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2017

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Biology And Ecology Of Melanoplus Borealis (Orthoptera: Acrididae) In Fairbanks, Alaska With Special Reference To Feeding Habits, Tohko Kaufmann Jul 2017

Biology And Ecology Of Melanoplus Borealis (Orthoptera: Acrididae) In Fairbanks, Alaska With Special Reference To Feeding Habits, Tohko Kaufmann

The Great Lakes Entomologist

Overwintered Melanoplus borealis (subspecies, borealis Fieber) eggs hatched within 10-15 days in mid-June. The nymphs molted 5 times and became adults in about 45 days in nature. In both sexes, sexual maturity was attained about 3 weeks after emergence and oviposition started 8-10 days after sexual maturity.

M. borealis is primarily a forb feeder as its mandibular morphology indicates but it also developed and reproduced exclusively on Gramineae in the laboratory.

In the Fairbanks area, Alaska, these grasshoppers were found in sunny open fields where vegetation was short and sparse enough to allow sunrays to penetrate to the ground surface. …


Studies On The Feculae Of Selected Michigan Acrididae (Orthoptera), Michael Tyrkus, S.K. Gangwere Jul 2017

Studies On The Feculae Of Selected Michigan Acrididae (Orthoptera), Michael Tyrkus, S.K. Gangwere

The Great Lakes Entomologist

Feculae have been used for some years in the study of insect food-habits and biology. Among the past authors who have used them are Frost (1928), Hodson and Brooks (1956), and Morris (1942), who discussed the use of feculae and frass in the identification of insect species in general; Boldyrev (1928), who figured the feculae of the bradyporine katydid Bradyporus multituberculatus; Brown (1937), who described in detail fecular microstructure in the spine-breasted grasshopper Melanoplus bivittatus; Weiss and Boyd (1 950. 1 952), who figured the feculae of representatives of selected insect orders; Gangwere (1 962). who described the …


A New Generalized Burr Family Of Distributions For The Lifetime Data, M. Arslan Nasir, M. H. Tahir, Farrukh Jamal, Gamze Ozel Jul 2017

A New Generalized Burr Family Of Distributions For The Lifetime Data, M. Arslan Nasir, M. H. Tahir, Farrukh Jamal, Gamze Ozel

Journal of Statistics Applications & Probability

We propose a new family of distributions called the generalized Burr-G (GBG) family of distributions motivated mainly for lifetime phenomenon. Some mathematical properties of the new family are obtained such as quantile function, linear representation of the family density, moments and incomplete moments, moment generating function, mean deviations, stochastic ordering, stressstrength reliability parameter and order statistics. The model parameters are estimated by the method of maximum likelihood for complete and censored samples. Four special models are discussed and the properties of one special model, the generalized Burruniform (GBU), are obtained. A simulation study is carried out to check the performance …


The European Politics Of Animal Experimentation: From Victorian Britain To ‘Stop Vivisection’, Pierre-Luc Germain, Luca Chiapperino, Giuseppe Testa Jul 2017

The European Politics Of Animal Experimentation: From Victorian Britain To ‘Stop Vivisection’, Pierre-Luc Germain, Luca Chiapperino, Giuseppe Testa

Attitudes Toward Animal Research Collection

This paper identifies a common political struggle behind debates on the validity and permissibility of animal experimentation, through an analysis of two recent European case studies: the Italian implementation of the European Directive 2010/63/EC regulating the use of animals in science, and the recent European Citizens' Initiative (ECI) 'Stop Vivisection'. Drawing from a historical parallel with Victorian antivivisectionism, we highlight important threads in our case studies that mark the often neglected specificities of debates on animal experimentation. From the representation of the sadistic scientist in the XIX century, to his/her claimed capture by vested interests and evasion of public …


Aquilegia Volume 41 No. 4 Summer 2017, Jan Loechell Turner, Rob Pudim, Linda Smith, Nan Daniels, Charlie Turner Jul 2017

Aquilegia Volume 41 No. 4 Summer 2017, Jan Loechell Turner, Rob Pudim, Linda Smith, Nan Daniels, Charlie Turner

Aquilegia - Colorado Native Plant Society

No abstract provided.


