Digital Commons Network^™

Clinical And Genome-Wide Analysis Of Cisplatin-Induced Peripheral Neuropathy In Survivors Of Adult-Onset Cancer, Heather E. Wheeler

Bioinformatics Faculty Publications

Purpose: Our purpose was to characterize the clinical influences, genetic risk factors, and gene mechanisms contributing to persistent cisplatin-induced peripheral neuropathy (CisIPN) in testicular cancer survivors (TCSs).

Experimental Design: TCS given cisplatin-based therapy completed the validated EORTC QLQ-CIPN20 questionnaire. An ordinal CisIPN phenotype was derived, and associations with age, smoking, excess drinking, hypertension, body mass index, diabetes, hypercholesterolemia, cumulative cisplatin dose, and self-reported health were examined for 680 TCS. Genotyping was performed on the Illumina HumanOmniExpressExome chip. Following quality control and imputation, 5.1 million SNPs in 680 genetically European TCS formed the input set. GWAS and PrediXcan were used to …

Clinical And Genome-Wide Analysis Of Cisplatin-Induced Peripheral Neuropathy In Survivors Of Adult-Onset Cancer, M. Eileen Dolan, Omar El Charif, Heather E. Wheeler, Eric R. Gamazon, Shirin Ardeshir-Rouhani-Fard, Patrick Monahan, Darren R. Feldman, Roebrt J. Hamilton, David J. Vaughn, Clair J. Beard, Chunkit Fung, Jeri Kim, Sophie D. Fossa, Daniel L. Hertz, Taisei Mushiroda, Michiaki Kubo, Lawrence H. Einhorn, Nancy J. Cox, Louis B. Travis

Biology: Faculty Publications and Other Works

No abstract provided.

The Normal Review, A Literary And Arts Publication, Fall 2017, The Normal Review

The Normal Review

No abstract provided.

The Effects Of Physical Activity, Sedentary Time, And Atherosclerosison Fluid Flow In The Lumbar Intervertebral Disc, Jennifer Ann Bowden

Theses and Dissertations

Physical activity impacts health and disease in multiple body tissues including the intervertebral discs. Fluid flow within the disc is an indicator of disc health that can be observed using diffusion weighted magnetic resonance imaging. We monitored activity levels of 26 participants, age 35 to 55 yrs, using Actigraph accelerometers for four days to evaluate vigorous-intensity activity, moderate to vigorous-intensity activity, and sedentary time. Participants underwent structural and diffusion weighted magnetic resonance imaging to evaluate intervertebral disc health and fluid flow. They also underwent bone density scans, carotid artery ultrasounds, a treadmill test, and a physical exam for pain, range …

Modeling The Influence Of Early Skin-To-Skin Contact On Exclusive Breastfeeding In A Sample Of Hispanic Immigrant Women, Ana Maria Linares, Karen Wambach, Mary Kay Rayens, Amanda Wiggins, Elizabeth Coleman, Mark B. Dignan

Nursing Faculty Publications

Using data from a longitudinal study of breastfeeding in Hispanics, this study evaluated the influence of early skin-to-skin contact (SSC) on initiation and sustained exclusive breastfeeding (EBF) at 1 month postpartum. Two-thirds of the women in the sample participated in early SSC. At discharge, over half of the women were EBF; this proportion decreased to one-third at 1 month postpartum. Controlling for demographic and clinical variables in the model, participation in early SSC was associated with a greater than sevenfold increase in the odds of EBF at discharge (p = .005) but was not predictive of EBF at 1 …

No Parents Allowed: The Problem With Special Immigrant Juvenile Status, Javeria Ahmed

Cardozo Journal of Equal Rights & Social Justice

The note critically examines the Special Immigrant Juvenile Status (SIJS) provision, highlighting its unintended consequences that undermine family unity and harm children's well-being. While SIJS aims to protect children from abusive, neglectful, or abandoning parents, its current interpretation penalizes all natural parents, raising Equal Protection concerns and causing emotional and financial strain on families. The ntoe advocates for a more nuanced approach to SIJS, aligning it with humanitarian goals and child welfare principles.

