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Plasmodium Falciparum 26s Proteasome Network: A Mystery Solved, Christina Grogan

D.U.Quark

One ofthe most devastating diseases thatthreatens the world population is malaria. The 26S proteasome complex of the malaria parasite Plasmodium falciparum, which was previously unknown, was characterized by the authors through an affinity purification protocol that isolated functional 26S proteasome complexes. This allowed for the identification of subunit composition and PfUSP14, a proteasomeassociated deubiquitinase. This new understanding presents a potential target to disrupt protein regulation in thequest for effective antimalarial strategies.

Gadgets And Grieving: A Chronological Analysis On The Ways In Which Advancements In Medical Technologies Have Altered The Grieving Process, Grace Mcnair

Dialogue & Nexus

Since the 1940s, both end-of-life care and advancements in medical technologies have expanded exponentially. This article explores the advancements in medical technologies and how these have altered the way that Western society grieves death. With the capabilities to prolong life, the family, the patient, and the medical team, all grieve the end of life in different ways. This article provides a chronological analysis of palliative care, hospice care, and various medical advancements. These changes in medicine are then paralleled with alterations in the bereavement process. This article explores historical narratives of Western society’s transformation of grief through the lens of …

Pollen Forecasting In Sarasota, Florida, Daniel J. Gessman

USF Tampa Graduate Theses and Dissertations

Current predictions of pollen levels rely strictly on historical Averages, regardless of environmental factors that might affect the timing of pollen release by different plants. For this thesis, the goal was to develop a statistical model that will accurately forecast pollen levels by correlating those daily counts to atmospheric and meteorological conditions. This project used ARIMA modeling on IBM’s SPSS Statistics 24 of daily pollen count information for multiple allergenic pollens in the Sarasota County, Florida area over a 11-year period. The pollen species in question for this project are oak and cypress trees, grass, and ragweed pollens; and Alternaria …

Development Of Bone Targeting Drugs., Molly Stapleton, Kazuki Sawamoto, Carlos J. Alméciga-Díaz, William G. Mackenzie, Robert W. Mason, Tadao Orii, Shunji Tomatsu

Department of Pediatrics Faculty Papers

The skeletal system, comprising bones, ligaments, cartilage and their connective tissues, is critical for the structure and support of the body. Diseases that affect the skeletal system can be difficult to treat, mainly because of the avascular cartilage region. Targeting drugs to the site of action can not only increase efficacy but also reduce toxicity. Bone-targeting drugs are designed with either of two general targeting moieties, aimed at the entire skeletal system or a specific cell type. Most bone-targeting drugs utilize an affinity to hydroxyapatite, a major component of the bone matrix that includes a high concentration of positively-charged Ca(2+). …

The Effect Of Antigen Polymorphisms On Serological Antibody Detection Assays Based Upon The, Kristi M. Miley

USF Tampa Graduate Theses and Dissertations

Onchocerca volvulus is a filarial parasite transmitted to humans by female Simulium spp. black flies. Infection with this parasite can cause blindness and severe skin disease among humans in Africa and the Americas. Enzyme-linked Immunosorbent Assay serological testing of OV-16 antigen is a diagnostic tool for determining effective elimination of the parasite. Programs typically rely on OV–16 ELISA to evaluate the progress towards interruption and/or elimination of disease by mass drug distribution of ivermectin and vector larvicidal control efforts. As elimination grows closer, monoclonal antibody positive controls for OV-16 ELISA become important to develop for Onchocerca testing due to the …

Implementing The International Health Regulations (2005) With Search Engine-Based Syndromic Surveillance, Ryan Sullivan

Georgia Journal of International & Comparative Law

No abstract provided.

Dismukes, 'Role Model To All,' Passes Away, Carolyn Walsh

Browse All News

No abstract provided.

Authority And Scope Of Vaccination: How States Differ, Sharon Xavioer, Jeff Goad

Pharmacy Faculty Articles and Research

"Despite all this, vaccine rates still fall short of desirable goals, such as those outlined in the Healthy People 2020 national initiative.⁷ Although the CDC and APhA promote the “immunization neighborhood” concept, meaning all appropriate professions should coordinate, communicate, and collaborate to increase immunization rates, challenges are still evident for pharmacies.⁸ One major factor is the variability in state laws and regulations that govern vaccine administration by pharmacists.⁵ Significant regulation differences limit which vaccines are permitted, which age groups of patients can be immunized, and which practice model pharmacists may operate under.⁹"

Analysis Of A Potential A(H7n9) Influenza Pandemic Outbreak In The U.S., Walter A. Silva Sotillo

USF Tampa Graduate Theses and Dissertations

This dissertation presents a collection of manuscripts that describe development of models and model implementation to analyze impact of potential A(H7N9) pandemic influenza outbreak in the U.S. Though this virus is still only animal-to-human transmittable, it has potential to become human-to-human transmittable and trigger a pandemic. This work is motivated by the negative impact on human lives that this virus has already caused in China, and is intended to support public health officials in preparing to protect U.S. population from a potential outbreak of pandemic scale.

