Digital Commons Network^™

Predicting The Consequence Of Natural And Chemical Dispersion For Oil Slick Size Over Time, Marieke Zeinstra-Helfrich, Wierd Koops, Albertinka Murk

C-IMAGE Publications

Application of dispersants aims to enhance the natural dispersion process in order to reduce the size of the slick and the amount of oil at the surface. This study presents an approach for modeling the development of the surface oil slick as a function of the wind speed, oil viscosity, and dispersant application. We modeled the oil slick mass distribution across a transect through the slick over time taking into account the continuous entrainment of oil, resurfacing process of the different oil droplet size classes and horizontal transport. Outcomes show distinctively different oil slick features, depending on how favorable conditions …

White-Nose Syndrome Fungus In A 1918 Bat Specimen From France, Michael G. Campana, Naoko P. Kurata, Jeffrey T. Foster

KIP Articles

White-nose syndrome, first diagnosed in North America in 2006, causes mass deaths among bats in North America. We found the causative fungus, Pseudogymnoascus destructans, in a 1918 sample collected in Europe, where bats have now adapted to the fungus. These results are consistent with a Eurasian origin of the pathogen.

Kytc Maintenance Overview And Budget Analysis, Nancy Albright, Bryan Gibson, Steven Douglas Kreis

Kentucky Transportation Center Research Report

The Kentucky Transportation Cabinet (KYTC) manages over 27,500 miles of the state’s roadways and is responsible for preserving many assets in a good state of repair, including bridges, traffic signals, lighting features, traffic signs, and guardrails. The Cabinet’s Maintenance function, which encompasses maintenance (e.g., patching potholes, repainting roadway lines and markings, cleaning bridges, mowing) and operations (e.g., plowing and salting roadways; keeping signs, traffic signals, and roadway signals functional), had a budget in FY 2018 of roughly $350 million. This report describes core maintenance functions and reviews their importance for preserving Kentucky’s roadway network and analyzes trends in KYTC’s maintenance …

The Effects Of Seizure Modeling And Polyphenols On Behavior In Bang-Sensitive Drosophila, Alphonso A. Smith

Loma Linda University Electronic Theses, Dissertations & Projects

Epilepsy is a worldwide public health concern associated with debilitating neurological, cognitive, and psychosocial consequences. Current antiepileptic drugs can have debilitating side effects and new treatments are needed for individuals with pharmaco-resistant seizures like those observed in temporal lobe epilepsy (TLE). Ellagic acid (EA), a polyphenol present in several fruits and nuts, has shown beneficial effects in rodent models of epilepsy and anxiety, possibly mediated through GABAergic pathways. Bang-Sensitive Drosophila mutants model epileptic seizures following mechanical shock and provide a high-throughput alternative to costly rodent studies. The objectives of this study were to: 1) examine the effectiveness of seizure modeling …

The Role Of Vegf And Smooth Muscle Phenotype In Hypoxic Remodeling Of Ovine Carotid And Cerebral Arteries, Margaret C. Hubbell

Loma Linda University Electronic Theses, Dissertations & Projects

Arteries are a dynamic tissue with multiple cell types that incorporate systemic and local factors to maintain homeostasis. Hypoxia stimulates capillary angiogenesis to effectively match metabolic demand with perfusion. With chronic hypoxia, vascular remodeling of even large vessels can occur. This predisposes to pathologic states as seen with atherosclerosis, hypoxic brain injury, myocardial ischemia, diabetes, and developmental anomalies. With this remodeling comes changes in vessel structure including medial thickness and organization of contractile proteins as well as changes in myogenic tone. All of these factors culminate in changes in status or behavior of the vascular smooth muscle within the vessel …

Erp And Theta Activity Associated With Facial Emotion Memory, Shaina Roxanne Herman