Fast Estimation Model Of Pressure-Temperature Response For Planning Focused Ultrasound Surgery, Tariq Mohammad Arif Jul 2017

Fast Estimation Model Of Pressure-Temperature Response For Planning Focused Ultrasound Surgery, Tariq Mohammad Arif

Dissertations

High Intensity Focused Ultrasound (HIFU) is becoming a widely accepted modality for extracorporeal non-invasive hyperthermia and surgical procedures. Since ultrasonic transducers need to operate in various challenging body locations, the arrangement of their array elements can be optimized to improve the capability of controlling focus intensity. In the first part of this dissertation, patterns of pressure field variations with several selected design variables (kerf, transducer element’s number and element’s width-height) are studied. These patterns indicate that there is a more suitable shape and arrangement of transducer elements in a specified area to achieve highest possible pressure. In order to obtain …


Design And Synthesis Of Selective Estrogen Receptor Β Agonists And Their Pharmacology, K. L. Iresha Sampathi Perera Jul 2017

Design And Synthesis Of Selective Estrogen Receptor Β Agonists And Their Pharmacology, K. L. Iresha Sampathi Perera

Dissertations (1934 -)

Estrogens (17β-estradiol, E2) have garnered considerable attention in influencing cognitive process in relation to phases of the menstrual cycle, aging and menopausal symptoms. However, hormone replacement therapy can have deleterious effects leading to breast and endometrial cancer, predominantly mediated by estrogen receptor-alpha (ERα) the major isoform present in the mammary gland and uterus. Further evidence supports a dominant role of estrogen receptor-beta (ERβ) for improved cognitive effects such as enhanced hippocampal signaling and memory consolidation via estrogen activated signaling cascades. Creation of the ERβ selective ligands is challenging due to high structural similarity of both receptors. Thus far, several ERβ …


Biology, Saint Mary's College Of California Jul 2017

Biology, Saint Mary's College Of California

Academic Catalog

No abstract provided.


Biospeciation Of Cr(Iii) Nutritional Supplements In Biological Fluids, Anna Safitri, Aviva Levina, Peter A. Lay Jun 2017

Biospeciation Of Cr(Iii) Nutritional Supplements In Biological Fluids, Anna Safitri, Aviva Levina, Peter A. Lay

Makara Journal of Science

Metal ion speciation in various biological systems has been extensively studied to elucidate its biological role and the toxicity of the element of interest. In the present study, chromium speciation was performed by reacting Cr(III) nutritional supplements [Cr(pic)3], where pic = 2-pyridinecarboxylato(-), and a Cr(III) propionate complex, [Cr3O(OCOEt)6(OH2)3])+, in calf serum. Cr(III) complexes in serum were fractionated using size-exclusion chromatography, and the Cr(III) concentrations in each fraction were determined using graphite furnace atomic absorption spectroscopy. The results showed that Cr(III) bound to both high-and low-molecular weight serum fractions. While Cr(III) was mainly bound toalbumin or transferrin, unknown low-molecular-weight serum fractions …


A Global Community Effort To Decipher The Unique Biology Of Annual Killifish, Nibia Berois, Graciela Garcia, Rafael O. De Sá Jun 2017

A Global Community Effort To Decipher The Unique Biology Of Annual Killifish, Nibia Berois, Graciela Garcia, Rafael O. De Sá

Biology Faculty Publications

Over the past 50 years, annual killifishes arose as alternative model organisms for studies of vertebrate biology. The annual fish offers exceptional advantages for studies of genetics, genomics, developmental biology, population dynamics, ecology, biogeography, and evolution. They inhabit extremely variable freshwater environments in Africa and South America, have a short lifespan and a set of unique and fascinating developmental characteristics. Embryos survive within the dry substrate during the dry season, whereas the adult population dies. Thus, the survival of the populations is entirely dependent on the buried embryos that hatch the next rainy season. Although Old and New World species …


Droplet-Microfluidic Device For The Characterization Of Perfluorinated Emulsions, Daniel Horvath, Nam Ahn Tran Jun 2017

Droplet-Microfluidic Device For The Characterization Of Perfluorinated Emulsions, Daniel Horvath, Nam Ahn Tran