An agent-based (AB) simulation model is used to replicate the social dynamics of the …

Influenza Virus: The Evolution Of A Deadly Virus In Our World, Cathy M. St. Pierre

International Nursing Research Congress (INRC)

Despite significant advances in health care today and the fact that influenza illness is a preventable disease, Influenza virus continues to be a significant cause of morbidity and mortality in the world. Influenza continues to rank in the top 10 causes of death in the world and infects up to 5 million people annually (WHO, 2014). The Influenza virus is compose of three types: A, B and C. Initially, Influenza virus A was thought to be only present in birds and poultry. However, in recent years, it has come to light that strains of the Influenza virus A, known as …

Immunizations And Health Disparities: Immunizations Provided Across A Diverse Population, Jeffery A. Goad, Tania Gregorian

Pharmacy Faculty Articles and Research

"Vaccines help contain the spread of diseases and reduce morbidity and mortality. For any vaccination effort to succeed, vaccine uptake must be widespread across the entire population. However, the US population is very diverse, and there are various groups with different attitudes and beliefs regarding vaccination; this leads to disparities in vaccination rates. The Healthy People initiative, a program managed by Office of Disease Prevention and Health Promotion at the US Department of Health and Human Services HHS that aims to provide Americans with evidence-based, 10-year national objectives for improving their health defines a disparity in health care as 'a …

Evolution Of Mammalian Migrations For Refuge, Breeding, And Food, Gitanjali E. Gnanadesikan, William D. Pearse, Allison K. Shaw

Biology Faculty Publications

Many organisms migrate between distinct habitats, exploiting variable resources while profoundly affecting ecosystem services, disease spread, and human welfare. However, the very characteristics that make migration captivating and significant also make it difficult to study, and we lack a comprehensive understanding of which species migrate and why. Here we show that, among mammals, migration is concentrated within Cetacea and Artiodactyla but also diffusely spread throughout the class (found in 12 of 27 orders). We synthesize the many ecological drivers of round-trip migration into three types of movement—between breeding and foraging sites, between breeding and refuge sites, and continuous tracking of …

Outcomes Of Post-Neurosurgical Ventriculostomy-Associated Infections, Muhammad Ehsan Bari, Ghani Haider, Komail Malik, Muhammad Waqas, Syed Faisal Mahmood, Mubbashira Siddiqui

Section of Neurosurgery

Background: Ventriculostomy-associated infection (VAI) is a major concern to physicians. Limited studies have looked at the outcomes of external ventricular drain (EVD) infection and predictors of unfavorable outcomes. In this study, we assessed the outcomes of EVD infection and predictors of unfavorable outcomes.
Methods: This was a retrospective medical chart review, conducted at the Aga Khan University Hospital. All the patients irrespective of age and gender, fulfilling the diagnostic criteria of VAI were included. Patients with preexisting bacterial meningitis or ventriculitis were excluded from the study. Outcome assessment was based on Glasgow outcome scale (GOS) at 1 and 3 months …

Group A Streptococcal Pericarditis In A Four-Month-Old Infant : Case Report, Badria R. Al-Waili, Sunny K. Zacharias, Emad

Sultan Qaboos University Medical Journal

Purulent pericarditis is uncommon among paediatric patients and cases caused by group A Streptococcus (GAS) are even rarer. We report a four-month-old female infant who was referred to the Royal Hospital, Muscat, Oman, in 2015 with pericardial effusion and cardiac tamponade. She had initially presented to a secondary hospital with a two-week history of fever, a runny nose and shortness of breath. Blood and pericardial fluid cultures confirmed GAS isolates. The infant was treated with a two-week course of antibiotics and made a complete recovery with no echocardiographical evidence of pericardial effusion at a two-month follow-up. To the best of …

Improving Dual Diagnosis Care In Acute Psychiatric Inpatient Settings Through Education, Kofi Bonnie

International Nursing Research Congress (INRC)