Loma Linda University Electronic Theses, Dissertations & Projects

Facial emotion recognition is an important component of daily functioning and is highly connected to the social element of human interaction. At present, it is not clear whether initial stimulus encoding or memory maintenance of the face promotes accurate facial emotion memory. The purpose of this study was to explore the mechanisms of facial affect memory. Specifically, we aimed to compare whether type of emotion, length of delay interval, or robustness of encoding the initial stimulus were associated with accurate facial emotion recognition and memory. A task of explicit emotion memory was given to 30 participants. A visual stimulus of …

Modulation Of Cellular Energetics By Galactose And Pioglitazone., David Grimm, Leonardo Altamirano, Sudip Paudel, Leah Welker, Mary E. Konkle, Nilay Chakraborty, Michael Menze

Faculty and Staff Scholarship

The Warburg effect is ameliorated by culturing transformed cells in the presence of galactose instead of glucose as the primary carbon source. However, metabolic consequences that are in addition to sensitizing the cells to mitochondrial toxins may occur. As such, the screening of pharmaceutical agents against transformed cells while using galactose must be carefully evaluated. Pioglitazone is used in clinical applications to treat type-2 diabetes, but clearly has other off target effects. Human hepatocellular carcinoma cells (HepG2) were cultured in glucose or galactosecontaining medium to investigate the role of pioglitazone on cellular bioenergetics employing calorimetry and respirometry. Compared to cells …

Heart Failure–Related Hyperphosphorylation In The Cardiac Troponin Ic Terminus Has Divergent Effects On Cardiac Function In Vivo, Yuejin Li, Guangshuo Zhu, Nazareno Paolocci, Pingbo Zhang, Cyrus Takahashi, Nazli Okumus, Amir Heravi, Gizem Keceli, Genaro A. Ramirez-Correa, David A. Kass

School of Medicine Publications

Background

In human heart failure, Ser199 (equivalent to Ser200 in mouse) of cardiac troponin I (cTnI) is significantly hyper-phosphorylated and in vitro studies suggest it enhances myofilament calcium sensitivity and alters calpain-mediated cTnI proteolysis. However, how its hyper-phosphorylation affects cardiac function in vivo remains unknown.

Methods and Results

To address the question, two transgenic mouse models were generated: a phospho-mimetic cTnIS200D and a phospho-silenced cTnIS200A, each driven by the cardiomyocyte-specific α-MHC promoter. Cardiac structure assessed by echocardiography and histology were normal in both transgenic models compared to littermate controls (n=5). Baseline in vivo hemodynamics and isolated muscle studies showed that …

Ontogeny Of Myosin Isoform Expression And Prehensile Function In The Tail Of The Gray Short-Tailed Opossum ( Monodelphis Domestica), Dylan R. Thomas, Brad A. Chadwell, Gary R. Walker, Julio E. Budde, John L. Vandeberg, Michael T. Butcher

School of Medicine Publications

Terrestrial opossums use their semiprehensile tail for grasping nesting materials as opposed to arboreal maneuvering. We relate the development of this adaptive behavior with ontogenetic changes in myosin heavy chain (MHC) isoform expression from 21 days to adulthood. Monodelphis domestica is expected to demonstrate a progressive ability to flex the distal tail up to age 7 mo, when it should exhibit routine nest construction. We hypothesize that juvenile stages (3-7 mo) will be characterized by retention of the neonatal isoform (MHC-Neo), along with predominant expression of fast MHC-2X and -2B, which will transition into greater MHC-1β and -2A isoform content …

Reduction Of Cognitive Decline In Patients With Or At High Risk For Diabetes, Gladys E. Maestre

School of Medicine Publications

Purpose of review—The incidence of Alzheimer’s disease and related disorders is expected to triple by 2050. People with type 2 diabetes and prediabetes have a higher risk of cognitive dysfunction, including Alzheimer’s disease and vascular dementia. Controversy remains about when and how to prevent and treat cognitive dysfunction in people with or at high risk of diabetes.

Recent findings—In our review of ongoing clinical trials, we have found that there has been an increase in the number of studies assessing the efficacy of pharmacological and non-pharmacological approaches to prevent or slow down cognitive impairment among people with or …

Fors 333.01: Fire Ecology, Philp Higuera

University of Montana Course Syllabi, 2016-2020

No abstract provided.

