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The Insects Of Treeholes Of Northern Indiana With Special Reference To Megaselia Scalaris (Diptera: Phoridae) And Spilomyia Longicornis (Diptera: Syrphidae), Robert S. Copeland

The Great Lakes Entomologist

The aquatic insect community of treeholes in northern Indiana was surveyed from 1983-1986. Twenty-three species, representing three orders and nine families, were found. Megaselia scalaris (Diptera: Phoridae) was collected on several occasions from rotholes, the first member of this family from treeholes. Examination of puparia of Spilomyia longicornis (Diptera: Syrphidae) indicated that the larva of this species has been previously described, but incorrectly associated with the genus Xylata.

The Synthesis Of A Novel Bibenzopyran Relied On Electrooxydation Of Malloapelta B By Cyclic Voltammetry, Binh Phan Thi, Ninh Bui Hai, Minh Chau Van, Nam Nguyen Hoai, Huong Le Mai, Kiem Phan Van

ASEAN Journal on Science and Technology for Development

A novel bibenzopyran named bimalloapelta (1) was synthesized relying on electrooxydation of malloapelta B by cyclic voltammetry in acetonitril adding LiClO4 0.1 M as supporting electrolyte. Its structure determination based on extensive NMR studies and ESI mass spectral measurements. The new compound showed significant cytotoxicity againsts two cancer cell lines as human hepatocellular carcinoma (Hep-2; IC50: 0.46 µg/m) and rhabdosarcoma (RD; IC50: 0.33 µg/m). These results were the same that of malloapelta B (Hep-2, IC50: 0.49 µg/ml and KB, IC50: 0.54 µg/ml).

Annual Global Mean Temperature Explains Reproductive Success In A Marine Vertebrate From 1955 To 2010, Robert A. Mauck, Donald C. Dearborn, Charles E. Huntington

All Faculty Scholarship

The salient feature of anthropogenic climate change over the last century has been the rise in global mean temperature. However, global mean temperature is not used as an explanatory variable in studies of population-level response to climate change, perhaps because the signal-to-noise ratio of this gross measure makes its effect difficult to detect in any but the longest of datasets. Using a population of Leach's storm-petrels breeding in the Bay of Fundy, we tested whether local, regional, or global temperature measures are the best index of reproductive success in the face of climate change in species that travel widely between …

Linking Heart Attack Damage With The Spleen And Kidney, An Integrated Approach To The Study Of Heart Failure, Jeff Hansen

Browse All News

No abstract provided.

Linking Heart Attack Damage With Spleen, Kidney, An Integrated Approach To Heart Failure, Public Relations

Browse All News

No abstract provided.

Genetic And Genomic Characterization Of 462 Melanoma Patient-Derived Xenografts, Tumor Biopsies, And Cell Lines., Bradley Garman, Ioannis N. Anastopoulos, Clemens Krepler, Patricia Brafford, Katrin Sproesser, Yuchao Jiang, Bradley Wubbenhorst, Ravi Amaravadi, Joseph Bennett, Marilda Beqiri, David Elder, Keith T. Flaherty, Dennie T. Frederick, Tara C. Gangadhar, Michael Guarino, David Hoon, Giorgos Karakousis, Qin Liu, Nandita Mitra, Nicholas J. Petrelli, Lynn Schuchter, Batool Shannan, Carol L. Shields, Jennifer Wargo, Brandon Wenz, Melissa A. Wilson, Min Xiao, Wei Xu, Xaiowei Xu, Xiangfan Yin, Nancy R. Zhang, Michael A. Davies, Meenhard Herlyn, Katherine L. Nathanson

Wills Eye Hospital Papers

Tumor-sequencing studies have revealed the widespread genetic diversity of melanoma. Sequencing of 108 genes previously implicated in melanomagenesis was performed on 462 patient-derived xenografts (PDXs), cell lines, and tumors to identify mutational and copy number aberrations. Samples came from 371 unique individuals: 263 were naive to treatment, and 108 were previously treated with targeted therapy (34), immunotherapy (54), or both (20). Models of all previously reported major melanoma subtypes (BRAF, NRAS, NF1, KIT, and WT/WT/WT) were identified. Multiple minor melanoma subtypes were also recapitulated, including melanomas with multiple activating mutations in the MAPK-signaling pathway and chromatin-remodeling gene mutations. These well-characterized …

