Digital Commons Network^™

Baroque Bodies In Post-Franco Era Literature By Spanish Women Writers From 1980-2011, Karina Miccio Walker

Legacy Theses & Dissertations (2009 - 2024)

Abstract

Mesh-Based Fourier Imaging For Biological And Security Applications, Danielle Justine Hayden

Legacy Theses & Dissertations (2009 - 2024)

Traditional x-ray imaging provides only low contrast from low atomic number materials, like soft tissue, due to the small attenuation variations producing very small intensity changes. Higher contrast can be achieved through phase information. The phase change is obtained from the x-ray refracting in a sample, or phase object, due to the difference in refractive indexes. This causes a small angular deviation from the original path. Phase contrast imaging has not been realized in everyday practice due to the requirement for large spatial coherence width of the x-ray beam which typically requires sources on the order of 10-50 m, the …

Differentiation, Distribution, And Diversity Of The Borrelia Burgdorferi Sensu Lato Virulence Gene, Ospc, And The Overwintering Survivability Of The Tick Vector, Ixodes Scapularis, Melissa Beth Stone

Legacy Theses & Dissertations (2009 - 2024)

The causative agents of Lyme disease, or Lyme Borreliosis, are spirochetes in the Borrelia burgdorferi sensu lato (s.l.) species complex that are transmitted by ticks in the genus Ixodes. Certain B. burgdorferi s.l. genotypes are more likely to cause invasive, disseminated infection in humans, and the gene, ospC, has been identified as a molecular marker that can be used to predict virulence. ospC is the most polymorphic locus in the B. burgdorferi s.l. genome, and different alleles have been assigned to Major ospC Groups based on sequence dissimilarity. Issues with the Major ospC Group definition and nomenclature are pervasive in …

Intra-Exposure Levels Of Anxious Arousal In A Lab-Based Exposure Intervention For Fear Of Public Speaking, Matteo Bugatti

Legacy Theses & Dissertations (2009 - 2024)

Background. Exposure therapy is effective for addressing social anxiety and public speaking fears, yet there are differences in suggested exposure strategies among empirically supported, manualized treatments. Manualized exposure strategies differ in the relative theoretical emphasis that underpins the specific procedural approach. Some approaches rely more heavily on the principle of habituation and formal cognitive restructuring; alternative approaches emphasize inhibitory learning and the individual's response to his/her own negative emotions, while promoting present-focused awareness. Innovative process methods can shed light on the similarities and differences between these approaches. Objectives. The goal of this study was to examine differences in anxious arousal …

Profiling Resistance To P450-Activated Food Carcinogens Using Toxicogenomic Approaches In Budding Yeast, Nicholas Stjohn

Legacy Theses & Dissertations (2009 - 2024)

The human response to environmental carcinogens, some of which require metabolic activation, is highly variable. Factors such as environment, lifestyle, and genetics all influence the rates of exposure to and ultimate bioactivation of these compounds. Genetic factors include mutations to cell-cycle regulation, cell proliferation, and DNA repair genes; however, epidemiological studies may lack significance due to inadequate patient numbers. We used budding yeast as a model organism to determine genetic susceptibility to food-associated carcinogens, including aflatoxin (AFB1) and heterocyclic aromatic amines (HAAs). Budding yeast does not contain P450s that activate these compounds, so expression vectors were induced that contain human …

Dna Aptamer-Based Smart Mri Contrast Agent For Dopamine, Angel D. Thompson

Legacy Theses & Dissertations (2009 - 2024)

A smart contrast agent is a molecule whose relaxivity changes in response to a biological trigger such as a biomolecule, enzymatic activity, or pH. The focus of my graduate project was to develop a DNA aptamer-based smart MRI contrast agent capable of sensing dopamine. Aptamers are single-stranded oligonucleotides that form stable three-dimensional structures efficient in binding with high affinity and specificity for a range of targets. The DNA aptamer has an attached lanthanide-based probe, consisting of a metal ion Gd(III) and a macrocyclic DOTA ligand. The aptamer was assembled using solid phase oligonucleotide synthesis. Nuclear magnetic resonance was used to …

Does Multiracial Identity Integration Moderate The Relation Between Racism And Health?, Michael Gale

Legacy Theses & Dissertations (2009 - 2024)

Current estimates suggest that approximately 9 million U.S. citizens identify as biracial or multiracial (henceforth “multiracial”) and that the multiracial population grew 32% from 2000 to 2010 (Humes et al., 2011). Despite the growth and increased visibility of this population, the psychological research on this group is limited and further research is needed to address the potential unique needs of multiracial individuals with regard to experiences of racial oppression, racial identity, and connections to health (Choi, Harachi, Gillmore, & Catalano, 2006). Past findings have suggested a significant, direct relation between perceived racial discrimination and psychological distress among multiracial individuals and …