Parasite Biodiversity Faces Extinction And Redistribution In A Changing Climate, Colin J. Carlson, Kevin R. Burgio, Eric R. Dougherty, Anna J. Phillips, Veronica M. Bueno, Christopher F. Clements, Giovanni Castaldo, Tad A. Dallas, Carrie A. Cizauskas, Graeme S. Cumming, Jorge Doña, Nyeema C. Harris, Roger Jovani, Sergey Mironov, Oliver C. Muellerklein, Heather C. Proctor, Wayne M. Getz

Faculty Publications

Copyright © 2017 The Authors, some rights reserved. Climate change is a well-documented driver of both wildlife extinction and disease emergence, but the negative impacts of climate change on parasite diversity are undocumented. We compiled the most comprehensive spatially explicit data set available for parasites, projected range shifts in a changing climate, and estimated extinction rates for eight major parasite clades. On the basis of 53, 133 occurrences capturing the geographic ranges of 457 parasite species, conservative model projections suggest that 5 to 10% of these species are committed to extinction by 2070 from climate-driven habitat loss alone. We find …

Characteristics Of Ovarian Cancer Detection By A Near-Infrared Fluorescent Probe Activated By Human Nad(P)H: Quinone Oxidoreductase Isozyme 1 (Hnqo1), Yuko Nakamura, Zhenhua Shen, Toshiko Harada, Tadanobu Nagaya, Kazuhide Sato, Shuhei Okuyama, Fusa Ogata, Peter L. Choyke, Robin L. Mccarley, Hisataka Kobayashi

Faculty Publications

© Nakamura et al. Near-infrared (NIR) fluorescent probes are ideal for in vivo imaging, because they offer deeper tissue penetration by the light and lower background autofluorescence than fluorophores that emit in the visible range. Q3STCy is a newly synthesized, NIR light-emitting probe that is activated by an enzyme commonly overexpressed in tumor cells, human nicotinamide adenine dinucleotide (phosphate): quinone oxidoreductase isozyme 1, known as hNQO1 or DT-diaphorase. The purpose of this study is to compare the sensitivity of detecting peritoneal ovarian cancer metastasis (POCM) with Q3STCy and gGlu-HMRG, a green fluorescent probe, upon their surface application. In vitro uptake …

Alu Insertion Polymorphisms As Evidence For Population Structure In Baboons, Mark Batzer, Cody J. Steely, Jerilyn A. Walker, Vallmer E. Jordan, Thomas O. Beckstrom, Cullen L. Mcdaniel, Corey P. St. Romain, Emily C. Bennett, Arianna Robichaux, Brooke N. Clement, Muthuswamy Raveendran, Kim C. Worley, Jane Phillips-Conroy, Clifford J. Jolly, Jeff Rogers, Miriam K. Konkel

Faculty Publications

Male dispersal from the natal group at or near maturity is a feature of most baboon (Papio) species. It potentially has profound effects upon population structure and evolutionary processes, but dispersal, especially for unusually long distances, is not readily documented by direct field observation. In this pilot study, we investigate the possibility of retrieving baboon population structure in yellow (Papio cynocephalus) and kinda (Papio kindae) baboons from the distribution of variation in a genome-wide set of 494 Alu insertion polymorphisms, made available via the recently completed Baboon Genome Analysis Consortium. Alu insertion variation in a mixed …

Integrating Soil Silicon Amendment Into Management Programs For Insect Pests Of Drill-Seeded Rice, James M. Villegas, Michael O. Way, Rebecca A. Pearson, Michael J. Stout

Faculty Publications

© 2017 by the authors. Licensee MDPI, Basel, Switzerland. Silicon soil amendment has been shown to enhance plant defenses against insect pests. Rice is a silicon-accumulating graminaceous plant. In the southern United States, the rice water weevil and stem borers are important pests of rice. Current management tactics for these pests rely heavily on the use of insecticides. This study evaluated the effects of silicon amendment when combined with current management tactics for these rice insect pests in the field. Field experiments were conducted from 2013 to 2015. Rice was drill-planted in plots subjected to factorial combinations of variety (conventional …