Bioengineering Senior Theses

Microfluidics is being used throughout academia and industry today to perform large numbers of experiments with extremely small volumes of fluids. By doing this, those that study microfluidics hope to raise through-put, lower cost and limit the environmental impact of scientific research.2 Complementing the increased use of microfluidics, the use of perfluorinated emulsions in the field of droplet-based microfluidics is also experiencing large growth.3 However, many of the products available today are either proprietary and/or poorly understood. While some chemical structures are known, some of the most scientifically intriguing perfluorinated oils and surfactants do not have their chemical structures or …


Synthesis, Characterization And Biological Activity Of Schiff Bases Chelates With Mn(Ii),Co(Ii),Ni (Ii),Cu(Ii) And Hg(Ii), Lecturer. Dr. Rehab K. Al Shemary, Assist. Prof. Dr. Lekaa K. Abdul Karim, Lecturer. Dr. Wurood A. Jaafar Jun 2017

Synthesis, Characterization And Biological Activity Of Schiff Bases Chelates With Mn(Ii),Co(Ii),Ni (Ii),Cu(Ii) And Hg(Ii), Lecturer. Dr. Rehab K. Al Shemary, Assist. Prof. Dr. Lekaa K. Abdul Karim, Lecturer. Dr. Wurood A. Jaafar

Baghdad Science Journal

In this paper, some series of new complexes of Mn(II), Co(II), Ni (II) Cu(II) and Hg(II) are prepared from the Schiff bases (L1,L2). (L1) derived from 4-aminoantipyrine and O-phenylene dia mine then (L2) derived from (L1) and 2-benzoyl benzoic acid. Structural features are obtained from their elemental microanalyses, molar conductance, IR, UV–Vis, 1H, 13CNMR spectra and magnetic susceptibility. The magnetic susceptibility and UV–Vis, IR spectral data of the ligand (L1) complexes get square–planar and tetrahedral geometries and the complexes oflig and (L2) get an octahedral geometry. Antimicrobial examinations show good results in the sharing complexes.


Lichen Conservation In Eastern North America: Population Genomics, Climate Change, And Translocations, Jessica Allen Jun 2017

Lichen Conservation In Eastern North America: Population Genomics, Climate Change, And Translocations, Jessica Allen

Dissertations, Theses, and Capstone Projects

Conservation biology is a scientific discipline that draws on methods from diverse fields to address specific conservation concerns and inform conservation actions. This field is overwhelmingly focused on charismatic animals and vascular plants, often ignoring other diverse and ecologically important groups. This trend is slowly changing in some ways; for example, increasing number of fungal species are being added to the IUCN Red-List. However, a strong taxonomic bias still exists. Here I contribute four research chapters to further the conservation of lichens, one group of frequently overlooked organisms. I address specific conservation concerns in eastern North America using modern methods. …


Deconstructing Medicine: The Intersections Of Racism And Health Disparities Within Pre-Medical Education, Allison F. Dormanesh Jun 2017

Deconstructing Medicine: The Intersections Of Racism And Health Disparities Within Pre-Medical Education, Allison F. Dormanesh

Ethnic Studies

The purpose of this project is to evaluate ways in which historical racism and lack of it in pre- medical curriculum shapes future health professionals and results in negative medical treatment of under-represented groups. Research found in the literature review reveals a strong history of racism within medical practice and medical research, as well as unconscious bias that follows knowledge taught during undergraduate education and onwards. An intersectionality approach is used to show the affect of race and class on health disparities and unethical abuse. This research includes data analyzing the pre-medical curriculums of the ten pre-medical universities that produce …


A Comparison Of Nucleosome Organization In Drosophila Cell Lines, Rebecca L. Martin, John Maiorano, Greg J. Beitel, John F. Marko, Graham Mcvicker, Yvonne N. Fondufe-Mittendorf Jun 2017

A Comparison Of Nucleosome Organization In Drosophila Cell Lines, Rebecca L. Martin, John Maiorano, Greg J. Beitel, John F. Marko, Graham Mcvicker, Yvonne N. Fondufe-Mittendorf

Molecular and Cellular Biochemistry Faculty Publications

Changes in the distribution of nucleosomes along the genome influence chromatin structure and impact gene expression by modulating the accessibility of DNA to transcriptional machinery. However, the role of genome-wide nucleosome positioning in gene expression and in maintaining differentiated cell states remains poorly understood. Drosophila melanogastercell lines represent distinct tissue types and exhibit cell-type specific gene expression profiles. They thus could provide a useful tool for investigating cell-type specific nucleosome organization of an organism’s genome. To evaluate this possibility, we compared genome-wide nucleosome positioning and occupancy in five different Drosophila tissue-specific cell lines, and in reconstituted chromatin, and then …


