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“Vidas Virtuales, Memorias Postizas: Teorías De La Identidad Personal En Lágrimas En La Lluvia”, Dale J. Pratt

Alambique. Revista académica de ciencia ficción y fantasía / Jornal acadêmico de ficção científica e fantasía

“Vidas virtuales, memorias postizas: teorías de la identidad personal en Lágrimas en la lluvia”

En Lágrimas en la lluvia (2011) de Rosa Montero, mientras la detective tecnohumana Bruna Husky investiga un complot para exterminar los replicantes del Madrid del siglo XXII, se despliega un estudio profundo sobre qué es la identidad. Se presentan en la novela varias teorías de la identidad personal, con divergentes posturas sobre los estados mentales y emocionales, las memorias personales, la pervivencia corporal, la esencia espiritual y la posibilidad de la existencia del alma. Bruna paulatinamente llega a aceptar que su identidad surge de un …

Influence Of Two Ovulation-Inducing Agents On The Pituitary Response And Follicle Blood Flow In Mares, Y. L. Boakari, J. C. Ferreira, H. S. Canesin, D. L. Thompson, F. S. Lima, J. C.F. Pantoja, C. Meira

Faculty Publications

© 2017 The objective of the current study was to evaluate the effects of deslorelin and hCG, two ovulation-inducing therapies, on LH surge and follicle vascularity in mares. Thirty mares were either treated with 1.5 mg IM of deslorelin, 2,500 IU IV of hCG or 2 mL IM of NaCl 0.9% (GnRH, hCG and Saline groups, respectively). Power-flow Doppler examination and blood collection were performed every hour during the first 12 hours after treatment (H0) and every six hours between hours 12 (H12) and 30 (H30) after treatment. Moreover, endpoints were evaluated every hour through the last six hours before …

Design, Synthesis, And Biological Activity Of 5'-Phenyl-1,2,5,6-Tetrahydro-3,3'-Bipyridine Analogues As Potential Antagonists Of Nicotinic Acetylcholine Receptors, Yafei Jin, Xiaoqin Huang, Roger L. Papke, Emily M. Jutkiewicz, Hollis D Showalter, Chang-Guo Zhan

Pharmaceutical Sciences Faculty Publications

Starting from a known non-specific agonist (1) of nicotinic acetylcholine receptors (nAChRs), rationally guided structural-based design resulted in the discovery of a small series of 5′-phenyl-1,2,5,6-tetrahydro-3,3′-bipyridines (3a – 3e) incorporating a phenyl ring off the pyridine core of 1. The compounds were synthesized via successive Suzuki couplings on a suitably functionalized pyridine starting monomer 4 to append phenyl and pyridyl substituents off the 3- and 5-positions, respectively, and then make subsequent modifications on the flanking pyridyl ring to provide target compounds. Compound 3a is a novel antagonist which is highly selective for α3β4 nAChR (K_i = 123 nM) …

Loss Of Fructose-1,6-Bisphosphatase Induces Glycolysis And Promotes Apoptosis Resistance Of Cancer Stem-Like Cells: An Important Role In Hexavalent Chromium-Induced Carcinogenesis, Jin Dai, Yanli Ji, Wei Wang, Donghern Kim, Leonard Yenwong Fai, Lei Wang, Jia Luo, Zhuo Zhang

Toxicology and Cancer Biology Faculty Publications

Hexavalent chromium (Cr(VI)) compounds are confirmed human carcinogens for lung cancer. Our previous studies has demonstrated that chronic exposure of human bronchial epithelial BEAS-2B cells to low dose of Cr(VI) causes malignant cell transformation. The acquisition of cancer stem cell-like properties is involved in the initiation of cancers. The present study has observed that a small population of cancer stem-like cells (BEAS-2B-Cr-CSC) exists in the Cr(VI)-transformed cells (BEAS-2B-Cr). Those BEAS-2B-Cr-CSC exhibit extremely reduced capability of generating reactive oxygen species (ROS) and apoptosis resistance. BEAS-2B-Cr-CSC are metabolic inactive as evidenced by reductions in oxygen consumption, glucose uptake, ATP production, and lactate …

The 9th Conference On Metal Toxicity And Carcinogenesis: The Conference Overview, James T. F. Wise, Lei Wang, Zhuo Zhang, Xianglin Shi

Pharmacology and Nutritional Sciences Faculty Publications

Heavy metals, such as arsenic, chromium, cadmium, nickel, mercury, and uranium are known to cause many human diseases and health complications after occupational or environmental exposure. Consequently, metals are environmental health concerns. This manuscript is an overview of the 9th Conference on Metal Toxicity and Carcinogenesis held in October 2016 in Lexington, Kentucky. Since 2000, this biennial meeting brings together experts in the field to discuss current and prospective research in an effort to advance research pertaining to metal toxicity and carcinogenesis. In this review we summarize the major topics discussed and provide insight regarding current research in the field …

