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Sell Side Benchmarks, Ohad Kadan, Leonardo Madureira, Rong Wang, Tzachi Zach

Research Collection Lee Kong Chian School Of Business

Sell-side analysts employ different benchmarks when defining their stock recommendations. For example, a ‘buy’ for some brokers means the stock is expected to outperform its peers in the same sector (“sector benchmarkers”), while for other brokers it means the stock is expected to outperform the market (“market benchmarkers”), or just some absolute return (“total benchmarkers”). We explore the validity and implications of the adoption of these different benchmarks. Analysis of the relation between analysts’ recommendations and their long-term growth and earnings forecasts suggests that analysts indeed abide by their benchmarks: Sector benchmarkers rely less on across-industry information, and focus more …

Plekhg5-Regulated Autophagy Of Synaptic Vesicles Reveals A Pathogenic Mechanism In Motoneuron Disease., Patrick Lüningschrör, Beyenech Binotti, Benjamin Dombert, Peter Heimann, Angel Perez-Lara, Carsten Slotta, Nadine Thau-Habermann, Cora R. Von Collenberg, Franziska Karl, Markus Damme, Arie Horowitz, Isabelle Maystadt, Annette Füchtbauer, Ernst-Martin Füchtbauer, Sibylle Jablonka, Robert Blum, Nurcan Üçeyler, Susanne Petri, Barbara Kaltschmidt, Reinhard Jahn, Christian Kaltschmidt, Michael Sendtner

Department of Medicine Faculty Papers

Autophagy-mediated degradation of synaptic components maintains synaptic homeostasis but also constitutes a mechanism of neurodegeneration. It is unclear how autophagy of synaptic vesicles and components of presynaptic active zones is regulated. Here, we show that Pleckstrin homology containing family member 5 (Plekhg5) modulates autophagy of synaptic vesicles in axon terminals of motoneurons via its function as a guanine exchange factor for Rab26, a small GTPase that specifically directs synaptic vesicles to preautophagosomal structures. Plekhg5 gene inactivation in mice results in a late-onset motoneuron disease, characterized by degeneration of axon terminals. Plekhg5-depleted cultured motoneurons show defective axon growth and impaired autophagy …

Sex-Biased Microrna Expression In Mammals And Birds Reveals Underlying Regulatory Mechanisms And A Role In Dosage Compensation, Maria Warnefors, Katharina Mössinger, Jean Halbert, Anja Studer, Tania Studer, John L. Vandeberg, Isa Lindgren, Amir Fallahshahroudi, Per Jensen, Henrik Kaessmann

School of Medicine Publications

Sexual dimorphism depends on sex-biased gene expression, but the contributions of microRNAs (miRNAs) have not been globally assessed. We therefore produced an extensive small RNA sequencing data set to analyze male and female miRNA expression profiles in mouse, opossum, and chicken. Our analyses uncovered numerous cases of somatic sex-biased miRNA expression, with the largest proportion found in the mouse heart and liver. Sex-biased expression is explained by miRNA-specific regulation, including sex-biased chromatin accessibility at promoters, rather than piggybacking of intronic miRNAs on sex-biased protein-coding genes. In mouse, but not opossum and chicken, sex bias is coordinated across tissues such that …

Trak2, A Novel Regulator Of Abca1 Expression, Cholesterol Efflux And Hdl Biogenesis, Nicole J. Lake, Rachael L. Taylor, Hugh Trahair, K. N. Harikrishnan, Joanne E. Curran, Marcio Almeida, Hemant Kulkarni, Matthew P. Johnson, Thomas D. Dyer, Michael Mahaney, Harald H. H. Goring, John Blangero

School of Medicine Publications

Aims: The recent failures of HDL-raising therapies have underscored our incomplete understanding of HDL biology. Therefore there is an urgent need to comprehensively investigate HDL metabolism to enable the development of effective HDL-centric therapies. To identify novel regulators of HDL metabolism, we performed a joint analysis of human genetic, transcriptomic, and plasma HDL-cholesterol (HDL-C) concentration data and identified a novel association between trafficking protein, kinesin binding 2 (TRAK2) and HDL-C concentration. Here we characterize the molecular basis of the novel association between TRAK2 and HDL-cholesterol concentration.

