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2017

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Colorimetric Detection Of Cysteine Using Silver-Hydroxyapatite Nanoparticles, Retno Prasetia Jan 2017

Colorimetric Detection Of Cysteine Using Silver-Hydroxyapatite Nanoparticles, Retno Prasetia

Chulalongkorn University Theses and Dissertations (Chula ETD)

Cysteine is a sulphur-containing amino acid that acts as an effective antioxidant in human body. An excessive amount of cysteine leads to cystine formation that causes the stone formation in kidney, bladder, and ureters. A new method was developed for detection of cysteine in urine samples based on the aggregation of silver nanoparticles (AgNPs) on Hydroxyapatite (HAp) in the presence of cysteine. Transmission Electron Microscope (TEM) was used to observe the morphology of prepared HAp and AgNPs on HAp. The presence of cysteine of different concentrations resulted in different cluster sizes of AgNPs on HAp and hence different solid color. …

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Colorimetric Determination Of Thiocyanate Ion Using Modified Polymer Resins, Sujinda Khaosaard Jan 2017

Colorimetric Determination Of Thiocyanate Ion Using Modified Polymer Resins, Sujinda Khaosaard

Chulalongkorn University Theses and Dissertations (Chula ETD)

A new method for thiocyanate determination in milk samples based on the formation of dithiocyanato dipyridine copper(II) [Cu(SCN)2(Py)2] complex on polymer resin surface is proposed. Amberlite XAD-7 resin on was modified with copper-pyridine complex and used as the material for detection. The color of resin changed from blue to green with the increase of thiocyanate concentration. It could be observed by naked-eye and the color intensity used as quantitative data was measured via Image-J software. The effect of various parameters was investigated including Cu2+ concentration, time for resin modification with reagents, sample volume, detection time and pyridine volume. Under the …

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Characterization Of Non-Volatile Compounds In Tom Yum Soup Using High Performance Liquid Chromatography-Tandem Mass Spectrometry, Wanabud Wongbubpha Jan 2017

Characterization Of Non-Volatile Compounds In Tom Yum Soup Using High Performance Liquid Chromatography-Tandem Mass Spectrometry, Wanabud Wongbubpha

Chulalongkorn University Theses and Dissertations (Chula ETD)

In this work, high performance liquid chromatography hyphenated with tandem mass spectrometry (HPLC-MS/MS) was developed and validated for simultaneous determination of 31 targeted non-volatile compounds, such as 2 organic acids, 20 amino acids and 9 phenolic acids, in Tom Yum ingredient, Tom Yum soup made from the fresh ingredients and commercial Tom Yum pastes, where the main Tom Yum ingredients include galangal, lemongrass, kaffir lime leaves, Bird's eye chili, lime juice and fish sauce. The following HPLC-MS/MS conditions were used: a PoroShell C18 column (4.6 x 100 mm, 2.7 µm) using a gradient elution of A:B mobile phase at a …

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Metabolic Responses Of Aspergillus Niger Es4 To Ethanol Stress, Wimonsiri Kongchai Jan 2017

Metabolic Responses Of Aspergillus Niger Es4 To Ethanol Stress, Wimonsiri Kongchai

Chulalongkorn University Theses and Dissertations (Chula ETD)

Aspergillus niger ES4 is a fungus isolated from the top wall of an ethanol tank of the PTT public company limited. Because normally, microorganism cannot tolerate high amount of ethanol, the growth of A. niger ES4 on the ethanol tank indicates the special properties of this fungal strain in response to ethanol. This research was therefore aimed at studying the effects of ethanol on the metabolites production of A. niger ES4 by using both untargeted and targeted metabolomics. When A. niger ES4 cultures were grown in minimal media containing 4% of ethanol for 3 days, A. niger ES4 responded to …

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Mechanisms Of Thai Medicinal Plant Extracts On The Attenuation Of Glutamate-Mediated Neurotoxicity, Anchalee Prasansuklab Jan 2017