Role Of Inward Rectifier Potassium Channels In Salivary Gland Function And Sugar Feeding Of The Fruit Fly, Drosophila Melanogaster, Daniel R. Swale, Zhilin Li, Felix Guerrero, Adalberto A. Pérez De León, Lane D. Foil

Faculty Publications

© 2016 The Authors The arthropod salivary gland is of critical importance for horizontal transmission of pathogens, yet a detailed understanding of the ion conductance pathways responsible for saliva production and excretion is lacking. A superfamily of potassium ion channels, known as inward rectifying potassium (Kir) channels, is overexpressed in the Drosophila salivary gland by 32-fold when compared to the whole body mRNA transcripts. Therefore, we aimed to test the hypothesis that pharmacological and genetic depletion of salivary gland specific Kir channels alters the efficiency of the gland and reduced feeding capabilities using the fruit fly Drosophila melanogaster as a …

An Overview Of Research At University Of Kalyani In Exploring Some Basic Issues Of Homoeopathy, Anisur Khuda-Bukhsh

Indian Journal of Research in Homoeopathy

Homoeopathy has been confronted with certain major issues such as (i) how is medicinal property of homoeopathic drug transferred to and retained by the vehicle; (ii) how can it act in biological system in the absence of any original drug substance in ultra high diluted remedies? and (iii) plausible mechanism and pathways of biological action including mysteries of ‘like cured by likes’. We demonstrated through controlled studies the ability of ultra-highly diluted homoeopathic drugs in rendering protection/repair of cytogenetic damages inflicted by whole-body X-irradiation in mammalian model mice in vivo. We examined cytogenetic damages in arsenic, cadmium, mercury and stannum …

Anti-Inflammatory Homoeopathic Drug Dilutions Restrain Lipopolysaccharide-Induced Release Of Pro-Inflammatory Cytokines: In Vitro And In Vivo Evidence, Umesh Mahajan, Ajit Walke, Mahendra Kardile, Sameer Goyal, Sumit Siddharth, Chanakya Kundu, Shreesh Ojha, Chandragouda Patil

Indian Journal of Research in Homoeopathy

Context: The lipopolysaccharide (LPS)-induced cytokine release and oxidative stress are validated experimental parameters used to test anti-inflammatory activity. We investigated the effects of homoeopathic mother tinctures, 6 CH, 30 CH and 200 CH dilutions of Arnica montana, Thuja occidentalis and Bryonia alba against LPS (1 μg/ml)-induced cytokine release from RAW-264.7 cells and human whole-blood culture. Materials and Methods: For in vivo evaluations, mice were orally treated with 0.1 ml drug dilutions twice a day for 5 days followed by an intraperitoneal injection of 0.5 mg/kg LPS. After 24 h, the mice were sacrificed and serum levels of pro-inflammatory cytokines and …

Rendezvous With The Past: Review Of The Central Council For Research In Homoeopathy Quarterly Bulletin 2006 (Volume 1, 2, 3 And 4), Deepti Dewan

Indian Journal of Research in Homoeopathy

No abstract provided.

Impact Of Socioeconomic Factors On Florida Consumers' Perceptions On Use Of Chemical In Locally Or Regionally Produced Livestock Products, David Nii O. Tackie, Akua Adu-Gyamfi, Janette R. Bartlett, Bridget J. Perry

Professional Agricultural Workers Journal

Abstract

The use of chemicals in livestock production has been an issue for consumers for several decades. This study, therefore, assessed the impact of socioeconomic factors on Florida consumers’ perceptions on the use of chemicals in locally or regionally produced livestock products. Data were collected from a sample of 404 participants from several Florida counties and were analyzed using descriptive statistics and ordinal logistic analysis. Most of the respondents were of the opinion that using chemicals in locally or regionally produced and sold beef or goat meat was a serious or somewhat serious hazard. The ordinal logistic regression results showed …