Methods and results: Analysis of lymphocyte transcriptomic data together with plasma HDL from the …

Identity-By-Descent Mapping Identifies Major Locus For Serum Triglycerides In Amerindians Largely Explained By An Apoc3 Founder Mutation, Wen-Chi Hsueh, Anup K. Nair, Sayuko Kobes, Peng Chen, Harald H. H. Goring, Toni I. Pollin, Alka Malhotra, William C. Knowler, Leslie J. Baier, Robert L. Hanson

School of Medicine Publications

Background—Identity-by-descent (IBD) mapping using empirical estimates of IBD allele sharing may be useful for studies of complex traits in founder populations, where hidden relationships may augment the inherent genetic information that can be used for localization.

Methods and Results—Through IBD mapping, using ~400,000 SNPs, of serum lipid profiles we identified a major linkage signal for triglycerides (TG) in 1,007 Pima Indians (LOD=9.23, p=3.5×10−11 on chromosome 11q). In subsequent fine-mapping and replication association studies in ~7,500 Amerindians, we determined that this signal reflects effects of a loss-of-function Ala43Thr substitution in APOC3 (rs147210663) and 3 established functional SNPs in APOA5. …

Bioresorbable Scaffolds In Spontaneous Coronary Artery Dissection: Long-Term Follow-Up In 4 Patients, Santiago Jesús Camacho Freire, Antonio Enrique Gómez Menchero, Jessica Roa Garrido, Javier León Jiménez, Rosa Cardenal Piris, José Francisco Díaz Fernández

The Texas Heart Institute Journal

Spontaneous coronary artery dissection is a rare condition, and diagnosis and treatment are challenging among patients who present with acute coronary syndrome. Typically, the condition affects young females who have no underlying atherosclerotic disease. To date, few cases of bioresorbable scaffold implantation for the treatment of spontaneous coronary artery dissection have been reported. Therefore, we describe the cases of 4 patients whom we treated with scaffolds. We evaluated the long-term results by using intravascular ultrasound and optical coherence tomographic scanning.

The Audacity Of Protecting Racist Speech Under The National Labor Relations Act, Michael Z. Green

Faculty Scholarship

This Article, written for a symposium hosted by the University of Chicago Legal Forum on the Disruptive Workplace, analyzes the most recent failures of the National Labor Relations Board (NLRB) to determine a thoughtful and balanced approach in addressing racist speech. Imagine two employees in the private sector workplace are discussing the possibility of selecting a union to represent their interests regarding wages and working conditions. During this conversation, a black employee notes the importance of using their collective voices to improve working conditions and compares the activity of selecting a union with the Black Lives Matter protests aimed at …

The Long-Run Performance Of U.S. Firms Pursuing Ipos In Foreign Markets, Robert N. Killins, Peter V. Egly

School of Economics and Finance Faculty Publications

Purpose

The purpose of this paper is to investigate the long-run performance of a unique set of US domiciled firms that have bypassed the US capital markets in pursuit of their initial public offering (IPO) overseas. Additionally, this paper then tests the popular underwriter prestige impact and the window of opportunity hypothesis on this unique subset of IPOs.

