Digital Commons Network^™

College Health Clinic Population Health Improvement Plan Project, Kathryn M. Flynn

Walden Dissertations and Doctoral Studies

A college community health improvement plan (CHIP) focusing on the indicators of nutrition and weight status, and physical activity and fitness is designed with the goal of reducing obesity risk, improving health, and preventing chronic disease. The precede proceed model, logic model, innovative care for chronic conditions model, self-care theory, and Bandura's social cognitive learning theory were used as a research design framework for assessing, planning, and managing sustainability through a two-year college health clinic. The research questions were: what are the current health promotion inputs and activities in terms of environment, ecology, education, and policy and what could be …

Breastfeeding Perceptions Of First-Time African American Mothers, Deborah Annmarie Jarrett

Walden Dissertations and Doctoral Studies

Breastfeeding is associated with numerous health and social benefits. Although support for breastfeeding is promoted globally, disparities in breastfeeding rates and support continue. African American mothers have lower breastfeeding rates than do Hispanic and Caucasian mothers. Several researchers have focused on the benefits of breastfeeding support, but no available research has explained any specific ethnic group perceptions of breastfeeding. This study explored 10 first-time African American mothers' perceptions of the breastfeeding support they received from physicians, nurses, midwives, and lactation consultants. The purposeful criterion sampling strategy was used to recruit participants, and data were collected through semistructured telephone interviews. The …

Hassles Of African Americans With Type 2 Diabetes, Sharon H. Murff

Walden Dissertations and Doctoral Studies

There has been a steady increase in the incidence of diabetes in the United States. The purpose of this study was to determine whether there was a difference in the daily hassles of African American adults with a self-reported diagnosis of type 2 diabetes compared to those of African American adults without a self-reported diagnosis of type 2 diabetes. The theoretical underpinning for this quantitative, descriptive study was the cognitive appraisal theory (CAT), but the concept of stress and the effects stress has on the body was the broad framework that connected all the variables. The CAT was used to …

Role Of Midline Catheters In Patient Care, Tina K. Schlegel

Walden Dissertations and Doctoral Studies

Central line-associated bloodstream infections (CLABSIs) are responsible for 100,000 patient deaths per year, creating a critical need for prevention of these deadly infections that occur with central venous lines (CVLs). Alternative forms of IV access such as midline catheters (MLCs) may offer lower rates of infection than those seen with CVLs. MLCs were implemented at the practice setting in 2016; however, no evaluation of their effectiveness had been conducted. The purpose of this project was to evaluate the effectiveness of MLCs using a retrospective, pre- post- comparison of CLABSI rates and device utilization rates (DUR) obtained from the practice setting …

Influence Of Sex And Blood Collection Method On Innate Immune Response Following Lipopolysaccharide Administration In Sheep, Hoda Nikpour

Graduate Theses, Dissertations, and Problem Reports (ETD)

Wethers and ewes were used to study the effect of catheter or repeated venipuncture on circulating cortisol and leukocyte concentrations and physical behaviors following administration of lipopolysaccharide (LPS), a gram-negative bacteria cell wall component. Animals were injected with LPS or saline, as a control, to induce an innate immune system response. In addition, blood leukocytes and cortisol levels were studied to determine the effect of sex on immunological and stress responses. Thirty-eight mature Dorset and Suffolk wethers and ewes were assigned into one of four treatment groups: 1.) no-catheter + LPS treated ewes (n=5) and wethers (n=4) that were restrainted …

Inventory Of Wildlife Use Of Mortality Pits As Feeding Sites: Implications Of Pathogen Exposure, Jeremy W. Ellis, Susan A. Shriner, Hailey E. Mclean, Lauren Petersen, J. Jeffrey Root

Human–Wildlife Interactions

To better understand the use of mortality pits by wildlife and possible pathogen dissemination from the resulting wildlife contact in these areas, we used 8 camera traps on 4 mortality pits in Colorado from June to December 2014 to create a species inventory and establish use estimates for those species. We observed 43 species visiting (in or near) the mortality pits during 1,168 total camera trap days. Of these, 24 species directly interacted with the mortality pits or carcasses contained within them. The most common visitors to mortality pits were raccoons (Procyon lotor), coyotes (Canis latrans), domestic dogs (Canis lupus …

