinforcement In Polypropylene Composites, Patcharaporn Chuayplod Jan 2017

Surface Modification Of Microcrystalline Cellulose From Parawood Sawdust Via Mechanochemical Process For Reinforcement In Polypropylene Composites, Patcharaporn Chuayplod

Chulalongkorn University Theses and Dissertations (Chula ETD)

The objective of this study is to prepare and modify parawood microcrystalline cellulose (PW-MCC) for applying as reinforced material for polypropylene composites. PW-MCC was prepared from parawood sawdust using acid hydrolysis method with pulp to acid ratio at 1:15 and temperature at 80oC for 2 hours. The obtained PW-MCC exhibited the cellulose type I with CrI at 60%. Moreover, PW-MCC had higher thermal stability than parawood sawdust. PW-MCC was further modified with various types of coupling agent such as maleic anhydride-grafted-polypropylene (PP-G-MA), organosilane, and acid chloride. Vinyltrimethoxysilane and three different acid chlorides such as benzoyl chloride, hexanoyl chloride, and lauroyl …

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Comparision Of Fly Ash And Metakaolin Based Geopolymer Properties For Heavy Metal Adsorption, Sujitra Onutai Jan 2017

Comparision Of Fly Ash And Metakaolin Based Geopolymer Properties For Heavy Metal Adsorption, Sujitra Onutai

Chulalongkorn University Theses and Dissertations (Chula ETD)

This work aims to evaluate the effectiveness of fly ash and metakaolin based geopolymer powder and fly ash and metakaolin based geopolymer composite fiber as an adsorbent for removal of heavy metal ions from aqueous solution. The fly ash and metakaolin used as raw materials in this research was from Thailand. Fly ash based geopolymer (FAG) was synthesized by mix with an alkali solution. After that, the geopolymerization process was occurred and then cured geopolymer samples at 60oC for 24 h and left at 25 oC for 6 days. The fly ash based geopolymer was ground, washed and sieved through …

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Measurement Of Eye Lens Dose In Interventional Radiologist From Tace Procedures Using Osld, Mananchaya Vimolnoch Jan 2017

Measurement Of Eye Lens Dose In Interventional Radiologist From Tace Procedures Using Osld, Mananchaya Vimolnoch

Chulalongkorn University Theses and Dissertations (Chula ETD)

For routine clinical service at Section of Interventional Radiology, Department of Radiology, King Chulalongkorn Memorial Hospital (KCMH), TACE procedure has been one of the high exposure procedures, which result in increasing eye lens dose in interventional radiologists. Thus, radiation dose should be evaluated in interventional radiology staff who may receive high eye lens dose. Currently, there is insufficient information to comply with the ICRP dose limit on the occupation exposure to the eye lens. One of the factors affecting the eye lens dose is the variation in tube directions in the interventional radiology (IR) laboratories. A preliminary study about tube …

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Radiation Dose And Image Quality In Chest Region Using Single- And Dual-Energy Ct: Phantom Study, Taninchai Jutawiriya Jan 2017

Radiation Dose And Image Quality In Chest Region Using Single- And Dual-Energy Ct: Phantom Study, Taninchai Jutawiriya

Chulalongkorn University Theses and Dissertations (Chula ETD)

Chest CT examinations are routinely performed by using single energy protocol (SE). As CT had been evolved by using dual energy protocol (DE), the patients with underlying lung nodules or pulmonary nodules will be followed up by CT examination several times. The purpose of this study is to study the radiation dose and image quality between single-energy CT (SECT) and dual-energy CT (DECT) protocols in chest phantom at King Chulalongkorn Memorial Hospital. The Lungman Kyoto Kagaku phantom inserted by five simulated lesions of various diameters was scanned by dual-source CT system (Somatom Force, Siemens Healthineers). The acquisition protocols consist of …

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Involvement Of Notch Signaling In Interleukin-4-Stimulated Human Macrophages, Naunpun Sangphech Jan 2017

Involvement Of Notch Signaling In Interleukin-4-Stimulated Human Macrophages, Naunpun Sangphech

