Digital Commons Network^™

The Bison, September 1, 2017

The Bison Newspapers

No abstract provided.

Temporal Changes In Cortical And Hippocampal Expression Of Genes Important For Brain Glucose Metabolism Following Controlled Cortical Impact Injury In Mice, June Zhou, Mark Burns, Linda Huynh, Sonia Villapol, Daniel D. Taub, Juan M. Saavedra, Marc R. Blackman

Pharmacology and Physiology Faculty Publications

Traumatic brain injury (TBI) causes transient increases and subsequent decreases in brain glucose utilization. The underlying molecular pathways are orchestrated processes and poorly understood. In the current study, we determined temporal changes in cortical and hippocampal expression of genes important for brain glucose/lactate metabolism and the effect of a known neuroprotective drug telmisartan on the expression of these genes after experimental TBI. Adult male C57BL/6J mice (n = 6/group) underwent sham or unilateral controlled cortical impact (CCI) injury. Their ipsilateral and contralateral cortex and hippocampus were collected 6 h, 1, 3, 7, 14, 21, and 28 days after injury. …

The Other White-Nose Syndrome Transcriptome: Tolerant And Susceptible Hosts Respond Differently To The Pathogen Pseudogymnoascus Destructans, Christina M. Davy, Michael E. Donaldson, Craig K. R. Willis, Barry J. Saville, Liam P. Mcguire, Heather Mayberry, Alana Wilcox, Gudrun Wibbelt, Vikram Misra, Trent Bollinger, Christopher J. Kyle

KIP Articles

Mitigation of emerging infectious diseases that threaten global biodiversity requires an understanding of critical host and pathogen responses to infection. For multihost pathogens where pathogen virulence or host susceptibility is variable, host–pathogen interactions in tolerant species may identify potential avenues for adaptive evolution in recently exposed, susceptible hosts. For example, the fungus Pseudogymnoascus destructans causes white‐nose syndrome ( WNS ) in hibernating bats and is responsible for catastrophic declines in some species in North America, where it was recently introduced. Bats in Europe and Asia, where the pathogen is endemic, are only mildly affected. Different environmental conditions among Nearctic and …

Creche Herald Vol. 21, No. 3, Rita B. Bocher

Creche Herald

The Fall 2017 publication features nativity sets and personal reflections from members in the organization; information about nativities and nativity exhibits; and information about the Friends of the Creche annual meeting.

The Activity Of The Serotonin Receptor 2c Is Regulated By Alternative Splicing, Stefan Stamm, Samuel B. Gruber, Alexander G. Rabchevsky, Ronald B. Emeson

Molecular and Cellular Biochemistry Faculty Publications

The central nervous system-specific serotonin receptor 2C (5HT2C) controls key physiological functions, such as food intake, anxiety, and motoneuron activity. Its deregulation is involved in depression, suicidal behavior, and spasticity, making it the target for antipsychotic drugs, appetite controlling substances, and possibly anti-spasm agents. Through alternative pre-mRNA splicing and RNA editing, the 5HT2C gene generates at least 33 mRNA isoforms encoding 25 proteins. The 5HT2C is a G-protein coupled receptor that signals through phospholipase C, influencing the expression of immediate/early genes like c-fos. Most 5HT2C isoforms show constitutive activity, i.e., signal without ligand binding. The constitutive activity of 5HT2C is …

Enhanced Physical Endurance And Improved Memory Performance Following Taurine Administration In Rats, Irfan Sajid, Saara Muddasir, Shaista Emad, Zehra Batool, Saima Khaliq, Lubna Anis, Saiqa Tabassum, Syeda Madiha, Laraib Liaquat, Sadia Sadir, Tahira Perveen, Saida Haider

Department of Biological & Biomedical Sciences

Energy drinks enhance physical endurance and cognitive ability. The ingredients present in these drinks are considered as ergogenic and have memory boosting effects. In the present study effects of taurine administration for one week was monitored on physical exercise and memory performance in rats. Animals were divided into two groups namely control and test. Taurine was injected intraperitoneally to the test group at the dose of 100mg/kg. After one week of treatment rats were subjected to physical exercise and memory task. Results of this study revealed that rats injected with taurine for one week exhibited improved muscular strength as well …