Salmonid Response To Habitat Restoration In A High-Elevation West Virginia Watershed, Cory T. Trego

Graduate Theses, Dissertations, and Problem Reports (ETD)

Brook trout Salvelinus fontinalis have experienced significant population declines throughout much of their native range, largely due to habitat loss. Increasing effort has been put toward restoring and preserving existing brook trout habitat in the face of continued loss under uncertain future conditions (e.g., climate change). We conducted a study designed to analyze both macroscale (i.e. at channel unit level) and microscale (i.e. within individual pools) habitat use in the context of stream restoration by brook trout and two competing nonnative salmonid species: brown trout Salmo trutta and rainbow trout Oncorhynchus mykiss. First we conducted a before-after-control-impact assessment of a …

The Amoy China Mission Of The Reformed Church In America, 1937-1951, Jame E. Bell

Grand Valley Journal of History

This article analyzes how successful the Reformed missionaries operating in Amoy and the surrounding region were in accomplishing their objectives of evangelism and the establishment of an indigenous Chinese Church from 1937 to 1951. Through a combination of evangelism, education, and medical work the missionaries sought to spread their faith to the lay population of Fujian province. The missionaries’ work became much more difficult in the late 1930s with the Japanese invasion, World War II, and the eventual Communist takeover. In spite of this, their efforts, in conjunction with other missions, built a dedicated Chinese Christian community that proved hardy …

The Emerging Role Of Hiv Peer Navigators As Associate Medical Case Managers In Northeast Florida, Graham F. Watts Sr

Florida Public Health Review

What is the role of policy in improving the system of care for people living with HIV/AIDS, (PLWHAs)? This policy brief describes an innovation in medical case management within the Jacksonville Transitional Grant Area. Emphases center on how the innovation originated, why the innovation matters, the participants’ involved, outcomes, and the potential impact of the innovation on jurisdictional HIV health services.

A Survey Of Clinicians Regarding Respiratory Physiotherapy Intervention For Intubated And Mechanically Ventilated Patients With Community‐Acquired Pneumonia. What Is Current Practice In Australian Icus?, L Van Der Lee, A Hill, S Patman

Physiotherapy Papers and Journal Articles

Rationale, aims, and objectives: Community-acquired pneumonia (CAP) is a common cause for intensive care unit (ICU) admission resulting in high morbidity and mortality. There is a paucity of evidence regarding respiratory physiotherapy for intubated and mechanically ventilated patients with CAP, and anecdotally clinical practice is variable in this cohort. The aims of this study were to identify the degree of variability in physiotherapy practice for intubated adult patients with CAP and to explore ICU physiotherapist perceptions of current practice for this cohort and factors that influence physiotherapy treatment mode, duration, and frequency.

Method: A survey was developed based on common …

Impacts Of Aplysina Red Band Syndrome On Secondary Metabolite Profiles And Antibacterial Activity Of The Caribbean Sponge Genus Aplysina, Mafie Claire Vickers

Honors Theses

Coral reef ecosystems continue to decline due to abiotic and biotic factors, including disease. Although much of the existing scientific literature has focused on coral diseases, reports of sponge diseases have been increasing. This is a cause for concern, as sponges are increasingly dominant components of coral reef communities, where they are responsible for a wide range of ecological functions. A sponge disease of particular interest is Aplysina Red Band Syndrome (ARBS), which impacts the Caribbean's most abundant genus of sponges, Aplysina. Three morphotypes of branching sponges within this genus are affected, including Aplysina fulva, and the thin and thick …

Biomedical Informatics Seminar Series (Biomiss) 2017 - 2018, Philip J. Kroth

Biomedical Informatics Seminar Series (BioMISS)

No abstract provided.