Landowners' Willingness To Supply Woody Biomass For Biofuel In West Alabama, Gilbert Adjoyi, Ellene Kebede

Professional Agricultural Workers Journal

Abstract

The Concern for national energy security, rural development, and climate change has created a wider attention for biofuels from woody biomass in recent times. For instance, West Alabama is an area of interest for stakeholders regarding the production of woody biomass. Therefore, the main objective of this study was to examine landowners’ willingness to supply woody biomass for biofuel in West Alabama. A mail survey of randomly selected landowners was conducted in eight selected counties. The results indicated that the average forestland owner is male, between ages of 40 and 57, with an average of 27 years of land …

Korean Through Folktales, Kyungah Yoon

PDXOpen: Open Educational Resources

Korean Through Folktales consists of four chapters and each centers on a famous Korean folktale. The lessons and values that famous folktales teach are embedded and permeated in various aspects of the Koran culture. Using folktales in the curriculum will provide an engaging way to expose students to a slice of the target culture that native Koreans are naturally exposed to at an early age. Through the selected folktales and various activities offered in the book, students can gain cultural knowledge and insights into traditional and cultural values while they are given linguistic lessons to reinforce their acquired skills and …

Studying The Mechanisms Of Developmental Vocal Learning And Adult Vocal Performance In Zebra Finches Through Lentiviral Injection, Zhimin Shi, Ofer Tchernichovski, Xiaoching Li

Publications and Research

Here we provide a detailed step-by-step protocol for using lentivirus to manipulate miRNA expression in Area X of juvenile zebra finches and for analyzing the consequences on song learning and song performance. This protocol has four parts: 1) making the lentiviral construct to overexpress miRNA miR-9; 2) packaging the lentiviral vector; 3) stereotaxic injection of the lentivirus into Area X of juvenile zebra finches; 4) analysis of song learning and song performance in juvenile and adult zebra finches. These methods complement the methods employed in recent works that showed changing FoxP2 gene expression in Area X with lentivirus or adeno-associated …

Swanton Pacific Ranch: Student Research Bibliography, Jeanine Marie Scaramozzino, Cameron Anvari, Bailey Kirby, Duncan Davis-Hall, Kate Tenley

Library Scholarship

Swanton Pacific Ranch (SPR) is a 3,200-acre ranch in Santa Cruz County, California, outside the town of Davenport. The ranch is an educational and research facility owned by the Cal Poly Corporation and managed by the California Polytechnic State University (Cal Poly) College of Agriculture, Food and Environmental Sciences. SPR is a learning laboratory that employs Cal Poly’s Learn By Doing philosophy. Many students have completed research projects at SPR but no complete list of student projects exists.

This bibliography includes Cal Poly authored student research and those co-authored with Cal Poly faculty and staff. Documents include senior projects, master’s …

Phrynosoma Cornutum (Texas Horned Lizard). Predation., Jennie Mook, Monika Burchette, Brett Degregorio, Victor Bogosian Iii, Eric M. Schauber, Raymond W. Moody

Publications

No abstract provided.

Effect Of Dietary Salt Intake On Epithelial Na+ Channels (Enac) In Vasopressin Magnocellular Neurosecretory Neurons In The Rat Supraoptic Nucleus, Kaustubh Sharma, Masudul Haque, Richard Guidry, Yoichi Ueta, Ryoichi Teruyama

Faculty Publications

© 2017 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society Key points: A growing body of evidence suggests that epithelial Na+ channels (ENaCs) in the brain play a significant role in the regulation of blood pressure; however, the brain structures that mediate the effect are not well understood. Because vasopressin (VP) neurons play a pivotal role in coordinating neuroendocrine and autonomic responses to maintain cardiovascular homeostasis, a basic understanding of the regulation and activity of ENaC in VP neurons is of great interest. We show that high dietary salt …