Mechanisms Of Thai Medicinal Plant Extracts On The Attenuation Of Glutamate-Mediated Neurotoxicity, Anchalee Prasansuklab

Chulalongkorn University Theses and Dissertations (Chula ETD)

As the world population ages, neurodegenerative diseases, particularly Alzheimer's disease, are becoming a major public health concern with increasing incidence and prevalence worldwide while no cure currently exists. To challenge this situation, herbal medicine may provide a potential alternative treatment as use of natural-derived substances has been proven to be effective in the prevention and/or treatment of several diseases. During the past decades, increasing evidence has implicated excessive glutamate levels in the pathway of neuronal cell death. Thailand is a place known for cultivating a variety of tropical plants and herbs, so far many of them have never been examined …

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Effects Of Plant Extracts On Melanin Biosynthesis And Melanogenetic Gene Expression In B16f10 Melanoma Cells, Moragot Chatatikun Jan 2017

Effects Of Plant Extracts On Melanin Biosynthesis And Melanogenetic Gene Expression In B16f10 Melanoma Cells, Moragot Chatatikun

Chulalongkorn University Theses and Dissertations (Chula ETD)

Ultraviolet radiation from sunlight is a significant environmental factor in skin damage and can induce hyperpigmentation disorder and aesthetic problem. Development of novel whitening phytochemical compounds from natural products has been become trends recently. The purpose of this study was to find some plant extracts that reduce melanin synthesis and melanogenetic gene expression in alpha-MSH-induced B16F10 mouse melanoma cells. To screen total phenolics and flavonoids, antioxidant activity, and anti-mushroom tyrosinase activity, we used 13 plants which were extracted with petroleum ether, dichloromethane and ethanol solvents, subsequently. We found that total phenolic content of 13 plants extracts was found in the …

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Role Of Progesterone Receptor A And B Isoforms In Lung Neuroendocrine Tumors, Teeranut Asavasupreechar Jan 2017

Role Of Progesterone Receptor A And B Isoforms In Lung Neuroendocrine Tumors, Teeranut Asavasupreechar

Chulalongkorn University Theses and Dissertations (Chula ETD)

Lung neuroendocrine tumors (NETs) incidences are increasing in recent years. Women with lung NETs have significantly better survival rates as compared to men suggesting the involvement of sex steroids and their receptors in the progression of lung NETs. Recent data suggested that progesterone receptor (PR) may play a role in the survival of lung NET patients. PR exists as two major isoforms, PRA and PRB. How expression of PR isoforms affects proliferation of lung NETs and patient's survival is not known. To determine the role of PR isoforms in lung NETs, we constructed H727 lung NET cell models expressing PRB …

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Discovery Of Relation Between Listeria And Other Bacterial Contamination Using Classification Refinement Technique, Napas Jeamchotpatanakul Jan 2017

Discovery Of Relation Between Listeria And Other Bacterial Contamination Using Classification Refinement Technique, Napas Jeamchotpatanakul

Chulalongkorn University Theses and Dissertations (Chula ETD)

People often use chicken to prepare their diary meal which creates a great demand for food producers and exporters in Thai food industry. Thailand is ranked fourth in chicken exporters in the world. Standards on chicken meat regulations differ from country to country. One commonality remains: controlling the bacteria that can affect human life, particularly pregnant women and the unborn. One of the important bacteria is called Listeria which receives high attention for the industry to prevent their contamination in chicken. A microbiological test is usually conducted to analyze the data from industry. However, the microbiological test is incapable of …

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Tobacco Use, Health Care Utilization, Household Expenditure And Smoking Cessation In China, Changle Li Jan 2017

Tobacco Use, Health Care Utilization, Household Expenditure And Smoking Cessation In China, Changle Li

Chulalongkorn University Theses and Dissertations (Chula ETD)