Practical Guide And Atlas For The Diagnosis Of Fungal Infections, Afia Zafar, Kauser Jabeen, Joveria Farooqi

Books

Laboratory diagnosis of fungal infections remains challenging in South East Asia as it is a neglected field in most diagnostic centres in the developing world. Initial microscopic examination of clinical specimens for the presence of fungal elements followed by growth and eventual identification of isolates up to genus and species levels are very basic and important services that must be provided by any clinical microbiology laboratory. These services have considerable impact on selection of appropriate antifungal therapy and ultimate reduction in morbidity and mortality. With the realisation of scarcity of this service and expertise in Pakistan, our group decided to …

Assessment Of The Current Reporting Requirements Of The Kentucky Immunization Registry, Lindsey Lewis

MPA/MPP/MPFM Capstone Projects

Immunizations are essential to societal health and wellbeing. Throughout one’s lifespan, immunizations are to be administered incrementally to decrease the prevalence of preventable diseases. Despite this, there are disparities in the rates of vaccinations across the country. Numerous guidelines and regulations have been published regarding the administration and scheduling of vaccines. Certain vaccinations are mandatory in order to be able to attend school or hold certain occupational positions and normally proof of administration is required.

Immunization registries were created to monitor and record patient-specific data about administered vaccines. These confidential reporting systems were developed to improve population health by allowing …

Analysis Of The Liberian Ebola Survivors Support System (Esss), Jessi Hanson, Patrick Seeco Faley, Megan Quinn

ETSU Faculty Works

A systems theoretical analysis to capture the evolution and transition of the network systems supporting Ebola survivors and their affected communities, during the 2014-15 Ebola outbreak and recovery phases. The qualitative analysis includes a literature review, archival review, and interviews with representatives of key actors operating in strategic action fields. This paper uses a series of Diagrams that visually illustrate the various complex phases and their network changes that occurred and were established during the outbreak. This case analysis provides crucial phase information that both captures the historical events that informed the systems changes, including the development of the Ebola …

Viral And Cellular Micrornas In Regulation Of Ebv Latency And Oncogenesis, Ling Wang, Shunbin Ning

ETSU Faculty Works

Epstein-Barr virus (EBV), an oncogenic virus that ubiquitously establishes life-long persistence in humans, encodes viral miRNAs in two clusters, BHRF1 and BART. EBV also regulates expression of a large pool of cellular miRNAs, including miR-155, miR-146a, miR-21, miR-29, and miR-34a. These miRNAs targets both viral and cellular genes involved in the entire viral lifetime from lytic infection to oncogenesis, including viral replication, immune responses, cell cycle regulation, apoptosis, and cell proliferation, and are indispensable for persistent infection, latency establishment and maintenance, and cancer development. Among them, circulating miRNAs and unique miRNA profiles are promising diagnosis and prognosis biomarkers alone or …

Developmental Measures: The Zika Virus, Microcephaly, And Histories Of Global Northern State Anxieties, Eden Noa Amital

Scripps Senior Theses

This project seeks to understand anxious and fearful responses to the Zika virus and microcephaly that began circulating widely in February, 2016. My project works to uncover racial histories embedded in the contemporary scientific and medical practice of measuring head circumference. By arguing that microcephaly is a racialized metric of civilizational and human development, I show that responses to Zika’s proliferation invoke state security because Global Northern states imagine microcephaly as a developmental, economic, and cultural lag. Dominant scientific and medical characterizations of microcephaly constitute modern, developed states as such by making political conceptions of normalcy and capacity seem natural: …

Global Health Security In An Era Of Explosive Pandemic Potential, Lawrence O. Gostin, Ana Ayala

Georgetown Law Faculty Publications and Other Works

Pandemics pose a significant risk to security, economic stability, and development. Annualized expected losses from pandemics are estimated at $60 billion per year. Despite the certainty and magnitude of the threat, the global community has significantly underestimated and underinvested in avoidance of pandemic threats.

We cannot wait or continue with the status quo, in which we pay attention to infectious disease threats only when they are at their peak and then are complacent and remain vulnerable until the next major outbreak. To reinforce and sustain international focus, funding, and action, it is crucial that pandemics rise to the level of …

Correlation Of The Boost Risk Stratification Tool As A Predictor Of Unplanned 30-Day Readmission In Elderly Patients, Carol K. Sieck

Dissertations

Carol K. Sieck

Loyola University Chicago

CORRELATION OF THE BOOST RISK STRATIFICATION TOOL AS A PREDICTOR OF UNPLANNED 30-DAY REAMDISSION IN ELDERLY PATIENTS

Risk stratification tools can identify patients at risk for 30-day readmission but available tools lack predictive strength. While physical, functional and social determinants of health have demonstrated an association with readmission, available risk stratification tools have been inconsistent in their use of variables to predict readmission. The Better Outcomes by Optimizing Safe Transitions (BOOST) 8 P's tool is a risk stratification tool developed by the Society of Hospital Medicine but has no published validation studies. The theoretical …