Background: Patients with co-existing substance use and mental disorder (dual diagnosis) have complex and challenging care needs. They have an increased risk of homicide, suicide, homelessness, incarceration, multiple admissions and infectious diseases such as hepatitis C and HIV. Acute psychiatric care settings play a vital role in providing services for dual diagnosis patients who often do not voluntarily seek treatment. There is evidence that nurses working in these settings often have unmet learning needs regarding dual diagnosis care, posing a challenge to nursing practice with this clientele. This is significant in that recent data reveals that 57% of the psychiatric …

Influencing Global Health: Creating An Interprofessional Global And Rural Health Certificate Program, Wendy Renee Thal, Emily S. Merrill, Rosalinda Jimenez

International Nursing Research Congress (INRC)

This presentation details the development process and implementation of a graduate level, inter-professional global health certificate program in a graduate level nursing program. The on- line program was developed in direct response to an identified need from the student body within the HSC. The certificate program, a set of three core courses, a total of 12 credit hours, is designed to prepare professionals with in-depth knowledge to enhance the care of populations in underserved global and rural communities both at home and abroad. Healthy People 2020 (ODPHP, N.D.) and the United Nations Sustainable Development Goals (UN, N.D.) guided the development …

Trafficking Victims In The Emergency Room Setting, Lisa M. Archer

Theses and Graduate Projects

Human trafficking, a form of modern-day slavery, is a violation of human rights and a public health issue. Affecting millions worldwide, a high prevalence of human trafficking exists in the United States (US). Traffickers target vulnerable victims in an effort, through coercion and exploitation, to benefit financially, perpetuating the issue of supply and demand. Lacking a specific demographic, traffickers opportunistically seek out victims, such as targeting runaway and homeless youth, those sold through poverty, or those surviving in conditions caused by natural disaster. Multidisciplinary health care staff are uniquely positioned to recognize, assess, and intervene when encountering victims who seek …

Analyzing Influenza-Like Illness With Unsupervised Machine Learning, Monique J. Bouvier, Mary Barger, David D'Ambrosio, John C. Arnold

International Nursing Research Congress (INRC)

Abstract Text:

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 Disclosure: The views expressed herein are those of the authors and do not reflect the official policy or position of the Department of the Navy, Department of Defense, or the United States Government.

Purpose:

The World Health Organization reports acute respiratory infections continue to be the leading cause of global infectious disease morbidity and mortality with almost 4 million deaths annually. An acute respiratory infection is caused by an infectious agent, bacterial or viral, with a wide spectrum of symptom presentation. There are over 200 viruses that can cause influenza-like illnesses (ILI), a sub-type of acute …

Blimp-1 Impairs T Cell Function Via Upregulation Of Tigit And Pd-1 In Patients With Acute Myeloid Leukemia., Liuluan Zhu, Yaxian Kong, Jianhong Zhang, David F. Claxton, W. Christopher Ehmann, Witold B. Rybka, Neil D. Palmisiano, Ming Wang, Bei Jia, Michael Bayerl, Todd D. Schell, Raymond J. Hohl, Hui Zeng, Hong Zheng

Department of Medical Oncology Faculty Papers

BACKGROUND: T cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif (ITIM) domain (TIGIT) and programmed cell death protein 1 (PD-1) are important inhibitory receptors that associate with T cell exhaustion in acute myeloid leukemia (AML). In this study, we aimed to determine the underlying transcriptional mechanisms regulating these inhibitory pathways. Specifically, we investigated the role of transcription factor B lymphocyte-induced maturation protein 1 (Blimp-1) in T cell response and transcriptional regulation of TIGIT and PD-1 in AML.

METHODS: Peripheral blood samples collected from patients with AML were used in this study. Blimp-1 expression was examined by flow cytometry. The correlation of …

Pengetahuan Dan Sikap Masyarakat Tentang Upaya Pencegahan Tuberkulosis, Fauzie Rahman, Adenan Adenan, Fahrini Yulidasari, Nur Laily, Dian Rosadi, Aulia Noor Azmi

Media Kesehatan Masyarakat Indonesia

Penyakit tuberkulosis paru adalah penyakit menular kronis yang disebabkan oleh bakteri Mycobacterium tuberculosis. World Health Organization (WHO) menyatakan bahwa 1/3 penduduk dunia telah terinfeksi kuman tuberkulosis. Pada tahun 2012 kasus penderita tuberkulosis baru di Kalimantan Selatan dilaporkan 96 per 100.000penduduk. Tujuan penelitian ini adalah mengetahui hubungan antara tingkat pengetahuan dan sikap dengan upaya pencegahan penyakit tuberkulosis di wilayah kerja Puskesmas Bawahan Selan tahun 2015. Metode penelitian ini adalah kuantitatif dengan pendekatan cross sectional study. Populasi penelitian sebanyak 24.410 orang, teknikpengambilan sampel menggunakan metode cluster random sampling, kemudian jumlah sampel ditentukan menggunakan rumus slovin dan didapat sampel sebanyak 100 orang. Instrumen …

