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2017

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Induction Of Haploid Plants In Citrus Through Gamma-Irradiated Pollen And Ascertainment Of Ovule Age For Maximum Recovery Of Haploid Plantlets, Manoj Kundu, Anil Dubey, Manish Srivastav, Surendra Kumar Malik Jan 2017

Induction Of Haploid Plants In Citrus Through Gamma-Irradiated Pollen And Ascertainment Of Ovule Age For Maximum Recovery Of Haploid Plantlets, Manoj Kundu, Anil Dubey, Manish Srivastav, Surendra Kumar Malik

Turkish Journal of Biology

The present investigation was carried out for the induction of haploid plants in Citrus grandis through in situ parthenogenesis by pollination with gamma-irradiated pollen of C. limetta and C. sinensis, treated with 50, 100, 200, 300, and 400 Gy gamma ray doses followed by in vitro ovule culture. Ovule culture at 50 days after pollination (DAP) was found optimum for the maximum recovery of in vitro-raised plantlets as compared to 35 and 20 DAP. At 50 DAP, irrespective of the pollen parent, plantlet regeneration capacity decreased at 300 and 400 Gy irradiation treatment (0.62% and 0.60%, respectively) with maximum recovery …


The Jasmonate-Zim Domain Protein Ftjaz2 Interacts With The R2r3-Mybtranscription Factor Ftmyb3 To Affect Anthocyanin Biosynthesis In Tartary Buckwheat, Xiao-Peng Luo, Shuang-Jiang Li, Pan-Feng Yao, Cheng-Lei Li, Hui Chen, Qi Wu, Hai-Xia Zhao Jan 2017

The Jasmonate-Zim Domain Protein Ftjaz2 Interacts With The R2r3-Mybtranscription Factor Ftmyb3 To Affect Anthocyanin Biosynthesis In Tartary Buckwheat, Xiao-Peng Luo, Shuang-Jiang Li, Pan-Feng Yao, Cheng-Lei Li, Hui Chen, Qi Wu, Hai-Xia Zhao

Turkish Journal of Biology

Tartary buckwheat is a type of coarse cereal that contains a rich supply of flavonoids. When suffering from certain stresses, tartary buckwheat can respond by promoting the biosynthesis of anthocyanins. It is well established that the jasmonate (JA) signaling pathway plays a critical role in plant resistance to disease by stimulating the production of anthocyanins; furthermore, the genes encoding the jasmonate-ZIM domain (JAZ) proteins have been shown to be key players in this process. However, the role of JAZ proteins in tartary buckwheat is poorly understood. In this study, we aimed to isolate FtJAZs from tartary buckwheat and identify FtJAZs …


Genetic Variation And Potential Genetic Resources Of Several Romanian Larch Populations, Alina Vilcan (Truta), Lucica Mihalte (Crisan), Adriana F. Sestras, Liviu Holonec, Radu E. Sestras Jan 2017

Genetic Variation And Potential Genetic Resources Of Several Romanian Larch Populations, Alina Vilcan (Truta), Lucica Mihalte (Crisan), Adriana F. Sestras, Liviu Holonec, Radu E. Sestras

Turkish Journal of Agriculture and Forestry

RAPD molecular markers and phenotypic growth traits were joined using different genotypes of Larix decidua (Mill.) to analyze genetic variation. Individual samples of vegetative clones were analyzed from Baciu orchard (obtained through a breeding program from regional stands from Romania) and pooled samples from places of origin (regional stands). Based on coefficients of variation for tree height, diameter, and volume, the greatest genetic variation in the orchard was observed at the Gura Humorului and Anina provenances (24.4%, 27.5%, and 14.4% for Gura Humorului and 26.9%, 29.46%, and 15.5% for Anina). In addition, the trees whose origins are Gura Humorului and …


An In Vitro Human Skeletal Muscle Model: Coculture Of Myotubes,Neuron-Like Cells, And The Capillary Network, Ayşe Burcu Ertan, Hali̇me Kenar, Tahsi̇n Beyza Beyzadeoğlu, Fatma Neşe Kök, Gamze Köse Jan 2017

An In Vitro Human Skeletal Muscle Model: Coculture Of Myotubes,Neuron-Like Cells, And The Capillary Network, Ayşe Burcu Ertan, Hali̇me Kenar, Tahsi̇n Beyza Beyzadeoğlu, Fatma Neşe Kök, Gamze Köse

