Digital Commons Network^™

An Innovative Approach To Teaching The History Of Physiology, Sowmya Anjur

Faculty Publications & Research

Physiology and Disease students at the Illinois Mathematics and Science Academy in Aurora employ inquiry driven activities to improve their understanding and articulation of the discipline. After covering the major physiological concepts for the semester, a novel assessment has been introduced as the final project in the class to help integrate the concepts and promote student creativity and learning. Students are asked to create and present several skits on the history of physiology for specific time periods ranging from times before Christ to the 21st century.

Changes In Behavior And Emotion Under Chicken Domestication, Martin Johnsson

Animal Sentience

Marino’s target article provides an overview of chickens’ cognition, emotion, and personality, with the aim of changing how people view chickens. In this commentary, I will agree that chickens deserve better than their reputation, but contend with a statement about the lack of behavioral change under chicken domestication.

Impacts Of Terrain Attributes In Economics And The Environment: Costs Of Reducing Potential Nitrogen Pollution In Wheat Production, Cory Walters, C. Richard Shumway, David R. Huggins

Department of Agricultural Economics: Faculty Publications

The economic cost of achieving desired environmental outcomes from uniform and variable rate fertilizer application technologies depends both on market forces and agronomic properties. Using spatial econometric methods, we analyze the impact of nitrogen fertilizer supply by terrain attribute on the yield and protein content of hard red spring wheat grown in EasternWashington as well as the impact on residual nitrogen.We find significant association with all three. The economic impact of nitrogen restrictions depends critically on both prices and level of the restriction. Uniform application of nitrogen was found to economically outperform variable rate application, but variable rate application provided …

Project H.0.P.E Helping Out People Everywhere Through Occupational Therapy, Shayla' Prioleau

MOT Student Capstones

In the community of Santo Domingo, Dominican Republic, there is a special needs orphanage in desperate need of assistance for children who have physical and/or intellectual difficulties; they lack the appropriate resources. These children and adolescents also lack various life skills due to either neurological or developmental disease. The diseases most commonly seen in the orphanage are severe cerebral palsy and muscular dystrophy. Areas affected by these neurological or developmental diseases allow for limitations in a plethora of occupations and performance skills areas. In addition to the children housed in this orphanage, there is also a staff of 33. This …

Late Adulthood And Meaningful Occupation: The Relationship Between Quality Of Life, Meaningful Activity, And Health, Dwight P. Mangum

MOT Student Capstones

Engagement in meaningful activity is critical to quality of life throughout the lifespan. Participation in such activity can become more challenging at retirement age due to a variety of health concerns and other issues. When an individual's ability to engage in meaningful activity (life roles, leisure activities, activities of daily living, etc.) is diminished due to age related health concerns, injury, or other factors, the resulting barriers to participation in meaningful activity can cause greater damage to quality of life. An understanding of the role that meaningful activity plays in sustaining quality of life is crucial for motivating recovery of …

Promoting Shade On A Public Playground: An Occupational Therapy Approach To Promoting Community Health, Andrew P. Baglia

MOT Student Capstones

Background Recent studies have raised concern regarding inadequate shade on public playgrounds, leading to an increased risk of sun and heat injury and decreased opportunities for play participation for children. Adequate shade has been shown to be an effective measure to mitigate heat and sun exposure. This Capstone project aimed to positively impact the community of the city of Saluda, North Carolina (NC), by using occupational therapy intervention approaches of promotion, modification, prevention, and education to promote the procurement of adequate shade at the Saluda Elementary School (SES) public playground. Methods This project employed a parent survey to measure attitudes …

2017 Spring - University School Alumni Newsletter, University School, East Tennessee State University

University School Newsletters

No abstract provided.

Not Mine Alone, Nor Mine To Own: Some Reflections On The Young Girl, Jacqueline Mabey

Journal of Feminist Scholarship

This essay looks at the role of the young girl in the curatorial practice of Jacqueline Mabey. Mabey reckons with the young girl as the signifier of a spectrum of mutable cultural signifieds and young girls as subjects on their own terms in the two exhibitions under review, Miss World and Utopia Is No Place, Utopia Is Process. In doing so, she recognizes a shift in motivations from an interest in what the young girls mean as a narcissistic reflection to how she could work in service of the development of young girls.

