Digital Commons Network^™

Parent And Child Report Of Pain And Fatigue In Jia: Does Disagreement Between Parent And Child Predict Functional Outcomes?, Amy C. Gaultney, Maggie H. Bromberg, Mark Connelly, Tracy Spears, Laura E. Schanberg

Manuscripts, Articles, Book Chapters and Other Papers

While previous research in juvenile idiopathic arthritis (JIA) has identified discrepancy between parent and child perception of disease-related symptoms such as pain, the significance and impact of this disagreement has not been characterized. We examined the extent to which parent-child discordance in JIA symptom ratings are associated with child functional outcomes. Linear regression and mixed effects models were used to test the effects of discrepancy in pain and fatigue ratings on functional outcomes in 65 dyads, consisting of youth with JIA and one parent. Results suggested that children reported increased activity limitations and negative mood when parent and child pain …

Inhibition Of The Integrin/Fak Signaling Axis And C-Myc Synergistically Disrupts Ovarian Cancer Malignancy, B. Xu, Jason R. Lefringhouse, Z. Liu, D. West, Lauren A. Baldwin, C. Ou, L. Chen, Dana L. Napier, Luksana Chaiswing, Lawrence D. Brewer, Daret K. St Clair, Olivier Thibault, John R. Van Nagell, Binhua P. Zhou, R. Drapkin, J.-A. Huang, M. L. Lu, Frederick R. Ueland, X. H. Yang

Pharmacology and Nutritional Sciences Faculty Publications

Integrins, a family of heterodimeric receptors for extracellular matrix, are promising therapeutic targets for ovarian cancer, particularly high-grade serous-type (HGSOC), as they drive tumor cell attachment, migration, proliferation and survival by activating focal adhesion kinase (FAK)-dependent signaling. Owing to the potential off-target effects of FAK inhibitors, disruption of the integrin signaling axis remains to be a challenge. Here, we tackled this barrier by screening for inhibitors being functionally cooperative with small-molecule VS-6063, a phase II FAK inhibitor. From this screening, JQ1, a potent inhibitor of Myc oncogenic network, emerged as the most robust collaborator. Treatment with a combination of VS-6063 …

Mcsa Forum Minutes 01/30/2017, Morris Campus Student Association

Morris Campus Student Association

No abstract provided.

Violating Equal Protection: Lynch V. Morales-Santana And The Ina’S Sex Discriminatory Physical Presence Requirement, Courtney Magnus

Duke Journal of Constitutional Law & Public Policy Sidebar

In Lynch v. Morales-Santana, the Supreme Court will consider whether the Immigration and Nationality Act’s physical presence requirement scheme violates the Fifth Amendment’s equal protection guarantee. Under 8 U.S.C. §§ 1401(a)(7) and 1409(c) (1952), an unwed U.S. citizen father wishing to convey citizenship at-birth to his child born abroad cannot do so unless he has been physically present in the United States for ten years prior to the child’s birth. In contrast, an unwed citizen mother only needs to be physically present for one continuous year. This commentary argues that because §§ 1401 and 1409 facially discriminate against unwed …

Global Proteome Changes In The Rat Diaphragm Induced By Endurance Exercise Training, Kurt J. Sollanek, Jatin G. Burniston, Andreas N. Kavazis, Aaron B. Morton, Michael P. Wiggs, Bumsoo Ahn, Ashley J. Smuder, Scott K. Powers

Health & Kinesiology Faculty Publications and Presentations

Mechanical ventilation (MV) is a life-saving intervention for many critically ill patients. Unfortunately, prolonged MV results in the rapid development of diaphragmatic atrophy and weakness. Importantly, endurance exercise training results in a diaphragmatic phenotype that is protected against ventilator-induced diaphragmatic atrophy and weakness. The mechanisms responsible for this exercise-induced protection against ventilator-induced diaphragmatic atrophy remain unknown. Therefore, to investigate exercise-induced changes in diaphragm muscle proteins, we compared the diaphragmatic proteome from sedentary and exercise-trained rats. Specifically, using label-free liquid chromatography-mass spectrometry, we performed a proteomics analysis of both soluble proteins and mitochondrial proteins isolated from diaphragm muscle. The total number …