Life History Of Mesovelia Mulsanti (Hemiptera: Mesoveliidae) In Southern Illinois, J. E. Mcpherson

The Great Lakes Entomologist

The life history of Mesovelia mulsanti was studied during 1983-1986. This species was apparently trivoltine with a partial 4th generation at the end of the year. It overwintered as eggs. First ins tars appeared in mid-April followed by marked overlapping of the subsequent instars and generations. The first adults appeared in early May. No active individuals were found after November.

Investigating The Mechanistic Mode Of Action Of Novel Cu(Ii) Complexes As Potential Chemotherapeutics Drugs, Garret Rochford

Doctoral

A new class of Cu(II) phenanthroline-phenazine complexes (developed in Dublin City University) have recently been reported to have the highest DNA binding constants of any copper therapeutic complex and at a similar level to Actinomycin. These new complexes show great clinical potential with their high activity against a range of in-vitro mammalian cell lines including those with cisplatin resistance however the underlying biological mechanism of their action has yet to be explored in-depth. The biological data generated in this project has examined the activity of the Cu(II) phenanthroline-phenazine complexes in selected mammalian cells lines in-vitro and demonstrated that the Cu(II) …

Phosphoproteomics Profiling Of Nonsmall Cell Lung Cancer Cells Treated With A Novel Phosphatase Activator, Danica Wiredja, Marzieh Ayati, Sahar Mazhar, Jaya Sangodkar, Sean Maxwell, Daniela Schlatzer, Goutham Narla, Mehmet Koyutürk, Mark R. Chance

Computer Science Faculty Publications

Activation of protein phosphatase 2A (PP2A) is a promising anti-cancer therapeutic strategy, as this tumor suppressor has the ability to coordinately downregulate multiple pathways involved in the regulation of cellular growth and proliferation. In order to understand the systems-level perturbations mediated by PP2A activation, we carried out mass spectrometry-based phosphoproteomic analysis of two KRAS mutated non-small cell lung cancer (NSCLC) cell lines (A549 and H358) treated with a novel Small Molecule Activator of PP2A (SMAP). Overall, this permitted quantification of differential signaling across over 1,600 phosphoproteins and 3,000 phosphosites. Kinase activity assessment and pathway enrichment implicated collective downregulation of RAS …

Study Of Y-Chromosome Str Markers In United Arab Emirates Population, Tareq Zeyad Mohammed Ahmed

Theses

The recently introduced 6-dye Yfiler Plus multiplex which includes 27 Y-STR loci (DYS576, DYS389I, DYS635, DYS389II, DYS627, DYS460, DYS458, DYS19, YGATAH4, DYS448, DYS391, DYS456, DYS390, DYS438, DYS392, DYS518, DYS570, DYS437, DYS385 a/b, DYS449, DYS393, DYS439, DYS481, DYF387S1a/b and DYS533) has been used to study 343 UAE Arab male individuals using Yfiler Plus® amplification kit. This set includes seven rapidly mutating loci (RM Y-STRs). These RM Y-STRs are useful for discriminating between closely related and unrelated males.. According to measures of genetic diversity the highest diversity were observed at loci DYS385=(0.94984), DYF387S1=(0.930523) and DYS449=(0.895402). Therefore, these loci should be considered the …

Interaction Of Cocoa Powder With Intestinal Microbiota, Martha M. Escoto Sabillon

LSU Master's Theses

Cocoa is the fully fermented and dried seed of the cacao tree (Theobroma cacao L.) which has prebiotic properties, due to their high concentration of polyphenols. Therefore, the ingestion of cocoa could cause changes in the proportions of the intestinal microbiota that can influence the intestinal immune response. The objective of this study was to determine the effect of alkalization process of the cocoa bean in the diversity of the gut microbiota. The samples were “lavado” unprocessed cocoa powder, “natural” unprocessed cocoa powder, “D-11-S” as alkalized cocoa powder, “D-11-B” heavily alkalized cocoa powder, and raw cocoa “shells” and a control …