Assessing Personality-Situation Interplay In Personnel Selection: Toward More Integration Into Personality Research, Filip Lievens

Research Collection Lee Kong Chian School Of Business

Over the years, the personnel selection field has developed methods to assess trait expression in particular situations, but these approaches have evolved mostly outside the field of personality psychology. In this article, I review available personnel selection evidence regarding two such approaches: (i) situational judgement tests that present short scenarios and ask job candidates how they would handle the situations and (ii) assessment centre exercises requiring candidates to display behaviour in specified interactive situations. I describe these approaches and discuss their relations with personality research. I posit that adapting these approaches to personality research creates methodological diversity to address key …

Community Engagement Through An Environmental Studies Lens, Jane T. Costlow

All Faculty Scholarship

Situated within a state strongly identified with pristine nature, our central Maine campus provides a fabulous "laboratory" for both environmental science and civic engagement. To take full advantage of this fortunate situation, Bates College's Environmental Studies (ES) program includes community civic engagement in many, if not all, of our classes and major requirements. Questions about community, diversity, and civic life help our students grapple with the complexity of environmental challenges, pushing them to consider the many kinds of knowledge essential to addressing problems at both local and more global scales. We strongly believe that a liberal arts environmental education can …

Amlexanox Enhances Premature Termination Codon Read-Through In Col7a1 And Expression Of Full Length Type Vii Collagen: Potential Therapy For Recessive Dystrophic Epidermolysis Bullosa., Velina S. Atanasova, Qiujie Jiang, Marco Prisco, Christina Gruber, Josefina Piñón Hofbauer, Mei Chen, Cristina Has, Leena Bruckner-Tuderman, John A. Mcgrath, Jouni Uitto, Andrew P. South

Department of Dermatology and Cutaneous Biology Faculty Papers

Recessive dystrophic epidermolysis bullosa (RDEB) is a rare monogenic blistering disorder caused by the lack of functional type VII collagen, leading to skin fragility and subsequent trauma-induced separation of the epidermis from the underlying dermis. A total of 46% of patients with RDEB harbor at least one premature termination codon (PTC) mutation in COL7A1, and previous studies have shown that aminoglycosides are able to overcome RDEB PTC mutations by inducing "read-through" and incorporation of an amino acid at the PTC site. However, aminoglycoside toxicity will likely prevent widespread clinical application. Here the FDA-approved drug amlexanox was tested for its ability …

Axon Determination Of Subtype Specific Myelin Ensheathment And Pruning, Erin Dankert, Heather Nelson, Samantha Lang, Madeline Martell

Student Research and Creative Projects 2017-2018

No abstract provided.

Sodium Homeostasis In Chronic Kidney Disease, Vivek Soi, Jerry Yee

Nephrology Articles

The pathologic consequences of sodium retention in the CKD population can lead to hypertension, edema, and progressive disease. Sodium excess is responsible for increases in oxidative stress, which alters kidney vasculature. As progression of CKD occurs, hyperfiltration by remaining nephrons compensates for an overall decrease in the filtered load of sodium. In the later stages of CKD, compensatory mechanisms are overcome and volume overload ensues. Nephrotic syndrome as it relates to sodium handling involves a different pathophysiology despite a common phenotype. Extrarenal sodium buffering is also examined as it has significant implications in the setting of advanced CKD.

Materials Of Trade Exemption Mot Transporting Chemicals Off Campus

Environmental Health & Safety Policies

Certain hazardous materials transported by private motor carriers, for the purpose of direct support of their business (e.g. clinical and laboratory research) are exempt from most of the Department of Transportation (DOT) hazardous materials regulations, as long as they adhere to the requirements described in the Materials of Trade (MOT) exception. Ultimately, by reviewing this policy, personnel should gain a better understanding of the MOT requirements and be better prepared to transport hazardous materials for University business. Note: This exemption does not apply to the relocation/movement of laboratories on or between University of Health Sciences and Pharmacy in St. Louis …

The Effects Of Chemical Coagulants On The Decolorization Of Dyes By Electrocoagulation Using Response Surface Methodology (Rsm), Erick B. Butler, Yung-Tse Hung, Oliver Mulamba