Design/methodology/approach

Using a sample of foreign and purely domestic IPOs made by US firms from 2000 to 2011, this study investigates the long-term performance, one-, two- and three-year by using two measures (buy-and-hold return and cumulative abnormal returns) to test the long-run …

Comparison Of Antibacterial Activity Of Ozonated Olive Oil And Chlorhexidine Gluconate, Changmin Lee

Loma Linda University Electronic Theses, Dissertations & Projects

Aim: The aim of this in vitro disk diffusion susceptibility test is to compare the antibacterial activity of ozonated olive oil (OzOO) with chlorhexidine gluconate (CHX) against periodontal pathogens, Porphyromonas gingivalis and Aggregatibacter Actinomycetemcomitans. Materials and Methods: The antibacterial activity of two antiseptics, OzOO and CHX, and, two controls, olive oil and normal saline was assessed by disk diffusion susceptibility test. For disk diffusion susceptibility test, two periodontal pathogens, 20 petri dishes for P. gingivalis and 18 petri dishes for A. actinomycetemcomitans, were used. To assess the antibacterial activity, the diameters of the growth inhibition zone were measured with a …

A Comparison Of Neuromuscular Control Between Subjects With And Without Chronic Ankle Instability, Hatem Jaber

Loma Linda University Electronic Theses, Dissertations & Projects

Ankle sprains are common and potentially disabling musculoskeletal injuries occur among physically active individuals. A subsequent problem that is commonly encountered by clinicians due to ankle sprains is the development of ongoing instability. The presence of ankle instability has been linked to impairments in postural and neuromuscular control; however, inconsistent findings have been reported. These discrepancies deem the need to further investigate and provide additional knowledge regarding postural and neuromuscular control strategies utilized by this population. This may enhance the current understanding of chronic ankle instability (CAI) and help to understand how rehabilitation can be customized to specifically target and …

Intervention Fidelity In The Definitive Cluster Randomised Controlled Trial Of The Healthy Lifestyles Programme (Help) Trial: Findings From The Process Evaluation, J Lloyd, S Dean, S Creanor, C Abraham, Et Al

Peninsula Medical School

BACKGROUND: The Healthy Lifestyles Programme (HeLP) was a novel school-located intervention for 9-10 year olds, designed to prevent obesity by changing patterns of child behaviour through the creation of supportive school and home environments using dynamic and creative delivery methods. This paper reports on both the quantitative and qualitative data regarding the implementation of the HeLP intervention in the definitive cluster randomised controlled trial, which was part of the wider process evaluation. METHODS: Mixed methods were used to collect data on intervention uptake, fidelity of delivery in terms of content and quality of delivery of the intervention, as well as …

Targeted Pre-Treatment Of Hemp Bast Fibres For Optimal Performance In Biocomposite Materials: A Review, Ming Liu, Anders Thygesen, John Summerscales, Anne S. Meyer

School of Engineering, Computing and Mathematics

Global interest in the use of plant fibres in natural fibre reinforced composites (NFCs) is growing rapidly. The increased interest is primarily due to the advantageous properties of natural fibres including biodegradability, low cost, low density and high stiffness and strength to weight ratio. In order to achieve strong NFCs, well separated and cellulose-rich fibres are required. Hemp is taking a center stage in this regard as a source of suitable natural plant cellulose fibres because natural hemp bast fibres are long and inherently possess high strength. Classical field and water retting methods have been used for centuries for removal …

Comparative Costs And Activity From A Sample Of Uk Clinical Trials Units, D Hind, Bc Reeves, S Bathers, C Bray, Et Al

Peninsula Medical School

BACKGROUND: The costs of medical research are a concern. Clinical Trials Units (CTUs) need to better understand variations in the costs of their activities. METHODS: Representatives of ten CTUs and two grant-awarding bodies pooled their experiences in discussions over 1.5 years. Five of the CTUs provided estimates of, and written justification for, costs associated with CTU activities required to implement an identical protocol. The protocol described a 5.5-year, nonpharmacological randomized controlled trial (RCT) conducted at 20 centres. Direct and indirect costs, the number of full time equivalents (FTEs) and the FTEs attracting overheads were compared and qualitative methods (unstructured interviews …

Parenting Stress And Emotion Dysregulation In Children With Dd: The Role Of Parenting Behaviors, Neilson Chan