Turkish Journal of Biology

This study reports the generation of a new human muscle tissue equivalent from skeletal muscle-derived stem cells and human umbilical vein endothelial cells (HUVECs). Skeletal muscle stem cells were isolated by the preplate technique and differentiated into neuron-like cells that were positive for neuronal beta-tubulin3 and nestin and negative for the astrocyte marker glial fibrillary acidic protein (GFAP). Coculture of skeletal muscle stem cells with the HUVECs under optimized fetal bovine serum and media conditions resulted in formation of a capillary network among the multinucleated myotubes. The neuron-like cells derived from the human skeletal muscle stem cells were seeded onto …


Tree-Induced Changes In A Terra Rossa Soil Under Olive.Observations From An Integrated Field Study, Salvatore Madrau, Claudio Zucca, İhsan Akşi̇t, Zülküf Kaya, Seli̇m Kapur Jan 2017

Tree-Induced Changes In A Terra Rossa Soil Under Olive.Observations From An Integrated Field Study, Salvatore Madrau, Claudio Zucca, İhsan Akşi̇t, Zülküf Kaya, Seli̇m Kapur

Turkish Journal of Agriculture and Forestry

A range of indicators including chemical, physical, morphological, and clay mineral properties were investigated to support an integrated evaluation of the changes induced by a long established olive grove on a red Mediterranean soil. The study area was located in Sardinia (Italy). Two soil profiles were studied in a site where land use had remained unchanged for the previous 150 years: one under the canopy and around the trunk of an olive tree and one between the trees. Chemical analyses including organic matter fractions were performed by horizon. Undisturbed soil samples were collected from aggregates for thin section and scanning …


Pre-Service Teachers’ Reflections: The Influence Of School 1:1 Laptop Programs On Their Developing Teaching Practice., Susan Blackley, Rebecca Walker Jan 2017

Pre-Service Teachers’ Reflections: The Influence Of School 1:1 Laptop Programs On Their Developing Teaching Practice., Susan Blackley, Rebecca Walker

Australian Journal of Teacher Education

Throughout Australia, many government and non-government schools have implemented a one-laptop-per-student (1:1) policy. Whilst there was initial interest in the implementation of these programs, little has been done to track the uptake of digital learning technologies afforded by access to the laptops. This study examined pre-service teachers’ reflections on their experiences with 1:1 laptop programs in their secondary schooling. The lens for this reflection was their consideration of their aspirational teaching practice. Qualitative data were collected from two successive cohorts (2014 and 2015) of the first year of a Bachelor of Education course. The objectives of the research presented in …


English Classrooms And Curricular Justice For The Recognition Of Lgbt Individuals: What Can Teachers Do?, Jane Pearce, Wendy Cumming-Potvin Jan 2017

English Classrooms And Curricular Justice For The Recognition Of Lgbt Individuals: What Can Teachers Do?, Jane Pearce, Wendy Cumming-Potvin

Australian Journal of Teacher Education

Discrimination against LGBT[1] individuals remains widespread across Australia. Since schools continue to promote regimes of heterosexuality and cis-normativity, teachers have a crucial role in creating contexts in which LGBT young people feel accepted and safe. Drawing on North’s (2006) work on social justice and Connell’s (2012) discussion of curricular justice, this article explores opportunities and constraints experienced by a group of English secondary teachers attempting to practise in socially just ways. Results indicate that through the English curriculum, it is possible for teachers to find moments to achieve social justice for LGBT individuals.

[1] In reference to lesbian, gay, …


Autism Spectrum Disorder Coursework For Teachers And Teacher-Aides: An Investigation Of Courses Offered In Queensland, Australia, Mitchell Coates, Janeen Lamb, Brendan Bartlett, Poulomee Datta Jan 2017

Autism Spectrum Disorder Coursework For Teachers And Teacher-Aides: An Investigation Of Courses Offered In Queensland, Australia, Mitchell Coates, Janeen Lamb, Brendan Bartlett, Poulomee Datta

Australian Journal of Teacher Education

The content and structure of pre-service and teacher-aide programs has major implications for training, management, support and deployment of teachers and teacher-aides in mainstream schools working with students who have ASD. Data pertaining to course content and structure were collected from university and teacher-aide training websites, program enrolment guides, and through direct contact with institutions in Queensland, Australia. 101 education programs were narrowed down to 45 in early-childhood/primary education, and 8 online teacher-aide training programs. Findings indicate the urgent need for academics in institutions to begin working towards redesigning programs that deliver best practices in ASD for pre-service educators.