Efektivitas Biaya Penggunaan Ampisilin Dansefotaksim Pada Pasien Anak Demam Tifoid, Nurmainah Nurmainah, Siti Syabriyantini, Ressi Susanti

Media Kesehatan Masyarakat Indonesia

Demam tifoid merupakan penyakit endemik yang angka kejadiannya masih tinggi di Indonesia. Pengobatan demam tifoid dapat dilakukan dengan cara pemberian terapi antibiotik, yaitu ampisilin dan sefotaksim. Penelitian ini dilakukan untuk mengetahui perbandingan efektivitas biaya penggunaan sefotaksim dan ampisilin pada pasien anak demam tifoid di RST TK II Kartika Husada Kubu Raya Tahun 2015. Metode yang digunakan dalam penelitian ini merupakan penelitian observasional dengan rancangan penelitian secara potong lintang (cross sectional) yang bersifat deskriptif. Pengumpulan data dilakukan secara retrospektif berdasarkan basis data rekam medik pasien demam tifoid yang dirawat inap di RST TK II Kartika Husada Kubu Raya periode Januari sampai …

Concept Development Of "Compassion Fatigue" In Clinical Nurses: Application Of Schwartz-Barcott And Kim's Hybrid Model, Mahdieh Sabery, Meimanat Hosseini, Mansoureh Zagheri Tafreshi, Jamileh Mohtashami, Abbas Ebadi

Asian/Pacific Island Nursing Journal

Compassion fatigue is not a new concept in nursing; yet, it is not well known and there is no fixed clear definition of the term. The ambiguity surrounding how to define compassion fatigue has challenged its measurement and evaluation. Thus, any attempt to determine attributes of this underdeveloped concept and studying it in a new socio-cultural context requires concept development. The purpose of this study is to clarify the concept of compassion fatigue through concept development and to produce a vivid and tentative definition of this concept in clinical practice.

Concept development was conducted using a three-step hybrid concept analysis …

“You Don’T Just Eat ‘Em, You Get Match Ready With ‘Em”: A Content Analysis Of Alcohol, Food, And Non-Alcoholic Beverage Advertising In The United States During The 2014 Fifa World Cup Brazil, Melissa M. Feulner

Master's Theses

No abstract provided.

Association Of Alzhemier's Disease With Hepatitis C Among Patients With Bipolar Disorder, Herng-Ching Lin, Sudha Xirasagar, Hsin-Chien Lee, Chung-Chien Huang, Chao-Hung Chen

Faculty Publications

Associations of hepatitis C virus infection with Alzheimer’s disease have not been studied among higher risk, bipolar disorder patients. This population-based case-control study investigated the risks of hepatitis C virus infection among Alzheimer’s disease patients with bipolar disorder in the years preceding their Alzheimer’s disease diagnosis. We used 2000–2013 data from the Longitudinal Health Insurance Database in Taiwan. Among patients with bipolar disorder, 73 were diagnosed with Alzheimer’s disease (cases), who were compared with 365 individuals with bipolar disorder but without Alzheimer’s disease (randomly selected controls matched on sex, age, and index year with cases). Prior claims (before the diagnosis …

Genetic Diversity Of Mycobacteriophages And The Unique Abilities Of Cluster K, Shea A. Morris

The Corinthian

Mycobacteriophage are a diverse set of viruses that infect a broad host range of mycobacterium. Genome analysis of this phage group reveals its diversity and provides evidence that they have experienced substantial horizontal gene transfer Collectively they have a large range of host bacteria they can infect, although each viral type may have a limited host range. However, this range is easily expanded and constantly changing in nature by mutation within and between virus types. These phages can lytically destroy their host mycobacteria, and it is this viral ability that have many mycobacteriophage researchers excited about the potential that phage …

Safety Of Induced Sputum Collection In Children Hospitalized With Severe Or Very Severe Pneumonia., Andrea N Deluca, Laura L Hammitt, Julia Kim, Melissa M Higdon, Henry C Baggett, Daniel E Park, +Several Additional Authors

Epidemiology Faculty Publications

Background.: Induced sputum (IS) may provide diagnostic information about the etiology of pneumonia. The safety of this procedure across a heterogeneous population with severe pneumonia in low- and middle-income countries has not been described.