Civil and Environmental Engineering Faculty Publications

This study assessed the efficiency of electrocoagulation (ECF) coupled with an addition of chemical coagulant to decolorize textile dye. Tests were conducted using Box Behnken methodology to vary six parameters: dye type, weight, coagulant type, dose, initial pH and current density. The combination of electrocoagulation and chemical coagulation was able to decolorize dye up to 99.42 % in 30 min of treatment time which is remarkably shorter in comparison with using conventional chemical coagulation. High color removal was found to be contingent upon the dye type and current density, along with the interactions between the current density and the coagulant …

History Of North Dakota, Elwyn B. Robinson

Open Educational Resources

Elwyn Robinson's sweeping History of North Dakota has become a classic in American state histories. One of the state's great professors and historians takes into account not only politics, but sociology, economics, ethnology, theology, nature studies and geography to describe North Dakota to the world and to itself.

Geography, in particular, formed the basis of Professor Robinson's historical interpretation. His 'too-much mistake,' the belief that North Dakota built too much, too fast, in an isolated area buffeted by difficult climate, has become the guiding principle for a quarter century of historical debate on Dakota plains history.

A Clinical Practice Guideline For The Management Of Patients With Acute Spinal Cord Injury: Recommendations On The Use Of Methylprednisolone Sodium Succinate, Michael G. Fehlings, Jefferson R. Wilson, Lindsay A. Tetreault, Bizhan Aarabi, Paul A. Anderson, Paul M. Arnold, Darrel S. Brodke, Anthony S. Burns, Kazuhiro Chiba, Joseph R. Dettori, Julio C. Furlan, Gregory W. Hawryluk, Langston T. Holly, Susan Howley, Tara Jeji, Sukhvinder Kalsi-Ryan, Mark R. Kotter, Shekar N. Kurpad, Brian Kwon, Ralph J. Marino, Allan R. Martin, Eric M. Massicotte, Geno J. Merli, James W. Middleton, Hiroaki Nakashima, Narihito Nagoshi, Katherine Palmieri, Andrea C. Skelly, Anoushka Singh, Eve Tsai, Alexander R. Vaccaro, Albert Yee, James S. Harrop

Department of Rehabilitation Medicine Faculty Papers

Introduction: The objective of this guideline is to outline the appropriate use of methylprednisolone sodium succinate (MPSS) in patients with acute spinal cord injury (SCI). Methods: A systematic review of the literature was conducted to address key questions related to the use of MPSS in acute SCI. A multidisciplinary Guideline Development Group used this information, in combination with their clinical expertise, to develop recommendations for the use of MPSS. Based on GRADE (Grading of Recommendation, Assessment, Development and Evaluation), a strong recommendation is worded as “we recommend,” whereas a weaker recommendation is indicated by “we suggest.” Results: The main conclusions …

Type And Timing Of Rehabilitation Following Acute And Subacute Spinal Cord Injury: A Systematic Review, Anthony S. Burns, Ralph J. Marino, Sukhvinder Kalsi-Ryan, James W. Middleton, Lindsay A. Tetreault, Joseph R. Dettori, Kathryn E. Mihalovich, Michael G. Fehlings

Department of Rehabilitation Medicine Faculty Papers

Objectives: The objective of this study was to conduct a systematic review of the literature to address the following clinical questions: In adult patients with acute and subacute complete or incomplete traumatic SCI, (1) does the time interval between injury and commencing rehabilitation affect outcome?; (2) what is the comparative effectiveness of different rehabilitation strategies, including different intensities and durations of treatment?; (3) are there patient or injury characteristics that affect the efficacy of rehabilitation?; and (4) what is the cost-effectiveness of various rehabilitation strategies? Methods: A systematic search was conducted for literature published through March 31, 2015 that evaluated …

Unh: The Magazine Of The University Of New Hampshire, Fall 2017, Unh Magazine

UNH Magazine

No abstract provided.