This dissertation studied the tobacco use impact of on health care utilization, household expenditure, and self-rated health among rural residents in rural China. The 2010-2014 China Family Panel Studies data were employed here. Moreover, this study also conducted the randomized controlled trial and analyzed the cost-effectiveness smoking cessation intervention among college-aged smokers in Inner Mongolia, China. The main findings showed: (1) Current and former smokers use more outpatient care than non-smokers. Moreover, former smokers use more inpatient care than non-smokers in rural China. (2) Long-term quitters decreased the probability of using inpatient care compared with recent and moderate-term quitters in …

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Education Management Reform Strategies For Enhancing The Quality Citizenship In Cambodia, Chuonnaron Hang Jan 2017

Education Management Reform Strategies For Enhancing The Quality Citizenship In Cambodia, Chuonnaron Hang

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research study aimed to 1) study the conceptual framework of education management reform and the quality citizenship; 2) study the current and desirable state of education management reform for enhancing the quality citizenship in Cambodia; 3) find out the needs in education management reform for enhancing the quality citizenship in Cambodia; 4) develop education management reform strategies for enhancing the quality citizenship in Cambodia. This study employed the research and development method (R&D). The data were collected from 710 respondents, consisting of 10 education policymakers, 30 Directors of MoEYS departments, 80 school administrators, 150 teachers, 80 School Support Committee …

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Effect Of Remineralization On Color Change Of Bleached Tooth, Panita Suttisakpakdee Jan 2017

Effect Of Remineralization On Color Change Of Bleached Tooth, Panita Suttisakpakdee

Chulalongkorn University Theses and Dissertations (Chula ETD)

The aim of this in vitro study was to investigate the effect of remineralization and time on the color and microhardness change of teeth bleached using 10% carbamide peroxide (10%CP) or 40% hydrogen peroxide (40%HP). Seventy-two 6x6x2 mm3 enamel slabs were prepared from human premolars. The specimens' color and Vickers' microhardness were recorded at baseline (T0). The specimens were divided into six groups, two groups were treated with 10%CP with or without casein phosphopeptides and amorphous calcium phosphate (CPP-ACP) (10%CP and 10% CP/CPP-ACP, respectively), two groups were treated with 40% HP with or without CPP-ACP (40%HP and 40%HP/CPP-ACP, respectively), one …

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Bioactive Clitoria Ternatea L. Flower Extract For The Glycemic Control To Carbohydrate Foods And Sugary Beverages, Charoonsri Chusak Jan 2017

Bioactive Clitoria Ternatea L. Flower Extract For The Glycemic Control To Carbohydrate Foods And Sugary Beverages, Charoonsri Chusak

Chulalongkorn University Theses and Dissertations (Chula ETD)

Clitoria ternatea L. flower, an edible plant containing anthocyanins, has been currently used as the source of natural colorant in foods, beverages and desserts worldwide. The previous report demonstrated its biological properties including antioxidant and antihyperglycemic activity. However, the various concentrations of Clitoria ternatea were used in food and beverages but the effective concentration of Clitoria ternatea on the digestibility of starch and glycemic response remains unknown. In this study, the effects of foods and beverage containing Clitoria ternatea L. flower extract (CTE) on starch digestibility in vitro, postprandial glycemic response and antioxidant capacity in human as well as sensory …

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The Effect Of Nutrition Education Intervention On The Amount Of School Lunch Consumption In Children Aged 3-5 Years: Case Study In Bangkok, Thailand, Hathaichanok Tirapongporn Jan 2017

The Effect Of Nutrition Education Intervention On The Amount Of School Lunch Consumption In Children Aged 3-5 Years: Case Study In Bangkok, Thailand, Hathaichanok Tirapongporn

Chulalongkorn University Theses and Dissertations (Chula ETD)

Low vegetable and fruit intake and micronutrient deficiency has been reported for Thai children aged three to five years. Many nutrition education programs have been recommended to solve these problems, especially for preschool children. This study aims to investigate the effect of the novel nutrition education program on the amount of vegetables, fruit, energy and nutrients consumption in school lunches of children aged three to five years. United for Healthier Kids is a nutrition education program that desires to motivate healthy eating via a set of nutrition education tools by encouraging variety in the types of food consumed, increase vegetables …