Heuristic Algorithm-Based Estimation Of Rotor Resistance Of An Induction Machine By Slot Parameters With Experimental Verification, Mehmet Çelebi̇, Murat Tören Jan 2017

Heuristic Algorithm-Based Estimation Of Rotor Resistance Of An Induction Machine By Slot Parameters With Experimental Verification, Mehmet Çelebi̇, Murat Tören

Turkish Journal of Electrical Engineering and Computer Sciences

The estimations of induction machine equivalent circuit parameters are still being widely used in the analysis and in determining the characteristics of the machine. Since the most important part of the machine is the rotor where torque is produced, the calculation of rotor resistance correctly will directly affect all other data. Almost all parameters belonging to the stator side can easily be determined through external measurements. However, due to the formulation of the rotor as a closed box, estimating rotor resistance and the rotor's slot shape by heuristic algorithms, without damaging the rotor physically, and comparing it with its actual …


A New Word-Based Compression Model Allowing Compressed Pattern Matching, Hali̇l Nusret Buluş, Aydin Carus, Altan Mesut Jan 2017

A New Word-Based Compression Model Allowing Compressed Pattern Matching, Hali̇l Nusret Buluş, Aydin Carus, Altan Mesut

Turkish Journal of Electrical Engineering and Computer Sciences

In this study a new semistatic data compression model that has a fast coding process and that allows compressed pattern matching is introduced. The name of the proposed model is chosen as tagged word-based compression algorithm (TWBCA) since it has a word-based coding and word-based compressed matching algorithm. The model has two phases. In the first phase a dictionary is constructed by adding a phrase, paying attention to word boundaries, and in the second phase compression is done by using codewords of phrases in this dictionary. The first byte of the codeword determines whether the word is compressed or not. …


Prognosis Of Muscular Dystrophy With Extrinsic And Intrinsic Descriptors Through Ensemble Learning, Sathyavikasini Kalimuthu, Vijaya Vijayakumar Jan 2017

Prognosis Of Muscular Dystrophy With Extrinsic And Intrinsic Descriptors Through Ensemble Learning, Sathyavikasini Kalimuthu, Vijaya Vijayakumar

Turkish Journal of Electrical Engineering and Computer Sciences

Muscular dystrophy is a neuromuscular disorder that impairs the functioning of the locomotive muscles. Large deletion and duplication mutations in the gene sequences pave the way for these muscular dystrophies. Any heritable change can be used as input in computational studies such as pattern and classification models. Mutated gene sequences are generated by adopting the positional cloning approach on the reference cDNA sequence with mutational information from the Human Gene Mutational Database (HGMD). The extrinsic and intrinsic descriptors of the mutated gene sequence are indispensable to identifying the disease. This work describes a computational approach of building a disease classification …


Concurrent Optimal Design Of Tcsc And Pss Using Symbiotic Organisms Search Algorithm, Muwaffaq Alomoush Jan 2017

Concurrent Optimal Design Of Tcsc And Pss Using Symbiotic Organisms Search Algorithm, Muwaffaq Alomoush

Turkish Journal of Electrical Engineering and Computer Sciences

The symbiotic organisms search (SOS), which has been recently introduced, is a robust powerful metaheuristic global optimizer. This nature-inspired algorithm imitates the symbiotic interaction strategies in an ecosystem exercised by organisms involved in interrelationships to survive and reproduce. One of the main beneficial features of the SOS in contrast to many other competent metaheuristic algorithms is that the algorithm does not need any specific algorithm parameters or tuning process. This paper applies the SOS algorithm to simultaneously design optimal controllers of a power system equipped with both a power system stabilizer (PSS) and a thyristor-controlled series compensator (TCSC). The algorithm …


Multiobjective Distributed Model Predictive Control Method For Facility Environment Control Based On Cooperative Game Theory, Huanliang Xu, Zhaoyu Zhai, Ke Wang, Shougang Ren, Haoyun Wang Jan 2017

