Digital Commons Network^™

Metastatic Biomarkers In Synovial Sarcoma, Rosalia De Necochea-Campion, Lee M. Zuckerman, Hamid R. Mirshahidi, Shahrzad Khosrowpour, Chien-Shing Chen, Saied Mirshahidi

Library Articles and Research

Synovial sarcoma (SS) is an aggressive soft tissue sarcoma (STS) that typically occurs in the extremities near a joint. Metastatic disease is common and usually occurs in the lungs and lymph nodes. Surgical management is the mainstay of treatment with chemotherapy and radiation typically used as adjuvant treatment. Although chemotherapy has a positive impact on survival, the prognosis is poor if metastatic disease occurs. The biology of sarcoma invasion and metastasis remain poorly understood. Chromosomal translocation with fusion of the SYT and SSX genes has been described and is currently used as a diagnostic marker, although the full impact of …

Adam19: A Novel Target For Metabolic Syndrome In Humans And Mice, Lakshini Weerasekera, Caroline Rudnicka, Qing-Xiang Sang, Joanne E. Curran, Matthew P. Johnson, Eric K. Moses, Harald H. H. Goring, John Blangero, Jana Hricova, Markus Schlaich, Vance B. Matthews

School of Medicine Publications

Obesity is one of the most prevalent metabolic diseases in the Western world and correlates directly with insulin resistance, which may ultimately culminate in type 2 diabetes (T2D). We sought to ascertain whether the human metalloproteinase A Disintegrin and Metalloproteinase 19 (ADAM19) correlates with parameters of the metabolic syndrome in humans and mice. To determine the potential novel role of ADAM19 in the metabolic syndrome, we first conducted microarray studies on peripheral blood mononuclear cells from a well-characterised human cohort. Secondly, we examined the expression of ADAM19 in liver and gonadal white adipose tissue using an in vivo diet induced …

Possible Role Of Common Spices As A Preventive And Therapeutic Agent For Alzheimer's Disease, Omid Mirmosayyeb, Amirpouya Tanhaei, Hamid R. Sohrabi, Ralph Martins, Mana Tanhaei, Mohammad Admin Najaf, Ali Safaei, Rokhsareh Meamar

Research outputs 2014 to 2021

For centuries, spices have been consumed as food additives or medicinal agents. However, there is increasing evidence indicating the plant-based foods in regular diet may lower the risk of neurodegenerative diseases including Alzheimer disease. Spices, as one of the most commonly used plant-based food additives may provide more than just flavors, but as agents that may prevent or even halt neurodegenerative processes associated with aging. In this article, we review the role and application of five commonly used dietary spices including saffron turmeric, pepper family, zingiber, and cinnamon. Besides suppressing inflammatory pathways, these spices may act as antioxidant and inhibit …

Alaska Oil & Gas Association V. Pritzker, Benjamin W. Almy

Public Land & Resources Law Review

In Alaska Oil & Gas Association v. Pritzker, the Ninth Circuit reversed the United States District Court for the District of Alaska’s decision to strike down the National Marine Fisheries Service’s (“NMFS”) listing of distinct population segments of the Pacific bearded seal. The court determined that the NMFS was in full compliance with the requirements of the Endangered Species Act and squarely rejected the district court’s demand for highly specific data pertaining to the projected effects of climate change on the bearded seal.

Emu, Julia Mulligan

Children's Book and Media Review

In an Australian eucalyptus forest, a male emu must hatch and protect his clutch of eggs completely on his own. From the moment the last egg is laid and the mother emu disappears from her family’s life, this gigantic flightless bird devotes himself entirely to their survival. He rarely eats or drinks in order to protect his eggs from hungry predators, and once they hatch he must closely supervise his foraging chicks for six months in order to guard them from goannas, dingoes, and eagles. Alongside the story of the emu family are relevant facts about emu biology and behavior.

Arts Trade Association Dinner: Speech Research (1963-1967): Report 04

Arts Trade Association Dinner: Speech Research (1963-1967)

No abstract provided.