Gene Coexpression Network Analysis Of Fruit Transcriptomes Uncovers A Possible Mechanistically Distinct Class Of Sugar/Acid Ratio-Associated Genes In Sweet Orange, Liang Qiao, Minghao Cao, Jian Zheng, Yihong Zhao, Zhi-Liang Zheng

Publications and Research

Background: The ratio of sugars to organic acids, two of the major metabolites in fleshy fruits, has been considered the most important contributor to fruit sweetness. Although accumulation of sugars and acids have been extensively studied, whether plants evolve a mechanism to maintain, sense or respond to the fruit sugar/acid ratio remains a mystery. In a prior study, we used an integrated systems biology tool to identify a group of 39 acid-associated genes from the fruit transcriptomes in four sweet orange varieties (Citrus sinensis L. Osbeck) with varying fruit acidity, Succari (acidless), Bingtang (low acid), and Newhall and Xinhui (normal …

The Genetics Of Research, Taylor University

2017 Website News Stories

No abstract provided.

Seasonal Emergence Patterns Of Black Flies (Diptera: Simuliidae) In Northwestern Pennsylvania, P. H. Adler, B. L. Travis, K. C. Kim, E. C. Masteller

The Great Lakes Entomologist

A two-year emergence trap study of black flies at four sites in northwestern Pennsylvania yielded 1%3 individuals of nine species. The collections included Prosimulium mixtum, P. jU5cum, Stegapterna mutata, Simulium aureum, S. excisum (recorded for the first time from Pennsylvania), S. gauldingi, S. sp. nr. innacens, S. vittatum, and S. tuberasum. Species richness for all sites peaked during May. Emergence collections below a sewage plant effluent outfall represented fewer individuals and species than collections above the effluent outfall. Chromosomal analysis of supplementary larval collections revealed the IIIL-l and IS-7 sibling species of S. vittatum and the FG sibling of S. …

Resource Partitioning By Two Species Of Stream Mayflies (Ephemeroptera: Heptageniidae), William O. Lamp, N. Wilson Britt

The Great Lakes Entomologist

We compared the phenology of nymph development, food type, and habitat selection of two stream mayflies, Stenacron interpunctatum (Say) and Stenonema pulchellum (Walsh) in Big Darby Creek, Ohio. Both species, which grow principally from autumn through early spring, emerged from the stream throughout the summer. The nymphs consumed the same sizes and types of food particles from deposits on stones, mostly in the form of detritus. As a result of morphological and behavioral adaptations, S. pulchellum lived on stones in swift water whereas S. interpunctatum lived on stones in a slower current.

Fourlined Plant Bug (Hemiptera: Miridae), A Reappraisal: Life History, Host Plants, And Plant Response To Feeding, A. G. Wheeler Jr, Gary L. Miller

The Great Lakes Entomologist

Phenology of the fourlined plant bug, Poecilocapsus lineatus, is presented for southcen- tral Pennsylvania; life history and habits are re-examined. Although breeding was previously thought to occur only on woody plants, we found that nymphs develop on numerous herbs. An extensive list of hosts, more than 250 species in 57 families, is compiled from the literature and the authors' observations; preferences are noted for plants in the Labiatae, Solanaceae, and Compositae. Damage consists of lesions on foliage, the size and shape of the spots varying with leaf texture, pubescence, and venation. Plant response to feeding is immediately visible, the lesions …

Annotated List Of Indiana Scolytidae (Coleoptera), Mark Deyrup

The Great Lakes Entomologist

A list of 80 species of Indiana Scolytidae (bark and ambrosia beetles) is presented. Notes on known Indiana hosts and distribution in the state are included for each species.