Loma Linda University Electronic Theses, Dissertations & Projects

Parents of children with developmental delays (DD) report higher levels of parenting stress compared to parents of typically developing children. High levels of parenting stress have been associated with negative outcomes for their children, including higher levels of emotion dysregulation. However, this relationship between parenting stress and child emotion dysregulation has rarely been examined in families of children with DD. Additionally, the mechanisms through which parenting stress influences child emotion dysregulation remain unclear; it may be that parenting stress impacts parenting behaviors (i.e., sensitive and intrusive parenting), which in turn influence the development of the child’s emotion regulatory abilities. In …

One Good Plaintiff Is Not Enough, Aaron-Andrew P. Bruhl

Faculty Publications

This Article concerns an aspect of Article III standing that has played a role in many of the highest-profile controversies of recent years, including litigation over the Affordable Care Act, immigration policy, and climate change. Although the federal courts constantly emphasize the importance of ensuring that only proper plaintiffs invoke the federal judicial power, the Supreme Court and other federal courts have developed a significant exception to the usual requirement of standing. This exception holds that a court entertaining a multiple-plaintiff case may dispense with inquiring into the standing of each plaintiff as long as the court finds that one …

Were The 1982 Merger Guidelines Old News?, Alan J. Meese, Sarah L. Stafford

Faculty Publications

This paper examines the impact of the 1982 Department of Justice Merger Guidelines on the stock market prices of publicly traded firms in the United States. We argue that those Guidelines were perceived by the market as a real change in enforcement policy that would result in substantial deregulation of mergers throughout the economy. We conduct an event study of S&P 500 firms to test this hypothesis and find evidence of a significant positive effect on the stock prices of firms in moderately concentrated industries subject to antitrust regulation, the firms for which the 1982 Guidelines articulate a substantially less …

Genetic Variation And Gene Expression Across Multiple Tissues And Developmental Stages In A Non-Human Primate, Anna J. Jasinska, Ivette Zelaya, Susan K. Service, Christine B. Peterson, Rita M. Cantor, Oi-Wa Choi, Joseph Deyoung, Eleazar Eskin, Lynn A. Fairbanks, John Blangero, Thomas D. Dyer

School of Medicine Publications

By analyzing multitissue gene expression and genome-wide genetic variation data in samples from a vervet monkey pedigree, we generated a transcriptome resource and produced the first catalog of expression quantitative trait loci (eQTLs) in a nonhuman primate model. This catalog contains more genome-wide significant eQTLs per sample than comparable human resources and identifies sex- and age-related expression patterns. Findings include a master regulatory locus that likely has a role in immune function and a locus regulating hippocampal long noncoding RNAs (lncRNAs), whose expression correlates with hippocampal volume. This resource will facilitate genetic investigation of quantitative traits, including brain and behavioral …

Orwell's 1984 And A Fourth Amendment Cybersurveillance Nonintrusion Test, Margaret Hu

Faculty Publications

This Article describes a cybersurveillance nonintrusion test under the Fourth Amendment that is grounded in evolving customary law to replace the reasonable expectation of privacy test formulated in Katz v. United States. To illustrate how customary law norms are shaping modern Fourth Amendment jurisprudence, this Article examines the recurrence of judicial references to George Orwell’s novel, 1984, within the Fourth Amendment context when federal courts have assessed the constitutionality of modern surveillance methods. The Supreme Court has indicated that the Fourth Amendment privacy doctrine must now evolve to impose meaningful limitations on the intrusiveness of new surveillance technologies. …

A Spiritual Framework Of Organic Oneness: The Eco-Theological Shift Towards A Collective Ecological Consciousness, Kjirsten Francisco José Durand