Burden Of Zinc (Zn) Deficiency: A High Volume Clinical Laboratory Data Analysis, Hafsa Majid, Shabnum Khawaja, Aysha Habib Khan, Imran Siddqui, Farooq Ghani, Lena Jafri

Department of Pathology and Laboratory Medicine

A cross-sectional survey was done at the Section of Chemical Pathology, Department of Pathology and Laboratory Medicine, AKUH, Karachi, to determine frequency of Zn deficiency, the second major micronutrient deficiency in developing countries, in subjects coming for investigations. Data of plasma Zn, from Jan 2013 to Dec 2014 was analyzed and deficiency was labeled at <65ug/dl. Total 469 subjects were tested for plasma Zn levels over the period of 24 months and complete information was available for 422 subjects, included in final analysis. Median age of subjects was 13 yrs (IQR 7-35) and 57% were male. Mean plasma Zn levels of the total subjects were 105±42.6ug/dl. Out of the total subjects 13.5% (n=57) had Zn deficiency (mean plasma Zn 52±11 ug/dl), and most of them were of age group 6-16yrs. These findings advocate that diet of Pakistani children should be revised in order to provide sufficient amounts of Zn.

Vitamin D Deficiency In Early Pregnancy, Diet And Physical Activity And Development Of Gestational Diabetes In Emirati Women, Sharifa Ali Abdulrahman Al Belooshi

Medical Education Dissertations

Vitamin D deficiency and Gestational Diabetes Mellitus (GDM) are common health problems among pregnant women in the Middle East region including the United Arab Emirates. However, a few prospective studies have investigated the association between vitamin D deficiency and the risk of GDM.

We estimated the incidence of GDM and examined the association of vitamin D status in early pregnancy and the development of GDM in Emirati pregnant women. In addition, we studied the association of diet, low physical activity and other covariates with the risk of GDM.

We conducted a prospective cohort study on Emirati pregnant women who visited …

October 2017, Swosu Bulldog Wellness Committee

SWOSU BULLDOG WELLNESS

No abstract provided.

A Family Approach To Emergent Reading And Writing, Amanda Jones

School of Education and Leadership Student Capstone Projects

The research question addressed in this project was, how can adult education programming be developed to support parents of emergent readers and writers? It discusses the importance of emergent literacy, brain development, and the role of parents in their child’s development. The stages of emergent literacy, including milestones of child’s development are included. The research of Malcolm Knowles is the framework used in order to create a presentation that supports literacy in the home. Specifically, the six assumptions of andragogy (adult learning) from Knowles’s theory are identified and described.

Mobility Limitations And Fear Of Falling In Non-English Speaking Older Mexican-Americans, Eric G. James, Phillip Conatser, Murat Karabulut, Suzanne G. Leveille, Jeffrey M. Hausdorff, Sarah Cote, Katherine L. Tucker, Bruce Barton, Jonathan F. Bean, Soham Al Snih, Kyriakos S. Markides

Health & Human Performance Faculty Publications

Objective: To determine whether older Mexican-Americans who cannot speak and/or understand spoken English have higher rates of mobility limitations or fear of falling than their English-speaking counterparts.

Design: We conducted a cross-sectional analysis of 1169 community-dwelling Mexican-Americans aged 72–96 years from the 2000–2001 wave of the Hispanic Established Population for the Epidemiological Study of the Elderly. Mobility limitations were defined as having a Short Physical Performance Battery score ≤9, and fear of falling by participant report of being somewhat, fairly, or very afraid of falling. We determined the rates and odds ratios, for having mobility limitations and fear of falling …

Vitamin D Supplementation To Prevent Asthma Exacerbations: A Systematic Review And Meta-Analysis Of Individual Participant Data, David Jolliffe, Lauren Greenberg, Richard Hooper, Christopher Griffiths, Carlos Camargo Jr., Mitsuyoshi Urashima, Conor Kerley, Megan Jensen, David Mauger, Iwona Stelmach, Adrian Martineau

Articles

No abstract provided.

Mobility Limitations And Fear Of Falling In Non-English Speaking Older Mexican-Americans, Eric G. James, Phillip Conatser, Murat Karabulut, Suzanne G. Leveille, Jeffrey M. Hausdorff, Sarah Cote, Katherine L. Tucker, Bruce Barton, Jonathan F. Bean, Soham Al Snih, Kyriakos S. Markides

Health & Human Performance Faculty Publications

Objective: To determine whether older Mexican-Americans who cannot speak and/or understand spoken English have higher rates of mobility limitations or fear of falling than their English-speaking counterparts.