Cover Crop Root Contributions To Soil Carbon In A No-Till Corn Bioenergy Cropping System, Emily E. Austin, Kyle Wickings, Marshall D. Mcdaniel, G. Philip Robertson, A. Stuart Grandy

Faculty Publications

Crop residues are potential biofuel feedstocks, but residue removal may reduce soil carbon (C). The inclusion of a cover crop in a corn bioenergy system could provide additional biomass, mitigating the negative effects of residue removal by adding to stable soil C pools. In a no-till continuous corn bioenergy system in the northern US Corn Belt, we used 13CO2 pulse labeling to trace plant C from a winter rye (Secale cereale) cover crop into different soil C pools for 2 years following rye cover crop termination. Corn stover left as residue (30% of total stover) contributed 66, corn roots 57, …

White Mountain National Forest Home To Nearly 140 Species Of Bees, Lori Tyler Gula

UNH Today Archive

No abstract provided.

Comparative Transcriptomics Of Elasmobranchs And Teleosts Highlight Important Processes In Adaptive Immunity And Regional Endothermy, Nicholas J. Marra, Vincent P. Richards, Angela Early, Steve M. Bogdanowicz, Paulina D. Pavinski Bitar, Michael J. Stanhope, Mahmood S. Shivji

Biology Faculty Articles

Background: Comparative genomic and/or transcriptomic analyses involving elasmobranchs remain limited, with genome level comparisons of the elasmobranch immune system to that of higher vertebrates, non-existent. This paper reports a comparative RNA-seq analysis of heart tissue from seven species, including four elasmobranchs and three teleosts, focusing on immunity, but concomitantly seeking to identify genetic similarities shared by the two lamnid sharks and the single billfish in our study, which could be linked to convergent evolution of regional endothermy.

Results: Across seven species, we identified an average of 10,877 Swiss-Prot annotated genes from an average of 32,474 open reading frames within each …

Week Of January 30, 2017, New York Medical College

InTouch

• Twenty-First Annual Medical Student Research Forum Set for February 9
• National Library of Medicine Exhibit Special Presentation

Portal Protein Functions Akin To A Dna-Sensor That Couples Genome-Packaging To Icosahedral Capsid Maturation., Ravi K. Lokareddy, Rajeshwer S. Sankhala, Ankoor Roy, Pavel V. Afonine, Tina Motwani, Carolyn M M. Teschke, Kristin N. Parent, Gino Cingolani

Department of Biochemistry and Molecular Biology Faculty Papers

Tailed bacteriophages and herpesviruses assemble infectious particles via an empty precursor capsid (or 'procapsid') built by multiple copies of coat and scaffolding protein and by one dodecameric portal protein. Genome packaging triggers rearrangement of the coat protein and release of scaffolding protein, resulting in dramatic procapsid lattice expansion. Here, we provide structural evidence that the portal protein of the bacteriophage P22 exists in two distinct dodecameric conformations: an asymmetric assembly in the procapsid (PC-portal) that is competent for high affinity binding to the large terminase packaging protein, and a symmetric ring in the mature virion (MV-portal) that has negligible affinity …

In-Situ Tem Lithiation Of Alternative Battery Electrode Materials, Matthew T. Janish

Doctoral Dissertations

The world-wide effort to produce and use cleaner energy also necessitates more advanced energy storage capabilities. For example, clean sources of electricity, such as wind or solar, are intermittent and require load leveling. Electric vehicles require more energy- and power-dense batteries in order to truly compete with fossil-fuel-based combustion engines. Lithium-ion batteries (LIBs) currently dominate the secondary battery market. However, in order to build a better LIB, there is a clear need for a better understanding of the fundamentals of lithiation processes. Transmission electron microscopy (TEM) is unique in its ability to correlate structural data with chemical information; as such, …

A Grounded Theoretical Analysis Of Team Resilience In The Us Army, Megan L. Dove-Steinkamp

Doctoral Dissertations

In order to develop a scientific understanding of team resilience, the three primary goals of the current research effort were to (1) summarize the research literature on resilience in and of small groups and systems, (2) articulate a framework to direct the synthesis of existing and future resilience-related research, and (3) construct a substantive theory of team resilience. This exploratory research used a grounded theory approach to explore resilience phenomena experienced by small unit members in the US Army. Participants were sampled from military occupational specialties within Combat Arms, as classified by the US Army Regimental System, and included members …

Analytic Methods For Geometric Modeling, Morad Behandish

Doctoral Dissertations

Current practice in mechanical product description and computational processing is rooted in the theory of solid modeling whose principles were established almost four decades ago. Despite providing a concrete foundation for computerizing the product development process at the time, the limited capacity of the traditional models to answer the growing design and manufacturing needs is only recently being recognized in the scientific and engineering communities.