Chulalongkorn University Theses and Dissertations (Chula ETD)

Macrophages respond to various stimuli, resulting in distinct effector phenotypes that range from LPS-stimulated proinflammatory to IL-4-activated pro-healing phenotype. The regulatory mechanism of this polarization is not fully understood. Notch signaling pathway is a conserved signaling pathway involved in polarization of macrophages, especially proinflammatory macrophages. However, the role of Notch signaling in IL-4 stimulated macrophages (M(IL-4)) is not well defined. PPARgamma is a signature nuclear receptor in M(IL-4) that function mainly in regulating lipid metabolism. There are many reports that revealed the interaction of Notch signaling and PPARgamma in various cells but not in macrophages. In this study, the interaction …

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Development Of Gold Nanoparticle-Based Lateral Flow Immunoassay For Detection Of Pathogenic Leptospiral Antigen, Prayoon Lae-Ngee Jan 2017

Development Of Gold Nanoparticle-Based Lateral Flow Immunoassay For Detection Of Pathogenic Leptospiral Antigen, Prayoon Lae-Ngee

Chulalongkorn University Theses and Dissertations (Chula ETD)

Leptospirosis, caused by pathogenic Leptospira spp., is a global re-emerging zoonosis and endemic disease in tropical and sub-tropical countries including Thailand. Point-of-care testing (POCT) for rapid diagnosis of leptospirosis is needed for prompt and appropriate treatment particularly in resource-poor settings. Lateral flow immunoassay (LFA)-based POCT devices are rapid, user friendly, cheap, have one-step analysis, and need no sophisticated equipment. LipL32 is a common target for diagnostic tests of leptospirosis because it is the major outer membrane protein (OMP) that is specific and highly conserved among pathogenic Leptospira. This study aimed to develop the gold nanoparticle (AuNP)-based LFA for detection of …

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Characterization Of T Cell Secreted Cytokines And Cytotoxic Mediators Profiling In Knee Osteoarthritis Patients, Thitiya Sae-Jung Jan 2017

Characterization Of T Cell Secreted Cytokines And Cytotoxic Mediators Profiling In Knee Osteoarthritis Patients, Thitiya Sae-Jung

Chulalongkorn University Theses and Dissertations (Chula ETD)

Osteoarthritis (OA) is a chronic disease associated with morphological joint changes that results in the breakdown of joint cartilage and underlying bone with erosive inflammation. Factors of OA are intrinsic factor and extrinsic factor. The pathogenesis of OA relates with immune responses and immune cells, T cells, B cells, and macrophages etc., T cells both CD4+ and CD8+ T cell are immune cells that have been suggested to play a role in OA. However, we found many finding in CD8+ T cells such as a high proportion of CD8+ T cell was observed in tissue of knee joint. In addition, …

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Immune Response In Pythiosis Patients Treated With Pythium Insidiosum Antigen (Pia), Navaporn Worasilchai Jan 2017

Immune Response In Pythiosis Patients Treated With Pythium Insidiosum Antigen (Pia), Navaporn Worasilchai

Chulalongkorn University Theses and Dissertations (Chula ETD)

Immunotherapy using Pythium insidiosum antigen (PIA) is one of the combination treatment for P. insidiosum infected patients along with amputation and certain antifungal agents. The protocol of first prime (day0) after diagnosis and six booster doses (at 0.5, 1, 1.5, 3, 6, 12 months; mo.) along a year period were performed based on previous study. The switching of T-helper2 (Th2) to Th1 after immunotherapy along with the clinical improvement in equine and rabbit models were revealed whereas studies in human are very limited. To investigate the immune response in PIA treated pythiosis patients, cytokine profile (CMI response), P. insidiosum specific …

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The Antiviral Activity Of Phenolic Lipids Group Against Dengue Virus, Parichat Kanyaboon Jan 2017

The Antiviral Activity Of Phenolic Lipids Group Against Dengue Virus, Parichat Kanyaboon

Chulalongkorn University Theses and Dissertations (Chula ETD)