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Effect Of Different Cooking Methods On The Bioaccessibility Of Polyphenols And Antioxidant Capacities Of Pakwan Ban (Sauropus Androgynus), Imas Arumsari Jan 2017

Effect Of Different Cooking Methods On The Bioaccessibility Of Polyphenols And Antioxidant Capacities Of Pakwan Ban (Sauropus Androgynus), Imas Arumsari

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study was aimed to assess the effect of different cooking methods on the amounts of phytochemical compounds and antioxidant capacities of sweet leaf (Sauropus androgynus) before and during in vitro simulated gastrointestinal digestion. The optimum cooking time of each cooking method was prior selected according to the total phenolic compounds, the ferric-reductase antioxidant power (FRAP) activity, the color characteristics, the hardness, and the texture preference of cooked sweet leaf samples. Consequently, the sweet leaf samples cooked by boiling for 5 mins or microwaving at 800 watts for 90 sec were compared with raw sweet leaf. The results showed that …

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The Inhibitory Effect Of Anthocyanins-Rich Thai Berries Extracts On Lipid Digestion And Absorption, Netima Chamnansilpa Jan 2017

The Inhibitory Effect Of Anthocyanins-Rich Thai Berries Extracts On Lipid Digestion And Absorption, Netima Chamnansilpa

Chulalongkorn University Theses and Dissertations (Chula ETD)

Dyslipidemia is one of the major risk factor that contributes to chronic diseases such as cardiovascular disease and diabetic mellitus. Anthocyanin-rich Thai berries have been documented to have hypolipidemic activity. However, no scientific data is available regarding the mechanism of lipid lowering property. Thus, the objective of this study was to elucidate the mechanism of action of Thai berries including Prunus domestica L., Antidesma bunius (L.) Spreng, Syzygium cumini (L.) Skeels, Syzygium nervosum A. Cunn. Ex DC, and Muntingia calabura L. on a reduction of lipid digestion and absorption in vitro. Phytochemical compounds of Thai berries, including total phenolic (TP), …

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Preparation And Antimicrobial Activity Of Olive Oil Nanoemulsions, Kusuma Jaemsak Jan 2017

Preparation And Antimicrobial Activity Of Olive Oil Nanoemulsions, Kusuma Jaemsak

Chulalongkorn University Theses and Dissertations (Chula ETD)

Due to their health benefits including antioxidant, anti-inflammatory and also antimicrobial activities, extra virgin olive oil (EVOO) has received much attention in food, cosmetics, and pharmaceutical industries. Nanoemulsions (NEs) solubilize and increase absorption and bioavailability of lipophilic substances (i.e. olive oil). However, there is insufficient data in the formation of olive oil NEs. This study aimed to investigate the formation of oil-in-water NEs containing EVOO using low-energy approach and high-energy approach. NEs were characterized for size, polydispersity and zeta potential after storage at different conditions for up to 180 days. They were determined for antimicrobial susceptibility. From the result, NEs …

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Relationship Between Depression And Metabolic Syndrome In Working Age Population In Bangkok, Matthawan Sujinnapram Jan 2017

Relationship Between Depression And Metabolic Syndrome In Working Age Population In Bangkok, Matthawan Sujinnapram

Chulalongkorn University Theses and Dissertations (Chula ETD)

The objectives of this observational descriptive cross-sectional study were to determine the prevalences of depression and metabolic syndrome and to examine the relationship between depression and metabolic syndrome and dietary pattern in working age people in Bangkok. The samples were 446 participants (123 males and 323 females) aged 20 and over who received an annual health examination 2017. The metabolic syndrome was defined by NCEP ATP III criteria. The data on waist circumference, fasting blood glucose, triglycerides, high-density lipoprotein cholesterol, blood pressure, depression score, and dietary pattern were collected. The relationship between depression and metabolic syndrome and dietary patterns were …

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Rapid Quality Determination Of Mulberry Leaf Tea During Storage Using Electronic Nose And Electronic Tongue, Anchalee Ruengdech Jan 2017