I propose an alternative approach that employs spatial functions (i.e., 3D signals) instead of (or in addition to) topological pointsets in the Euclidean 3-space to abstract physical objects and their various geometric, physical, and material …

Comparison Of Tetrel Bonds In Neutral And Protonated Complexes Of Pyridinetf3 And Furantf3 (T = C, Si, And Ge) With Nh3, Mingxiu Liu, Qing-Zhong Li, Steve Scheiner

Chemistry and Biochemistry Faculty Publications

Ab initio calculations have been performed for the complexes H+–PyTX3⋯NH3 and H+–furanTF3⋯NH3 (T = C, Si, and Ge; X = F and Cl) with focus on geometries, energies, orbital interactions, and electron densities to study the influence of protonation on the strength of tetrel bonding. The primary interaction mode between α/β-furanCF3/p-PyCF3 and NH3 changes from an F⋯H hydrogen bond to a C⋯N tetrel bond as a result of protonation. Importantly, the protonation has a prominent enhancing effect on the strength of tetrel bonding with an increase in binding energy from 14 to 30 kcal mol−1. The tetrel bonding becomes stronger …

Merlin Controls The Repair Capacity Of Schwann Cells After Injury By Regulating Hippo/Yap Activity, Thomas Mindos, Xin Peng Dun, Katherine North, Robin D.S. Doddrell, Alexander Schulz, Philip Edwards, James Russell, Bethany Gray, Sheridan L. Roberts, Aditya Shivane, Georgina Mortimer, Melissa Pirie, Nailing Zhang, Duojia Pan, Helen Morrison, David B. Parkinson

Peninsula Medical School

Loss of the Merlin tumor suppressor and activation of the Hippo signaling pathway play major roles in the control of cellproliferation and tumorigenesis. We have identified completely novel roles for Merlin and the Hippo pathway effectorYes-associated protein (YAP) in the control of Schwann cell (SC) plasticity and peripheral nerve repair after injury. Injuryto the peripheral nervous system (PNS) causes a dramatic shift in SC molecular phenotype and the generation of repaircompetent SCs, which direct functional repair. We find that loss of Merlin in these cells causes a catastrophic failure ofaxonal regeneration and remyelination in the PNS. This effect is mediated …

Doe Optimization Of Nano-Based Carrier Of Pregabalin As Hydrogel: New Therapeutic &Chemometric Approaches For Controlled Drug Delivery Systems, Mona Arafa, Bassam M. Ayoub

Pharmacy

© The Author(s) 2017. Niosomes entrapping pregabalin (PG) were prepared using span 60 and cholesterol in different molar ratios by hydration method, the remaining PG from the hydrating solution was separated from vesicles by freeze centrifugation. Optimization of nano-based carrier of pregabalin (PG) was achieved. Quality by Design strategy was successfully employed to obtain PG-loaded niosomes with the desired properties. The optimal particle size, drug release and entrapment efficiency were attained by Minitab ® program using design of experiment (DOE) that predicted the best parameters by investigating the combined effect of different factors simultaneously. Pareto chart was used in the …

Comparing Groundwater Model Calibration Approaches: Does An Optimized Model Better Reflect Reality When Both Flow And Transport Observations Are Applied?, Vivian E. Sovinsky

Master's Theses

This research compares two approaches to the application of formal calibration methods to groundwater modeling: sequential and combined. There exists research, both theoretical work and field studies, that point to improved estimation of hydraulic parameters when multiple types of observations, flow and transport, are applied simultaneously. There also exist theories about why combined calibration might not be compatible with the differing mathematical basis of flow compared to transport. This research has taken a closer look at the mechanisms at work by comparing these approaches when the input parameters are known. Using stochastic methods instead of field data, the original input …

