Digital Commons Network^™

Mutational Patterns In Chemotherapy Resistant Muscle-Invasive Bladder Cancer., David Liu, Philip Abbosh, Daniel Keliher, Brendan Reardon, Diana Miao, Kent Mouw, Amaro Weiner-Taylor, Stephanie Wankowicz, Garam Han, Min Yuen Teo, Catharine Cipolla, Jaegil Kim, Gopa Iyer, Hikmat Al-Ahmadie, Essel Dulaimi, David Y.T. Chen, R. Katherine Alpaugh, Jean Hoffman-Censits, Levi A. Garraway, Gad Getz, Scott L. Carter, Joaquim Bellmunt, Elizabeth R. Plimack, Jonathan E. Rosenberg, Eliezer M. Van Allen

Department of Medical Oncology Faculty Papers

Despite continued widespread use, the genomic effects of cisplatin-based chemotherapy and implications for subsequent treatment are incompletely characterized. Here, we analyze whole exome sequencing of matched pre- and post-neoadjuvant cisplatin-based chemotherapy primary bladder tumor samples from 30 muscle-invasive bladder cancer patients. We observe no overall increase in tumor mutational burden post-chemotherapy, though a significant proportion of subclonal mutations are unique to the matched pre- or post-treatment tumor, suggesting chemotherapy-induced and/or spatial heterogeneity. We subsequently identify and validate a novel mutational signature in post-treatment tumors consistent with known characteristics of cisplatin damage and repair. We find that post-treatment tumor heterogeneity predicts …

A Comparative Study Of Discovery Learning Scientific Community Laboratories And Traditional Laboratories In Physics At An Independent University, Florida, U. S., Muhammad Riaz

Theses and Dissertations

This study investigated the effects of two instructional approaches – Discovery Learning Scientific Community Laboratories (DL-SCL; Treatment) and non-DLSCL laboratories (Control) – on students’ conceptual understanding, epistemological views, and academic achievement in a Physics-1 lab. Conceptual understanding was measured pre/post using the Mechanics Baseline Test (MBT) and the Force Concept Inventory (FCI). Epistemological views were measured pre/post using the E-CLASS (Zwickl et al., 2014). Lab scores and final exam scores served as measures of academic achievement. This study used a quasi-experimental study design with mixed-methods data collection and analysis procedures. Sections of a Physics-1 Lab course in Fall 2016 were …

Angle-Resolved Observation Of X-Ray Second Harmonic Generation In Diamond, Björn Senfftleben

Department of Physics and Astronomy: Dissertations, Theses, and Student Research

This thesis reports angularly-resolved observation of X-ray second harmonic generation (XSHG) in diamond at several phase-matching geometries. The XSHG signal was produced by ultra-short, highly intense X-ray pulses with a photon energy of 9.831 keV generated by a free-electron laser. In some geometries for high pulse energies more than 10 second harmonic photons per pulse were generated.

Different phase-matched geometries were used for XSHG to investigate the angular dependence of the efficiency of the process. Furthermore, for each phase-matching condition, the quadratic dependence for second harmonic generation at each geometry was verified and the crystal rocking curves were measured. The …

A Measurement Of The Wy Cross Section At √S = 8 Tev In Pp Collisions With The Cms Detector, Ekaterina Avdeeva

Department of Physics and Astronomy: Dissertations, Theses, and Student Research

A measurement of cross section of the Wγ → lνγ production in proton-proton collisions using 19.6 fb − 1 of LHC data collected by CMS detector at the center- √ of-mass collision energy of s = 8 TeV is reported. The W bosons are identified in their electron and muon decay modes. The process of Wγ production in the Standard Model (SM) involves a pure gauge boson coupling, a WWγ vertex, which allows one to test the electroweak sector of the SM in a unique way not achievable by studies of other processes. In addition to the total cross section, …