Rapid Quality Determination Of Mulberry Leaf Tea During Storage Using Electronic Nose And Electronic Tongue, Anchalee Ruengdech

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study was aimed to develop rapid methods based on electronic nose (e-nose) and electronic tongue (e-tongue) to determine the quality attributes and phytochemicals of mulberry leaf tea. This study was divided into three parts: (1) to determine the effect of cultivar on the quality attributes and phytochemicals of mulberry leaf tea, (2) to evaluate the effect of packaging and storage time on quality attributes and phytochemicals of mulberry leaf tea, and (3) to employ e-tongue combined with chemometrics for prediction of phytochemicals and antioxidant activity of mulberry leaf tea. Mulberry leaf tea prepared from three different mulberry cultivars including …

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Pretreatment Prognostic Factors To Predict Survival Outcome In Advanced Non-Small Cell Lung Cancer With First Line Treatment In Thailand: A Retrospective Cohort Study, Sureerat Jaruhathai Jan 2017

Pretreatment Prognostic Factors To Predict Survival Outcome In Advanced Non-Small Cell Lung Cancer With First Line Treatment In Thailand: A Retrospective Cohort Study, Sureerat Jaruhathai

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Tumor genetic information and biologic markers are often used as prognostic factors. However, these have limited applicable in real daily practice due to their high cost . Objective: To evaluate which inexpensive, convenient simple prognostic factors are associated with survival outcome with first line treatment among patients with advanced non-small cell lung cancer (NSCLC). Methods: Retrospectively reviewed the charts of patients diagnosed with having advanced NSCLC with no previous treatment seen at King Chulalongkorn Memorial Hospital and Police General Hospital during 1 January 2008-31 Dec 2013. Results: A total of 301 patients were included in the study; 68.1% males. …

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Coal Combustion Products Utilization For Soil Amendment, Tran Thi Anh Tuyet Jan 2017

Coal Combustion Products Utilization For Soil Amendment, Tran Thi Anh Tuyet

Chulalongkorn University Theses and Dissertations (Chula ETD)

Nowadays, coal has a crucial role in generating energy all over the world. As a result, the consumption of coal creates a huge amount of coal combustion products, including bottom ash and fly ash. The coal ash has the potential characteristics to become a resource material in agriculture such as its texture, water holding capacity, bulk density, pH etc., and contains almost all the essential plant nutrients. However, most of the coal ash created is dumped into the landfill, which is a contributing factor in the environmental degradation. This study wants to use coal ash in agriculture as a way …

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Cost-Effectiveness Analysis Of Aripiprazole Compare With Risperidone In Patient With Autism Spectrum Disorders, Kridsadadanudej Wongwejwiwat Jan 2017

Cost-Effectiveness Analysis Of Aripiprazole Compare With Risperidone In Patient With Autism Spectrum Disorders, Kridsadadanudej Wongwejwiwat

Chulalongkorn University Theses and Dissertations (Chula ETD)

Autism spectrum disorders (ASD) are a group of deficits in social interaction and social communication (American Psychiatric Association, 2013). The result of a study in Thailand found that ASD patients with less self-reliance increased the number of caregivers, indirect costs and total costs (Naruemol Junsamut, 2014). Risperidone and aripiprazole showed the effectiveness for treating irritability/disruptive behavior in ASD (LeClerc & Easley, 2015). The objective of this research was to estimate the cost-effectiveness of aripiprazole compared with risperidone for treating ASD patient. Seven studies were selected to analyze the outcomes of effectiveness utilizing network meta-analysis. The number of improving symptoms that …

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Factors Associated With Infant And Under-Five Mortality In Myanmar, Lal Hrin Mawi Jan 2017

Factors Associated With Infant And Under-Five Mortality In Myanmar, Lal Hrin Mawi

Chulalongkorn University Theses and Dissertations (Chula ETD)