Acute And Sub-Acute Toxicity Of The Polycyclic Aromatic Hydrocarbon 1-Methylnaphthalene To The Shallow-Water Coral Porites Divaricata: Application Of A Novel Exposure Protocol, Dorothy-Ellen A. Renegar, Nick Turner, Bernhard Riegl, Richard E. Dodge, Anthony H. Knap, Paul Schuler

Marine & Environmental Sciences Faculty Articles

Previous research evaluating hydrocarbon toxicity to corals and coral reefs has generally focused on community-level effects, and results often are not comparable between studies because of variability in hydrocarbon exposure characterization and evaluation of coral health and mortality during exposure. Toxicity of the polycyclic aromatic hydrocarbon 1-methylnaphthalene to the coral Porites divaricata was assessed in a constant exposure toxicity test utilizing a novel toxicity testing protocol uniquely applicable to shallow-water corals, which considered multiple assessment metrics and evaluated the potential for post-exposure mortality and/or recovery. Acute and subacute effects (gross morphological changes, photosynthetic efficiency, mortality, and histologic cellular changes) were …

Distribution And Habitat Use Of The Golden Crab Chaceon Fenneri Off Eastern Florida Based On In Situ Submersible And Rov Observations And Potential For Impacts To Deep Water Coral/Sponge Habitat, John Reed, Stephanie Farrington, Charles Messing, Andre David

Marine & Environmental Sciences Faculty Articles

This study documents the distribution and habitat preferences of the golden crab, a commercially fished species, in relation to deep-sea coral/sponge ecosystems (DSCEs) at 200-900 m depths off eastern Florida. A total of 386 h of videotapes from 94 submersible and remotely operated vehicle (ROV) dives from 1999 to 2009, covering a total distance of 376 km, were reviewed and characterized for habitat type and presence of crabs. The DSCEs surveyed included Lophelia coral mounds, Miami Terrace, Pourtalès Terrace, and Tortugas Valleys. Video transect data also included environmental surveys of proposed deep-water routes for Liquid Natural Gas (LNG) pipelines, LNG …

Dna Analysis Of Surfactant-Associated Bacteria In A Natural Sea Slick Observed By Terrasar-X And Radarsat-2 Over The Gulf Of Mexico, Kathryn Howe, Cayla Whitney Dean, John Alexander Kluge, Alexander Soloviev, Aurelien Tartar, Mahmood S. Shivji, Susanne Lehner, Hui Shen, William Perrie

Marine & Environmental Sciences Faculty Articles

The damping of short gravity-capillary waves (Bragg waves) due to surfactant accumulation under low wind speed conditions results in the formation of natural sea slicks. These slicks are detectable visually and in synthetic aperture radar (SAR) imagery. Surfactants are produced by natural life processes of many organisms, such as bacteria, phytoplankton, seaweed, and zooplankton. By using DNA analysis, we are able to determine the relative abundance of surfactant-associated bacteria in the sea surface microlayer and the subsurface water column. A method to reduce contamination of samples during collection, storage, and analysis (Kurata et al., 2016; Hamilton et al., 2015) has …

A Principal Component Analysis Of Vertical Temperature Profiles For Tracking Movements Of Large Pelagic Fishes, Kathryn G. Carmody, Arthur Mariano, David Kerstetter

Marine & Environmental Sciences Faculty Articles

Pop-up satellite archival tag (PSAT) technology that records depth, temperature, and light-level data has expanded the understanding of free-swimming behavior for numerous pelagic animals. Astronomical algorithms using these light-level data have allowed geolocation estimates of daily longitude and latitude. However, many pelagic animals have a crepuscular behavior pattern in which individuals are at depths below the photic layer during the day, thus precluding the use of traditional light-based movement algorithms for geolocation in such species as swordfish. A principal component analysis (PCA) of temperature profiles is described herein that utilizes depth and temperature data rather than light to estimate the …

Supplemental Data, Russell J. Ingram, Foster Levy, Cindy L. Barrett, James T. Donaldson

ETSU Faculty Works

No abstract provided.