The Experiences Of African American Women Participating In Church-Based Weight Loss Programs, Mangle L. Shanks

Walden Dissertations and Doctoral Studies

While obesity is a nationwide phenomenon, African Americans - especially women - continue to be more severely affected than any other ethnic group. According to the Centers for Disease Control and Prevention, over 20% of African American women are obese compared to 15.6% of Caucasian women. The church is an important community center for many African Americans, and is often a site for health promotion programs, though little is known of the effectiveness of these programs. The purpose of this qualitative study was to study the experiences and attitudes of African American women who have gone through a church-based weight-loss …

Reassessing Survival, Movement, Resource Selection, And Sightability Of Pronghorn In Western South Dakota, Adam Kauth

Electronic Theses and Dissertations

Limited information exists on the survival, movements, resource selection, and densities of pronghorn (Antilocapra americana) inhabiting sagebrush-steppe regions within the Dakotas. Primary objectives of this study were to develop a sightability model for aerial surveying and to document survival rates and movement patterns for pronghorn in western South Dakota. Secondary objectives were to estimate seasonal home ranges, daily movements, determine cause-specific mortality, and evaluate summer and winter resource use and selection. Additionally, we evaluated exposure of pronghorn to novel diseases including Epizootic Hemorrhagic Disease (EHD), West Nile Virus (WNV), Blue Tongue Virus (BTV), Bovine Viral Diarrhea Virus (BVDV), Neospora, and …

Genetic Interference And Receptor Biology Of Neglected Influenza Viruses, Runxia Liu

Electronic Theses and Dissertations

Influenza B virus (IBV) is an important pathogen that infects humans and causes seasonal influenza epidemics. By using next-generation sequencing (NGS) approach, we analyzed total mRNAs extracted from A549 cells infected with B/Brisbane/60/2008, and identified four defective genomes in IBV with two from the polymerase basic subunit 1 (PB1) segment and the other two from the matrix (M) segment. Each of them can potently inhibit the replication of IBV. One derived from PB1 segment was able to interfere modestly with influenza A virus (IAV) replication. The productions of the four defective RNAs are not dependent on the cell types. The …

Is Tea Tree Oil Preparation An Effective Topical Therapy For Patients With Msra Colonized Wounds?, Mariah A. Gerald

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not tea tree oil preparation an effective topical therapy for patients with MRSA colonized wounds.

STUDY DESIGN: This review is based on three randomized controlled trials (RCTs) published in 2004,2013, and 2014. These studies compared the efficacy of tea tree oil (TIO) topical preparations in MRSA colonized wounds.

DATA SOURCES: All articles used were published in English, in peer-reviewed journals, and found using PubMed and Cochrane Review databases.

OUTCOMES MEASURED: The efficacy of tea tree oil preparations on MRSA colonized wounds were evaluated …

Is Methotrexate (Mtx) An Effective Treatment In Partially Or Totally Reducing The Symptoms Of Myasthenia Gravis (Mg) Patients?, Brandi S. Flyte

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not Methotrexate (MTX) is an effective treatment in partially or totally reducing the symptoms of Myasthenia Gravis (MG) patients.

STUDY DESIGN: Review of three English language studies; one Case Series Study following 3 patients with concomitant MG and Rheumatoid Arthritis treated with MTX published in 2014, one Single-Blind Randomized Control Trial (RCT) comparing MTX and AZA (Azathioprine) published in 2011, and one Double-blind, placebo-controlled Randomized Control Trial published in 2016.

