Digital Commons Network^™

Rapid Bactericidal Activity Of An Amphiphilic Polyacrylate Terpolymer System Comprised Of Same-Centered Comonomers With 2-Carbon And 6- Carbon Spacer Arms And An Uncharged Repeat Unit, Kamia Punia, Ashish Punia, Kaushiki Chatterjee, Sumit Mukherjee, Jimmie E. Fata, Probal Banerjee, Krishnaswami Raja, Nan-Loh Yang

Publications and Research

The global health threat of antimicrobial resistance has created a pressing need to develop practical alternatives to conventional antibiotic agents. Peptide mimetic synthetic amphiphilic polymers are known to non-specifically disrupt the bacterial cell surface thus leading to highly hindered bacterial resistance development. We investigated the antibacterial activities of a terpolymer macromolecular architecture with a combination of 6- carbon and 2-carbon spacer arms (distance from polymer backbone to pendent cationic center) interspersed with counits with hydrophobic side groups. A random copolymer with a combination of 6-carbon spacer arm repeat units (60 mol%) and 2-carbon spacer arm (40 mol%) units is moderately …

Mcsa Forum Minutes 02/06/2017, Morris Campus Student Association

Morris Campus Student Association

No abstract provided.

The Diamond, February 6, 2017, Dordt College

Dordt Diamond

• Front Page: Repeal and Replace: Understanding the Affordable Care Act; Matchmaker, Matchmaker, Make Me a Match
• News: Dordt Students Aid the State of Iowa; Coffee Beant: The Fruited Plain; Property for the Future; Recycling Art Competition Falls Through; Marching into History; International Students Ponder Effects of Immigration Ban; Executive Orders Protested at Battery Park; Fed Employees Use Encryption Software, Messaging Apps; Dordt Students Leadership Conference in D.C.; AMOR Takes on Tanzania; Student Employment Showdown; The Buffington Post In-Class Laptop Note Taking - The Keys to Failure; Reformed Colleges Get Political; "La La Land" is for Fools Who Dream
• Editorial: Finding …

Enzyme–Free Uric Acid Electrochemical Sensors Using Β–Cyclodextrin Modified Carboxylic Acid Functionalized Carbon Nanotubes, Mulugeta B. Wayu, Margaret A. Schwarzmann, Samuel D. Gillespie, Michael C. Leopold

Chemistry Faculty Publications

Carboxylic acid-functionalized multi-walled carbon nanotubes (COOH-MWCNT) were modified via ultrasonication with β-cyclodextrin (β-CD) to obtain a COOH-MWCNT:β-CD nanocomposite material for the purpose of developing an enzyme-free electrochemical sensor for uric acid—a clinically relevant molecule implemented in pregnancy-induced hypertension diagnosis. The nanocomposite material is deposited onto glassy carbon electrodes and subsequently capped with layers of Nafion and Hydrothane polyurethane. The surface morphology and electronic structure of the nanocomposite material were characterized using UV–Vis, TEM, and FTIR. The performance of the electrochemical sensor was measured through direct injection of UA during amperometry. With the high surface area of the COOH-MWCNT in concert …

February 6, 2017, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Volume 2, Chapter 17-1: Rodents - Muroidea: Muridae, Janice M. Glime

Bryophyte Ecology Subchapters

No abstract provided.

Developing And Evaluating A Flexible Wireless Microcoil Array Based Integrated Interface For Epidural Cortical Stimulation., Xing Wang, Sharjeel A Chaudhry, Wensheng Hou, Xiaofeng Jia

Medicine Faculty Publications

Stroke leads to serious long-term disability. Electrical epidural cortical stimulation has made significant improvements in stroke rehabilitation therapy. We developed a preliminary wireless implantable passive interface, which consists of a stimulating surface electrode, receiving coil, and single flexible passive demodulated circuit printed by flexible printed circuit (FPC) technique and output pulse voltage stimulus by inductively coupling an external circuit. The wireless implantable board was implanted in cats' unilateral epidural space for electrical stimulation of the primary visual cortex (V1) while the evoked responses were recorded on the contralateral V1 using a needle electrode. The wireless implantable board output stable monophasic …