Multiobjective Distributed Model Predictive Control Method For Facility Environment Control Based On Cooperative Game Theory, Huanliang Xu, Zhaoyu Zhai, Ke Wang, Shougang Ren, Haoyun Wang

Turkish Journal of Electrical Engineering and Computer Sciences

In order to achieve better control performance within the facility environment, this paper proposes a distributed model predictive control method, aiming at increasing the control precision of actuators, reducing energy consumption and equipment loss at the same time. Regarding optimizing this facility environment model, it could be treated as a multiobjective optimization problem. Referring to the cooperative game theory, each objective is regarded as a gamer. Each gamer considers both its own interests and other gamers' interests to achieve a balanced result when cooperation is achieved. The simulation experiments illustrate that the proposed control method is able to adjust the …


Breast-Region Segmentation In Mri Using Chest Region Atlas And Svm, Aida Fooladivanda, Shahriar Baradaran Shokouhi, Nasrin Ahmadinejad Jan 2017

Breast-Region Segmentation In Mri Using Chest Region Atlas And Svm, Aida Fooladivanda, Shahriar Baradaran Shokouhi, Nasrin Ahmadinejad

Turkish Journal of Electrical Engineering and Computer Sciences

An important step for computerized analysis of breast magnetic resonance imaging (MRI) is segmentation of the breast region. Due to the similar signal intensity of fibroglandular tissue and the chest wall, the segmentation process is difficult for breasts with fibroglandular tissue connected to the chest wall. In order to overcome this challenge, a new framework is presented that relies on a chest region atlas. The proposed method first detects the approximated breast-chest wall boundary using an intensity-based operation. A support vector machine (SVM) then determines the connectivity of fibroglandular tissue to the chest wall by the extracted features from the …


Power Search Algorithm (Psa) For Combined Economic-Emission Dispatch Problems Considering Valve Point Effects In Economic Load Dispatch, Prakash Arumugam, Ravichandran Coimbatore Subramanian Jan 2017

Power Search Algorithm (Psa) For Combined Economic-Emission Dispatch Problems Considering Valve Point Effects In Economic Load Dispatch, Prakash Arumugam, Ravichandran Coimbatore Subramanian

Turkish Journal of Electrical Engineering and Computer Sciences

Economic load dispatch has become the prime and major concern in power system networks. Use of nonrenewable fuels as an input to power systems results in toxic gas emission and depletion of resources for future generations. Allocation of optimal power to generators serves as a solution to this issue. The suggested power search algorithm (PSA) is a novel solution for the reduction of the fuel cost, emissions, and power loss. This algorithm searches its solution inside the search space from minimum to maximum in case of forward search. The global optimum solution is obtained with much less execution time compared …


Neoteric Chaff Generation Method Of Fingerprint Fuzzy Vault, Nancy Singla, Sanjeev Sofat, Manvjeet Kaur Jan 2017

Neoteric Chaff Generation Method Of Fingerprint Fuzzy Vault, Nancy Singla, Sanjeev Sofat, Manvjeet Kaur

Turkish Journal of Electrical Engineering and Computer Sciences

Authentication using biometrics has an edge over traditional authentication mechanisms. Fuzzy vault is an eminent biometric cryptosystem technique that aims to protect a secret using a biometric template. Authorized users can, however, access the secret by providing the valid biometric. In a fuzzy vault, noise is incorporated in the form of chaff points in order to increase the security. While implementing fuzzy vault schemes in real scenarios, the most critical but computing-intensive and time-consuming task is chaff generation. In this paper, a neoteric method for chaff generation is proposed, which is less time-consuming in generating large numbers of chaff points.