Urban Ecology & Conservation Symposium 2017: 15th Annual (Abstracts), Urban Ecosystem Research Consortium Of Portland/Vancouver

Urban Ecosystem Research Consortium of Portland/Vancouver

The UERC is a consortium of people from various universities and colleges, state and federal agencies, local governments, non-profit organizations and independent professionals interested in supporting urban ecosystem research and creating an information-sharing network of people that collect and use ecological data in the Portland/Vancouver area.

UERC Mission Statement:

To advance the state of the science of urban ecosystems and improve our understanding of them, with a focus on the Portland/Vancouver metropolitan region, by fostering communication and collaboration among researchers, managers and citizens at academic institutions, public agencies, local governments, non-profit organizations, and other interested groups.

The principal organizers span …

Exile Vol. Xxxii No. 1, Theresa Copeland, Susan Hanlon, Joan R. Dewitt, Jeff Masten, Karen J. Hall, Jennifer Miller, Betsy Oster, Reid Benes, Debra Benko, Judson B. Curry

Exile

ARTWORK

Red and White by Karen Koch (cover)

Vicissitudes I by Claudia H. Donegan 1

Untitled ('84} by Kok Fooi Yong 11

Lines by Don Jacobs 15

Vicissitudes II by Claudia H. Donegan 19

Waltham, Boston, Winter of '84 by Kok Fooi Yong 25

Statue You by Claudia H. Donegan 29

Museum Sketch by Deanna Lynne Bridgeforth 41

FICTION

Sheba by Theresa Copeland 4-9

Was There Really Someone in the Kitchen With Dinah? by Susan Hanlon 21-24

What Do You Say Liza Blue? by Joan R. DeWitt 32-40

POETRY

Ode by Jeff Masten 3

Misdemeanor by Karen J. Hall 10 …

The Ticker, February 6, 2017

The Ticker

The Ticker is the student newspaper of Baruch College. It has been published continuously since 1932, when the Baruch College campus was the School of Business and Civic Administration of the City College of New York.

Egg Freezing On Company Dollars: Making Biological Clock Irrelevant?, Madhumita Datta

DePaul Journal of Women, Gender and the Law

In an attempt to boost gender diversity, two of the technology giants of Silicon Valley, Apple and Facebook, announced in October 2014 that they would cover the costs of freezing eggs, so that women employees who want to pursue both motherhood and a serious career could conveniently ‘time’ their pregnancy. Intel followed suit in October 2015. Unlike other reproductive benefits aiming to cure a biological deficiency such as infertility, employers promote egg freezing as an investment towards women employees’ career success. Women employees may take advantage of this benefit for non-medical reasons to delay pregnancy and childbirth because of the …

Cseas Weekly Bulletin (February 6, 2017), Center For Southeast Asian Studies

CSEAS Bulletin

No abstract provided.

The Statesman, V. 60, I. 17, Stony Brook University

Stony Brook Statesman-Sucolian

v. 60;i. 17

Current, February 06, 2017, University Of Missouri-St. Louis

Current (2010s)

No abstract provided.

Effect Of Tobacco Smoking On The Clinical, Histopathological, And Serological Manifestations Of Sjögren’S Syndrome, Donald U. Stone, Dustin A. Fife, Michael Brown, Keith E. Earley, Lida Radfar, C. Erick Kaufman, David M. Lewis, Nelson L. Rhodus, Barbara M. Segal, Daniel J. Wallace, Michael H. Weisman, Swamy Venuturupalli, Michael T. Brennan

College of Science & Mathematics Departmental Research

Objectives

To assess the association of smoking habits with the clinical, serological, and histopathological manifestations of Sjögren’s syndrome (SS) and non-Sjögren’s sicca (non-SS sicca).

Methods

Cross-sectional case-control study of 1288 patients with sicca symptoms (587 SS and 701 non-SS sicca) evaluated in a multi-disciplinary research clinic. Smoking patterns were obtained from questionnaire data and disease-related clinical and laboratory data were compared between current, past, ever, and never smokers.