A Quantitative Lc-Ms/Ms Method For Simultaneous Determination Of Cocaine And Its Metabolites In Whole Blood, Xiabin Chen, Xirong Zheng, Kai Ding, Ziyuan Zhou, Chang-Guo Zhan, Fang Zheng

Molecular Modeling and Biopharmaceutical Center Faculty Publications

As new metabolic pathways of cocaine were recently identified, a high performance liquid chromatography tandem mass spectrometry (LC–MS/MS) method was developed to simultaneously determine cocaine and nine cocaine-related metabolites in whole blood samples. One-step solid phase extraction was used to extract all of the ten compounds and corresponding internal standards from blood samples. All compounds and internal standards extracted were separated on an Atlantis T3 (100 Å, 3 μm, 2.1 mm × 150 mm I.D) column and detected in positive ion and high sensitivity mode with multiple reaction monitoring. This method was validated for its sensitivity, linearity, specificity, accuracy, precision, …

Gosnell Studies And Communicates Ecological Concerns, Aldemaro Romero Jr.

Publications and Research

Scientists who study environmental problems know that the more you work in the field, the more insight you gain into how to solve problems. In other words, the more field experience you have, the deeper your understanding of nature.

One scientist who has had a lot of field experience is Dr. Stephen Gosnell, and his interest in the environment began when he was still a child. “I had interest really early. I grew up in rural South Carolina in a very small town called Landrum. I was outside on a regular basis, playing in the streams and creeks around me,” …

Are You My Mother? A Critique Of The Requirements For De Facto Parenthood In Maine Following The Law Court's Decision In Pitts V. Moore, Samuel G. Johnson

Maine Law Review

Are you my mother? The answer to this question may not have been very difficult to ascertain years ago, however it is not so easily answered today. With advancements in technology, shifts in family structures, and changes in social norms, new legal issues pertaining to parental rights have materialized. The right to raise a child as one sees fit is one of the oldest fundamental rights recognized and protected by the United States Constitution. However, courts are now being asked to consider the rights of “legal strangers” at the expense of the biological or legal parent. One method that a …

Biology Major Sophia Boothby Named Margaret Boyd Scholar, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Biology Major Lou Duloisy Named Margaret Boyd Scholar, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

A Dual-Modality System For Both Multi-Color Ultrasound-Switchable Fluorescence And Ultrasound Imaging, Jayanth Kandukuri, Shuai Yu, Bingbing Cheng, Venugopal Bandi, Francis D’Souza, Kytai Truong Nguyen, Yi Hong, Baohong Yuan, Jamal Zweit

Bioengineering Faculty Publications - Archive

Simultaneous imaging of multiple targets (SIMT) in opaque biological tissues is an important goal for molecular imaging in the future. Multi-color fluorescence imaging in deep tissues is a promising technology to reach this goal. In this work, we developed a dual-modality imaging system by combining our recently developed ultrasound-switchable fluorescence (USF) imaging technology with the conventional ultrasound (US) B-mode imaging. This dual-modality system can simultaneously image tissue acoustic structure information and multi-color fluorophores in centimeter-deep tissue with comparable spatial resolutions. To conduct USF imaging on the same plane (i.e., x-z plane) as US imaging, we adopted two 90 -crossed ultrasound …

Alumni Honor Legacy Of Distinguished Professor Emeritus Norman Cohn With Fellowship, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

A Dual-Modality System For Both Multi-Color Ultrasound-Switchable Fluorescence And Ultrasound Imaging, Jayanth Kandukuri, Shuai Yu, Bingbing Cheng, Venugopal Bandi, Francis D’Souza, Kytai Truong Nguyen, Yi Hong, Baohong Yuan, Jamal Zweit, Sundaresan Gobalakrishnan