Investigating Trends In Poly-Victimization Among Cps Involved Children And Families: A Study Of Allegations, Nicole A. Melita

Master's Theses

Children involved with child protective services (CPS) face high risk for significant mental health impairment and poor outcomes, which recent work suggests can be influenced by poly-victimization, or exposure to multiple forms of victimization (Grasso, Greene, & Ford, 2013). The present chart review study was intended to examine the incidence of trends in poly-victimization, child mental health outcomes, and caregiver impairment among a sample of randomly selected families in the state of Connecticut (N=100) that were referred to CPS during a 12-month period. Allegations were examined collectively regardless of allegation disposition. An extensive survey tool was created by …

Obtaining Accurate Glucose Measurements From Wild Animals Under Field Conditions: Comparing A Hand Held Glucometer With A Standard Laboratory Technique In Grey Seals, Kimberley A. Bennett, Lucy M. Turner, Sebastian Millward, Simon E.W. Moss, Ailsa J. Hall

School of Biological and Marine Sciences

No abstract provided.

Sleep Spindles And Intellectual Ability: Epiphenomenon Or Directly Related?, Zhuo Fang, Valya Sergeeva, Laura B. Ray, Adrian M. Owen, Stuart M. Fogel

Anatomy and Cell Biology Publications

Sleep spindlesshort, phasic, oscillatory bursts of activity that characterize non-rapid eye movement sleepare one of the only electrophysiological oscillations identified as a biological marker of human intelligence (e.g., cognitive abilities commonly assessed using intelligence quotient tests). However, spindles are also important for sleep maintenance and are modulated by circadian factors. Thus, the possibility remains that the relationship between spindles and intelligence quotient may be an epiphenomenon of a putative relationship between good quality sleep and cognitive ability or perhaps modulated by circadian factors such as morningness-eveningness tendencies. We sought to ascertain whether spindles are directly or indirectly related to cognitive …

The Evolution Of Experiential Learning: Tracing Lines Of Research In The Jee, Jayson O. Seaman, Mike Brown, John Quay

Kinesiology

This essay introduces a collection of past articles from the Journal of Experiential Education (JEE) focused on the concept of experiential learning. It outlines the historical trajectory of the concept beginning with human relations training practices beginning in 1946, as it came to be understood as a naturally occurring psychological process and a grounding for pedagogical reforms. The eight articles included in the issue reflect the way JEE authors have contended with problems arising from the concept’s departure from its origins in practice. We suggest that experiential learning’s evolution into a general theory was accomplished by decoupling it from its …

Healthcare Use Self-Efficacy In Adults Who Are Homeless, Jared Ian Israel

Dissertations

The physical and mental health care needs of homeless adults are extensive. However, these needs regularly go unmet. Healthcare use behavior is complex and involves a range of obstacles. As such, self-efficacy, an individual’s belief in his or her ability to perform a given behavior, appears to be a relevant factor in healthcare use. While current theory supports this notion and research has confirmed the role of self-efficacy in health behavior generally, a validated measure of healthcare use self-efficacy has not previously existed. The aim of this study was to develop and validate the Healthcare Use Self-Efficacy List (HUSEL) in …

Mechanisms Of Ikbke Activation In Cancer, Sridevi Challa

USF Tampa Graduate Theses and Dissertations

Cancer is the second leading cause of death in the USA and it is expected to surpass heart diseases making it important to understand the underlying mechanisms of cancer. The efforts to target single signaling molecule showed little success in increasing the patient survival and it can be due to increased compensation for cell survival by alternative pathway activations. Hence comprehensive understanding of the alternative signaling pathways may help us treat cancer better. Chronic inflammation is attributed to increased risk of cancer and emerging studies show the growing importance of both canonical and non-canonical IκB kinases such as IKKα, IKKβ, …

Bioethics In The Work Of Ernest Everett Just: + Missing - Some 400 Pages, Theodore Walker

Perkins Faculty Research and Special Events

Biology + ethics = bioethics. Here we see that Howard University biologist Ernest Everett Just (born 1883, died 1941) connected biology to ethics.