Electronic Theses and Dissertations 2020 - Present

Earth’s environment has been undergoing unprecedented rates of degradation during the Anthropocene paradigm. Current projections for the near future show climate change producing grim outcomes for most habitable parts of the world. This thesis defends the argument that in order to adequately address the state of the environment, humanity must experience a shift in collective consciousness away from the current philosophical paradigm, and instead adopt a paradigm that enables a common mindset regarding the place of humans within the natural environment. Various forms of spiritual ecology are explored: deep ecology, biblical eco-theology, and eco-feminist theology. These positions are explored in …

The Acute Effects Of Resistance Exercise With Blood Flow Restriction Versus Traditional Resistance Exercise On Arterial Compliance And Energy Expenditure In Recreationally Active Males And Females, Danny D. Dominguez

Theses and Dissertations

PURPOSE: The aim of this study was to investigate the acute effects of various intensities of volume matched resistance exercise with blood flow restriction (BFR) and traditional resistance exercise on hemodynamic variables, arterial compliance, oxygen consumption (VO2), carbon dioxide production (VCO2), respiratory exchange ratio (RER), and energy expenditure (EE) during exercise and after exercise.

RESULTS: Significant condition main effects (p < 0.05) were found for RPE, HR, crPWV, fdPWV, LAE, SAE, TVI, RER during and postexercise. BFR25 cause greater increases in RPE and HR. BFR50 caused marked increases in SAE, crPWV, and fdPWV.

CONCLUSION: All BFR and traditional exercise conditions found no significant differences in EE, VCO2, and VO2. The lack of differences is likely due to time of protocol. Further protocols should implement greater time of exercise, as BFR had increased hemodynamic …

Coding The Discourse And Translingual Strategies Of Collaborative Writing Of Secondary Education Students, Zane Lee Arredondo

Theses and Dissertations

Kenneth Bruffee used collaborative writing pedagogy to help reacculturate students’ discoursal identities to help them adhere to the expectations of the academic community. Although studies have shown that reacculturation may not exactly happen, Collaborative writing pedagogy still has maintained its presence within Composition studies since then and has been adapted into being implemented into digitally shared spaces. However, one aspect has been overlooked about physical shared spaces, the conversations themselves being studied. This study explores Kenneth Bruffee’s constructive conversations among secondary students within collaborative writing pedagogy. The collaborative sessions are recorded and viewed with a translingual lens applying Johnny Saldana’s …

Aristotle, Redemption, And The Conquest Of The Americas, Luis Angel Buentello

Theses and Dissertations

The central question addressed in my thesis is the claim that the even though the conquest of the Americas by the Spaniards was a brutal and murderous process, the Spanish imperial project in the Americas, based on Aristotelian ideology, resulted in the most beneficial and least harmful form of conquest conceivable in comparison to the next great empire of the age, the British Empire.

The founding pillars of Spain’s overseas empire in the Americas, based on an Aristotelian framework, produced a synthesis of political thinking that brought about greater benefits to the native populations, and slave populations, subsumed under the …

Utilizing Accelerometer Telemetry Tags To Compare Red Snapper (Lutjanus Campechanus) Behavior On Artificial And Natural Reefs, Ethan T. Getz

Theses and Dissertations

The Texas Parks and Wildlife Department Artificial Reef Program has deployed over 2,800 hectares of reefing area composed of petroleum platforms, steel vessels, and concrete. Artificial reefs have been shown to support many important reef fishes such as red snapper (Lutjanus campechanus), however, few studies have compared fish behavior on artificial reefs and natural habitats. We examined activity levels, behavioral patterns and habitat preferences of red snapper over natural reefs, oil platforms and submerged ships. Telemetry tags (Sonotronics model MTT) with tri-axial acceleration range, average depth, and average temperature were programmed to optimize data collection and tag life. …

Utah 4-H, County Contests, Joshua Dallin, Kelsey W. Romney

All Current Publications

This manual gives information for conducting succesdsful county contests.