Results

Current smoking rates were 4.6% for SS patients compared to 14.1% in non-SS sicca (p = 5.17x10E-09), 18% in a local lupus cohort (p = 1.13x10E-14) and 16.8% in the community …

Food On Film Kicks Off With Packed House Discussing Sustainable, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Columbia Chronicle (02/06/2017), Columbia College Chicago

Columbia Chronicle

Student newspaper from February 6, 2017 entitled The Columbia Chronicle. This issue is 40 pages and is listed as Volume 85, Issue 18. Cover story: "'Trump's ban causes city 'fear and chaos'" Editor-in-Chief: Megan Bennett

Teacher Based A Varied Career On Plant Biology Degree, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

The Tiger Vol. 111 Issue 4 2017-02-06, Clemson University

Tiger Newspapers 2017

No abstract provided.

A Novel Microrna-1207-3p/Fndc1/Fn1/Ar Regulatory Pathway In Prostate Cancer, Dibash K. Das, Olorunseun O. Ogunwobi

Publications and Research

Prostate cancer (PCa) is the second most common cause of cancer-specific deaths in the U.S. Unfortunately, the underlying molecular mechanisms for its development and progression remain unclear. Studies have established that microRNAs (miRNAs) are dysregulated in PCa. The intron-derived microRNA-1207-3p (miR-1207-3p) is encoded at the non-protein coding gene locus PVT1 on the 8q24 human chromosomal region, an established PCa susceptibility locus. However, miR-1207-3p in PCa had not previously been investigated. Therefore, we explored if miR-1207-3p plays any regulatory role in PCa. We discovered that miR-1207-3p is significantly underexpressed in PCa cell lines in comparison to normal prostate epithelial cells, and …

The Rider (2017-02-06), Jesus Sanchez

The Rider Archives

Vol.2 No.18

Human Grooming In Comparative Perspective: People In Six Small-Scale Societies Groom Less But Socialize Just As Much As Expected For A Typical Primate, Adrian V. Jaeggi, Karen Kramer, Raymond Hames, Evan J. Kiely, Cristina Gomes, Hillard Kaplan, Michael Gurven

ESI Publications

Objectives—Grooming has important utilitarian and social functions in primates but little is known about grooming and its functional analogues in traditional human societies. We compare human grooming to typical primate patterns to test its hygienic and social functions.

Materials and Methods—Bayesian phylogenetic analyses were used to derive expected human grooming time given the potential associations between grooming, group size, body size, terrestriality, and several climatic variables across 69 primate species. This was compared against observed times dedicated to grooming, other hygienic behavior and conversation among the Maya, Pumé, Sanöma, Tsimane’, Yanomamö, and Ye’kwana (mean number of behavioral scans …

Daily Eastern News: February 06, 2017, Eastern Illinois University

February

No abstract provided.

Metalloproteinase-9 Contributes To Endothelial Dysfunction In Atherosclerosis Via Protease Activated Receptor-1, Jon M. Florence, Agnieszka Krupa, Laela M. Booshehri, Timothy C. Allen, Anna K. Kurdowska

Cellular and Molecular Biology Faculty Publications and Presentations

The atherosclerotic process begins when vascular endothelial cells undergo pro-inflammatory changes such as aberrant activation to dysfunctional phenotypes and apoptosis, leading to loss of vascular integrity. Our laboratory has demonstrated that exposure of mice to second hand smoke triggers an increase in expression of metalloproteinase-9. Further, metalloproteinase-9 released by second hand smoke--activated leukocytes may propagate pro-atherogenic alterations in endothelial cells. We have shown that levels of metalloproteinase-9 were increased in the plasma from apolipoprotein E deficient (ApoE-/-) mice exposed to second hand smoke relative to non-exposed controls. Moreover, we have collected data from two different, but complementary, treatments of second …

A Machine Learning Classifier Trained On Cancer Transcriptomes Detects Nf1 Inactivation Signal In Glioblastoma, Gregory P. Way, Robert J. Allaway, Stephanie J. J. Bouley, Camilo E. Fadul, Yolanda Sanchez, Casey Greene

