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Medicine@Yale April/May 2017 Volume 13, Issue 2, Yale School Of Medicine Office Of Communications

Medicine@Yale - development newsletter

Medicine@Yale : advancing biomedical science, education and health care was a print and online newsletter which published news about academics, research and philanthropy for alumni, donors, faculty, students and the general public. It was initially published 6 times a year and then changed to a quarterly schedule. The first issue came out June/Jul. 2005. The final issue was published in May/June 2022, vol. 17, issue 1. Published by Yale School of Medicine, Office of Communications.

Medicine@Yale June/July 2017 Volume 13 Issue 3, Yale School Of Medicine Office Of Communications

Medicine@Yale - development newsletter

Medicine@Yale : advancing biomedical science, education and health care was a print and online newsletter which published news about academics, research and philanthropy for alumni, donors, faculty, students and the general public. It was initially published 6 times a year and then changed to a quarterly schedule. The first issue came out June/Jul. 2005. The final issue was published in May/June 2022, vol. 17, issue 1. Published by Yale School of Medicine, Office of Communications.

Antagonizing Tubulin-Dependent Vdac Closure To Revert Warburg Metabolism In Cancer Cells, David Nicholas Dehart

MUSC Theses and Dissertations

Enhancement of aerobic glycolysis and suppression of mitochondrial metabolism characterize the proliferation-favoring Warburg phenotype of cancer cells, and suppression of mitochondrial metabolism contributes to a low cytosolic ATP/ADP ratio favoring enhanced aerobic glycolysis. High free tubulin in cancer cells closes voltage dependent anion channels (VDAC) to decrease mitochondrial membrane potential (ΔΨ), an effect antagonized by erastin, the canonical promotor of ferroptosis, a type of non-apoptotic, iron-dependent oxidative cell death. Here, we identified six compounds (X1-X6) that also block tubulin-dependent mitochondrial depolarization. The three most potent lead compounds were structurally very similar, each containing a phenylpyrimidine carboxamide scaffold. We performed a …

Property Rights, State Police Powers, And The Takings Clause: The Evolution Toward Dysfunctional Land-Use Management, Robert F. Pecorella

Fordham Urban Law Journal

No abstract provided.

Confronting Inequality In Metropolitan Regions: Realizing The Promise Of Civil Rights And Environmental Justice In Metropolitan Transportation Planning, Richard A. Marcantonio, Aaron Golub, Alex Karner, Louise Nelson

Fordham Urban Law Journal

No abstract provided.

Transcutaneous Auricular Vagus Nerve Stimulation (Tavns): Development, Safety, Parametric Optimization, And Neurophysiological Effects, Bashar W. Badran

MUSC Theses and Dissertations

Cervically implanted vagus nerve stimulation (VNS) is a FDA-approved treatment for epilepsy and major depressive disorder (MDD). Additionally, VNS is a reemerging area of interest, showing promise in numerous animal studies with significant translatable applications. The cost, surgical risk, and human translation difficulty makes noninvasive VNS a highly-desired alternative. We have developed a transcutaneous auricular vagus nerve stimulation (taVNS) system that electrically stimulates the auricular branch of the vagus nerve (ABVN). We aimed to answer the following questions in this body of work: 1) whether taVNS is safe and feasible 2) if taVNS stimulates the vagus system similarly to implanted …

Antisense Afp Transcripts In Mouse Liver And Their Potential Role In Afp Gene Regulation, Maria S. Dixon

Theses and Dissertations--Microbiology, Immunology, and Molecular Genetics

Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer, ranking the sixth most common cancer and third most common cause of cancer mortality worldwide. Alpha-fetoprotein (AFP) is a plasma protein that is highly expressed in the fetal liver and shut off after birth. AFP expression is elevated in regenerating adult liver and HCC and has been used extensively as a diagnostic marker of liver cancer. We have been studying mouse liver gene regulation to better understand mechanisms by which changes in gene expression contribute to liver development, homeostasis and disease. Zinc Fingers and Homeoboxes 2 (Zhx2) has …

Therapeutic Potential Of Targeting Reactive Oxygen Species (Ros) Stress In Myelodysplastic Syndrome (Mds), Karine Z. Oben

Theses and Dissertations--Microbiology, Immunology, and Molecular Genetics

Myelodysplastic syndromes (MDS) are a diverse group of clonal hematologic disorders characterized by ineffective blood cell production (hematopoiesis), dysplastic (abnormal) cell morphology in one or more hematopoietic lineages, and progression to acute myeloid leukemia (AML). The response rate to current FDA approved therapies is low and not durable. Just about 50% of MDS patients respond to these drug therapies and a majority of responders relapse within 2-3 years. Hence there is a compelling need to investigate new therapy options.