Design: We conducted a cross-sectional analysis of 1169 community-dwelling Mexican-Americans aged 72–96 years from the 2000–2001 wave of the Hispanic Established Population for the Epidemiological Study of the Elderly. Mobility limitations were defined as having a Short Physical Performance Battery score ≤9, and fear of falling by participant report of being somewhat, fairly, or very afraid of falling. We determined the rates and odds ratios, for having mobility limitations and fear of falling …

The Long-Term Health Effects Of Fetal Malnutrition: Evidence From The 1959-1961 China Great Leap Forward Famine, Seonghoon Kim, Belton Fleisher, Jessica Ya Sun

Research Collection School Of Economics

We report evidence of long-term adverse health impacts of fetal malnutrition exposure of middle-aged survivors of the 1959-1961 China Famine using data from the China Health and Retirement Longitudinal Study. We find that fetal exposure to malnutrition has large and long-lasting impacts on both physical health and cognitive abilities, including the risks of suffering a stroke, physical disabilities in speech, walking and vision, and measures of mental acuity even half a century after the tragic event. Our findings imply that policies and programs that improve the nutritional status of pregnant women yield benefits on the health of a fetus that …

Measuring Home Environments Across Cultures: Invariance Of The Home Scale Across Eight International Sites From The Mal-Ed Study, Paul C. Jones, Laura L. Pendergast, Barbara A. Schaefer, Muneera Rasheed, Erling Svensen, Rebecca Scharf, Rita Shrestha, Angelina Maphula, Reeba Roshan, Zeba Rasmussen

Department of Paediatrics and Child Health

The home environment provides the context for much of a child's early development. Examples of important aspects of the home environment include safety, cleanliness, and opportunities for cognitive stimulation. This study sought to examine the psychometric properties of an adapted form of the Home Observation for the Measurement of the Environment (HOME; Caldwell & Bradley, 1984, 2003) across the eight international sites of the MAL-ED project (Dhaka, Bangladesh; Vellore, India; Bhakatapur, Nepal; Naushahro Feroze, Pakistan; Fortaleza, Brazil; Loreto, Peru; Venda, South Africa; Haydom, Tanzania), to identify a factor structure that fit the data at all sites, and to derive a …

Twenty First Anniversary Scientific Meeting

Journal of the Hong Kong College of Cardiology

No abstract provided.

Sleeper Cells: The Stringent Response And Persistence In The Borreliella (Borrelia) Burgdorferi Enzootic Cycle, Felipe C. Cabello, Henry Godfrey, J Bugrysheva, Stuart A. Newman

NYMC Faculty Publications

Infections with tick-transmitted Borreliella (Borrelia) burgdorferi, the cause of Lyme disease, represent an increasingly large public health problem in North America and Europe. The ability of these spirochetes to maintain themselves for extended periods of time in their tick vectors and vertebrate reservoirs is crucial for continuance of the enzootic cycle as well as for the increasing exposure of humans to them. The stringent response mediated by the alarmone (p)ppGpp has been determined to be a master regulator in B. burgdorferi. It modulates the expression of identified and unidentified open reading frames needed to deal with and overcome the many …

Evaluation Of Trends In Diabetes Care In A Patient-Centered Medical Home, Ashley N. Saucier, Danielle Mcmechan, Julie Dahl-Smith, Carla Duffie, Denise M. Hodo, Holly E. Andrews, Joseph Hobbs

Journal of the Georgia Public Health Association

Background: The patient-centered medical home (PCMH) is a model used in primary care to achieve effective management of chronic diseases. The Augusta University Health Family Medicine Center (AUFMC), a PCMH recognized by the National Committee for Quality Assurance, has implemented strategies to manage its patient population with diabetes. The present study evaluated the effects of these interventions through trend analysis of selected diabetic core measures by use of a qualified clinical data registry, the Practice Partner Research Network.