Adverse Childhood Experiences And Life Opportunities: Shifting The Narrative, Marilyn Metzler, Melissa T. Merrick, Joanne Flevens, Katie A. Ports

United States Public Health Resources

Substantial research shows that early adversity, including child abuse and neglect, is associated with diminished health across the life course and across generations. Lesswell understood is the relationship between early adversity and adult socioeconomic status, including education, employment, and income. Collectively, these outcomes provide an indication of overall life opportunity. We analyzed data from 10 states and the District of Columbia that used the adverse childhood experiences (ACE) module in the 2010 Behavioral Risk Factor Surveillance System to examine the association between ACEs and adult education, employment, and income. Compared to participants with no ACEs, those with higher ACE scores …

Kinase Suppressor Of Ras 2 (Ksr2) Expression In The Brain Regulates Energy Balance And Glucose Homeostasis, Lili Guo, Diane L. Costanzo-Garvey, Deandra R. Smith, Beth K. Neilsen, Richard G. Macdonald, Robert E. Lewis

United States Public Health Resources

Objective: Kinase Suppressor of Ras 2 (KSR2) is a molecular scaffold coordinating Raf/MEK/ERK signaling that is expressed at high levels in the brain. KSR2 disruption in humans and mice causes obesity and insulin resistance. Understanding the anatomical location and mechanism of KSR2 function should lead to a better understanding of physiological regulation over energy balance.

Methods: Mice bearing floxed alleles of KSR2 (KSR2^fl/fl) were crossed with mice expressing the Cre recombinase expressed by the Nestin promoter (Nes-Cre) to produce Nes-CreKSR2^fl/fl mice. Growth, body composition, food consumption, cold tolerance, insulin and free fatty acid …

Evaluation Of Divided Attention Psychophysical Task Performance And Effects On Pupil Sizes Following Smoked, Vaporized And Oral Cannabis Administration, Matthew N. Newmeyer, Madeleine J. Swortwood, Megan E. Taylor, Osama A. Abulseoud, Thomas H. Woodward, Marilyn A. Huestis

United States Public Health Resources

Establishing science-based driving per se blood Δ⁹-tetrahydrocannabinol (THC) limits is challenging, in part because of prolonged THC detection in chronic, frequent users. Therefore, documenting observable signs of impairment is important for driving under the influence of drugs. We evaluated frequent and occasional cannabis smokers’ performance on the modified Romberg balance, one leg stand (OLS), and walk and turn (WAT) tasks, and pupil size effects following controlled placebo (0.001% THC), smoked, vaporized and oral (6.9% [~50.4mg] THC) cannabis administration. Significant effects following inhaled doses were not observed due to delayed tasks administration 1.5 and 3.5 h post-dose, but significant …

Looming Threats And Animacy: Reduced Responsiveness In Youth With Disrupted Behavior Disorders, Stuart F. White, Laura C. Thornton, Joseph Leshin, Roberta Clanton, Stephen Sinclair, Dionne Coker-Appiah, Harma Meffert, Soonjo Hwang, James R. Blair

United States Public Health Resources

Theoretical models have implicated amygdala dysfunction in the development of Disruptive Behavior Disorders (DBDs; Conduct Disorder/Oppositional Defiant Disorder). Amygdala dysfunction impacts valence evaluation/response selection and emotion attention in youth with DBDs, particularly in those with elevated callous-unemotional (CU) traits. However, amygdala responsiveness during social cognition and the responsiveness of the acute threat circuitry (amygdala/ periaqueductal gray) in youth with DBDs have been less well-examined, particularly with reference to CU traits. 31 youth with DBDs and 27 typically developing youth (IQ, age and gender-matched) completed a threat paradigm during fMRI where animate and inanimate, threatening and neutral stimuli appeared to loom …

Using Cerebrospinal Fluid Biomarker Testing To Target Treatment To Patients With Mild Cognitive Impairment: A Cost-Effectiveness Analysis, Tzeyu L. Michaud, Robert L. Kane, J. Riley Mccarten, Joseph E. Gaugler, John A. Nyman, Karen M. Kuntz

United States Public Health Resources

Objective Cerebrospinal fluid (CSF) biomarkers are shown to facilitate a risk identification of patients with mild cognitive impairment (MCI) into different risk levels of progression to Alzheimer’s disease (AD). Knowing a patient’s risk level provides an opportunity for earlier interventions, which could result in potential greater benefits. We assessed the cost effectiveness of the use of CSF biomarkers in MCI patients where the treatment decision was based on patients’ risk level.