Go Open Fund Publications-Archive

Simultaneous imaging of multiple targets (SIMT) in opaque biological tissues is an important goal for molecular imaging in the future. Multi-color fluorescence imaging in deep tissues is a promising technology to reach this goal. In this work, we developed a dual-modality imaging system by combining our recently developed ultrasound-switchable fluorescence (USF) imaging technology with the conventional ultrasound (US) B-mode imaging. This dual-modality system can simultaneously image tissue acoustic structure information and multi-color fluorophores in centimeter-deep tissue with comparable spatial resolutions. To conduct USF imaging on the same plane (i.e., x-z plane) as US imaging, we adopted two 90 -crossed ultrasound …

Strategic Leadership Newsletter: Volume 3, Number 1, Larry M. Starr Phd

Leadership Doctorates Newsletter (Formerly Strategic Leadership Newsletter)

Strategic Leadership Newsletter reports information relevant to the Philadelphia University Doctor of Management in Strategic Leadership program including personal and professional events and accomplishments, new practices, research and opportunities, and suggestions. You are encouraged to forward the Newsletter to friends and colleagues to expand awareness and to brand yourself as a community member. You are also invited to recommend people or organizations to be added to the mailing list. Contact Strategic Leadership Newsletter by emailing the Editor [email protected]

Protein Calorie Malnutrition, Nutritional Intervention And Personalized Cancer Care, Anju Gangadharan, Sung-Eun Choi, Ahmed Hassan, Nehad M. Ayoub, Gina Durante, Sakshi Balwani, Young Hee Kim, Andrew Pecora, Andre Goy, K. Stephen Suh

Publications and Research

Cancer patients often experience weight loss caused by protein calorie malnutrition (PCM) during the course of the disease or treatment. PCM is expressed as severe if the patient has two or more of the following characteristics: obvious significant muscle wasting, loss of subcutaneous fat; nutritional intake of <50% of recommended intake for 2 weeks or more; bedridden or otherwise significantly reduced functional capacity; weight loss of >2% in 1 week, 5% in 1 month, or 7.5% in 3 months. Cancer anorexiacachexia syndrome (CACS) is a multifactorial condition of advanced PCM associated with underlying illness (in this case cancer) and is characterized by loss of muscle with or without loss of fat mass. Cachexia is defined as weight loss of …

Inconvenient Truths: Facts And Frictions In Defense Of Guardians Ad Litem For Children, Dana E. Prescott

Maine Law Review

During the 2013 Maine legislative session, citizens, elected officials, and professionals passionately expressed their beliefs concerning the legitimacy and efficacy of guardian ad litem [GAL] appointments in private child custody cases. In many respects, this policy discussion mirrored national trends in the scholarly and social science literature concerning allegations of the overuse or capacious role of a GAL. Establishing the proper legal and scientific contours within which GALs may serve the best interests of children and simultaneously provide constructive investigative and evidence-informed recommendations to judicial fact finding remains a proper concern for proponents and critics alike. The challenge, in this …

Dual Mechanism For Toughening And Sustained Aminoglycoside Elution From A Polyphosphate Hydrogel, Dwight D. Lane, Russell J. Stewart Phd

Biomedical Engineering Western Regional Conference

No abstract provided.

Differentiation And Containment Of Derived Pancreatic Beta Cells, Caden Duffy, Alonzo Cook Ph.D.

Biomedical Engineering Western Regional Conference

Currently, the only permanent cure for Type 1 Diabetes is a pancreatic or islet transplant. With the shortage of donors, we are progressing research towards alternative therapies by differentiating induced pluripotent stem cells into derived pancreatic β-cells that can be transplanted and used as treatment for Type 1 Diabetes. We are investigating methods to increase the yield of fully derived, insulin producing pancreatic β-cells and are additionally researching the use of hydrophilized expanded polytetrafluoroethylene for use in cell containment devices. These devices could offer a future alternative for islet transplantation in human patients.

Utilizing Microfluidics Devices To Monitor Endothelial Cell Migration., Tsz Ming Jeremy Tsang, Jacob Lefler, Charles Voyton, Kenneth Christensen

Biomedical Engineering Western Regional Conference

Utilizing microfluidics devices to monitor endothelial cell migration.