Forage News [2017-09], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• Mid-October is Ideal Time to Plant Small Grains
• Grazing Corn
• Weeds or Wonders?
• Successful Establishment of Novel Tall Fescues

East African Weathering Dynamics Controlled By Vegetation-Climate Feedbacks, Sarah J. Ivory, Michael M. Mcglue, Geoffrey S. Ellis, Adam Boehlke, Anne-Marie Lézine, Annie Vincens, Andrew S. Cohen

Earth and Environmental Sciences Faculty Publications

Tropical weathering has important linkages to global biogeochemistry and landscape evolution in the East African rift. We disentangle the influences of climate and terrestrial vegetation on chemical weathering intensity and erosion at Lake Malawi using a long sediment record. Fossil pollen, microcharcoal, particle size, and mineralogy data affirm that the detrital clays accumulating in deep water within the lake are controlled by feedbacks between climate and hinterland forest composition. Particle-size patterns are also best explained by vegetation, through feedbacks with lake levels, wildfires, and erosion. We develop a new source-to-sink framework that links lacustrine sedimentation to hinterland vegetation in tropical …

Bacterial Diversity Impacts As A Result Of Combined Sewer Overflow In A Polluted Waterway, Olga Calderón, Holly Porter-Morgan, Joby Jacob, Willis Elkins

Publications and Research

Newtown Creek is an industrial waterway and former tidal wetland in New York City. It is one of the most polluted water bodies in the United States and was designated as a superfund site in 2010. For over a century, organic compounds, heavy metals, and other forms of industrial pollution have disrupted the creek’s environment. The creek is also impacted by discharges from twenty combined sewer overflow pipes, which may deposit raw sewage or partially treated wastewater directly into the creek during heavy or sustained rain events. Combined sewer overflow events and associated nutrient over-enrichment at the creek drive eutrophication …

Diet And Habitat Analysis Of Barn Owls (Tyto Alba) Nesting At Ponca State Park, Ann Spilker, Joseph A. Gubanyi

Nebraska Bird Review

In 2015 Barn Owls (Tyto alba) nested on the floor of a grain bin in Ponca State Park, Dixon County. Seven nestlings were observed (Figure 1). It is believed that 6 fledged (one carcass was found on the floor of the bin September 26). Barn Owls were not observed the following spring (Jan Johnson, personal communication). Because there are few records of Barn Owls in the region, we collected data to better understand the Barn Owl nesting in Ponca State Park. Barn Owl prey and their importance to reproductive success has been well documented (Marti et al. 2005; Gubanyi et …

The Nebraska Bird Review, Volume 85 September 2017 Number 3

Nebraska Bird Review

Summer Field Report, June - July 2017, by W. Ross Silcock …94

Diet and Habitat Analysis of Barn Owls (Tyto alba) Nesting at Ponca State Park, by Ann Spilker and Joseph Gubanyi … 121

2016 (28th) Report of the NOU Records Committee, by Mark A. Brogie …128

Subscription and Organization Information … 143

Summer Field Report, June - July 2017, W. Ross Silcock

Nebraska Bird Review

Changes in breeding ranges and numbers of Nebraska breeding birds are the primary focus of a Summer Seasonal Report. Every year there are changes to be noted; this year is no exception. Although most of the phenomena listed below are examples of dispersing individuals without breeding evidence, these often indicate breeding range expansion. White-winged Doves are becoming numerous in southern and western Nebraska, although breeding in far eastern Nebraska was only the 5th report for the state. Chuckwill’s- widow continues to creep westward in the south; the westernmost report to date was of one that crossed the 100-mile gap from …

Probing The Metabolic Phenotype Of Breast Cancer Cells By Multiple Tracer Stable Isotope Resolved Metabolomics, Andrew N. Lane, Julie Tan, Yali Wang, Jun Yan, Richard M. Higashi, Teresa W. -M. Fan

Center for Environmental and Systems Biochemistry Faculty Publications

Breast cancers vary by their origin and specific set of genetic lesions, which gives rise to distinct phenotypes and differential response to targeted and untargeted chemotherapies. To explore the functional differences of different breast cell types, we performed Stable Isotope Resolved Metabolomics (SIRM) studies of one primary breast (HMEC) and three breast cancer cells (MCF-7, MDAMB-231, and ZR75-1) having distinct genotypes and growth characteristics, using ¹³C₆-glucose, ¹³C-1+2-glucose, ¹³C₅,¹⁵N₂-Gln, ¹³C₃-glycerol, and ¹³C₈-octanoate as tracers. These tracers were designed to probe the central energy producing …