Methods We developed a state-transition model to project lifetime quality-adjusted life-years (QALYs) and costs for a cohort of 65-year-old MCI patients from a US societal perspective. We compared four …

A Prospective Study Of Cancer Risk Among Agricultural Health Study Farm Spouses Associated With Personal Use Of Organochlorine Insecticides, Lydia M. Louis, Catherine C. Lerro, Melissa C. Friesen, Gabriella Andreotti, Stella Koutros, Dale P. Sandler, Aaron Blair, Mark G. Robson, Laura E. Beane Freeman

United States Public Health Resources

Background: Organochlorine insecticides (OCs) have historically been used worldwide to control insects, although most have now been banned in developed countries. Evidence for an association between OC exposures and cancer predominantly comes from occupational and population based-studies among men. We evaluated the association between the use of specific OCs and cancer among the female spouses of pesticide applicators in the Agricultural Health Study.

Methods: At enrollment (1993–1997), spouses of private applicators in the cohort provided information about their own use of pesticides, including seven OCs (aldrin, chlordane, dieldrin, DDT, heptachlor, lindane, and toxaphene), and information on potential confounders. We …

Neoadjuvant Treatment Of Pancreatic Adenocarcinoma: A Systematic Review And Meta-Analysis Of 5520 Patients, Mashaal Dhir, Gautam K. Malhotra, Davendra P. S. Sohal, Nicholas A. Hein, Lynette M. Smith, Eileen M. O'Reilly, Nathan Bahary, Chandrakanth Are

United States Public Health Resources

Background: Recent years have seen standardization of the anatomic definitions of pancreatic adenocarcinoma, and increasing utilization of neoadjuvant therapy (NAT). The aim of the current review was to summarize the evidence for NAT in pancreatic adenocarcinoma since 2009, when consensus criteria for resectable (R), borderline resectable (BR), and locally advanced (LA) disease were endorsed.

Methods: PubMed search was undertaken along with extensive backward search of the references of published articles to identify studies utilizing NAT for pancreatic adenocarcinoma. Abstracts from ASCO-GI 2014 and 2015 were also searched.

Results: A total of 96 studies including 5520 patients were included in …

Nanoscale Characterization Of Interaction Of Apobec3g With Rna, Yangang Pan, Zhiqiang Sun, Atanu Maiti, Tapan Kanai, Hiroshi Matsuo, Ming Li, Reuben S. Harris, Luda S. Shlyakhtenko, Yuri L. Lyubchenko

United States Public Health Resources

The human cytidine deaminase APOBEC3G (A3G) is a potent inhibitor of the HIV-1 virus in the absence of viral infectivity factor (Vif). The molecular mechanism of A3G antiviral activity is primarily attributed to deamination of singlestranded DNA (ssDNA); however, the nondeamination mechanism also contributes to HIV-1 restriction. The interaction of A3G with ssDNA and RNA is required for its antiviral activity. Here we used atomic force microscopy to directly visualize A3G− RNA and A3G−ssDNA complexes and compare them to each other. Our results showed that A3G in A3G−RNA complexes exists primarily in monomeric−dimeric states, similar to its stoichiometry in complexes …

Toward Solving The Etiological Mystery Of Primary Biliary Cholangitis, Atsushi Tanaka, Patrick S.C. Leung, Howard A. Young, M. Eric Gershwin

United States Public Health Resources

Primary biliary cholangitis (PBC) is considered a model autoimmune disease due to its signature anti-mitochondrial antibody (AMA) autoantibody, female predominance, and relatively specific portal infiltration and cholestasis. The identification and cloning of the major mitochondrial autoantigens recognized by AMA have served as an immunologic platform to identify the earliest events involved in loss of tolerance. Despite the relatively high concordance rate in identical twins, genome-wide association studies have not proven clinically useful and have led to suggestions of epigenetic events. To understand the natural history and etiology of PBC, several murine models have been developed, including spontaneous models, models induced …

Wild Stimulant Production Methods For American Ginseng Farms In Tennessee, Shannon Smith, John Dubois, Nate Phillips, Arvazena Clardy

Extension Publications

No abstract provided.