Dengue virus causes a global burden that specific chemotherapy has not been established in a clinical setting. A previous report suggested that anacardic acid saturated (C15:0), a member of phenolic lipids, inhibited hepatitis C virus infection. Here, we explored structure activity relationship of phenolic lipids homologues with anti-DENV properties in the cell-based system. Our results indicated that Cardol triene (C15:3) expressed DENV1-4 inhibition, but not to Zika virus (SV0010/15) with the EC50s of 5.35 ± 1.16 µM, 7.13 ± 0.72 µM, 8.98 ± 1.77 µM, and 8.21 ± 0.34 µM, respectively. Also, the compound showed good CC50s to Vero cells …

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Induction Of Interleukin-1 Receptor Antagonist (Il-1ra) By Porcine Reproductive And Respiratory Syndrome Virus (Prrsv), Teerawut Nedumpun Jan 2017

Induction Of Interleukin-1 Receptor Antagonist (Il-1ra) By Porcine Reproductive And Respiratory Syndrome Virus (Prrsv), Teerawut Nedumpun

Chulalongkorn University Theses and Dissertations (Chula ETD)

Porcine respiratory and reproductive syndrome virus (PRRSV) is one of the major pathogens affecting pig production industry worldwide. Impaired innate and adaptive immune responses are evidenced through the course of PRRSV infection. Several evidences indicate that PRRSV suppresses host immune responses via several immune evasion strategies. Interleukin-1 receptor antagonist (IL-1Ra) is known as an early inhibitory cytokine that suppresses innate immune functions and T lymphocyte responses. The aims of this study were to explore the induction of IL-1Ra by PRRSV and the negative immunomodulatory effects of PRRSV-induced IL-1Ra on porcine immune responses. In this study, the previous monocytes-derived dendritic cells …

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Molecular Epidemiology And Genome Analysis Of Hepatitis E Virus In Swine And Blood Donors, Duangnapa Intharasongkroh Jan 2017

Molecular Epidemiology And Genome Analysis Of Hepatitis E Virus In Swine And Blood Donors, Duangnapa Intharasongkroh

Chulalongkorn University Theses and Dissertations (Chula ETD)

Hepatitis E virus (HEV) infection affects approximately 20 million individuals and results in more than 50,000 deaths each year. The highest prevalence is in Asia where contaminated food and water are often the sources of infection. There was the difference among the genotype of human Hepatitis E virus which genotype 1 to 4 can infect human. HEV genotypes 1 and 2 are found only in humans and are responsible for viral hepatitis outbreaks, while genotypes 3 and 4 are zoonotic. The HEV infection in Thailand caused by HEV genotype 3f and usually found among adult males. However, the route of …

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Vitamin D Receptors Distribution And Mapk Activation In Cigarette Smoke Induced Emphysema Rats, Fatist Okrit Jan 2017

Vitamin D Receptors Distribution And Mapk Activation In Cigarette Smoke Induced Emphysema Rats, Fatist Okrit

Chulalongkorn University Theses and Dissertations (Chula ETD)

Rat model was used in this study in order to investigate subcellular vitamin D receptors (VDR) distribution and mitogen activated protein kinase (MAPK) alteration in the lungs of emphysema development after cigarette smoke exposure for 7 days (acute) and 14 days (subacute). Thirty male Wistar rats were randomly divided into 3 groups per each time point; 1) control (air exposed), 2) no-filter (smoke exposed without cigarette filter) and 3) filter (smoke exposed with cigarette filter) (n=5 per group). Each rat was daily and constantly exposed to 6 cigarettes smoke for 7 or 14 days. After 24 hours of the last …

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Molecular Epidemiology Of Human Enterovirus In Various Clinical Specimens With Suspected Enterovirus Infection, Jira Chansaenroj Jan 2017

Molecular Epidemiology Of Human Enterovirus In Various Clinical Specimens With Suspected Enterovirus Infection, Jira Chansaenroj

Chulalongkorn University Theses and Dissertations (Chula ETD)