We investigated the anticancer potential and possible underlying molecular mechanisms of action of a plant-derived compound, Withaferin A (WFA) in MDS. …

Sociodemographic And Clinical Predictors Of Triple Negative Breast Cancer, Madison Ries

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Background and Objectives

Breast cancer has the highest incidence rates among women and is the second leading cause of death due to cancer in women. Of all breast cancers, triple negative breast cancer (TNBC) accounts for about one-fifth of breast cancer and tends to result in an aggressive form with larger tumors and rates of metastasis and is more frequently found in younger women. This results in an important need in information regarding the risk of diagnosis with triple negative breast cancer over other forms and covariates associated with death and TNBC. This paper studies the relationship between race, tobacco …

2017 Commencement Program, Morehead State University. Registrar's Office.

Morehead State Commencement Programs

2017 commencement programs of Morehead State University.

Procedural Due Process And Intramural Hospital Dispute Resolution Mechanisms: The Texas Advance Directives Act, Thaddeus Pope

Faculty Scholarship

Increasingly, clinicians and commentators have been calling for the establishment of special adjudicatory dispute resolution mechanisms to resolve intractable medical futility disputes. As a leading model to follow, policymakers both around the United States and around the world have been looking to the conflict resolution provisions in the 1999 Texas Advance Directives Act (TADA).

In this article, I provide a complete and thorough review of the purpose, history, and operation of TADA. I conclude that TADA is a commendable attempt to balance the competing goals of efficiency and fairness in the resolution of these time-sensitive, life-and-death conflicts. But TADA is …

Refuting The Right Not To Know, Benjamin E. Berkman

Journal of Health Care Law and Policy

No abstract provided.

Parental Empathy, Aggressive Parenting And Child Adjustment In A High Risk Sample, Shuang Bi

Theses and Dissertations--Psychology

The current study examined the relation between parental empathy, parenting aggression and child maladjustment in a group of parents who perpetrated child abuse and neglect. Twenty parents who were court mandated to receive a parenting intervention program at the Nest Center for Women, Children, and Families participated in this research study. Information about parental dispositional empathy, parent-child specific empathy, parenting aggression and child internalizing and externalizing symptoms were collected through an interview with the parents. Parents in this study reported high levels of dispositional empathy, but exhibited low to moderate levels of empathy in a parent-child relationship rated by coders. …

Agricultural Land Use, Watershed Characteristics, And Hydrological Forces Contributing To The Impairment Of A Shallow Lake In The Western Corn Belt Ecoregion, Lynn Schultz

All Graduate Theses, Dissertations, and Other Capstone Projects

The Lake Titlow watershed (approximately 35,000 acres) in south-central Minnesota is part of the Minnesota River Basin. The lake is listed in the draft 2010 Clean Water Act Section 303d for nutrient pollution, eutrophication, and biological indicators for impairment of aquatic life and recreational use. Over 90 percent of pre-settlement wetlands are currently drained for agricultural land use. The Lake Titlow watershed is over 80 percent row crops and land use is implicated as a primary cause of impairment in the lake.

Water samples were collected from the Lake Titlow tributaries McLeod-Sibley Judicial Ditch Number 18 (JD18), Sibley County Ditch …

Maximizing Academic Success For Foster Care Students: A Trauma-Informed Approach, Anna A. Berardi Phd., Brenda M. Morton

Faculty Publications - College of Education

Children in foster care have experienced significant trauma due to the loss of primary attachment figures and the circumstances associated with that loss. Children who have suffered trauma generally present with cognitive, social, physical, and emotional vulnerabilities. These vulnerabilities are often expressed in the P–12 academic setting through difficulties with behavioral and emotional self-regulation, academic functioning, and physical ailments and illness related to chronic stress-induced compromised immune systems. This results in academic failure for half of all children in care. Training in how to respond to children who have suffered trauma is essential to ensure that children are comfortable and …

Evaluating The Impact Of An Evidence- Based Weight Reduction Program Among The Obese At A Medical Facility In North Central United States, Petronilla Eke

Walden Dissertations and Doctoral Studies

In September 2016, the Centers for Disease Control and Prevention (CDC) determined that more than one-third (36.5%) of U.S. adults have an obesity problem. According to the CDC, this issue results in other medical conditions such as type 11 diabetes, hypertension, cancer, heart disease, and stroke. This project was designed to evaluate the effectiveness of an evidence-based weight reduction program for obese individuals at a medical facility in the North Central United States. The methodology used consisted of a retrospective chart review of pre- and post-data for 45 people who participated in the medical facility's weight-reduction program over a 6 …