Elucidation And Optimization Of Resistive Random Access Memory Switching Behavior For Advanced Computing Applications, Zahiruddin Alamgir

Legacy Theses & Dissertations (2009 - 2024)

RRAM has recently emerged as a strong candidate for non-volatile memory (NVM). Beyond memory applications, RRAM holds promise for use in performing logic functions, mimicking neuromorphic activities, enabling multi-level switching, and as one of the key elements of hardware based encryption or signal processing systems. It has been shown previously that RRAM resistance levels can be changed by adjusting compliance current or voltage level. This characteristic makes RRAM suitable for use in setting the synaptic weight in neuromorphic computing circuits. RRAM is also considered as a key element in hardware encryption systems, to produce unique and reproducible signals. However, a …

Landscape Of War : A Spatial Analysis Of Village Settlements In The Middle Missouri Subregion Of The North American Great Plains, Andrew Clark

Legacy Theses & Dissertations (2009 - 2024)

From the modern protests of the Dakota Access Pipeline to feuding between village dwelling horticulturalists, there is a long history of conflict along the banks of the Missouri River. This dissertation aims to investigate the interplay between the unique landscape of the semi-arid river valley and the continuing influx of culturally diverse people moving to the region, specifically, the semi-sedentary hunting farmers living in the Middle Missouri division of the North American Great Plains, between A.D. 1000 and 1750. I use a combination of ethnohistorical analysis, cross-cultural comparison, settlement history and spatial analysis (clustering, viewshed and topographic analyses) to explore …

Keats And Food : Language Of The Edible In John Keats's Letters And Poems, Kaitlin Resler

Legacy Theses & Dissertations (2009 - 2024)

This thesis is an exploration of the language of food and drink in the letters and poetry of John Keats. In sifting through his letters, famous for his unselfconscious thoughts on the nature of poetry and poetic composition, it is possible to construct the details of his culinary life not only as it pertains to daily eating habits but also in how he uses the language of food to articulate the sensations achieved in the course of writing and reading poetry. Keats frequently adapted this language to describe these activities because for him, the way food is consumed and synthesized …

Depression And Anxiety In Emerging Adults : The Impact Of Executive Function And Coping, Elisabeth J. O'Rourke

Legacy Theses & Dissertations (2009 - 2024)

Emerging adulthood is a developmental period marked by increased anxiety related to academic, social, and professional stressors. The ability to successfully cope with stress is strongly negatively related to mental health outcomes. Furthermore, recent studies indicate a connection between executive function impairment, anxiety and depression. The current study examines executive functioning (EF), coping, anxiety, and depression in a sample of 210 emerging adults (NMales = 131, Mage = 19.14). Additionally, the relation between EF and coping is explored. Finally, coping’s effect on the relation between EF and outcome (anxiety and depression) is investigated. The results demonstrate that males and females …

Computational Optimization And Characterization Of Molecularly Imprinted Polymers, Jacob Jordan Terracina

Legacy Theses & Dissertations (2009 - 2024)

Molecularly imprinted polymers (MIPs) are a class of materials containing sites capable of selectively binding to the imprinted target molecule. Computational chemistry techniques were used to study the effect of different fabrication parameters (the monomer-to-target ratios, pre-polymerization solvent, temperature, and pH) on the formation of the MIP binding sites. Imprinted binding sites were built in silico for the purposes of better characterizing the receptor – ligand interactions. Chiefly, the sites were characterized with respect to their selectivities and the heterogeneity between sites.

The Partners Of Transgender People : Gender, Sexuality, And Embodiment In Relationships Through Transition, Carey Jean Sojka

Legacy Theses & Dissertations (2009 - 2024)

In this dissertation, I explore the gendered, sexual, and embodied negotiations of the social world by thirty-five partners of transgender people as their significant other experienced various aspects of gender transition. This research shows the ways that people peripheral to a gender transition can be intimately impacted by it. Participants in this study demonstrated shifted understandings of their own and their partner’s gender and sexuality (i.e. Jason Cromwell’s (1999) transsituated perspective), as well as shifted understandings of gender and sexuality on a structural level, thus expanding our understanding of transgender studies by addressing how the perspectives of intimate partners of …

A Critical Review Of The Application Of Kolb's Experiential Learning Theory Applied Through The Use Of Computer Based Simulations Within Virtual Environments, 2000-2016, Daniel J. Grady

Legacy Theses & Dissertations (2009 - 2024)

This integrative research review aims to examine the application of Kolb’s theory of experiential learning through the use of simulations within virtual learning environments. It will first cover the framework of experiential learning as stated by Kolb, a learning theory that is finding new life within the context of simulations, role-playing games (RPGs), massive multiplayer role playing games (MMORPGs) and virtual environments. This analysis was conducted by making use of combined research strategies that focused specifically on both qualitative and quantitative reviews that utilized Kolb’s experiential theory of learning (ELT) within the context of the application of computer based simulations …