Methods: For this retrospective study, de-identified data were abstracted for adult patients with diabetes for the period of 2013-2015. Process and outcome …

Effect Of Exercise Intervention On Flow-Mediated Dilation In Overweight And Obese Adults: Meta-Analysis, Younsun Son, Kyungun Kim, Soeun Jeon, Minsoo Kang, Sukho Lee, Yoonjung Park

Kinesiology Faculty Publications (Archived)

The objective of this meta-analysis is to summarize the effect of exercise intervention on flow-mediated dilatation (FMD) in overweight and obese adults. We searched four electronic databases (PubMed/Medline, Scopus, and CINAHL) through June 2016 for relevant studies pertaining to the effectiveness of exercise intervention on FMD. Seventeen of the 91 studies identified met the inclusion criteria. Comprehensive Meta-Analysis software (version 3) was used to compute the standardized mean difference effect size (ES) and 95% CI using a random effects model. We calculated 34 ESs. We found that exercise intervention had medium and positive effects on FMD, with an overall ES …

Sustainable Solutions

Sustainable Solutions Newsletter (2016-2021)

• Director's Message
• Campus Opportunities
• 3rd Annual Pallet Challenge
• Sustainability Seminar: Dr. Vandana Shiva
• Apartment Gardening 101 Workshop
• After School Garden Program
• Green Ambassadors- a Green Student Organization
• Tailgate Game- day Recycling
• Bee-Well Workshop
• Environmental Community Cinema: Life Off Grid
• Residence Hall Recycling Incentive Program
• Individual Student and Organization Mini-Grants
• Adopt-A-Stream volunteers needed
• NC's Vermiculture Conference

Sustainable Solutions, Georgia Southern University

Sustainable Solutions Newsletter (2016-2021)

• Campus Opportunities
• GreenFest
• 3rd Annual Pallet Challenge
• Sustainability Seminar: Dr. Vandana Shiva
• Environmental Community Cinema Presents: The True Cost
• Sustainability Social
• Georgia Southern Sustainability Network Annual Conference
• After School Garden Program
• Green Ambassadors- a Green Student Organization
• Tailgate Game-day Recycling
• Residence Hall Recycling Incentive Program
• Campus in the Spotlight
• Lunch and Learn with the Botanic Garden at Georgia Southern
• Adopt-A-Stream volunteers needed
• Georgia Conservancy: Sapelo Island Service Weekend
• Georgia Conservancy: Yellow River & Paddle Jame
• Forest Therapy Retreat
• Conferences
• EPA: Campus RainWorks Challenge
• Sustainability related Study Abroad
• Webinars
• Jobs/Internships
• FIRST Green Carpet Fashion Awards, Italia
• Green Tip

Lack Of Consensus Among Sentiment Analysis Tools: A Suitability Study For Sme Firms, A Connelly, M Palomino, V Kuri

School of Engineering, Computing and Mathematics

Small and medium-sized enterprises (SMEs) are a large and integral part of the UK’s economy, with over 99% of all Britain’s businesses classified as small or medium. Supporting the needs of SMEs across the UK has become crucial, while the demands for software tools placed by such businesses keep growing. We are particularly interested in the case of tools for sentiment analysis, because such tools have emerged lately as a good prospect for SMEs to turn data into opportunities. We have compared five of the most well-regarded sentiment analysis tools, and have concluded that none of them is sufficiently reliable …

Holistic Approach In Microalgae Conversion To Bioproducts And Biofuels Through Flash Hydrolysis, Ali Teymouri

Civil & Environmental Engineering Theses & Dissertations

In recent years, the demand for renewable energy, mainly biomass has increased. The U.S. Energy Information Administration reported that more than 13.3% of the total energy production in the first seven months of 2017 was produced from a biomass source. Among all biomass resources, microalgae has brought a lot of attention due to their numerous advantages such as higher growth rate and productivity compared with the conventional energy crops, higher energy conversion efficiency by photosynthesis, and less water requirement than terrestrial crops. However, its development is far behind industrial production. Several research efforts across the globe have been concerned with …

Leader-Parent Relationships In The Early Childhood Education Context: An Exploration Of Testimonial And Epistemic Justice, Shirley Eileen Adams

Educational Leadership & Workforce Development Theses & Dissertations

In this qualitative study, I examined epistemic justice and testimonial injustice experienced by parents of children enrolled in preschool programs. I used a triadic model arising from the synthesis of Fricker’s (2003) markers of epistemic justice, Hoy and Tschannen Moran’s (1999) Five Facets of Trust and Lea’s (2006) markers of collaboration, and employed modified grounded theory (Charmaz, 2008). Public preschool programs often promise that they can ameliorate cognitive and experiential gaps experienced by children who at risk and allow them to enter kindergarten on an equal footing with their more privileged peers (Hulme, Goetz, Gooch, Adams & Snowling, 2007; Camilli …

Understanding The Contributions Of Beef Cattle To Greenhouse Gas Emissions, Elizabeth Stewart, Eric Thacker, Matthew D. Garcia, Juan J. Villalba

All Current Publications

This fact sheet describes current and projected beef consumption, methane, nitrogen, beef cattle production, and possibilities for more sustainable beef production.