Many infectious diseases have been well recognized caused by several genotypes of human enterovirus species which significantly in public health. Publications worldwide have reported on the emerging and re-emerging of enteroviruses. Until now, epidemiological surveillance data, clinical complication and evolutionary history regarding these viruses in actual on the Asia continent are still limited. To address these concerns, this study aimed to establish comprehensive population-based surveillances, and provided evidence for the evolution in many diseases such as acute haemorrhagic conjunctivitis, herpangina, hand foot mouth disease, acute gastroenteritis, poliovirus and meningitis caused by enteroviruses. Employing reverse transcription-polymerase chain reaction and sequencing approaches …

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Assessment Of Human Papillomavirus Detection Using Different Methods And Clinical Samples, Pornjarim Nilyanimit Jan 2017

Assessment Of Human Papillomavirus Detection Using Different Methods And Clinical Samples, Pornjarim Nilyanimit

Chulalongkorn University Theses and Dissertations (Chula ETD)

Human papillomavirus (HPV) is the etiological agent implicated cancers include those of the cervix, vulva, vagina, penis, anus, rectum and oropharynx. Currently, the Papanicolaou (Pap) smear is the recommended for cervical cancer screening but only a small percentage of women follow this screening. Overall, this thesis aimed to develop the technique and type of specimen to detect HPV DNA in Thai population and to characterize of the HPV genotypes in Thai patients with anogenital warts. Cervical swab and urine sample of 116 women and 100 men were collected before the Pap smear test. The histological examination of women can classified …

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Lipoic Acid-Incorporated Calcium Carbonate Nanoparticlesfor Controlling Of Adipose Derived Stem Cells (Adscs) Differentiation And Adipocyte Function, Sarocha Cherdchom Jan 2017

Lipoic Acid-Incorporated Calcium Carbonate Nanoparticlesfor Controlling Of Adipose Derived Stem Cells (Adscs) Differentiation And Adipocyte Function, Sarocha Cherdchom

Chulalongkorn University Theses and Dissertations (Chula ETD)

CaCO3 NPs has received a growing interest due to its potential properties as a safe drug carrier. The LA-CaCO3 NPs were synthesized by a chemical precipitation method and characterized using transmission electron microscopy, thermogravimetric analysis, and zeta potential measurement. We used LA-CaCO3 NPs to evaluate their therapeutic effects in lipid accumulation, lipolysis, adipogenesis, and adipokines expression in ADSCs and differentiated adipocytes. The average particle sizes were observed to be 10-20 nanometers. Thermogravimetric analysis results confirmed the percentages of LA in CaCO3 NPs. The zeta potential showed a negative charge -30.9 mV. Our findings indicated that LA-CaCO3 NPs were apparently more …

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Effects Of Genistein On Non-Alcoholic Steatohepatitis (Nash) Induced By High-Fat High-Fructose Diet In Bilateral Ovariectomized Rats, Sudaporn Pummoung Jan 2017

Effects Of Genistein On Non-Alcoholic Steatohepatitis (Nash) Induced By High-Fat High-Fructose Diet In Bilateral Ovariectomized Rats, Sudaporn Pummoung

Chulalongkorn University Theses and Dissertations (Chula ETD)

To investigate the effects of genistein on estrogen deficiency with high-fat high-fructose (HFHF) diet-induced NASH rats. Female Sprague-Dawley rats (n=48) were randomly divided into ovariectomized (OVX) and non-ovariectomized (non-OVX) group. Both rat groups, further allocated into 3 subgroups; controls, rats fed with HFHF diet (NASH), and rats fed with HFHF diet plus daily 16 mg/kg BW of genistein (NASH+Gen) for 8 weeks. Serum samples were collected for liver enzymes (AST and ALT) and TNF-α level analysis. Liver tissue samples were harvested for histopathology, hepatic lipid accumulation (oil red o stained, FFA and TG level), hepatic lipid peroxidation (MDA level), hepatic …

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Evaluation Of Lipid Accumulation And Lipolysis Activity In Human Subcutaneous Adipocytes And Human Visceral Adipocytes By Α-Lipoic Acid, Α-Lipoic Acid-Incorporated Caco3 Nanoparticles And Caffeine., Sunisa Kaewdang Jan 2017