The Lived Experience Of Caregivers For Children With Asthma, Caroline Weiss Dawson

Legacy Theses & Dissertations (2009 - 2024)

The Lived Experience of Caregivers for Children with Asthma

Novel Approaches To Mitigating Bacterial Biofilm Formation And Intercellular Communication, Stephen Kasper

Legacy Theses & Dissertations (2009 - 2024)

Long thought of as solitary single-cell organisms, it is now widely accepted that bacteria can act and cooperate as social organisms. Phenomena such as biofilm formation and quorum sensing (QS) are two intimately intertwined cooperative behaviors that significantly contribute to the pathogenesis of many bacteria. Biofilms are surface associated communities of bacteria encased in a secreted extracellular matrix, which provides several advantages over an individualized lifestyle, such as increased protection from antimicrobial agents as well as enhanced opportunity for the exchange of genetic material. Bacterial QS is a system of population-based communication through the production, sensing, and response to chemical …

Altered Lipid Metabolism And Adipocyte Activity Support Her2+ Breast Cancer Progression, Jason Wong

Legacy Theses & Dissertations (2009 - 2024)

Overexpression of HER2 (ERBB2/neu) in breast cancer is an established clinical marker for aggressive disease and increased mortality. HER2+ breast cancers have increased protein levels of Human Epidermal Growth Factor Receptor 2 and overexpression of its coding gene, ERBB2. Many HER2+ tumors feature concomitant co-expression of the Nuclear Receptor subfamily 1, Group D, Member 1 (NR1D1/RevERBα) which regulates adipogenesis and circadian rhythm; the dysregulation of these two processes are known risk factors for breast cancer. HER2+ breast cancer cells have increased lipid synthesis, with evidence suggesting that NR1D1 is responsible for the upregulation of several genes in the de novo …

Structural And Functional Characterization Of An Unusual Camp Responsive Transcription Factor, Cmr, In Tb Complex Mycobacteria, Sridevi Ranganathan

Legacy Theses & Dissertations (2009 - 2024)

Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis in humans, is an intracellular pathogen that infects millions of people every year. Mtb can survive inside the host for extended periods of time by sensing and adapting to the host environmental stressors. Transcriptional gene regulation plays a critical role in this adaptation. This dissertation focuses on understanding the structural and functional aspects of one such transcriptional regulatory unit, Cmr (Rv1675c), in Mtb.

The Technology Development And Commercialization Of 'Smart' Scientific Instrumentations, Tony Hoang

Legacy Theses & Dissertations (2009 - 2024)

The technology development of two centrifuge-based instruments gave rise to an Internet-of-Things (IOT) biotech startup. The first instrument: the centrifuge force microscope (CFM) was recently introduced as a platform for massively parallel single-molecule manipulation and analysis. Here we developed a low-cost and self-contained CFM module that works directly within a commercial centrifuge, greatly improving accessibility and ease of use. Our instrument incorporates research grade video microscopy, a power source, a computer, and wireless transmission capability to simultaneously monitor many individually tethered microspheres. Building off of the first project, the second instrument we introduced was the “smart” centrifuge-test tube holder. The …

Study Of Biologically Important Macromolecules By Nuclear Magnetic Resonance, Christopher Michael Demott

Legacy Theses & Dissertations (2009 - 2024)

Intrinsically disordered proteins or unstructured segments within proteins play an important role in cellular physiology and pathology. A combination of peptide aptamers selected by using the yeast-two-hybrid scheme, and in-cell NMR identified high affinity binders to a transiently structured intrinsically disordered proteins (IDP). This method was validated using the prokaryotic ubiquitin-like protein, Pup, of the Mycobacterium proteasome. We discover two peptide aptamers that bind to opposite sites of a transient helix in Pup, an intrinsically disordered protein, that have vastly different effects on the survival of Mycobacterium bovis BCG.

Towards A Biomimetic Elastin-Based Nanofiber Scaffold For Salivary Gland Tissue Regeneration And Growth Factor Delivery, Zahraa Ismail Ahmed Foraida

Legacy Theses & Dissertations (2009 - 2024)

Development of electrospun nanofibers that mimic the structural, mechanical and biochemical properties of natural extracellular matrices (ECMs) and the basement membranes is a promising approach for tissue regeneration. Electrospun fibers of synthetic polymers partially mimic the topography of the ECM, however, their high stiffness, poor hydrophilicity and lack of in vivo-like biochemical cues is not optimal for epithelial cell self-organization and function. In search of a biomimetic scaffold for salivary gland tissue regeneration, we utilized proteins and peptides to induce biomechanical and biochemical cues that resembles the native tissue environment. These functional molecules were introduced to our previously-developed poly lactic-co-glycolic …