Gucy2c Signaling Opposes The Acute Radiation-Induced Gi Syndrome., Peng Li, Evan Wuthrick, Jeff A. Rappaport, Crystal Kraft, Jieru E. Lin, Glen Marszalowicz, Adam E. Snook, Tingting Zhan, Terry M. Hyslop, Scott A. Waldman

Department of Pharmacology and Experimental Therapeutics Faculty Papers

High doses of ionizing radiation induce acute damage to epithelial cells of the gastrointestinal (GI) tract, mediating toxicities restricting the therapeutic efficacy of radiation in cancer and morbidity and mortality in nuclear disasters. No approved prophylaxis or therapy exists for these toxicities, in part reflecting an incomplete understanding of mechanisms contributing to the acute radiation-induced GI syndrome (RIGS). Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury. Here, we reveal a role for the GUCY2C paracrine axis in compensatory mechanisms opposing RIGS. …

Impact Of Vitamin A And Carotenoids On The Risk Of Tuberculosis Progression, Omowunmi Aibana, Molly F Franke, Chuan-Chin Huang, Jerome T Galea, Roger Calderon, Zibiao Zhang, Mercedes C Becerra, Emily R Smith, Alayne G Ronnenberg, Carmen Contreras, Rosa Yataco, Leonid Lecca, Megan B Murray

Faculty, Staff and Student Publications

BACKGROUND: Low and deficient levels of vitamin A are common in low- and middle-income countries where tuberculosis burden is high. We assessed the impact of baseline levels of vitamin A and carotenoids on tuberculosis disease risk.

METHODS: We conducted a case-control study nested within a longitudinal cohort of household contacts (HHCs) of pulmonary tuberculosis case patients in Lima, Peru. We defined case patients as human immunodeficiency virus (HIV)-negative HHCs with blood samples in whom tuberculosis disease developed ≥15 days after enrollment of the index patient. For each case patient, we randomly selected 4 controls from among contacts in whom tuberculosis …

Posttranscriptional Regulation Of Parg Mrna By Hur Facilitates Dna Repair And Resistance To Parp Inhibitors, Saswati N. Chand, Mahsa Zarei, M. J. Schiewer, Akshay R. Sanan, Carmella Romeo, Shruti Lal, Joseph A. Cozzitorto, Avinoam Nevler, Laura Scolaro, Eric R. Londin, Wei Jiang, Nicole Meisner-Kober, Michael J. Pishvaian, Karen E. Knudsen, Charles Yeo, John M Pascal, Jordan M. Winter, Jonathan R. Brody

Department of Surgery Faculty Papers

The majority of pancreatic ductal adenocarcinomas (PDAC) rely on the mRNA stability factor HuR (ELAV-L1) to drive cancer growth and progression. Here, we show that CRISPR-Cas9–mediated silencing of the HuR locus increases the relative sensitivity of PDAC cells to PARP inhibitors (PARPi). PDAC cells treated with PARPi stimulated translocation of HuR from the nucleus to the cytoplasm, specifically promoting stabilization of a new target, poly (ADP-ribose) glycohydrolase (PARG) mRNA, by binding a unique sequence embedded in its 3⁰ untranslated region. HuR-dependent upregulation of PARG expression facilitated DNA repair via hydrolysis of polyADP-ribose on related repair proteins. Accordingly, strategies to …

Evidence For The Early Onset Of The Ipswichian Thermal Optimum: Palaeoecology Of Last Interglacial Deposits At Whittlesey, Eastern England, H Langford, S Boreham, Rm Briant, Gr Coope, Et Al

School of Geography, Earth and Environmental Sciences

Fossiliferous deposits infilling a channel at Whittlesey, eastern England, are dated by amino acid racemization to the Last Interglacial, and pollen analysis indicates deposition in Ipswichian biozones Ip Ib and Ip IIb. Multidisciplinary palaeoenvironmental analyses of these deposits provide a rare insight into Ip Ib subzone conditions. Specifically, the Ip Ib deposits contain exotic thermophiles Naias minor, Belgrandia marginata, Bembidion elongatum, Pelochares versicolor, Caccobius schreberi, Onthophagus massai and Emys orbicularis, usually associated with Ip IIb. Combined palaeotemperature reconstructions based on beetle, ostracod and vertebrate assemblages of the Ip Ib deposits indicate that summers (mean July range +19 to +22°C) were …