Horticulture For Pollinator Conservation, Carter M. Westerhold

Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research

Pollinators worldwide are declining. Consequently, the agricultural and ecological services these insects provide are in danger of being lost. Land use intensification, via urbanization, has greatly influenced this decline in pollinators. Luckily, through targeted horticultural practices, stable populations of pollinators can be sustained within urban areas. The horticultural practices of planting diverse floral resources and managing pollinator habitat in urban areas can sustain these populations. Two studies were conducted with the intent to identify horticultural knowledge gaps that could be reduced to aid in pollinator conservation efforts. First, a study to compare Nebraska native and non-native ornamental plants was conducted. …

The Effects Of Real-Time Visual Performance Feedback Using A Tier Approach For Increasing Behavior Specific Praise On Teachers, Elizabeth Lown

Master's Theses

A number of studies have found behavior specific praise to be effective in increasing academically engaged behaviors and decreasing disruptive behaviors of students. The proposed study evaluated the effects of real-time visual performance feedback as a strategy for promoting teacher use of behavior-specific praise. An ABCBC design was utilized to determine the efficacy of real-time visual performance feedback in comparison to delayed visual performance feedback. The primary dependent variable measured was teacher use of behavior-specific praise. Additionally, student outcomes were assessed to determine the relationship between teacher use of behavior-specific praise and student behavior. The results from the study provide …

Portrayals Of The Pharisees And The Sadducees In The Qumran Texts And Josephus, Kenneth Atkinson

Faculty Publications

The accuracy of Josephus's portrayals of the three major schools of Jewish thought, namely the Pharisees, the Sadducees, and the Essenes, continues to be the subject of scholarly debate. A related issue is whether he accurately portrayed the relationships between theses haireseis and the Hasmoneans. This paper uses a variety of Qumran texts often ignored in Josephus studies to suggest that Josephus correctly described political and religious alliances between the Pharisees, the Sadducees, and the members of the Hasmonean royal family.

Best Practices For Preparing For The Reno Commercial Problem, Cole Range

Construction Management

The ASC Region 7 Commercial competition is one of the largest and most popular student competition in the country. Students from some of the most prestigious construction management and construction engineering schools compete in a rigorous eighteen hour competition. These teams have around 6 months to prepare for the competition. Their preparation methods have a significant impact on how they place in the competition. The amount of time spent with the teams industry sponsor, number of practice problems completed, hours spent practicing, number of team bonding events, and many other factors contribute to the team’s success. Many of the schools …

Bridging The Gap Between Technology Usage In The Construction Industry And In The Classroom, Marco Maffioli

Construction Management

As construction begins to advance more and more every day, technology is one of the most volatile aspects due to its ever changing nature. Technology, and all the software’s that encompass it, is the future of this industry and if we want to keep improving and growing as an industry we need to better align our future new hires with the most prevalent technology and that starts in the classroom. Specifically, the Construction Management Department at Cal Poly, San Luis Obispo, one of the most advanced in Nation, still struggles to align with the expectations and reality of the CM …

Case Study On Student Competence In Construction Surveying And Layout, Dejah Hilliard

Construction Management

The Cal Poly San Luis Obispo Construction Management (CM) curriculum requires its students to enroll in BRAE 239, a course that educates students on field surveying using equipment such as a total station and an automatic optical level (builder’s level). The class focuses on how to use the specified equipment to calculate distances, heights, and angles over fixed benchmarks to create labeled contour maps and land plot diagrams. The information and methods of calculation are taught in a classroom, and the physical surveying with the provided equipment is done in the agricultural field on campus. The course does touch on …

Case Study: Mitigating Schedule Impacts From Oshpd Regulations On Medical Equipment, Peter K. Lee

Construction Management

The vast majority of healthcare construction projects in the state of California work with OSHPD—Office of Statewide Health Planning and Development—to meet California’s Hospital Seismic Safety Law. While meeting the state’s Hospital Seismic Safety Law is important and even critical, working with OSHPD’s stringent regulations does imply additional concerns to be addressed by the project team. One concern regards the approval of bigger medical equipment and its impact on the overall construction schedule. This paper examines the factors that contribute to delays in the construction schedule, responsible parties for the delay, and responsibilities of each involved party. Based on an …