Hopelessness Depression As A Predictive Risk Factor For Recidivism And Survival Time Among Juvenile Offenders, Todd Milton Mcginnis

Walden Dissertations and Doctoral Studies

In the United States, there is a high incidence of recidivism among juvenile offenders with mental health disorders. This is a critical social issue facing the public and the Department of Juvenile Justice Administration today. However, research is not clear on the role of psychological factors in recidivism frequency and survival time. The purpose of this study was to examine whether hopelessness depression, as measured by suicidal-ideation, depression-anxiety, anger-irritation, and alcohol-drug use, and offense type, were predictors of recidivism frequency and survival time when controlling for age, gender, and race. The total sample consisted of archival data from 404 juvenile …

Attack At Fort Hood: Experiences And Suggestions For Security, William P. Moravits

Walden Dissertations and Doctoral Studies

In the past 8 years, at least 4 lone wolf terrorists have targeted military bases or recruiting centers in the United States and research suggests attack on the US military are increasing globally. The problem was that research had not addressed the lived experiences of survivors of lone wolf attacks or how they could inform procedures regarding a sense of security for military men and women. The purpose of this research was to establish a need to address threats to the security of the military from these attacks, to provide a rich description of survivors' experiences of the attack at …

Lived Experiences Of African American Males With Fibromyalgia, Ethel Denise Perry

Walden Dissertations and Doctoral Studies

Fibromyalgia (FM) is a musculoskeletal and neurological disorder that causes constant pain, cognitive problems with short term memory, and sleep disorders. There are more females diagnosed with FM than males, and research has therefore primarily been conducted with females. Because little is known about African American males with FM, biopsychosocial theory was used in this phenomenological study to examine how African American males with FM are affected biologically, psychologically, and socially. Eight African American males diagnosed with FM were recruited from Houston, Texas and were interviewed about their lived experiences with FM, including experiences with the healthcare system, and how …

Possible Risk Factors For Multidrug-Resistant Tuberculosis Infection In The Philippines, Molovon Jr Pasagui Azores

Walden Dissertations and Doctoral Studies

Multidrug-resistant Mycobacterium tuberculosis (MDR-TB) is a leading cause of morbidity and mortality in the Philippines. The purpose of this study was to gain knowledge about the relationship between potential risk factors and MDR-TB. Risk factors (the independent variables) for MDR-TB (the dependent variable) include previous TB treatment, infection with HIV, exposure to patients with drug-susceptible TB/MDR-TB, delays in diagnosis and treatment, employment status, smoking, imprisonment, alcohol abuse, and poor compliance with TB treatment regimens. The study was based on the epidemiological approach to causal inference work. A case-control study design was used wherein a quantitative method was applied in data …

Biosociocultural Factors And Motivation To Lose Weight Among Obese African American Women, Odette Marie Russell

Walden Dissertations and Doctoral Studies

Obesity is a pandemic that has a substantial impact among African American women. Biological, social, and cultural acceptance of obesity, collectively referred to as biosociocultural factors, represents an obstacle to efforts to address this health risk among this group. The purpose of this study was to develop a better understanding of the relationship between biosociocultural factors and motivation to lose weight. Self-determination theory, objectification theory, and social learning theory formed the study's theoretical framework. The key research question concerned the extent to which the investigated constructs (BMI, internalized body image, and social networks) helped to explain motivation for weight loss …

Strategies To Promote It Project Success, Gerald Scheuchner

Walden Dissertations and Doctoral Studies

Many project managers and business leaders lack effective strategies to manage information technology (IT) projects, which may inhibit business leaders from successfully implementing IT changes. The purpose of this multiple case study was to explore strategies that IT leaders use to successfully implement IT projects. The target population consisted of IT leaders in IT organizations located in the Saint Louis Metro East area. The conceptual framework consisted of the general systems theory and the coordination theory. Data collection included organizational documents and semistructured interviews with 6 qualified participants. Data analysis included coding and thematic analysis, member checking, and methodological triangulation. …

Parents' Perception Of A School-Based Inclusion Program For Their Children With Autism, Sarah Lynn Ary

Walden Dissertations and Doctoral Studies

As the number of students diagnosed with Autism Spectrum Disorder (ASD) increases, many classrooms are turning to an inclusion model of learning. To gain the perspective of program users rather than providers, this study explored parents' perceptions of the inclusion model. Pearlin's stress process model served as the theoretical framework for this study. Ten parents in Pennsylvania were recruited via snowball sampling for participation, and 7 completed the study. Parents completed a short demographic questionnaire and then participated in individual interviews. The research questions were concerned with the lived experiences of parents of children with autism enrolled in inclusion programs …