Diverse Amide Analogs Of Sulindac For Cancer Treatment And Prevention, Bini Mathew, Judith V. Hobrath, Michele C. Connelly, R. Kiplin Guy, Robert C. Reynolds

Pharmaceutical Sciences Faculty Publications

Sulindac is a non-steroidal anti-inflammatory drug (NSAID) that has shown significant anticancer activity. Sulindac sulfide amide (1) possessing greatly reduced COX-related inhibition relative to sulindac displayed in vivoantitumor activity that was comparable to sulindac in a human colon tumorxenograft model. Inspired by these observations, a panel of diverse sulindac amide derivatives have been synthesized and their activity probed against three cancer cell lines (prostate, colon and breast). A neutral analog, compound 79 was identified with comparable potency relative to lead 1 and activity against a panel of lymphoblastic leukemia cell lines. Several new series also show good …

Observations Of The Habits Of Lygaeus Kalmii Angustomarginatus (Hemiptera: Lygaeidae) In Southern Michigan, Linda-Margaret Hunt

The Great Lakes Entomologist

Lygaeus kalmii Stal (Hemiptera: Lygaeidae) is an insect found throughout the eastern United States and Canada. There is extensive taxonomic literature on this insect (Stil, 1874; Townsend, 1887; Parshey, 1919, 1923; Slater and Knopf, 1969), but very little attention has been given to the rest of its biology. This study describes the habits of kalmii populations in southern Michigan.

Larval Ecology Of Some Lower Michigan Black Flies (Diptera: Simuliidae) With Keys To The Immature Stages, Richard W. Merritt, Douglas H. Ross, B. V. Peterson

The Great Lakes Entomologist

The species composition, succession, and seasonal abundance of -immature simuliids ocmrrhg in the Rose Lake Wildlife Research Area in lower Michigan are presented. Selected physical and chemical characteristics of streams in the above area were examined and compared in relation to faunal distributions. Comparisons of species differences between permanent and temporary streams were made utilizing the functional group concept based on feeding mechanisms.

Keys and illustrations are presented for the identiiication of larvae and pupae of four genera (Prosimulium, Simulium, Stegopterna, Cnephia) and 19 species of Simuliidae known to occur in lower Michigan. Two species, Cnephia ornithophilia and Simulium vemum, …

Baetis (Ephemeroptera: Baetidae) Of Wisconsin, Edward A. Bergman, William L. Hilsenhoff

The Great Lakes Entomologist

Data on life histories and environmental requirements for species in many mayfly genera remains sketchy at best This is certainly true of Baetis, which is one of the most common components of Wisconsin's lotic fauna. Most Wisconsin streams that are not grossly pobted contain one or more species of the minnow-like nymphs, which are usually found clinging to surfaces of rocks or aquatic plants. Biological studies of Baetis in North America have been neglected primarily because of their enigmatic taxonomy. Even keys of Needham et al. (1935) and Burks (1953), which are considered standard referenas, are either incomplete or difficult …

Male Behavior In Evagetes Subangulatus (Hymenoptera: Pompilidae), Edward M. Barrows

The Great Lakes Entomologist

Males of Evagetes subangulatus patrolled primarily among shrubs in an area where females dug in soil. Twenty-nine individually-marked males were seen from 0 to 16 days after marking. They shared a home range space of about 400 m3. Although they did not exhibit territoriality, they chased and pounced upon one another and upon unmarked, conspecific males and females.

Volume 5, Chapter 2-2: Medical Uses: Biologically Active Substances, Janice M. Glime

Bryophyte Ecology Subchapters

No abstract provided.

Keys And Notes On The Buprestidae (Coleoptera) Of Michigan, Stanley G. Wellso, Gary V. Manley, John A. Jackman

The Great Lakes Entomologist

The distribution and dates of adult activity for Michigan buprestids are discussed. Keys to the genera and species, as well as host information are presented for 116 species and one subspecies. Information on collecting techniques, illustrations of genitalia of 14 species, and scanning electron micrographs of certain structures useful in species identification are presented and discussed. In addition, Pachyschelus confusus, a new species, is described from bush clover.