Alu Insertion Polymorphisms As Evidence For Population Structure In Baboons, Cody J. Steely, Jerilyn A. Walker, Vallmer E. Jordan, Thomas O. Beckstrom, Cullen L. Mcdaniel, Corey P. St Romain, Emily C. Bennett, Arianna Robichaux, Brooke N. Clement, Muthuswamy Raveendran, Kim C. Worley, Jane Phillips-Conroy, Clifford J. Jolly, Jeff Rogers, Miriam K. Konkel, Mark A. Batzer, Yue Liu, Shwetha Murali, Tauras P. Vilgalys, Jerilyn A. Walker

Faculty Publications

© The Author 2017. Male dispersal from the natal group at or near maturity is a feature of most baboon (Papio) species. It potentially has profound effects upon population structure and evolutionary processes, but dispersal, especially for unusually long distances, is not readily documented by direct field observation. In this pilot study, we investigate the possibility of retrieving baboon population structure in yellow (Papio cynocephalus) and kinda (Papio kindae) baboons from the distribution of variation in a genome-wide set of 494 Alu insertion polymorphisms, made available via the recently completed Baboon Genome Analysis Consortium. Alu insertion variation in a mixed …

Cannibalism And Infectious Disease: Friends Or Foes?, Benjamin G. Van Allen, Forrest P. Dillemuth, Andrew J. Flick, Matthew J. Faldyn, David R. Clark, Volker H.W. Rudolf, Bret D. Elderd

Faculty Publications

© 2017 by The University of Chicago. Cannibalism occurs in a majority of both carnivorous and noncarnivorous animal taxa from invertebrates to mammals. Similarly, infectious parasites are ubiquitous in nature. Thus, interactions between cannibalism and disease occur regularly. While some adaptive benefits of cannibalism are clear, the prevailing view is that the risk of parasite transmission due to cannibalism would increase disease spread and, thus, limit the evolutionary extent of cannibalism throughout the animal kingdom. In contrast, surprisingly little attention has been paid to the other half of the interaction between cannibalism and disease, that is, how cannibalism affects parasites. …

Effects Of Tectonics And Large Scale Climatic Changes On The Evolutionary History Of Hyalomma Ticks, Arthur F. Sands, Dmitry A. Apanaskevich, Sonja Matthee, Ivan G. Horak, Alan Harrison, Shahid Karim, Mohammad K. Mohammad, Kosta Y. Mumcuoglu, Rupika S. Rajakaruna, Maria M. Santos-Silva, Joshua Kamani, Conrad A. Matthee

Faculty Publications

Hyalomma Koch, 1844 are ixodid ticks that infest mammals, birds and reptiles, to which 27 recognized species occur across the Afrotropical, Palearctic and Oriental regions. Despite their medical and veterinary importance, the evolutionary history of the group is enigmatic. To investigate various taxonomic hypotheses based on morphology, and also some of the mechanisms involved in the diversification of the genus, we sequenced and analysed data derived from two mtDNA fragments, three nuclear DNA genes and 47 morphological characters. Bayesian and Parsimony analyses based on the combined data (2242 characters for 84 taxa) provided maximum resolution and strongly supported the monophyly …

Effect Of Metabolic Status On Conceptus–Maternal Interactions On Day 19 In Dairy Cattle: Ii. Effects On The Endometrial Transcriptome, Stefan Bauersachs, Constantine A. Simintiras, Roger G. Sturmey, Stefan Krebs, Jochen Bick, Helmut Blum, Eckhard Wolf, Pat Lonergan, Niamh Forde

Faculty Publications

The aim of this study was to test the hypothesis that the metabolic stresses associated with lactation alter the ability of the endometrium to respond appropriately to the conceptus by examining endometrial gene expression on day 19 of pregnancy. Immediately after calving, primiparous Holstein cows with similar production and fertility estimated breeding values were randomly divided into two groups and either dried off (i.e. never milked) immediately or milked twice daily. Approximately 65–75 days postpartum, grade 1 blastocysts recovered from superovulated Holstein heifer donors (n = 5) were transferred (1 per recipient) into lactating (n = 11) and nonlactating (n …