Novel Spectroscopic Tools To Differentiate Drug-Dna Binding Interactions, Fadwa Dhafer Hamad Jun 2017

Novel Spectroscopic Tools To Differentiate Drug-Dna Binding Interactions, Fadwa Dhafer Hamad

Masters Theses

DNA-drug interactions play a major role in therapeutics, diagnostics, forensics and imaging. Drugs bind to DNA in several ways based on the mode of interaction and they alter protein-DNA interactions or breaks/cleaves DNA that can lead to the cure of the disease. The major goal of the research carried out in this thesis is to develop novel optical spectroscopic tools that can differentiate Drug-DNA binding interactions mode whether its intercalation or minor-groove binding. To achieve this goal, we developed two-photon absorption (2PA) cross-section based technique to differentiate between Drug-DNA binding modes. The investigations were carried out on two drug molecules, …


Surface-Modified Polyacrylonitrile Nanofibres As Supports, Chris Ademola Bode-Aluko, Omoniyi Pereao, Olanrewaju Fatoba, Leslie Petrik Jun 2017

Surface-Modified Polyacrylonitrile Nanofibres As Supports, Chris Ademola Bode-Aluko, Omoniyi Pereao, Olanrewaju Fatoba, Leslie Petrik

Mining Engineering Faculty Research & Creative Works

Polyacrylonitrile nanofibers (PAN-nfs) are one of the most studied nanofibers because of their excellent characteristics, such as good mechanical strength, chemical resistance, and good thermal stability. Due to the easy dissolution in polar organic solvents, PAN-nfs are mostly produced via electrospinning technique. The electro spun PAN-nfs surfaces are relatively in-active and hydrophobic, and, therefore, hinder some potential applications; however, chemical surface modification reactions, such as amination, reduction, hydrolysis, and amidoximation, have been carried out on them. These reactions bring about functional groups, such as amine, hydroxyl, carboxylic, imine etc., to the surface PAN-nfs and invariably make their surfaces active and …


Community Living Integration Club For Women In Recovery From Sex Trafficking, Toni Thompson May 2017

Community Living Integration Club For Women In Recovery From Sex Trafficking, Toni Thompson

Occupational Therapy Program Student Theses, Dissertations and Capstones

Sex trafficking is one form of human trafficking, a heinous human rights violation that transcends international borders. People who have been trafficked often present with complex neurobehavioral, psychological, emotional, physiological, sensory, and developmental difficulties. The United Nations developed the international 3 p protocol to guide governmental agencies, non-governmental groups, and individuals in developing programs and legal actions of trafficking prevention, protection, and prosecution. Protection encompasses the recovery of trafficking survivors and community integration has been identified as an essential foundation for successful recovery. Measurable components of community integration include safe housing, stable employment, and vocation-focused education. This Capstone describes the …


Inhabit The Storm : Emergency Evacuation Route, Anastasiia Isakova May 2017

Inhabit The Storm : Emergency Evacuation Route, Anastasiia Isakova

Masters Theses

Today a lot of design research is concentrated on problems of resiliency and performance in conditions of hazardous events, such as sea level rise, hurricanes, tsunamis, cyclones, earthquakes and drought. And while designers, architects and engineers try to convince people to care about these issues, offer building higher seawalls, recreating marshlands, reinforcing shorelines and various ecosystems, they never really address evacuation, which remains a big problem for vulnerable areas prone to cyclical occurrence of natural disasters.

More people die during evacuation - escaping the disaster site, rather than from the disaster itself; more people die because of the consequences of …


Sexual Education Pedagogy In The Global South: Pubmed Data In The Age Of Globalization, Grace A. Walker-Stevenson May 2017

Sexual Education Pedagogy In The Global South: Pubmed Data In The Age Of Globalization, Grace A. Walker-Stevenson

University Honors Theses

This systematic review and subsequent analysis examines the harm caused by inadequate sexual education in countries with minimal access to healthcare. This review relies on PubMed as its singular database. PubMed is a free search engine that utilizes the MEDLINE database of references on life sciences and biomedical topics. This database is maintained by The United States Library of Medicine and The National Institutes of Health, therefore it is an authoritative entity on the subject of health research. Assessing the breadth of knowledge represented in PubMed related to this issue can be extrapolated to estimate the current state of salient …