Spatial And Seasonal Distribution Of Pine Root Collar Weevil Eggs In Young Red Pine Plantations, Louis F. Wilson

The Great Lakes Entomologist

The pine root collar weevil (Hylobius radicis Buchanan) is a continuous threat to young pine plantations in the northeastern United States and the adjacent Canadian Provinces The female weevil oviposits during the daytime (Wilson, 1968a) near the root collars of red pine (Pinus resinosa Aiton), Scotch pine (P. sylvestris L.), and jack pine (P. hanksiana Lambert), and occasionally other pines. During recent studies on the weevil (Wilson 1968a, 1968b) in Michigan, egg data were taken for use in population and sampling research. Presented here are distribution patterns of eggs within and between trees and throughout the …

Aberrant Plant Diversity In The Purgatory Watershed Of Southeastern Colorado And Northeastern New Mexico, Joseph A. Kleinkopf, Dina A. Clark, Erin A. Tripp

Western North American Naturalist

Despite a dearth of biological study in the area, the Purgatory Watershed concentrated in southeastern Colorado and northeastern New Mexico is home to a number of unique land formations and endemic organisms. At onetime nonarable land where Dust Bowl storms of the 1930s originated, the Purgatory Watershed is presently home to the Comanche National Grasslands, the Picketwire Canyonlands, and the expansive Piñon Canyon Maneuver Site. The Purgatory Watershed is composed of deep canyons, eroded mesas, and extensive intact shortgrass plains, and is located at a crossroads of the biodiversity of the Southern Rocky Mountains, Great Plains, and Chihuahuan Desert. Here …

Biology Of A Philippine Population Of Toxorhynchites Splendens (Wiedemann) (Diptera: Culicidae: Toxorhynchitinae) Under Laboratory Conditions With Aedes Aegypti (L.) (Diptera: Culicidae: Culicinae) As Prey, Justine Bennette H. Millado, Augusto C. Sumalde, Loinda R. Baldrias, Jessamyn R. Adorada, Barbara L. Caoili

Journal Article

A local population of Toxorhynchites splendens (Wiedemann) (Diptera: Culicidae: Toxorhynchitinae) from the College of Forestry and Natural Resources (CFNR), University of the Philippines Los Banos, was observed under laboratory conditions to gather basic data on its biology. Immature stages are briefly described highlighting key characters that differentiate larval instars. Egg incubation and developmental period were shorter in males (1.77 ± 0.35, 36.16 ± 15.57) than in females (1.87 ± 0.26, 38.30 ± 16.23). Males also live shorter (12.9 ± 10.44) than females (18.38 ± 14.76). The number of preys, Aedes aegypti larvae, offered to T. splendens larvae was positively correlated …

Under The Wing Of A Creature Of The Night, Julia M. Chin

Wonders of Nature and Artifice

Magnificent in its sheer power and beauty, this owl wing has a wingspan of 18 inches and measures 10 inches from the shoulder bone to the secondary feathers. Wings such as the one displayed play a vital role in the lifestyle of owls and other hunting birds who fulfill their dietary requirements through stealthy foraging in the dark of the night. Being predatory animals, an owl depends upon its wings as a weapon, equipping it with an arsenal worthy of any hunter. Because of their composition of downy feathers, soft fringes, and comb-like primary feathers, these light appendages create less …

Unf Journal Fall 2017, University Of North Florida

UNF Journal

A university periodical for alumni and friends of the University of North Florida.

Synthesis, Characterization And Application Of Sugar-Based Low Molecular Weight Gelators, Ifeanyi Simeon Okafor

Chemistry & Biochemistry Theses & Dissertations

Low molecular weight gelators (LMWGs) are an interesting class of compound that have gained considerable attention especially because of their potential applications for soft biomaterials. Carbohydrate based low molecular weight hydrogelators and organogelators are able to selfassemble and form ordered supramolecular structures, which are useful for exploring biomedical applications. The resulting gelators are responsive to external stimuli because of the weak noncovalent intermolecular forces and interaction that influences self-assembly. Stimuli-responsive supramolecular organogels with interesting properties in response to external environmental stimuli have gained considerable attention due to their applications in biomaterials, sensors and for drug delivery.

One of the major …