Detecting Discordance Enrichment Among A Series Of Two-Sample Genome-Wide Expression Data Sets, Yinglei Lai, Fanni Zhang, Tapan Nayak, Reza Modarres, Norman H. Lee, Timothy A. Mccaffrey

Epidemiology Faculty Publications

Background

With the current microarray and RNA-seq technologies, two-sample genome-wide expression data have been widely collected in biological and medical studies. The related differential expression analysis and gene set enrichment analysis have been frequently conducted. Integrative analysis can be conducted when multiple data sets are available. In practice, discordant molecular behaviors among a series of data sets can be of biological and clinical interest.

Methods

In this study, a statistical method is proposed for detecting discordance gene set enrichment. Our method is based on a two-level multivariate normal mixture model. It is statistically efficient with linearly increased parameter space when …

Clinical And Mucosal Immune Correlates Of Hiv-1 Semen Levels In Antiretroviral-Naive Men., Brendan J W Osborne, Angie K Marsh, Sanja Huibner, Kamnoosh Shahabi, Cindy Liu, Tania Contente, Nico J D Nagelkerke, Colin Kovacs, Erika Benko, Lance Price, Kelly S Macdonald, Rupert Kaul

Environmental and Occupational Health Faculty Publications

Background.

This study was done to characterize parameters associated with semen human immunodeficiency virus (HIV)-1 ribonucleic acid (RNA) viral load (VL) variability in HIV-infected, therapy-naive men. Methods.

Paired blood and semen samples were collected from 30 HIV-infected, therapy-naive men who have sex with men, and 13 participants were observed longitudinally for up to 1 year. Human immunodeficiency virus RNA, bacterial load by 16S RNA, herpesvirus (Epstein-Barr virus and cytomegalovirus [CMV]) shedding, and semen cytokines/chemokines were quantified, and semen T-cell subsets were assessed by multiparameter flow cytometry. Results.

Semen HIV RNA was detected at 93% of visits, with >50% of men …

Routine Screening For Silent Atrial Fibrillation, Zach Stevens

Theses and Graduate Projects

Atrial fibrillation (AF) is the most common arrhythmia and is particularly prevalent in the elderly population. It is associated with an elevated stroke risk which can be easily minimized with anticoagulation. However, AF detection is often difficult due to infrequent or absent symptoms and the first presentation of AF may be a stroke. Advances in technology have made screening for AF more feasible and accessible. Opportunistic screening with pulse palpation and confirmatory ECG is now strongly supported by the evidence and more recent studies have demonstrated that systematic screening – particularly of those with AF risk factors – may be …

Schizophrenia’S Relationship With Cardiovascular Morbidity And Mortality, Hannah Jorgensen

Theses and Graduate Projects

Premature morbidity and mortality due to cardiovascular disease (CVD) disproportionately affects individuals with schizophrenia. This research paper systematically reviews articles that examine the theories and causes of increased CVD risk in individuals with schizophrenia. The findings of the review indicate that there are biological, environmental and sociocultural components of the relationship between schizophrenia and cardiovascular disease. Inflammation from the progression of chronic schizophrenia appears to play a part. The side-effect profile of the medications used to treat schizophrenia cause CVD risk factors. The secondary and tertiary symptoms of the disease process result in problems in motivation, cognitive function and self- …

Washington University Magazine, Fall/Winter 2017

Washington University Magazine

No abstract provided.

Washington University Magazine, Spring 2017

Washington University Magazine

No abstract provided.

Washington University Magazine, Summer 2017

Washington University Magazine

No abstract provided.