September 15, 2017, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Early Rearing History Influences Oxytocin Receptor Epigenetic Regulation In Rhesus Macaques, Maggie Baker, Stephen G. Lindell, Carlos A. Driscoll, Zhifeng Zhou, Qiaoping Yuan, Melanie L. Schwandt, Isaac Miller-Crews, Elizabeth A. Simpson, Annika Paukner, Pier Francesco Ferrari, Ravi Kumar Sindhu, Muslima Razaqya, Wolfgang H. Sommer, Juan F. Lopez, Robert C. Thompson, David Goldman, Markus Heilig, J. Dee Higley, Stephen J. Suomi, Christina S. Barr

Faculty Publications

Adaptations to stress can occur through epigenetic processes and may be a conduit for informing offspring of environmental challenge. We employed ChIP-sequencing for H3K4me3 to examine effects of early maternal deprivation (peer-rearing, PR) in archived rhesus macaque hippocampal samples (male, n = 13). Focusing on genes with roles in stress response and behavior, we assessed the effects of rearing on H3K4me3 binding by ANOVA. We found decreased H3K4me3 binding at genes critical to behavioral stress response, the most robust being the oxytocin receptor gene OXTR, for which we observed a corresponding decrease in RNA expression. Based on this finding, we …

Opening Reception: The Boy Who Lived: Harry Potter And The Culture Of Death, Suzie Asha Park

Twenty Years of Harry Potter: Celebrating a Phenomenon

As part of this exhibit opening and reception, a special musical program, "An Evening at Hogwarts," will be performed by the EIU Graduate/Faculty Brass Quintet, with members Jemmie Robertson, Andrew Cheetham, Ben Bruflat, Kevin Miescke, Eric Dawson and Jonathan Bowman. Light refreshments will be served.

Twenty years ago, readers became acquainted with Harry Potter, whose fame rests largely on being “the boy who lived.” J. K. Rowling’s epic series has invited millions of readers to reflect upon what it means to live by considering what it means to die. The condition of mortality is not what Harry needs simply to …

Chanticleer | September 14, 2017, Jacksonville State University

Chanticleer

No abstract provided.

Brief Of Amicus Curiae Fred T. Korematsu Center For Law And Equality In Support Of Appellant, Fred T. Korematsu Center For Law And Equality, Attorneys For Amicus Curiae

Fred T. Korematsu Center for Law and Equality

State of Washington v. Lares-Storms

Spartan Daily, September 14, 2017, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2017

Volume 149, Issue 10

Ua12/2/1 College Heights Herald, Vol. 93, No. 8, Wku Student Affairs

WKU Administration Documents

WKU campus newspaper reporting campus, athletic and Bowling Green, Kentucky news. This issue contains articles:

• Ziege, Nicole. Student Government Association to Fund Inaugural Pride Festival
• Austin, Emma. American Dreamer – Deferred Action for Childhood Arrivals, Immigration
• DeLetter, Emily. Second Tuesday Salons Focuses on Incarcerated Men, Songwriting
• Collins, Emma. Virtual Reality Event Focuses on Refugee Crisis – No Lost Generation
• Coyle, Cameron. Cage the Elephant Offers WKU Free Concert
• Eastham, Lillie. LGBTQ Groups Host Annual Ice Cream Social
• King, Jennifer. Editorial Cartoon re: Condoms
• Leonard, Nicole. The B Grade Women in the Public Eye: Sex Double Standards Impede Universal Respect
• Hovell, …

Transcript: The Boy Who Lived, Suzie Asha Park

Video and Documents - The Boy Who Lived: Harry Potter and the Culture of Death

No abstract provided.

Sex Differences In The Herding Styles Of Working Sheepdogs And Their Handlers, Erin Kydd, Paul Mcgreevy

Livestock and Working Dogs Collection

Working sheepdog trials test the attributes of dogs as well as the dogmanship and stockmanship skills of handlers. They generally include standard elements such as outrun, lift, fetch, drive, shed, pen and single to test all facets of the work that dogs perform on a farm. While both male and female handlers participate, these trials are traditionally dominated by male handlers. Both male and female dogs compete on equal terms within the same events. Drawing data from files (n = 60) downloaded from YouTube, the current study explores whether behaviours of dogs and their handlers during sheepdog trials differ between …

The Grizzly, September 14, 2017, Valerie Osborne, Courtney A. Duchene, Emily Jolly, Skyler L. Gailing, Emily Shue, Kevin Leon, Rachael Carter, David Mendelsohn, A. J. Cutrufello