Myanmar is committed to achieve unfinished agenda for reducing child mortality, fourth indicator of Millennium Development Goals (MDGs) and global target to achieve under-five mortality rate 25 per 1000 live births in 2030. Moreover, under-five mortality varies across states and regions within the country and the study aims to explore determinants of mortality across different health care planning zones. The results showed that infants who were breastfed had lower risk of death by 11.7 percent comparison with children who were not, and twin or multiple births were more likely to die by 8.1%. Moreover, short preceding birth interval, mothers with …

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Korean Wave And Korean Food Franchise Expansion In Bangkok Thailand, Chanika Siriwat Jan 2017

Korean Wave And Korean Food Franchise Expansion In Bangkok Thailand, Chanika Siriwat

Chulalongkorn University Theses and Dissertations (Chula ETD)

The objectives of this research were to investigate the relationship between Korean Wave and current Korean restaurant franchise business expansion in Bangkok and to investigate the factors affecting the decision of Thai customers who came to Korean franchise restaurants, such as general information, source of information, cost of meal, and motivation to have Korean food. This research aims to study the expansion and development of the Korean restaurant business in the case of changing popularity of Korea popular culture in the future from the perspective of Korean restaurant owners. The sample of research is customers who came to consume the …

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Effects Of Food On Growth And Gonadal Development Of Seahorse Hippocampus Sp., Thatpon Kamnurdnin Jan 2017

Effects Of Food On Growth And Gonadal Development Of Seahorse Hippocampus Sp., Thatpon Kamnurdnin

Chulalongkorn University Theses and Dissertations (Chula ETD)

Hippocampus sp. has received attention as a source of aquarium and ornamental trade. Seahorses have been threatened from non-target fisheries, habitat loss and traditional Chinese medicine (TCM). In response to concern about a decrease of population in the wild, an aquaculture of this species may provide the seahorse numbers for the commercial demands. However, one of the critical problems in aquaculture is the proper dietary for growth and their development. Therefore, this study was conducted on different types of preys on survival rates, growth rates and gonadal development in Hippocampus sp. during the day of birth until the 31day after …

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Assessment Of Human Papillomavirus Detection Using Different Methods And Clinical Samples, Pornjarim Nilyanimit Jan 2017

Assessment Of Human Papillomavirus Detection Using Different Methods And Clinical Samples, Pornjarim Nilyanimit

Chulalongkorn University Theses and Dissertations (Chula ETD)

Human papillomavirus (HPV) is the etiological agent implicated cancers include those of the cervix, vulva, vagina, penis, anus, rectum and oropharynx. Currently, the Papanicolaou (Pap) smear is the recommended for cervical cancer screening but only a small percentage of women follow this screening. Overall, this thesis aimed to develop the technique and type of specimen to detect HPV DNA in Thai population and to characterize of the HPV genotypes in Thai patients with anogenital warts. Cervical swab and urine sample of 116 women and 100 men were collected before the Pap smear test. The histological examination of women can classified …

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Effects Of Genistein On Non-Alcoholic Steatohepatitis (Nash) Induced By High-Fat High-Fructose Diet In Bilateral Ovariectomized Rats, Sudaporn Pummoung Jan 2017

Effects Of Genistein On Non-Alcoholic Steatohepatitis (Nash) Induced By High-Fat High-Fructose Diet In Bilateral Ovariectomized Rats, Sudaporn Pummoung

Chulalongkorn University Theses and Dissertations (Chula ETD)

To investigate the effects of genistein on estrogen deficiency with high-fat high-fructose (HFHF) diet-induced NASH rats. Female Sprague-Dawley rats (n=48) were randomly divided into ovariectomized (OVX) and non-ovariectomized (non-OVX) group. Both rat groups, further allocated into 3 subgroups; controls, rats fed with HFHF diet (NASH), and rats fed with HFHF diet plus daily 16 mg/kg BW of genistein (NASH+Gen) for 8 weeks. Serum samples were collected for liver enzymes (AST and ALT) and TNF-α level analysis. Liver tissue samples were harvested for histopathology, hepatic lipid accumulation (oil red o stained, FFA and TG level), hepatic lipid peroxidation (MDA level), hepatic …