A Cooperative Neural Network Approach For Enhancing Data Traffic Prediction, Salihu Aish Abdulkarim, Isa Abdullahi Lawal Jan 2017

A Cooperative Neural Network Approach For Enhancing Data Traffic Prediction, Salihu Aish Abdulkarim, Isa Abdullahi Lawal

Turkish Journal of Electrical Engineering and Computer Sciences

This paper addresses the problem of learning a regression model for the prediction of data traffic in a cellular network. We proposed a cooperative learning strategy that involves two Jordan recurrent neural networks (JNNs) trained using the firefly algorithm (FFA) and resilient backpropagation algorithm (Rprop), respectively. While the cooperative capability of the learning process ensures the effectiveness of the regression model, the recurrent nature of the neural networks allows the model to handle temporally evolving data. Experiments were carried out to evaluate the proposed approach using high-speed downlink packet access data demand and throughput measurements collected from different cell sites …


An Improved Omthd Technique For An N-Level Cascaded Multilevel Inverter With Adjustable Dc Sources, Hamidreza Toodeji Jan 2017

An Improved Omthd Technique For An N-Level Cascaded Multilevel Inverter With Adjustable Dc Sources, Hamidreza Toodeji

Turkish Journal of Electrical Engineering and Computer Sciences

Optimal minimization of total harmonic distortion (OMTHD) and selective harmonic elimination (SHE) switching techniques are usually employed to reduce generated harmonics of multilevel inverters. In the former technique, the THD of waveform is reduced without elimination of any harmonic order and the latter, in contrast, eliminates selected harmonic orders. In this paper, the harmonic elimination ability of the SHE technique is added to OMTHD and an improved OMTHD technique is proposed for an n-level cascaded multilevel inverter with adjustable DC sources. The main novelty of this switching technique is elimination of some harmonic orders, beside THD minimization. Moreover, optimal DC …


Transcription Factor 7-Like 2 (Tcf7l2) Gene Polymorphisms Are Strong Predictorsof Type 2 Diabetes Among Nonobese Diabetics In The Turkish Population, Dudu Erkoç Kaya, Hi̇lal Arikoğlu, Seyi̇t Ali̇ Kayiş, Onur Öztürk, Mustafa Sai̇t Gönen Jan 2017

Transcription Factor 7-Like 2 (Tcf7l2) Gene Polymorphisms Are Strong Predictorsof Type 2 Diabetes Among Nonobese Diabetics In The Turkish Population, Dudu Erkoç Kaya, Hi̇lal Arikoğlu, Seyi̇t Ali̇ Kayiş, Onur Öztürk, Mustafa Sai̇t Gönen

Turkish Journal of Medical Sciences

Background/aim: Type 2 diabetes (T2D) is a multifactorial disease, determined by environmental and genetic factors. Currently, the transcription factor 7-like 2 (TCF7L2) gene shows the strongest association with T2D. In this study, we investigated whether TCF7L2 gene polymorphisms are associated with T2D in a Turkish population. Materials and methods: Using PCR-RFLP and PCR-SSCP, we genotyped six intronic polymorphisms in the TCF7L2 gene, commonly associated with T2D, in 169 individuals with diabetes and 119 healthy controls. Results: We found that rs7903146 C -> T substitution in intron 3 (OR: 1.9, P = 0.005) and rs12255372 G -> T substitution in intron …


Is There Any Difference In Tetanus Igg Levels Of Diabetic Patientswith Respect To The Presence Of Foot Ulcers?, Fati̇h Teki̇n, Mehmet Sürmeli̇, Zeynep Çi̇zmeci̇, Özlem Teki̇n, Ergi̇n Işik, Ömer Faruk Taner, Derun Taner Ertuğrul Jan 2017

Is There Any Difference In Tetanus Igg Levels Of Diabetic Patientswith Respect To The Presence Of Foot Ulcers?, Fati̇h Teki̇n, Mehmet Sürmeli̇, Zeynep Çi̇zmeci̇, Özlem Teki̇n, Ergi̇n Işik, Ömer Faruk Taner, Derun Taner Ertuğrul

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to reveal the tetanus immunization status of diabetic patients and to determine whether diabetic patients with foot ulcers have different TIG levels. Materials and methods: A cross-sectional study was designed that included diabetic patients with foot ulcers (n = 30) and diabetic patients without ulcers (n = 30). The groups were compared for serum TIG levels along with total serum protein, albumin, C-reactive protein (CRP), and total immunoglobulin G (Ig G). Results: For diabetic patients without foot ulcers, 17 of 30 (56.6%) patients were found to have nonprotective TIG levels whereas for diabetic …


Sex-Related Differences In Copd Assessment Test Scores Of Copd Populationswith Or Without Significant Anxiety And/Or Depression, Yelda Varol, Ceyda Anar, Pinar Çi̇men, Mehmet Ünlü, Hüseyi̇n Hali̇lçolar, Sali̇h Zeki̇ Güçlü Jan 2017