Evaluation Of Lipid Accumulation And Lipolysis Activity In Human Subcutaneous Adipocytes And Human Visceral Adipocytes By Α-Lipoic Acid, Α-Lipoic Acid-Incorporated Caco3 Nanoparticles And Caffeine., Sunisa Kaewdang

Chulalongkorn University Theses and Dissertations (Chula ETD)

Recently, much attention has been paid to natural plant-derived compounds as an alternative strategy for developing anti-obesity agents with minimal detrimental effects. Among various natural compounds, caffeine (1, 3, 7-trimethyl xanthine) and alpha lipoic acid (1, 2-dithiolane-3-pentanoic acid; LA) are the natural agents which show a promising result in decreasing fat deposit. Moreover, we have improved efficiencies of LA by CaCO3 NPs because LA had low bioavailability. In the present study, we investigated the effect of combination between caffeine and LA-CaCO3 NPs in lipid accumulation reduction and lipolysis stimulation in human subcutaneous adipocytes and human visceral adipocytes. Our results showed …

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Effects Of Curcumin On Oxidative Stress, Inflammation And Apoptosis In L-Arginine Induced Acute Pancreatitis In Mice, Thidarat Chingchit Jan 2017

Effects Of Curcumin On Oxidative Stress, Inflammation And Apoptosis In L-Arginine Induced Acute Pancreatitis In Mice, Thidarat Chingchit

Chulalongkorn University Theses and Dissertations (Chula ETD)

L-arginine (L-arg) is an amino acid that has been used to induce acute pancreatitis (AP) in mice. Curcumin is an active ingredient constituent of rhizomes of the plant Curcuma longa Linn. It has been used for the treatment of inflammatory conditions and shown to exhibit a variety of biological activities such as anti-inflammatory and anti-oxidant. The present study aims to examine the effects of curcumin on oxidative stress, inflammation and apoptosis in AP. Male ICR mice were randomly divided into 4 groups. 1) Control group, mice will be received i.p. of 1% DMSO as a vehicle. 2) AP group, mice …

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Effect Of Calcium Citrate In Calcium Carbonate Nanoparticles On Hk-2 Cells In Acidic Environment, Tipagorn Udomsinsirikul Jan 2017

Effect Of Calcium Citrate In Calcium Carbonate Nanoparticles On Hk-2 Cells In Acidic Environment, Tipagorn Udomsinsirikul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Metabolic acidosis exerts several cellular and tissue dysfunctions, such as increases mineral bone and protein degradation, induces inflammation, oxidative stress and cell death. These complications lead to multiple organ failure, including chronic kidney disease. Sodium bicarbonate and Shohl's solution are commonly used to treat metabolic acidosis. However, these agents cause frequent gastrointestinal adverse effects. Hence, we invented the new calcium carbonate nanoparticles to use as a drug delivery system for carrying citrate to renal cell which we hypothesize to reduce adverse effects of metabolic acidosis. We studied the physical characteristics and pharmacological effects of calcium citrate nanoparticle (Cacit) and calcium …

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Carotenoids And Metabolism Of The Green Microalga Chlorococcum Sp. 8367re Under Stress Conditions, Kantima Janchot Jan 2017

Carotenoids And Metabolism Of The Green Microalga Chlorococcum Sp. 8367re Under Stress Conditions, Kantima Janchot

Chulalongkorn University Theses and Dissertations (Chula ETD)

Green microalgae are one of the natural resources for productions of various and beneficial bioactive compounds, such as UV-screening compounds and carotenoids. This study focuses on the changes of carotenoids and metabolisms in the green microalga Chlorococcum sp. 8367RE under stress conditions. The results showed that stresses by salt, light, drought, and nitrogen starvation affected on alterations of morphological characteristics. Interestingly, size of cells culturing under salt stresses dramatically increased. It should be noted that KCl stress caused the enlargement of cell sizes approximately 5 folds. Carotenoids were identified and quantified by using ultra-high performance liquid chromatography (UHPLC) and mass …

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