Lean Construction Teaching Module: Push/Pull Planning, James M. Iroz

Construction Management

The Construction Management Department at California Polytechnic University at San Luis Obispo has taken interests into the topics of Lean Construction to be a part of its curriculum. Lean Construction is a methodology in the built environment that tries to establish a leaner and more efficient work place in the industry. Within this broad spectrum of methodology, scheduling and more specifically, “push pull scheduling” is one of its many trademark applications. As the demand for more efficient projects rise, it is increasingly important for the next generation of construction students to be aware and educated with efficient skills. This experimental …

Forney Residence Accessory Dwelling Unit, Nicholas J. Zygutis

Construction Management

This project involves the project management of a proposed 1,000 square foot accessory dwelling unit that is to be constructed in Alamo, California. The objective is to provide the necessary and efficient means of construction in order to properly establish this unit from conception to permitting. This has been done by obtaining all necessary paperwork, forms, and stamp approvals needed to allow for groundbreaking. The design of the project includes the basic pre-construction activities required to obtain an issued building permit such as collecting bids from architects, working with the client, obtaining plans, developing an adequate schedule and cost estimate, …

Shaping Health Policy For Low-Income Populations: An Assessment Of Public Comments In A New Medicaid Waiver Process, Marian Jarlenski, Philip Rocco, Renuka Tipimeni, Amy Jo Kennedy, Nivedita Gunturi, Julie Donohue

Political Science Faculty Research and Publications

Since the Supreme Court decided that the Affordable Care Act's (ACA) Medicaid expansion is optional for the states, several have obtained federal approval to use Section 1115 waivers to expand Medicaid while changing its coverage and benefits design. There has long been concern that policy making for Medicaid populations may lack meaningful engagement with low-income constituents, and therefore the ACA established a new process under which the public can submit comments on pending Medicaid waiver applications. We analyzed 291 comment letters submitted to federal regulators pertaining to Medicaid Section 1115 waiver applications in the first five states to seek such …

A Comparison Of Two Innovation Tools: Application On Smart Kitchen Design, Burcu Taşkın

Electrical and Computer Engineering Faculty Publications and Presentations

The process is one of the significant issues of companies in innovative product design. The designers and the management deal with producing high quality products with the creativity in a short-term period. The researchers developed techniques to solve that problem as TRIZ. The TRIZ-based techniques aim to recover the gaps of the creative innovation to solve specific problems of technical products and technologies. However, the traditional innovation techniques are still preferred for the design process. This study conducted a comparative research on outcomes regarding the process of two design groups. The assignment is given to ten design students to identify …

Partial Rank Data With The Hyper2 Package: Likelihood Functions For Generalized Bradley-Terry Models, Robin K. S Hankin

The R Journal

Here I present the hyper2 package for generalized Bradley-Terry models and give examples from two competitive situations: single scull rowing, and the competitive cooking game show Master Chef Australia. A number of natural statistical hypotheses may be tested straightforwardly using the software.

Anomalydetection: Implementation Of Augmented Network Log Anomaly Detection Procedures, Robert J. Gutierrez, Bradley C. Boehmke, Air Force Institute Of Technology, Cade M. Saie, Trevor J. Bihl

The R Journal

As the number of cyber-attacks continues to grow on a daily basis, so does the delay in threat detection. For instance, in 2015, the Office of Personnel Management discovered that approximately 21.5 million individual records of Federal employees and contractors had been stolen. On average, the time between an attack and its discovery is more than 200 days. In the case of the OPM breach, the attack had been going on for almost a year. Currently, cyber analysts inspect numerous potential incidents on a daily basis, but have neither the time nor the resources available to perform such a task. …

Liureg: A Comprehensive R Package For The Liu Estimation Of Linear Regression Model With Collinear Regressors, Muhammad Imdadullah, Muhammad Aslam, Saima Altaf

The R Journal

The Liu regression estimator is now a commonly used alternative to the conventional ordinary least squares estimator that avoids the adverse effects in the situations when there exists a considerable degree of multicollinearity among the regressors. There are only a few software packages available for estimation of the Liu regression coefficients, though with limited methods to estimate the Liu biasing parameter without addressing testing procedures. Our liureg package can be used to estimate the Liu regression coefficients utilizing a range of different existing biasing parameters, to test these coefficients with more than 15 Liu related statistics, and to present different …