Dartmouth Scholarship

We have identified molecules that exhibit synthetic lethality in cells with loss of the neurofibromin 1 (NF1) tumor suppressor gene. However, recognizing tumors that have inactivation of the NF1 tumor suppressor function is challenging because the loss may occur via mechanisms that do not involve mutation of the genomic locus. Degradation of the NF1 protein, independent of NF1 mutation status, phenocopies inactivating mutations to drive tumors in human glioma cell lines. NF1 inactivation may alter the transcriptional landscape of a tumor and allow a machine learning classifier to detect which tumors will benefit from synthetic lethal molecules. We …

Ikhlas Khan Becomes Ncnpr Director, Sydney Slotkin Dupriest

University of Mississippi News

Former associate director takes lead after 25 years with UM research center

Refugee Roulette: A Comparative Analysis Of Gender-Related Persecution In Asylum Law, Joanna J. Kallinosis

DePaul Journal of Women, Gender and the Law

From the moment Rodi Alvarado Pena married a Guatemalan army officer at the age of 16, she was subjected to intensive abuse, and all her efforts to get help where unsuccessful. Her husband raped and sodimized her repeatedly, attempted to abort their child by violently kicking her in the spine, dislocated her jaw, attempted to cut her hands off with a machete, kicked her in her genitals and used her head to break windows. He terrified her by bragging about his power to kill innocent civilians with impunity and all of Rodi’s pleas for help from the Guatemalan government were …

The Landscape Of Extreme Genomic Variation In The Highly Adaptable Atlantic Killifish, Noah M. Reid, Craig E. Jackson, Don Gilbert, Patrick Minx, Michael J. Montague, Thomas H. Hampton, Lily W. Helfrich, Benjamin L. King, Diane E. Nacci, Neel Aluru

Dartmouth Scholarship

Understanding and predicting the fate of populations in changing environments require knowledge about the mechanisms that support phenotypic plasticity and the adaptive value and evolutionary fate of genetic variation within populations. Atlantic killifish (Fundulus heteroclitus) exhibit extensive phenotypic plasticity that supports large population sizes in highly fluctuating estuarine environments. Populations have also evolved diverse local adaptations. To yield insights into the genomic variation that supports their adaptability, we sequenced a reference genome and 48 additional whole genomes from a wild population. Evolution of genes associated with cell cycle regulation and apoptosis is accelerated along the killifish lineage, which …

Faculty Senate Monthly Packet February 2017, Portland State University Faculty Senate

Faculty Senate Monthly Packets

The February 2017 Monthly packet includes the February agenda and appendices and the Faculty Senate minutes and attachments from the meeting held January 2017.

Caregivers' And Professionals' Perceptions On Collaboration In Early Intervention, Sara J. Edwards

Theses and Dissertations

The current study explored the perceptions of collaborative practices and possible methods to overcome the challenges identified by caregivers and professionals in Early Intervention by documenting the perspectives of four multidisciplinary team members. This qualitative study included in-depth interviews with a caregiver, service coordinator, occupational therapist, and developmental therapist/hearing specialist whom all shared an Individual Family Service Plan within the past year. Data analysis revealed five major themes that included: 1) communication, 2) best practices, 3) co-treating, 4) knowledge, and 5) respect. Future research ideas and implications for caregivers, early intervention professionals, early intervention program managers, and agencies employing early …

A Problem Of Competing Interests: A Detailed Look At Transgender Children In Schools, Corinne Cundiff

DePaul Journal of Women, Gender and the Law

Discrimination of transgender students is an area of the law that is rapidly developing. Unfortunately for schools trying to find guidance in the law, there are conflicts regarding how schools are to work with their transgender students when it comes to access to gender specific spaces, including bathrooms and locker rooms. There is currently a disagreement among federal agencies, the courts, and the legislature regarding the protection gender identity should receive in the law. The difference of opinion among the various branches of the government equates to problems for schools that are trying to navigate this area of the law. …