Morphological And Molecular Identification Of Four Groups Desert Green Algae, Qelbinur Eyit, Aishanjian G, Nurgul Rahman May 2017

Morphological And Molecular Identification Of Four Groups Desert Green Algae, Qelbinur Eyit, Aishanjian G, Nurgul Rahman

Food and Machinery

Four groups of algas, isolated from the Taklimakan desert, were identified by morphological characters in this study. The pH effect of the growth of algae is analyzed according to the growth curve, and the phylogenetic tree was pictured. It shows that the group a belongs to the oval algae, and group b, c and d belong to the spherical algae. The optimum suitable pH values for the group a desert algae was 6.0, 8.0 for the group b and d; the same value of original BG-11 for the group c. Four representative strains of desert algae gene sequences were identified …


Some Contributions To The Analysis Of Dual-Record System For Estimating Human Population Size., Kiranmoy Chatterjee Dr. May 2017

Some Contributions To The Analysis Of Dual-Record System For Estimating Human Population Size., Kiranmoy Chatterjee Dr.

Doctoral Theses

Dual-record System (DRS) The problem of population size estimation is a very important administrative and statistical concern which includes a vast area of application in the fields of epidemiology, demography and official statistics. Federal agencies are generally interested to know the actual size (say, N ) of a specified population or any vital event that occurred in a specified area within a given time span. Census or civil registration system often fails to extract the true size of the population. The degree of inaccuracy depends on the actual size of the population, its diversity and of course, on the quality …


Stereochemical Preference Toward Oncotarget: Design Synthesis And In Vitro Anticancer Evaluation Of Diastereomeric B-Lactams, Fabian Olazarán-Santibáñez, Debasish Bandyopadhyay, Pilar Carranza-Rosales, Gildardo Rivera, Isias Balderas-Rentería May 2017

Stereochemical Preference Toward Oncotarget: Design Synthesis And In Vitro Anticancer Evaluation Of Diastereomeric B-Lactams, Fabian Olazarán-Santibáñez, Debasish Bandyopadhyay, Pilar Carranza-Rosales, Gildardo Rivera, Isias Balderas-Rentería

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

Purpose: In the battle against cancer discovery of new and novel chemotherapeutic agent demands extreme obligation. Development of anticancer compounds with higher potency and reduced side-effects is timely and challenging.

Experimental Design: A small series of fourteen diastereomeric β-lactams (seven pairs) were synthesized through multi-step process exploring [2+2] ketene-imine cycloaddition as the key step. Comparative stereochemical preferences were studied through computational docking and validated by in vitro evaluation. β-tubulin was considered as possible molecular target and in vitro anticancer evaluation was conducted against SiHa, B16F10, K562 and Chang cell lines. Caspase-3 activation assay and hematoxylin/eosin staining of the cells were …


Teleterrestrial: The Universe Of Technological And Natural Scenes, Nat Rainer May 2017

Teleterrestrial: The Universe Of Technological And Natural Scenes, Nat Rainer

Graduate School of Art Theses

In the Universe of Technical and Natural scenes, is Telerrarin. Telerrain is composed from my point of view as an artist. This terrain of combined forms is seen in three scenes that assemble technology, humanity, and the natural world. Each scene is set in different landscapes: the desert, the countryside, and the ocean. As an artist, I see these settings with the vision of a director that drives the atmosphere, life forms, and cyclical verves that make these landscapes real. As a writer, my voice describes how technology, humanity, and the natural world fit together, and then asserts the kinds …


B7h6: A Cancer Biomarker For The Development Of Novel Immunotherapy Approaches, Mariana Phillips May 2017

B7h6: A Cancer Biomarker For The Development Of Novel Immunotherapy Approaches, Mariana Phillips

Seton Hall University Dissertations and Theses (ETDs)

Cancer-based immunotherapy has led the evolution of biologics that can stimulate immune responses towards tumor eradication. The synthesis of small to intermediate size molecules with the targeting and effector functions of mAb may represent a novel class of immunotherapeutics that may overcome the limitations of their biological counterparts.Towards this objective, B7H6 has been identified as a protein ligand localized on the cell surface of transformed tumor cells. B7H6 binds specifically to the activating receptor NKp30, constitutively expressed on all resting and active NK cells. Upon ligand:receptor binding, B7H6 triggers NK cell activation and release of chemokines and pro-inflammatory cytokines such …