Ider: Intrinsic Dimension Estimation With R, Hideitsu Hino

The R Journal

In many data analyses, the dimensionality of the observed data is high while its intrinsic dimension remains quite low. Estimating the intrinsic dimension of an observed dataset is an essential preliminary step for dimensionality reduction, manifold learning, and visualization. This paper introduces an R package, named ider, that implements eight intrinsic dimension estimation methods, including a recently proposed method based on a second-order expansion of a probability mass function and a generalized linear model. The usage of each function in the package is explained with datasets generated using a function that is also included in the package

Crtgeedr: An R Package For Doubly Robust Generalized Estimating Equations Estimations In Cluster Randomized Trials With Missing Data, Melanie Prague, Rui Wang, Victor De Gruttola

The R Journal

Semi-parametric approaches based on generalized estimating equations (GEE) are widely used to analyze correlated outcomes in longitudinal settings. In this paper, we present a package CRTgeeDR developed for cluster randomized trials with missing data (CRTs). For use of inverse probability weighting to adjust for missing data in cluster randomized trials, we show that other software lead to biased estimation for non-independence working correlation structure. CRTgeeDR solves this problem. We also extend the ability of existing packages to allow augmented Doubly Robust GEEestimation (DR). Simulation studies demonstrate the consistency of estimators implemented in CRTgeeDR compared to packages such as geepack and …

Queueing: A Package For Analysis Of Queueing Networks And Models In R, Pedro Cañadilla Jiménez, Yolanda Román Montoya

The R Journal

queueing is a package that solves and provides the main performance measures for both basic Markovian queueing models and single and multiclass product-form queueing networks. It can be used both in education and for professional purposes. It provides an intuitive, straightforward wayto build queueing models using S3 methods. The package solves Markovian models of the form M/M/c/K/M/FCFS, open and closed single class Jackson networks, open and closed multiclass networks and mixed networks. Markovian models are used when both the customer inter-arrival time and the server processing time are exponentially distributed. Queueing network solvers are useful for modelling situations in which …

Allele Imputation And Haplotype Determination From Databases Composed Of Nuclear Families, Nathan Medina-Rodríguez, Ángelo Santana

The R Journal

The alleHap package is designed for imputing genetic missing data and reconstruct non recombinant haplotypes from pedigree databases in a deterministic way. When genotypes of related individuals are available in a number of linked genetic markers, the program starts by identifying haplotypes compatible with the observed genotypes in those markers without missing values. If haplotypes are identified in parents or offspring, missing alleles can be imputed in subjects containing missing values. Several scenarios are analyzed: family completely genotyped, children partially genotyped and parents completely genotyped, children fully genotyped and parents containing entirely or partially missing genotypes, and founders and their …

Zika Virus Encoding Nonglycosylated Envelope Protein Is Attenuated And Defective In Neuroinvasion, Arun S. Annamalai, Aryamav Pattnaik, Bikash R. Sahoo, Ezhumalai Muthukrishnan, Sathish Kumar Natarajan, David Steffen, Hiep Vu, Gustavo Delho, Fernando Osorio, Thomas M. Petro, Shi-Hua Xiang, Asit K. Pattnaik

School of Veterinary and Biomedical Sciences: Faculty Publications

Zika virus (ZIKV), a mosquito-transmitted flavivirus responsible for sporadic outbreaks of mild and febrile illness in Africa and Asia, reemerged in the last decade causing serious human diseases, including microcephaly, congenital malformations, and Guillain-Barré syndrome. Although genomic and phylogenetic analyses suggest that genetic evolution may have led to the enhanced virulence of ZIKV, experimental evidence supporting the role of specific genetic changes in virulence is currently lacking. One sequence motif, VNDT, containing an N-linked glycosylation site in the envelope (E) protein, is polymorphic; it is absent in many of the African isolates but present in all isolates from the recent …

You're A Genius All The Time: Analyzing The Effectiveness Of Kerouac's Spontaneous Prose On Empowering English Language Learners, Robert Casas