Regression-Discontinuity Analysis Of The Effects Of Government Housing Policies, Alejandro Rojas

Theses and Dissertations

An influential literature has applied regression-discontinuity (RD) analysis to investigate the effects of government housing policies. This literature has failed to identify substantial effects of these policies, but may also suffer from various biases and limitations. This dissertation carefully examines what, if any, issues face RD analysis in this context. Chapter II considers the Affordable Housing Goals (AHGs) and Community Reinvestment Act (CRA), affordable housing policies that compel Fannie Mae and Freddie Mac (F&F) and depository institutions, respectively, to increase access to mortgage credit for borrowers perceived by some as “underserved” by the mortgage market. Chapter III considers the overall …

Dementia Survey Among Attendees Of A Dementia Awareness Event In Karachi, Pakistan, Qurat Ul Ain Khan, Yusra Hanif Khan, Mohammad Zaman Khan, Shireen Najam

Pakistan Journal of Neurological Sciences (PJNS)

There is little information available about peoples'knowledgeregarding symptoms of dementia, dementia diagnosis, and care arrangementsfor dementia patients in Pakistan. Aims: We aimed to find out if patients with dementia and their caregivers were aware of diagnosis, the most common and most distressing symptoms, and care arrangement for these patients.

Establishing The Theoretical Components Of Alexithymia Via Factor Analysis: Introduction And Validation Of The Attention-Appraisal Model Of Alexithymia, David Preece, Rodrigo Becerra, Alfred Allan, Ken Robinson, Justine Dandy

Research outputs 2014 to 2021

Alexithymia is an important mental health construct, but there is continuing debate regarding its definition and measurement. We attempt to resolve this definitional uncertainty in two ways. Firstly, we trace the development of the alexithymia construct, focusing particularly on what we call the Toronto and Amsterdam models, and examine a body of empirical research that shows strong support for the hypothesis that alexithymia consists of three components (difficulty identifying feelings, difficulty describing feelings, and externally orientated thinking). Based on these components, we formulate an alternate theoretical model of alexithymia, the attention-appraisal model of alexithymia, that aligns alexithymia theory with …

Legal Punishment As Civil Ritual: Making Cultural Sense Of Harsh Punishment, Professor Spearit

The Bridge: Interdisciplinary Perspectives on Legal & Social Policy

This article is an excerpt American Prisons: A Critical Primer on Culture and Conversion to Islam. The central aim of this chapter is to examine the post-civil rights push toward harsh punishment through the cultural lens of ritual. The United States is one of the most punitive countries on the planet--the country is the world leader in imprisonment and is one of the top five that executes capital defendants. However, determining the catalysts of this turn to harsh punishment has proved vexing. Scholars have adequately explained how the end of the welfare state, followed by a proliferation of drug laws, …

Report On The Texas Legislature, 85th Session: An Urban Perspective-Criminal Justice Edition, Sarah R. Guidry, Zahra Buck Whitfield, Amber K. Walker, Marshaun Williams, Grady Paris

The Bridge: Interdisciplinary Perspectives on Legal & Social Policy

In Texas, the legislature meets every 2 years and at the end of a regular legislative session, hundreds of passed bills will have been sent to the governor for approval. The large number of bills and the wide range of topics they cover can make it difficult to gain an understanding of all the new laws that were passed. At the close of each legislative session the Earl Carl Institute publishes, for the benefit of its constituents, highlights from the session in a bi-annual legislative report. In this year’s publication entitled Report on the Texas Legislature, 85th Session: An Urban …

Augmented Reality Photography Assistant, Andre Le

Defensive Publications Series

An augmented reality photography assistant or a virtual reality photography assisted mode allows a photographer to compose a particular shot and save the settings for that particular shot. The settings can include more than just typical camera settings like white balance, aperture, shutter speed, and ISO settings. The saved settings can also include positions of objects or persons within the particular shot, orientation of the camera itself, or physical location of the camera. The photographer can pass the camera or the saved settings to another person to take the particular shot. In a viewfinder or other shot-framing device of a …