High-Density Non-Fouling Bioactive Coatings: Development And Characterization, Bonan Yu, Ramya Raman, Karl Schlike

Biomedical Engineering Western Regional Conference

No abstract provided.

Engineering Fret Biosensors For Microrna Presence/Absence Analysis, Nicholas E. Larkey, Sean M. Burrows

Biomedical Engineering Western Regional Conference

No abstract provided.

Portable, Powerless Automation Of Valve Actuation For Microfluidic Large-Scale Integration Technology, Andrew Schmidt Mr., Matt Fitzgerald Mr., Emre Araci Mr., Connor Mcloughlin Mr.

Biomedical Engineering Western Regional Conference

Portable, powerless automation of valve actuation for microfluidic large-scale integration technology

Optimizing The Growth And Characterization Of Retinal Pigment Epithelial Cells, Ian Wadsworth

Biomedical Engineering Western Regional Conference

Age related macular degeneration (AMD) is the leading cause of blindness in developed countries. One major difficulty in studying AMD is modeling the retinal pigment epithelium (RPE) in vitro. The RPE grows on the acellular Bruch’s membrane, which sits directly superior to the choroid layer. RPE cells have characteristic dark pigment and grow in tight polygonal cell junctions. When grown in tissue culture flasks, these characteristics are not exhibited. In this study, spider silk coated substrates were used to replicate the surface chemistry of Bruch’s membrane and promote RPE growth, morphology, and differentiation

Unusual Hprt Expression In Prostate Cancer Cells And Its Impact On Potential Treatment, Michelle H. Townsend, Abi M. Felsted, Michael D. Anderson, Richard A. Robison, Kim L. O'Neill

Biomedical Engineering Western Regional Conference

Unusual HPRT Expression in Prostate Cancer Cells and its Impact on Potential Treatment

In Vitro Antioxidant Oxidative Stress Treatment Model In Microgravity, Matt Clegg, Charles P. Harding, Taylor Clegg, Jon Takemoto, Elizabeth Vargis

Biomedical Engineering Western Regional Conference

We propose that the use of individual or a combination of antioxidants (specifically DL-alpha tocopherol phosphate disodium salt, mesobiliverdin, and L-glutathione) with astronauts in microgravity will reduce the effects of oxidative stress caused by ionizing radiation and muscular atrophy.

Molecular Modeling Of Antibody-Antigen Binding Near Solid Surfaces, Derek Bush, Thomas Knotts

Biomedical Engineering Western Regional Conference

Antibody microarrays are biosensors that have the potential to revolutionize molecular detection in medicine, scientific research, and national defense. However, current microarrays are not widely used due to problems including poor reproducibility and signal quality, unbalanced antibody performance, and cross-reactivity. Prior work in the area focused mainly on the stability of the antibody alone and not its affinity for its antigen. This presentation shows results of using molecular simulation to determine how different types of surfaces affect antigen binding to surface-tethered antibodies. The results offer an unprecedented, molecular-level view into these protein-protein-surface interactions and how to drive binding to occur.

Litigating The Blue Wall Of Silence: How To Challenge The Police Privilege To Delay Investigation, Aziz Z. Huq, Richard H. Mcadams

University of Chicago Legal Forum

No abstract provided.

Chemical Deposits In Evaporite Caves: An Overview, Paolo Forti

International Journal of Speleology

Chemical deposits inside evaporite (gypsum, anhydrite and halite) caves are far less common than those developed within limestone or volcanic cavities. Moreover they exhibit a lower scarce mineralogical variability due to several reasons, the most important of which are: 1) calcium sulfate and sodium chloride are by far less reactive than calcium carbonate; 2) evaporite outcrops normally have a low mineralogical variability within the cave recharge areas. Therefore these karst environments were less investigated from this point of view in the past: no general paper exists on speleothems developing in halite and anhydrite caves until present, while the last printed …