Sex-Related Differences In Copd Assessment Test Scores Of Copd Populationswith Or Without Significant Anxiety And/Or Depression, Yelda Varol, Ceyda Anar, Pinar Çi̇men, Mehmet Ünlü, Hüseyi̇n Hali̇lçolar, Sali̇h Zeki̇ Güçlü

Turkish Journal of Medical Sciences

Background/aim: Sex-related differences have not been thoroughly explored in chronic obstructive pulmonary disease (COPD). We aimed to evaluate possible sex-related differences in COPD Assessment Test (CAT) scores of COPD patients with or without significant anxiety and/or depression. Materials and methods: Stable COPD patients were prospectively enrolled in the study between July 2013 and April 2014. Levels of anxiety, depression, dyspnea, and health-related quality of life parameters were assessed using specific questionnaires, including the CAT and others. Demographic and clinical data were recorded and physiological tests were performed. All the data were compared to determine any sex-related differences. Results: A total …


Nitric Oxide In Cerebrospinal Fluid Of Central Nervous System Tuberculosis: Correlations With Culture, Antibody Response, And Cell Count, Kavitha Kumar, Prashant Giribhattanavar, Shripad Patil Jan 2017

Nitric Oxide In Cerebrospinal Fluid Of Central Nervous System Tuberculosis: Correlations With Culture, Antibody Response, And Cell Count, Kavitha Kumar, Prashant Giribhattanavar, Shripad Patil

Turkish Journal of Medical Sciences

Background/aim: The role of nitric oxide (NO) has been established in infection over the years. NO functions by inhibiting the growth of intracellular pathogens. The present study was undertaken to ascertain the role of NO in central nervous system (CNS) infection by Mycobacterium tuberculosis. Materials and methods: A total of 781 chronic meningitis cerebrospinal fluid (CSF) samples suspected of CNS tuberculosis (TB) were categorized based on M. tuberculosis culture positivity, anti-TB antibody response, and CSF cell count and were analyzed for NO. Results: We found that NO levels were positive in 10.88% of the CSF samples. Positivity for NO was …


Significant Association Between Scgb1d4 Gene Polymorphisms And Susceptibility To Adenoid Hypertrophy In A Pediatric Population, Tali̇h Özdaş, Si̇bel Özdaş, Mehmet Ali̇ Babademez, Sami̇ Engi̇n Muz, Mahmut Huntürk Ati̇lla, Si̇bel Başti̇mur, Afi̇fe İzbirak, Kenan Kurt, Işilay Öz Jan 2017

Significant Association Between Scgb1d4 Gene Polymorphisms And Susceptibility To Adenoid Hypertrophy In A Pediatric Population, Tali̇h Özdaş, Si̇bel Özdaş, Mehmet Ali̇ Babademez, Sami̇ Engi̇n Muz, Mahmut Huntürk Ati̇lla, Si̇bel Başti̇mur, Afi̇fe İzbirak, Kenan Kurt, Işilay Öz

Turkish Journal of Medical Sciences

Background/aim: Adenoid hypertrophy (AH) is chronic enlargement of the adenoid tissue. The pathophysiology of the disease is unclear. We analyzed SCGB1D4 gene polymorphisms in order to determine the effect of the variants or their genetic combinations on AH. Materials and methods: We genotyped the SCGB1D4 (IIS) gene in 167 participants (95 children with AH and 72 controls) by performing DNA sequencing in blood samples. Results: We genotyped three single nucleotide polymorphisms (SNPs). In the analysis, we found that in the presence of those SNPs and the minor alleles of individual SNPs four haplotypes were associated with an increased risk of …


A Novel Mutation In Exon 1 Of Gata4 In Egyptian Patients With Congenital Heart Disease, Olfat Shaker, Salwa Omran, Eman Sharaf, Gehan A. Hegazy, Mohamed Mashaly, Nagwa E.A. Gaboon Jan 2017

A Novel Mutation In Exon 1 Of Gata4 In Egyptian Patients With Congenital Heart Disease, Olfat Shaker, Salwa Omran, Eman Sharaf, Gehan A. Hegazy, Mohamed Mashaly, Nagwa E.A. Gaboon