Theses and Dissertations

The engineer of the Beat Movement, Jack Kerouac, began his writing career as an ELL. Kerouac’s Spontaneous Prose helped him navigate through language acquisition to establish rhetoric in English, and empowered other Beat Writers to expressively develop their thoughts. Spontaneous Prose can also help other ELLs develop their own rhetorical agency. For ELL writers, writing in English often makes them feel disenfranchised, disempowered, and discouraged. However, Spontaneous Prose as a pedagogical tool empowers ELL writers to begin the process of transculturally repositioning themselves in using writing as a form of rhetorical expression. This study investigates the pedagogical effectiveness of Spontaneous …

Three Flute Chamber Works By Alberto Ginastera: Intertwining Elements Of Art And Folk Music, Breta L. Neel

Glenn Korff School of Music: Dissertations, Theses, Student Creative Work, and Performances

Alberto Ginastera’s output includes three chamber works containing the flute, all composed within the period of objective nationalism (1934-1947), a designation provided by the composer to encompass those works that present folk elements in an overt manner in a largely tonal framework. Impresiones de la Puna and Cantos del Tucumán, written in 1934 and 1938 respectively, contain salient folk elements and are thus representative pieces of this stylistic period. In addition to folk characteristics, these early works also contain pitch-class sets which serve to unify the pieces, thereby suggesting future elements of the composer’s style. The Duo for Flute …

Volume 101, Number 4 (Winter 2017)

Judicature

No abstract provided.

Attitudes And Perceived Legitimacy Of Police: Crises, Responses, And How Race Influences Perceptions, Brigitte Bonaci

Theses and Dissertations

Public relations is a strategic field because an organization may need to structure a message with the intent of persuading the public and making it respond to a crisis and a message in a certain way. This study will help introduce the concept of a lingering crisis that is hardly present in research and could be put under the public relations umbrella. Using a survey of communications students, this study will compare the public attitudes and perceptions of perceived legitimacy of a police department after it experiences one of three crisis types, one of which being a lingering crisis. Attitudes …

Effects Of Cultural Factors In Sports-Related Concussion Testing Performance Of Collegiate Athletes, Gabriela Andrea González Torres

Theses and Dissertations

The purpose of the current study was to explore potential differences in preseason baseline concussion testing between an ethnically and linguistically diverse sample of Division 2 NCAA collegiate student-athletes. A value-added second aim was to create awareness regarding the implications of multiculturalism as it relates to neuropsychological testing of sport related concussions. This study is part of a, slow yet steady, growing body of research concerning diversity issues within the sport setting. 479 Division II collegiate athletes from the Florida Institute of Technology were assessed during mandatory preseason baseline testing. The Immediate Post-Concussion Assessment and Cognitive Testing, the Sports Concussion …

The “Singapore Model” In Gaming: Applications In South Korea, Young Gi Lee

UNLV Theses, Dissertations, Professional Papers, and Capstones

The gaming governance system in Singapore is a very well-known and internationally renowned model. Singapore began to launch their gaming regulation system in 2005 by establishing a national framework on gambling prior to opening two integrated resorts in the country in 2010 (Winslow, Cheok, & Subramaniam, 2015). In contrast, the South Korean “model” is much less renowned. Though there have been discussions about introducing full-scale integrated resorts, the government currently allows South Korean citizens to gamble in only one property - Kangwon Land (Research, 2016). However, Kangwon Land’s situation is controversial in South Korea, with concerns about problem gambling issues …

Remember The Country And The Age In Which We Live": The British Gothic Novel In The Age Of Enlightenment, 1764-1798, Garland David Beasley

UNLV Theses, Dissertations, Professional Papers, and Capstones

Remember the Country and the Age in Which We Live” argues that the British Gothic novels produced in the late eighteenth century were not, as has traditionally been assumed, written in reaction against Enlightenment values in the face of rising political and social discord. Instead, I contend that eighteenth-century Gothic novels take part in a larger tradition of the novel that sought to impart the values of Enlightenment into a modernist genre still on the rise. By exploring the influence of Samuel Richardson on the development of the Gothic novel, the role of formal and informal educational structures, representations of …