DATA SOURCES: Three primary research studies published in peer reviewed journals; found on the …

Is Povidone-Iodine Safe And Effective In The Treatment Of Children And Adults With Viral Conjunctivitis?, Danielle M. Mazzuca

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not, “Is povidone-iodine safe and effective in the treatment of children and adults with viral conjunctivitis?” STUDY DESIGN: Review of three English language primary studies, published between 2002 and 2015. DATA SOURCES: Two randomized controlled trials (RCTs) and one non-randomized, prospective, interventional pilot study were found using PubMed and the Cochrane database. OUTCOMES MEASURED: Each study evaluated the efficacy of povidone-iodine for the treatment of viral conjunctivitis measured by days until cured as determined by patient rating of symptom strength and ophthalmological grading of ocular signs. …

Is Intravenous Peramivir 300mg Effective And Safe In Treating Seasonal Influenza?, Michael P. Phytides

PCOM Physician Assistant Studies Student Scholarship

A. Objective: The objective of this selective EBM review is to determine whether or not intravenous Peramivir 300mg is effective and safe in treating seasonal influenza.

B. Study Design: Review of two randomized controlled trials (RCTs) and one randomized open-label study, all published in 2010, 2011, and 2014, respectively.

C. Data sources: Two randomized controlled trials and one randomized open- label study were all researched through the use of PubMed and belonged to peer reviewed journals.

D. Outcome(s) Measured: Primary efficacy endpoint analyzed was time to alleviation of symptoms measured by influenza symptom severity scale (ISS), …

Is Phototherapy An Effective Treatment For Herpes Simplex Labialis?, Sarah Landis

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this evidence based medicine review is to determine if laser phototherapy is an effective treatment for herpes simplex labialis.

Study Design: Review of one case study published in 2009, and two randomized controlled trials published in 2010 and 2013. All studies were published in English.

Data Source: One case study and two randomized controlled trials were retrieved from PubMed database to write this EBM review

Outcomes measured: Decreases in healing time or size based on patient reporting, scoring systems, or photo documentation.

Results: The study conducted by Marotti et al determined …

Vitamin D3 And Suppressor Of Cytokine Signaling Proteins Reduces Pro-Inflammatory Cytokines In An Alzheimer's Disease Like-Model Consisting Of Microglial And Neuronal Co-Cultures, Alexander Evdokiou

Browse all Theses and Dissertations

This study examined the inflammatory effects of amyloid-beta (A[beta]42) in a microglial-neuronal co-culture system and determined whether 1a, 25-dihydroxyvitamin D3 (1,25-(OH)2D3) along with suppressor of cytokine signaling (SOCS)1 and SOCS 3 mimetics would attenuate the inflammatory response to A[beta]42. This culture system, when seeded with A[beta]42, serves as an in vitro model for Alzheimer's disease (AD). In a neuronal-microglia co-culture, A[beta]42 stimulated microglia to secrete TNF-a, but with the addition of 1,25-(OH)2D3, TNF-a levels dropped by nearly eight-fold and to near zero values in the presence of both 1,25-(OH)2D3 and SOCS1 and SOCS 3 mimetics. The reduction of the inflammatory …

Effect Of Hyperglycemia And Thiazolidinediones On Cardiac Angiotensin Converting Enzyme 2 (Ace2) And Neprilysin (Nep) In Db/Db Diabetic Mice, Rucha Fadnavis

Browse all Theses and Dissertations

Type 2 diabetes mellitus is strongly associated with increased risk of cardiovascular disease. Despite availability of several antidiabetic medications, the cardiovascular outcomes remain unchanged. Activation of renin angiotensin system is one of the critical factors in development of diabetic complications. Hyperglycemia causes an increase in tissue and circulating Angiotensin II. Angiotensin converting enzyme (ACE2) and neprilysin (NEP) are angiotensin (1-7) forming enzymes. ACE2 was first cloned from heart failure patients and has cardioprotective and renoprotective properties. Combination of angiotensin receptor antagonism and NEP inhibition is a new therapeutic strategy for treatment of heart failure. The aim of this study was …

Dnp63a Suppresses Cell Invasion By Targeting Rac1 Through Mir-320a, Amjad Ahmed Aljagthmi

Browse all Theses and Dissertations

DNp63a, a member of the p53 family of transcription factors, is overexpressed in a number of cancers and known to play a role in proliferation, differentiation, migration and invasion. DNp63a has been shown to regulate several microRNAs that play a role in both development and cancer, but to date there has not been a global analysis of p63- regulated miRNA. Using next-generation sequencing of small RNA from wild type and sip63 transfected HaCaT cells, our laboratory recently identified a number of DNp63a- regulated miRNAs by RNA-Seq studies which may serve as biomarkers of cancer progression. We identified a novel miRNA, …