The Effectiveness Of Course-Based Health Education Interventions Towards Increased Physical Activity Among College Students, Jay Morris Martin

Walden Dissertations and Doctoral Studies

Despite the many health benefits, physical activity participation among those between 18 to 24 years is in significant decline during the college-age years. Postsecondary education has been identified as an ideal environment where young adults should be targeted for physical activity participation. However, a limited number of studies have assessed the effectiveness of college-level health education and physical education program interventions to increase physical activity levels among college students. The purpose of this study was to examine current physical activity levels of college age students who have completed a college-level health education course and laboratory to gain a better understanding …

Experiences Of Community Leaders Following An Enhanced Fujita 5 Tornado, Thomas Edward Orr

Walden Dissertations and Doctoral Studies

Many U.S. communities experience tornadoes each year, causing a significant number of deaths and injuries. Proper community preparation and response can help reduce human suffering and psychological trauma that occur following a tornado. However, according to the National Institute of Standards and Technology most U.S. communities in tornado-prone areas are unprepared for a violent tornado, and there are few national, state, or local tornado-related definitions, standard or code to guide preparations. Social constructionism was the underlying theory of this qualitative study. The purpose of this study was to improve tornado preparations by examining the experiences of community leaders following a …

Discovering Opportunities To Improve Profitability At A Federally Qualified Health Center, Robert Jackson Jackson

Walden Dissertations and Doctoral Studies

Federally Qualified Health Center (FQHC) organizations, which provide health care services to low-income, underserved patients, are underfunded. From 2000 to 2007, the cost of treating an FQHC patient increased by $146, while federal compensation to FQHCs increased by only $44 per patient. One FQHC organization in rural Alabama experienced financial losses from the fiscal year 2011 through 2014, jeopardizing services to approximately 6,000 low-income patients. The purpose of this qualitative case study was to analyze the subject organization and discover opportunities to improve financial performance. The research question pertained to the opportunities for improving profitability at the subject organization. The …

Health Promotion Behavior Among Hypertensive And Normotensive Armenian Americans, Zoya Minasyan

Walden Dissertations and Doctoral Studies

Hypertension presents a significant health risk to both developed and developing countries, affecting approximately 78 million Americans of various ethnic backgrounds. Though a great deal of research about hypertension and minority groups has been published, few studies have examined hypertension in the Armenian American population in the Los Angeles area, one of the most concentrated Armenian American communities in the United States. The purpose of this study was to examine the differences in health promotion behavior between hypertensive and normotensive Armenian Americans. The theoretical basis for this study was Pender's health promotion model and the health promoting lifestyle profile (HPLP-II), …

Ptsd With Substance Use Disorders Female Versus Male Veterans: An Archival Study, Geri Cribbs

Walden Dissertations and Doctoral Studies

The present study examined men and women veterans diagnosed with posttraumatic stress disorder (PTSD) and substance use disorder (SUD). Women in the general public have been found to be at greater risk for a diagnosis of PTSD with life-long symptoms. Current literature involving military men and women veterans is at odds over which gender is more likely to have both PTSD and SUD. This study assessed the variables of gender and diagnosis. It also studied whether the age of female veterans affects their likelihood of having both PTSD and SUD. Archival data were gathered from the Veterans Administration (VA) for …

The Development Of Narcissism Among Lawyers And Farmers: A Quantitative Study, Steve Murdock Murdock

Walden Dissertations and Doctoral Studies

Narcissism has been identified as a threat to society and the individual. Individuals with high levels of narcissism (narcissistic personality disorder) struggle to maintain jobs, stable relationships, and healthy life perspectives. Without knowledge about the origins of narcissism, mental health professionals may only be treating the symptoms of narcissism and not the factors that perpetuate its development. The purpose of this study was to measure narcissism in farming and law careers and to determine whether career is a factor in the development of narcissism. It was predicted that career would be an important developmental event and process that would have …

How Women Experience And Respond To Singlism: Stereotyping And Discrimination Of Singles, Lisa Lynn Hancock

Walden Dissertations and Doctoral Studies

Society views and treats women who are single differently than women who are not single. This practice of stereotyping and discrimination towards singles is called singlism. The purpose of this qualitative study was to use grounded theory methodology to explore and explain how women experience singlism and what explains how women experience singlism. Social constructionism, cognitive dissonance theory, and social identity theory were used as conceptual foundations in explaining how society constructs the status of single women, how single women are viewed and treated, and how single women manage their single social identity. The participants of the study included women …