Socio-Demographic Determinants Of Racial Disparities In Stage At Diagnosis Of Prostate Cancer In New York State, Christophe Maxime Fokoua Dongmo

Legacy Theses & Dissertations (2009 - 2024)

ABSTRACT

Multifunctional Nanomaterials Utilizing Hybridization Chain Reaction For Molecular Diagnostics And Bioanalytical Applications, Md Muhit Rana

Legacy Theses & Dissertations (2009 - 2024)

DNA nanotechnology has shown great promise in molecular diagnostic, bioanalytical and biomedical applications. The great challenge of detecting target analytes, biomarkers and small molecules, in molecular diagnostics is low yield sensitivity. To address this challenge, different nanomaterials have been used for a long time and to date there is no such cost-effective bioanalytical technique which can detect these target biomarkers (DNA, RNA, circulating DNA/miRNA) or environmental heavy metal ions (Hg2+ and Ag+) in a cost-effective and efficient manner.

The Association Of Comorbid Chronic Physical Conditions And Psychological Illness With Health Care Utilization In Middle-Aged And Older People, Allison Houston

Legacy Theses & Dissertations (2009 - 2024)

Abstract

A Laser-Pulse Photolysis Study Of The Mechanism Of Potentiation Of The Glua2qflip Ampa Receptors By Cx546, Yu-Chuan Shen

Legacy Theses & Dissertations (2009 - 2024)

Insufficient activity of the α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate ion channels is involved in neurological disorders and developmental problems, such as schizophrenia, one of the most serious psychiatric diseases. Use of regulatory agents to enhance AMPA receptor activity under the circumstance has been shown therapeutically beneficial. Specifically, small-molecule compounds generally termed as potentiators or positive modulators of AMPA receptors have long been pursued as drug candidates for a potential treatment of these neurological disorders and diseases. The goal of my MS thesis work is to investigate the mechanism of potentiation on AMPA receptor by a classic potentiator known as CX546. The …

The New Right In Europe : Supply, Demand, And Electoral Performance : A Qualitative Comparative Analysis Of New Right Parties, 2000-2016, Rachel Rappaport

Legacy Theses & Dissertations (2009 - 2024)

The New Right is the fastest growing party family in Europe. Factors contributing to its success have been grouped broadly into two types: demand-side factors and supply-side factors. Demand-side factors comprise socio-economic developments such as unemployment, public mistrust in the political establishment, and levels of immigration. Supply-side factors relate to the mechanics of the party system, the type of the electoral system, and endogenous features of parties such as ideology, leadership and organization. Demand-side factors dominate in the literature on New Right party success. This study concentrates on party ideology in order to explain the electoral credibility of the New …

Immigration And Victimization : Applications Of Criminological Concepts To The Lesser-Known Side Of The Immigration And Crime Nexus, Allen W.C.P. Wong

Legacy Theses & Dissertations (2009 - 2024)

In recent decades, scholarly interest on immigration and crime has been on the rise. This increase in interest has even recently produced an academic consensus on the structural-level relationship between immigration and crime: on average, changes in immigration levels do not disproportionately increase crime rates. However, what is less explored in the literature is the individual-level relationship between immigration and criminal victimization, and specifically, the role played by criminological variables among generations of immigrant ethnic groups and their victimization experiences.

Elucidating The Transcriptional Regulation Underlying Neural Induction, Sarah E. Hirsch

Legacy Theses & Dissertations (2009 - 2024)

The brain is one of the most complicated structures in the human body and its development is also elusive. Great strides have been made in expounding some of the complex mechanisms of neural development, which allows for the creation of innovative, less invasive, and more effective treatments for neurodevelopmental and neurodegenerative disorders. The advent of stem cell technology has brought therapy development for these disorders closer to a reality, as stem cells provide a platform to model early stages of human neural development. This is of great importance, as only through studying neurodevelopment will the various transcriptional and molecular components …

Early Diagnosis And Intervention For Young Children With Autism Spectrum Disorder In New York State, Grace Ester Caroline Korompis

Health Policy, Management & Behavior Theses & Dissertations

This study examined the prevalence of autism spectrum disorder (ASD), analyzed the trends, assessed children’s sociodemographic characteristics and examined timing of ASD diagnosis among children who enrolled in the New York State Early Intervention Program (NYSEIP).

Secondary data from the New York State Early Intervention data systems were used. The systems include NYEIS (New York State Early Intervention System), a centralized web-based system that electronically manages the NYSEIP administrative tasks and was designed to support the NYSEIP's services, and the legacy data system: KIDS (Kids Integrated Data System). The time-trend design employed in this study was a form of longitudinal …

Disease In A Dish : Modeling Tau Pathology For Future Antibody Testing, Leneea Toyisha Warner

Legacy Theses & Dissertations (2009 - 2024)

ABSTRACT