The Sage Page Fall 2017, Winthrop University Honors Association

The Sage Page (2009 - 2021)

Inside this issue:

Welcome by Dr. Lyon
Meet the Officers
Letter from WUHA!
President Photo Story: Awesome Honors Events
Alumni Story
2017 Seniors
How the Honors Program Helped me Earn Five Scholarships
Being Honors and Greek
Studying Abroad As an Honors Student
Opinion of one of the Cool Honors Classes: Bob Dylan
Photo Story: Bigs and Littles
Honors Program’s Growth

Maturational Timing And Swim Performance In Collegiate Female Swimmers, Brian V. Wright, Andrew C. Cornett, Sierra Wagner, Alan Duski, Joel M. Stager

Kinesiology Faculty Publications

The purpose of this study was to determine if maturational timing is related to collegiate swim performance. Maturational timing was estimated using age at menarche (AaM), which was determined retrospectively in collegiate swimmers (N = 273). Each swimmer’s best performance during the 2015-2016 NCAA season was obtained from the USA Swimming database and selected based on Power Point Score (PPS), a standardized score given to all performances in the database. Independent samples t tests were used to compare (i) PPS and body mass index (BMI; from selfreported height and weight) between earlier maturing (youngest 33% at menarche) and later maturing …

Usefulness Of Delivery Methods For Climate Change Programming: Perspectives Of Extension And Research Faculty, Kaila Thorn, Daniel Tobin, Rama Radhakrishna, Allison Chatchyan, Joana Chan, Shorna Allred

Journal of Extension

Extension is responding to climate change through programming intended to encourage adaptation and mitigation in agricultural production and natural resources management. However, effectively engaging target audiences requires identifying appropriate delivery methods. We conducted a study to identify delivery methods researchers and Extension professionals at land-grant universities in the northeastern United States perceive as useful for climate change outreach. Respondents viewed all delivery methods as only slightly useful, though traditional options, including face-to-face interactions and the use of videos and websites, were perceived as slightly more useful than other delivery methods. Therefore, we in Extension must experiment with various delivery methods …

Perceptions Of Crop Consultants And Crop Producers On Grazing Corn Residue In Nebraska, Jordan L. Cox-O'Neill, Kristen M. Ulmer, Manbir Rakkar, Lisa Franzen-Castle, Humberto Blanco-Canqui, Mary E. Drewnoski, James C. Macdonald, Richard J. Rasby

Journal of Extension

We conducted a survey to evaluate factors influencing consultant recommendations on grazing and producer grazing practices in Nebraska. Producers who did not graze cited soil compaction, inconvenience (lack of watering and fencing), and lack of access to livestock as major reasons for not grazing. Producers who allowed grazing and consultants who recommended grazing were more likely than those who did not favor grazing to perceive that grazing increased subsequent grain yields. Most consultants and producers reported making decisions on the basis of their personal observations. Findings from the survey can be used for enhanced Extension dissemination and research activities regarding …

The Prospects Of Zinc As A Structural Material For Biodegradable Implants—A Review Paper, Galit Katarivas Levy, Jeremy Goldman, Eli Aghion

Michigan Tech Publications, Part 1

In the last decade, iron and magnesium, both pure and alloyed, have been extensively studied as potential biodegradable metals for medical applications. However, broad experience with these material systems has uncovered critical limitations in terms of their suitability for clinical applications. Recently, zinc and zinc-based alloys have been proposed as new additions to the list of degradable metals and as promising alternatives to magnesium and iron. The main byproduct of zinc metal corrosion, Zn²⁺, is highly regulated within physiological systems and plays a critical role in numerous fundamental cellular processes. Zn²⁺ released from an implant may suppress …