Turkish Journal of Medical Sciences

Background/aim: Congenital heart disease (CHD) is a common birth defect. Many studies have reported GATA4 mutations in patients with CHD, mainly septal defects. This study aimed to investigate the GATA4 exon 1 mutation in Egyptian patients with isolated congenital heart defects as a possible causative mutation. Materials and methods: Screening for mutations or any sequence variations in exon 1 of the GATA4 gene was carried out by PCR amplification followed by direct sequencings in 165 Egyptian patients with different nonsyndromic congenital heart diseases and 93 controls who were matched in terms of age and sex. Thorough clinical assessments were done …


Physicochemical And Biochemical Parameters In Milk Of Serbian Breastfeeding Women, Slavica Sunaric, Marko Denic, Jelena Lalic, Tatjana Jovanovic, Ana Spasic, Jelena Zivkovic, Natasa Trutic, Gordana Kocic Jan 2017

Physicochemical And Biochemical Parameters In Milk Of Serbian Breastfeeding Women, Slavica Sunaric, Marko Denic, Jelena Lalic, Tatjana Jovanovic, Ana Spasic, Jelena Zivkovic, Natasa Trutic, Gordana Kocic

Turkish Journal of Medical Sciences

Background/aim: This study was undertaken to determine the changes and relationships between some important milk constituents as well as physical, rheological, and biochemical parameters of milk obtained from Serbian breastfeeding mothers. Materials and methods: Physicochemical and biochemical parameters and the concentrations of vitamins, uric acid, and minerals were determined during the three periods of lactation covering colostrum, transitional, and mature milk collected from 67 mothers who had a term-pregnancy. Results: Large interindividual variations regarding many parameters were found between mothers at the same period of lactation, but the average values were mostly in the expected and recommended ranges. For some …


The Role Of Outer Inflammatory Protein A (Oipa) In Vaccination Of Thec57bl/6 Mouse Model Infected By Helicobacter Pylori, Mohaddese Mahboubi, Tahereh Falsafi, Majid Sadeghizadeh, Fatemeh Mahjoub Jan 2017

The Role Of Outer Inflammatory Protein A (Oipa) In Vaccination Of Thec57bl/6 Mouse Model Infected By Helicobacter Pylori, Mohaddese Mahboubi, Tahereh Falsafi, Majid Sadeghizadeh, Fatemeh Mahjoub

Turkish Journal of Medical Sciences

Background/aim: Outer inflammatory protein A (OipA) is an important adhesin of Helicobacter pylori. Our goal was to assess the role of OipA in protection of C57BL/6 mice against H. pylori. Materials and methods: C57BL/6 mice were mucosally immunized with recombinant OipA protein, OipA + propolis, propolis, and phosphate-buffered saline. After vaccination, anti-OipA IgA was measured. Mice were challenged three times with 5 x 107 CFU of the H. pylori B19 strain. Two weeks later, bacterial colonization and inflammation in the stomach was analyzed using standard methods. Results: The CFU number in the OipA group was significantly (P < 0.05) lower than that of the control. The CFU number in the OipA + propolis group was higher than those of the OipA and propolis groups. IgA titers were significantly higher (P < 0.0001) in the OipA group compared to the control and OipA + propolis groups. Propolis did not play an adjuvant effect but it interfered with the efficient vaccine effect of OipA. Conclusion: Results show the effect of vaccination by OipA in protection of the mouse model and the importance of OipA in H. pylori pathogenesis. OipA may be proposed as a suitable oral vaccine candidate against H. pylori infection; however, further study is required to determine adjuvant or adverse effects of propolis toward OipA.


The Effect Of Kisspeptin On Spermatogenesis And Apoptosis In Rats, Ni̇lüfer Aytürk, Tüli̇n Firat, Aysel Kükner, Candan Özoğul, Fatma Töre, İsmai̇l Engi̇n Kandirali, Bayram Yilmaz Jan 2017

The Effect Of Kisspeptin On Spermatogenesis And Apoptosis In Rats, Ni̇lüfer Aytürk, Tüli̇n Firat, Aysel Kükner, Candan Özoğul, Fatma Töre, İsmai̇l Engi̇n Kandirali, Bayram Yilmaz