Biophysical Studies Of The Intracellular Domains Of The Egfr Family Of Receptor Tyrosine Kinases, Kwabena A N Sarpong May 2017

Biophysical Studies Of The Intracellular Domains Of The Egfr Family Of Receptor Tyrosine Kinases, Kwabena A N Sarpong

Arts & Sciences Graduate Student Theses and Dissertations

The epidermal growth factor receptor and its three orthologues, HER2, HER3 and HER4 have been the subject of intensive basic, clinical and translational research due to their involvement in cancers. These proteins are part of elaborate networks that interact with a myriad of other molecules to effect diverse signaling pathways and affect cellular processes such as migration, apoptosis, cell differentiation and so on. In addition to the formation of preformed dimers, it is well established that ligand engagement leads to receptor dimerization in all family members, except HER2. In the past decade, it has been shown that their intracellular domains …


Madness Uncaged: A History Of Psychiatric Practice And Its Expansion Into The Everyday, Max Alexander Ferrer May 2017

Madness Uncaged: A History Of Psychiatric Practice And Its Expansion Into The Everyday, Max Alexander Ferrer

Honors Theses

This study project provides a history and evaluation of the growth of psychology since its inception during the Middle Ages. Through secondary research on trends and breakthroughs in psychological practice, this project provides a periodization by which the history of psychology can be evaluated through a critical philosophical lens. This periodization includes four distinct time periods: The Age of Jails or "Old Asylums" (middle ages to early 19th century), The Age of Asylums (early 19th century to early 20th century), and The Age of Private Psychiatry (early to mid 20th century). Eventually, this trajectory will result in a fourth period, …


New Constuctivism Or [Re] Defining Utopia, Anna Pack May 2017

New Constuctivism Or [Re] Defining Utopia, Anna Pack

Bachelor of Architecture Theses - 5th Year

In contemporary Practice what makes a society successful and how can we achieve it?

Defined as “the aggregate of people living together in a more or less ordered community.” It’s a structure, flexible, movable, and, therefore, shape-able. In the roots of Constructivist Utopia lays the idea of achieving the perfect society through the means of practicing new methods of design and productions. The Revolutionized ideas of propaganda and communal living in total equality were the key points in Constructivist Agenda. Their Utopia was to erase all boundaries and to build total equality. What is Utopia today? In my thesis I …


Elemental Contamination Of An Ancient Copper Mine In Killarney, Ireland, Courtney Chouinard May 2017

Elemental Contamination Of An Ancient Copper Mine In Killarney, Ireland, Courtney Chouinard

Celebration of Learning

Ross Island Copper Mine, located in Killarney National Park, Killarney, Ireland, is known for archeological artifacts of copper from the Bronze Age. Copper production surged in the late 1700s and into the mid-1800s. The mine included both open pits (e.g. Blue Hole) and underground excavations (e.g. Western Mine). Copper veins were found in the Mississippian-aged limestone bedrock along with chalcopyrite and tennantite ore. In 1912, tourism had become the main source of income in the area, and the mines and the land surrounding them were remediated and became a part of the national park. Mine shafts were filled in, waste …


Development Of New Routes For The Synthesis Of Carbaporphyrins And Carbachlorins, Navneet Sahota May 2017

Development Of New Routes For The Synthesis Of Carbaporphyrins And Carbachlorins, Navneet Sahota

Theses and Dissertations

Carbaporphyrins and carbachlorins are porphyrin analogs in which one of the nitrogens is replaced with a carbon atom within a porphyrin-like cavity. These systems form stable organometallic derivatives and exhibit unusual chemical reactivity. In the monocarbaporphyrinoids such as benzocarbaporphyrins, one of the pyrrole rings is replaced by an indene unit. Although syntheses of monocarbaporphyrins with fused rings have been widely investigated over the past 20 years, a few examples of carbaporphyrins without fused rings have been reported in the literature.

In this thesis, two projects were conducted to further explore carbaporphyrin and carbachlorin chemistry. The first project utilized a ‘3+1’ …