According to Just, various forms of specific biology (including especially cell biology) plus “general biology” are necessary for explaining adequately the origin of ethical behaviors. Social ethical behaviors, especially mutual aid and cooperative interactions with others and the environment, are essential to evolutionary advances among living creatures, ranging from humans to cells. Accordingly, theory of ethics (moral theory) should have roots in biology.

Also, Just wrote an unpublished book-length manuscript—“some 400 typed pages” (Just 1940)—on seeking the …

Investigating The Nucleic Acid Interactions Of Histone-Derived Antimicrobial Peptides, Sukin Sim, Penny Wang, Brittany N. Beyer, Kara J. Cutrona, Mala L. Radhakrishnan, Donald E. Elmore

Faculty Research and Scholarship

While many antimicrobial peptides (AMPs) disrupt bacterial membranes, some translocate into bacteria and interfere with intracellular processes. Buforin II and DesHDAP1 are thought to kill bacteria by interacting with nucleic acids. Molecular modeling and experimental measurements were used to show that neither nucleic acid binding peptide selectively binds DNA sequences. Simulations and experiments also showed that changing lysines to arginines enhances DNA binding, suggesting that including additional guanidinium groups is a potential strategy to engineer more potent AMPs. Moreover, the lack of binding specificity may make it more difficult for bacteria to evolve resistance to these and other similar AMPs.

Daphnia Inhibits The Emergence Of Spatial Pattern In A Simple Consumer-Resource System, Gustavo S. Betini, Tal Avgar, Kevin S. Mccann, John M. Fryxell

Wildland Resources Faculty Publications

Spatial self-organization can occur in many ecosystems with important effects on food web dynamics and the maintenance of biodiversity. The consumer-resource interaction is known to generate spatial patterning, but only a few empirical studies have investigated the effect of the consumer on resource distribution. Here we report results from a large aquatic mesocosm experiment used to investigate the effect of the consumer Daphnia magna on the distribution of its resource, the green algae Chlorella vulgaris. We maintained large tanks with capacity for 26 ,000 L with either algae or both algae and Daphnia in different temperature conditions. We found that …

Twelfth Night (2017), William Shakespeare

Season 2016-2017

No abstract provided.

Study On Phosphorylated Modification And Properties Of Pasteurized Egg White, Zhang Gensheng, Li Tingting, Ding Jian, Chang Hong, Wang Rui, Chi Tianqi, Tang Min

Food and Machinery

Pasteurized egg white was used as raw material and modified by sodium tripolyphosphate (STP). The optimum conditions for the phosphorylation of egg white were determined by single factor and orthogonal test, for the reaction pH 7.5, the amount of STP 4%, the reaction temperature 40 ℃, and the reaction time 4 h. Under the optimal conditions, the degree of phosphoryl-ation reached 50.96 mg/g. The low-field nuclear magnetic resonance (LF-NMR) was used to observe the binding of proteins to water during the process. The results showed that the solubility, water - holding capacity, foaming property and emulsifying property of egg albumin …

Design Of A New Microwave-Vacuum Dryer, Yang Xiaotong, Duan Xu, Ren Guangyue

Food and Machinery

A new type of microwave and vacuum drying device combining waveguide and wave source cooling device was designed. This improvement helped to solve two big problems effectively, uneven distribution of microwave and wave source easily broken on heat. Because the material chamber is the intersection of microwave and vacuum chambers, material could be in microwave radiation as well as in vacuum environment. Thus, the material plates were hierarchical designed. On the one hand, they were easily tear down, on the other hand, material room space could be made full use. Moreover, the cold traps designed by modular to make it …

A Street Child’S Perspective: A Grounded Theory Study Of How Street Children Experience And Cope With Grief, Somidha Ray

The Qualitative Report

The research project entitled – “A Street Child’s Perspective: A Grounded Theory Study of How Street Child Experience and Cope with Grief,” seeks to understand and explain how street children experience and cope with grief. Grief is multi-faceted and highly subjective. However, most street children, sharing the same contexts and backgrounds show some commonality in their experiences and coping styles. The paper attempts to understand grief as it is subjectively experienced by street children. The research employed qualitative techniques – In-Depth Interviewing, Focus Group Discussions (FGDs) and field notes. The researcher contacted an NGO and through them, gained access to …