Ursinus College Grizzly Newspaper, 1978 to Present

Three Workers Injured in IDC Construction Accident • Rush Week Comes Early This Year • Have You Seen Scene / Unseen? • Ursinus Welcomes a New AD to Main Street • A Fairy Tale in the English Department • Opinions: Trump's Move to End DACA is One of his Most Disgusting Acts Yet; Why Resident Advisers Could Benefit From a Union • Fresh Voice for UC Volleyball • Bears Beat Bison and Bullets for Hot Start to Season

Degree Of Twisting And Duration Of Symptoms Are Prognostic Factors Of Testis Salvage During Episodes Of Testicular Torsion, Adam S. Howe, Vinaya Vasudevan, Michael Kongnyuy, Kevin Rychik, Lisa A. Thomas, Maria Matuskova, Steven C. Friedman, Jordan S. Gitlin, Edward F. Reda, Lane S. Palmer

Publications and Research

Background: Testicular torsion is surgical emergency. Prompt diagnosis and treatment of testicular torsion is essential for testicular viability. At surgical exploration, the spermatic cord is seen twisted a variable number of times around its longitudinal axis. There is scant data regarding the degree of twisting and its association with testis outcomes. The purpose of our study is to explore how the degree of torsion factors into testicular outcome using follow-up data.

Methods: We retrospectively reviewed the records of adolescent males who presented with testicular torsion to our institution, looking at duration of pain symptoms, degree of torsion documented in the …

The Missouri Miner, September 14, 2017

The Missouri Miner Newspaper

No abstract provided.

El Agradecimiento De Una Madre Protectora, Rosa Montero

Alambique. Revista académica de ciencia ficción y fantasía / Jornal acadêmico de ficção científica e fantasía

No abstract provided.

Fischer V. Croston Appellant's Reply Brief Dckt. 44887

Idaho Supreme Court Records & Briefs, All

No abstract provided.

Hawks' Herald -- Sep. 14, 2017, Roger Williams University

Hawk's Herald

No abstract provided.

How Helpful Is Voluntary Stopping Of Eating And Drinking (Vsed) To Avoid Dementia?, Dena S. Davis

Seattle Journal for Social Justice

No abstract provided.

The Morality Of Superheroes: Gods No More, Jessica Testerman

The University Honors Program

Do you think a superhero is a god or a mortal?

Modern pop culture is saturated with superheroes; in fact, it feels like there is a new superhero movie every three months or so. Thus, it is no wonder that after being soaked in this culture of superheroes that act with impunity in worlds of their author’s creation that a someone should wonder at the morality of superheroes. In my work, I argue against the popular belief that anyone who acts “good” and has a superpower is a superhero.

I propose a new way of defining the superhero that removes …

Prevention Of Renal Apob Retention Is Protective Against Diabetic Nephropathy: Role Of Tgf-Β Inhibition, Patricia G. Wilson, Joel C. Thompson, Meghan S. Yoder, Richard Charnigo, Lisa R. Tannock

Internal Medicine Faculty Publications

Animal studies demonstrate that hyperlipidemia and renal lipid accumulation contribute to the pathogenesis of diabetic nephropathy (DN). We previously demonstrated that renal lipoproteins colocalize with biglycan, a renal proteoglycan. The purpose of this study was to determine whether prevention of renal lipid (apoB) accumulation attenuates DN. Biglycan-deficient and biglycan wild-type Ldlr^−/− mice were made diabetic via streptozotocin and fed a high cholesterol diet. As biglycan deficiency is associated with elevated transforming growth factor-β (TGF-β), in some experiments mice were injected with either the TGF-β-neutralizing antibody, 1D11, or with 13C4, an irrelevant control antibody. Biglycan deficiency had no significant effect …

Genomics Symposium: Translational Genomics To Improve Fertility Of Animals, M. A. Mirando

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

In 2010, the USDA National Institute of Food and Agriculture (NIFA) launched the Agriculture and Food Research Initiative (AFRI) Food Security Challenge Area program. The goal of this program was to support integrated research, extension, and education projects directed at increasing the agricultural production of plants and animals (Mirando et al., 2012) needed to feed a burgeoning global population that is expected to be almost 9.8 billion people by the year 2050 (United Nations, Department of Economic and Social Affairs, Population Division, 2017). One program area in the 2010 AFRI Food Security Challenge Area request for applications (RFA) focused on …

Vista: September 14, 2017, University Of San Diego

USD Vista (1965-)

No abstract provided.

The Chicken Or The Egg? Adaptation To Desiccation And Salinity Tolerance In A Lineage Of Water Beetles, Susana Pallarés, Paula Arribas, David T. Bilton, Andrés Millán, Josefa Velasco, Ignacio Ribera

School of Biological and Marine Sciences

No abstract provided.