Methods.: IS specimens were obtained as part a 7-country study of the etiology of severe and very severe pneumonia in hospitalized childrenbefore, during, and after the procedure to record oxygen requirement, oxygen saturation, respiratory rate, consciousness level, and other evidence of clinical deterioration. Criteria for IS contraindications were predefined and serious adverse events (SAEs) were reported to ethics committees and a central safety monitor.

Results.: A …

Data Management And Data Quality In Perch, A Large International Case-Control Study Of Severe Childhood Pneumonia., Nora L Watson, Christine Prosperi, Amanda J Driscoll, Melissa M Higdon, Daniel E Park, Megan Sanza, Andrea N Deluca, Juliet O Awori, Doli Goswami, Emily Hammond, Lokman Hossain, Catherine Johnson, Alice Kamau, Locadiah Kuwanda, David P Moore, Omid Neyzari, Uma Onwuchekwa, David Parker, Patranuch Sapchookul

Epidemiology Faculty Publications

The Pneumonia Etiology Research for Child Health (PERCH) study is the largest multicountry etiology study of pediatric pneumonia undertaken in the past 3 decades. The study enrolled 4232 hospitalized cases and 5325 controls over 2 years across 9 research sites in 7 countries in Africa and Asia. The volume and complexity of data collection in PERCH presented considerable logistical and technical challenges. The project chose an internet-based data entry system to allow real-time access to the data, enabling the project to monitor and clean incoming data and perform preliminary analyses throughout the study. To ensure high-quality data, the project developed …

Colonization Density Of The Upper Respiratory Tract As A Predictor Of Pneumonia-Haemophilus Influenzae, Moraxella Catarrhalis, Staphylococcus Aureus, And Pneumocystis Jirovecii., Daniel E Park, Henry C Baggett, Stephen R C Howie, Qiyuan Shi, Nora L Watson, W Abdullah Brooks, Perch Study Group

Epidemiology Faculty Publications

Background.

There is limited information on the association between colonization density of upper respiratory tract colonizers and pathogen-specific pneumonia. We assessed this association for Haemophilus influenzae, Moraxella catarrhalis, Staphylococcus aureus, and Pneumocystis jirovecii. Methods.

In 7 low- and middle-income countries, nasopharyngeal/oropharyngeal swabs from children with severe pneumonia and age-frequency matched community controls were tested using quantitative polymerase chain reaction (PCR). Differences in median colonization density were evaluated using the Wilcoxon rank-sum test. Density cutoffs were determined using receiver operating characteristic curves. Cases with a pathogen identified from lung aspirate culture or PCR, pleural fluid culture or …

Microscopic Analysis And Quality Assessment Of Induced Sputum From Children With Pneumonia In The Perch Study., David R Murdoch, Susan C Morpeth, Laura L Hammitt, Amanda J Driscoll, Daniel E Park, +Several Additional Authors

Epidemiology Faculty Publications

Background.

It is standard practice for laboratories to assess the cellular quality of expectorated sputum specimens to check that they originated from the lower respiratory tract. The presence of low numbers of squamous epithelial cells (SECs) and high numbers of polymorphonuclear (PMN) cells are regarded as indicative of a lower respiratory tract specimen. However, these quality ratings have never been evaluated for induced sputum specimens from children with suspected pneumonia. Methods.

We evaluated induced sputum Gram stain smears and cultures from hospitalized children aged 1–59 months enrolled in a large study of community-acquired pneumonia. We hypothesized that a specimen representative …

Is Higher Viral Load In The Upper Respiratory Tract Associated With Severe Pneumonia? Findings From The Perch Study., Daniel R Feikin, Wei Fu, Daniel E Park, Qiyuan Shi, Melissa M Higdon, Henry C Baggett, +Several Additional Authors

Epidemiology Faculty Publications

Background.

The etiologic inference of identifying a pathogen in the upper respiratory tract (URT) of children with pneumonia is unclear. To determine if viral load could provide evidence of causality of pneumonia, we compared viral load in the URT of children with World Health Organization–defined severe and very severe pneumonia and age-matched community controls.

Methods.

In the 9 developing country sites, nasopharyngeal/oropharyngeal swabs from children with and without pneumonia were tested using quantitative real-time polymerase chain reaction for 17 viruses. The association of viral load with case status was evaluated using logistic regression. Receiver operating characteristic (ROC) curves were constructed …