Turkish Journal of Medical Sciences

Background/aim: To study the effect of kisspeptin, a gonadotropin release stimulator, on the testicular tissue of the rat. Materials and methods: Four groups were formed as follows: control, Kiss-10 50 nmol administration for 1 day, Kiss-10 administration for 13 days, and one last group kept for 7 days following Kiss-10 applied for 13 days. Testicular tissues were stained with hematoxylin-eosin, periodic acid Schiff, Masson trichrome staining, terminal deoxynucleotidyl transferased UTP nick-end labeling, and Ki-67 immune staining. Serum testosterone levels were determined. Results: Serum testosterone level increased following acute application, while it was reduced by chronic treatment. Spermatogenic cells as stained …


Metoclopramide Inhibits Trigeminovascular Activation:Evidence For Effective Acute Attack Treatment In Migraine, Hacer Doğanay Aydin, Doğa Vuralli, Di̇dem Tuba Akçali, Hayrunni̇sa Bolay Belen Jan 2017

Metoclopramide Inhibits Trigeminovascular Activation:Evidence For Effective Acute Attack Treatment In Migraine, Hacer Doğanay Aydin, Doğa Vuralli, Di̇dem Tuba Akçali, Hayrunni̇sa Bolay Belen

Turkish Journal of Medical Sciences

Background/aim: Metoclopramide is an effective and commonly used medication in acute migraine treatment but an experimental evidence base is lacking. We aimed to investigate the antimigraine effect of metoclopramide in a migraine model and whether the analgesic effect of metoclopramide was likely to be D2 receptor-mediated. Materials and methods: Cortical spreading depression (CSD) was used to model migraine in adult male Wistar rats. Five CSDs were induced by pinprick. Metoclopramide (two different doses), raclopride, or 0.9% saline were administered 30 min before CSD induction. Two hours after the experiments, brain tissues were examined for c-fos activation. Results: In metoclopramide groups …


Dysregulation Of The Dkk1 Gene In Pediatric B-Cell Acute Lymphoblastic Leukemia, Si̇nem Firtina, Özden Hatirnaz Ng, Yücel Erbi̇lgi̇n, Uğur Özbek, Müge Sayi̇toğlu Jan 2017

Dysregulation Of The Dkk1 Gene In Pediatric B-Cell Acute Lymphoblastic Leukemia, Si̇nem Firtina, Özden Hatirnaz Ng, Yücel Erbi̇lgi̇n, Uğur Özbek, Müge Sayi̇toğlu

Turkish Journal of Medical Sciences

Background/aim: The canonical Wingless-type (WNT) pathway is involved in normal hematopoietic cell development and deregulated WNT signaling is implicated in the development of hematological malignancies. Dickkopf 1 (DKK1) acts as a modulator of the β-catenin regulated canonical pathway. Activation of DKK1 leads to apoptosis and growth suppression, whereas silencing by promoter hypermethylation results in abnormal WNT activation. The secreted inhibitor Dickkopf can antagonize WNT signaling by competitively binding to low density lipoprotein receptors (LRPs) 5 and 6. Materials and methods: We studied DKK1 gene promoter methylation and investigated DKK1, β-catenin, LRP5, and LRP6 mRNA levels in B-cell acute lymphoblastic leukemia …


Proton--Proton And Proton--Antiproton Differential Elastic Cross Sections Modeling At High And Ultra-High Energies Using A Hybrid Computing Paradigm, Elsayed Eldahshan Jan 2017

Proton--Proton And Proton--Antiproton Differential Elastic Cross Sections Modeling At High And Ultra-High Energies Using A Hybrid Computing Paradigm, Elsayed Eldahshan

Turkish Journal of Physics

This work presents a hybrid computing technique for modeling the differential elastic cross section of both proton--proton ``pp'' and proton--antiproton ``pp(bar)'' collisions from high to ultra-high energy regions (from 13.9 GeV to 14 TeV) as a function of the center-of-mass energy ``s'' squared and four momentum transfer squared ``t''. We proposed a genetic algorithm (GA) and support vector regression (SVR) hybrid techniques to calculate and predict the ``differential elastic cross section'' of both ``pp'' and ``pp(bar)''. Our proposed GA-SVR hybrid model shows a good match to the available experimental data, as well as predicting the latest and future ``TOTEM'' experiments …