Overdose Deaths Related To Fentanyl And Its Analogs – Ohio, January-February 2017, Raminta Daniulaityte, Matthew P. Juhascik, Kraig E. Strayer, Ioana E. Sizemore, Kent E. Harshbarger, Heather M. Antonides, Robert G. Carlson

Population and Public Health Sciences Faculty Publications

What is already known about this topic? Illicitly manufactured fentanyl has become a significant contributor to unintentional overdose deaths in the United States. What is added by this report? Approximately 90% of unintentional overdose deaths examined in 24 Ohio counties that occurred during January–February 2017 involved fentanyl, fentanyl analogs, or both, whereas heroin was identified in the minority (6%) of cases, with somewhat higher prevalence in Appalachian counties. Fentanyl is commonly appearing in combination with other analogs. What are the implications for public health practice? These findings highlight the urgent need to make illicitly manufactured fentanyl testing a part of …

Biennial Faculty Activities Report To The Board Of Regents, State Of Iowa, 2017, University Of Northern Iowa, University Of Iowa, Iowa State University

Institutional Effectiveness & Planning Documents

Report of faculty activity broken down by rank and compared to the other Regents institutions.

The Function Of Religion In The Israeli-Palestinian Conflict, Stephanie Claire Mitchell

Dissertations and Theses

The role of religion in politics has been rising to the forefront of history in the Middle East for a number of decades and more so since 9/11, raising significant questions as to whether religion functions as a catalyst for conflict or peace. This thesis focuses specifically on the role of religion in the Israeli-Palestinian conflict and the manner in which actors incorporate religion into their national politics. In doing so, the inquiry focuses on the proponents of religion on both the Jewish and the Palestinian sides in addressing a) territorial rights, b) interpretations in the use of deadly force …

Redefining The Endophenotype Concept To Accommodate Transdiagnostic Vulnerabilities And Etiological Complexity, Theodore P. Beauchaine, John N. Constantino

Open Access Publications

In psychopathology research, endophenotypes are a subset of biomarkers that indicate genetic vulnerability independent of clinical state. To date, an explicit expectation is that endophenotypes be specific to single disorders. We evaluate this expectation considering recent advances in psychiatric genetics, recognition that transdiagnostic vulnerability traits are often more useful than clinical diagnoses in psychiatric genetics, and appreciation for etiological complexity across genetic, neural, hormonal and environmental levels of analysis. We suggest that the disorder-specificity requirement of endophenotypes be relaxed, that neural functions are preferable to behaviors as starting points in searches for endophenotypes, and that future research should focus on …

Sex Differences And The Effects Of Exercise Training On Functional Vasodilation Following Arterial Occlusion In The Balb/C Mouse Spinotrapezius, Britta Nelson

Master's Theses

Peripheral arterial occlusive disease (PAOD) often presents as intermittent claudication, which may be caused by impaired vasodilation. Impairment of resistance vessels may contribute to the pathogenesis of PAOD, and explain the poor correlation between resting blood flow and limb function. Collateral function following arterial occlusion is not well defined, however collaterals and arterialized collateral capillaries (ACCs) in male and female animal models exhibit impaired vasodilation following arterial occlusion, which can potentially be improved with exercise training. Furthermore, resistance vessels in the ischemic tree and stem are likely involved in the pathogenesis of PAOD, however the relative importance of each is …

The Role Of Efferent Reduction Of Cochlear Compression In The Detection Of Tones In Noise, Shaum Bhagat, Anusha Yellamsetty

Faculty Publications

Stimulation of medial olivocochlear (MOC) efferent neurons reduces basilar membrane (BM) sensitivity and increases the slope of BM input-output (I/O) functions in animal models. Decreased compression of I/O functions associated with activation of MOC efferent neurons may assist in extending the neural response to the tone above that of noise, leading to an improvement in masked thresholds. To evaluate this hypothesis, the distortion-product otoacoustic emission (DPOAE) I/O function, a proxy measure of BM compression, was examined in conditions with presentation of contralateral noise. DPOAE I/O functions were measured at f2 frequencies of 1000 and 2000 Hz in 16 normal-hearing adults. …