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Evaluation Of Lipid Accumulation And Lipolysis Activity In Human Subcutaneous Adipocytes And Human Visceral Adipocytes By Α-Lipoic Acid, Α-Lipoic Acid-Incorporated Caco3 Nanoparticles And Caffeine., Sunisa Kaewdang Jan 2017

Evaluation Of Lipid Accumulation And Lipolysis Activity In Human Subcutaneous Adipocytes And Human Visceral Adipocytes By Α-Lipoic Acid, Α-Lipoic Acid-Incorporated Caco3 Nanoparticles And Caffeine., Sunisa Kaewdang

Chulalongkorn University Theses and Dissertations (Chula ETD)

Recently, much attention has been paid to natural plant-derived compounds as an alternative strategy for developing anti-obesity agents with minimal detrimental effects. Among various natural compounds, caffeine (1, 3, 7-trimethyl xanthine) and alpha lipoic acid (1, 2-dithiolane-3-pentanoic acid; LA) are the natural agents which show a promising result in decreasing fat deposit. Moreover, we have improved efficiencies of LA by CaCO3 NPs because LA had low bioavailability. In the present study, we investigated the effect of combination between caffeine and LA-CaCO3 NPs in lipid accumulation reduction and lipolysis stimulation in human subcutaneous adipocytes and human visceral adipocytes. Our results showed …

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Effect Of Calcium Citrate In Calcium Carbonate Nanoparticles On Hk-2 Cells In Acidic Environment, Tipagorn Udomsinsirikul Jan 2017

Effect Of Calcium Citrate In Calcium Carbonate Nanoparticles On Hk-2 Cells In Acidic Environment, Tipagorn Udomsinsirikul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Metabolic acidosis exerts several cellular and tissue dysfunctions, such as increases mineral bone and protein degradation, induces inflammation, oxidative stress and cell death. These complications lead to multiple organ failure, including chronic kidney disease. Sodium bicarbonate and Shohl's solution are commonly used to treat metabolic acidosis. However, these agents cause frequent gastrointestinal adverse effects. Hence, we invented the new calcium carbonate nanoparticles to use as a drug delivery system for carrying citrate to renal cell which we hypothesize to reduce adverse effects of metabolic acidosis. We studied the physical characteristics and pharmacological effects of calcium citrate nanoparticle (Cacit) and calcium …

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Self-Care Of Older Persons Living With Diabetes In Vietnam: A Qualitative Study, Quyen Truong Thi Mai Jan 2017

Self-Care Of Older Persons Living With Diabetes In Vietnam: A Qualitative Study, Quyen Truong Thi Mai

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study aimed to describe the meaning of "self-care" from the perspectives of older persons living with diabetes and explored the self-care behaviors of older persons living with diabetes. The qualitative method was applied in this study. Data were collected by in-depth interview of 16 older persons with Type 2 diabetes in Vietnam. In addition, field note and observation note were written on the reflections, ideas, and meaning of self-care and self-care practices during the data collection process. All data were analyzed by using content analysis method. The results of the study were reflected the self-care from the perspective of …

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The Effect Of Uncertainty Management Program On Quality Of Life Among Vietnamese Women With Post Mastectomy, Xuan Ha Thi Nhu Jan 2017

The Effect Of Uncertainty Management Program On Quality Of Life Among Vietnamese Women With Post Mastectomy, Xuan Ha Thi Nhu

Chulalongkorn University Theses and Dissertations (Chula ETD)

The aim of this study was to test the effect of the Uncertainty Management Program (UMP) on quality of life among Vietnamese women at 3-weeks post mastectomy. The quasi-experimental design with posttest only was conducted in 115 women with post mastectomy who were assigned in experimental group (n=57) and control group (n=58). The experimental group received the UMP and routine care while the control group received only routine care. Participants were assessed at 3-weeks post mastectomy using the modified Quality of Life Index Scale Vietnamese version with Cronbach's alpha coefficient of .81. It was found that at 3-weeks post-mastectomy, the …

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