Digital Commons Network^™

Regulation Of The Amyloid Precursor Protein By Prostaglandin J2, A Mediator Of Inflammation: Relevance To Alzheimer’S Disease, Teneka L. Jean-Louis

Dissertations, Theses, and Capstone Projects

Inflammation plays a major role in Alzheimer’s disease (AD). Investigating how specific mediators of inflammation contribute to neurodegeneration in AD is crucial. Our studies focused on cyclooxygenases, which are key enzymes in inflammation and highly relevant to AD. Cyclooxygenases (COX -1, constitutive; COX-2, inducible) have emerged as important determinants of AD pathogenesis and progression. COX-2 is highly induced in AD, correlating with AD severity, and COX-1 is also involved in AD. Cyclooxygenases are the rate-limiting enzymes that convert arachidonic acid into prostaglandins (PGs), the principal mediators of CNS neuroinflammation.

The overall GOAL of these studies was to address the mechanisms …

September 30, 2017 (Pages 6027-6164), Pennsylvania Legislative Reference Bureau

Volume 47 (2017)

No abstract provided.

The Role Of Pitx Proteins In Early Xenopus Development, Ye Jin

Dissertations, Theses, and Capstone Projects

Embryos of the African clawed frog Xenopus laevis are widely used for the study of early vertebrate development. The cement gland, which secrets mucus to help tadpoles attach to solid supports and live in relative safety, has long been used as a model to study the interplay between cell signaling pathways and transcription factors. It has been proposed that an intermediate level of Bone Morphogenetic Protein (BMP) signaling is essential for cement gland formation. In addition, several transcription factors have been linked to cement gland development. Among them, the homeodomain proteins Pitx1 and the closely related Pitx2c can generate ectopic …

Efikasi-Diri Siswa Pada Model Siklus Belajar 5e Terintegrasi Peer Instruction, Putri Dwi Sundari, Parno Parno, Sentot Kusairi

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

Self-efficacy is an aspect of self-regulation that supports individual success. Teachers must design appropriate learning to improve students' self-efficacy. The purpose of this study is to analyze students' self-efficacy on 5E learning cycle model integrated peer instruction. Mixed-method research with embedded experimental design was conducted to 33 students. Research instrument is self-efficacy questionnaire with reliability 0,95. Quantitative data on self-efficacy was analyzed using paired t-test, while qualitative data was analyzed by reduction results of student interviews. Results showed that students' self-efficacy improved after learning. Students have confidence in linking physics concepts with other concepts of science, investigating, and using physics …

Acute Maternal Oxidant Exposure Causes Susceptibility Of The Fetal Brain To Inflammation And Oxidative Stress, Feroz Akhtar, Christopher A. Rouse, Gabriel Catano, Marcus Montalvo, Sarah L. Ullevig, Reto Asmis, Kusum Kharbanda, Shivani K. Maffi

School of Medicine Publications

Background

Maternal exposure to environmental stressors poses a risk to fetal development. Oxidative stress (OS), microglia activation, and inflammation are three tightly linked mechanisms that emerge as a causal factor of neurodevelopmental anomalies associated with prenatal ethanol exposure. Antioxidants such as glutathione (GSH) and CuZnSOD are perturbed, and their manipulation provides evidence for neuroprotection. However, the cellular and molecular effects of GSH alteration in utero on fetal microglia activation and inflammation remain elusive.

Methods

Ethanol (EtOH) (2.5 g/kg) was administered to pregnant mice at gestational days 16–17. One hour prior to ethanol treatment, N-acetylcysteine (NAC) and L-buthionine sulfoximine (BSO) …

Use Of Gene Editing In Usda Research, Mark R. Mclellan, Patsy Brannon, Adriana Campa, Carrie Castille, Steven Daley-Laursen, Roch Gaussoin, Govind Kannan, Mark Lawrence, Dawn Thilmany

Biology Faculty Publications and Presentations

The Science Advisory Council was established in FY2016 as a subcommittee of the National Agricultural Research, Extension, Education, and Economics (NAREEE) Advisory Board by the Chief Scientist as a result of recommendations from the 2012 report on Agricultural Preparedness by the President’s Council of Advisors on Science and Technology. The Council's charge is to provide advice and guidance, on a scientific basis, on the overall strength, practicality, and direction of agricultural research, including emerging technology and scientific issues and report any findings publicly to the NAREEE Advisory Board.

The USDA Chief Scientist first asked the Council to examine rigor and …

Women’S Sexual Fantasies In Context: The Emotional Content Of Sexual Fantasies, Psychological And Interpersonal Distress, And Satisfaction In Romantic Relationships, Sarah Constantine

Dissertations, Theses, and Capstone Projects

Background: Psychoanalytic thinkers propose that aspects of an individual’s sexual fantasies are related to her psychological and interpersonal functioning. The present study aims to elucidate the significance of sexual fantasies with respect to women’s emotional and interpersonal lives. The study evaluated a model, which hypothesized that internal representations of self and others (e.g. attachment security, maturity of object relations) along with psychological and interpersonal factors would predict both the emotional content (guilt, fear, affection) of written sexual fantasy narratives, and overall romantic satisfaction in heterosexual women. Methods: Five hundred and thirty four women completed self-report questionnaires online. Subsequently, the sexual …

A Conceptualization Of The Body In Psychodynamic And Body-Based Psychotherapies: Areas Of Overlap And Possibilities For Integration, Aleksandra Rayska

Dissertations, Theses, and Capstone Projects

The distinction between verbal and nonverbal psychotherapies is clearly visible in theory and clinical practice. Moreover, this duality of approaches promotes a split between the body and the mind, defining them as separate from each other. This dissertation helps bridge the divide between the literature in body-based therapies and verbally-based psychotherapy by (i) exploring the conceptual frame used to understand the body in psychodynamic therapy (ii) identifying the areas of overlap between psychodynamic theory and theories that underlie body-based psychotherapies, and (iii) proposing ways in which psychodynamic and body-based theories can inform one another. A clinical case was used to …

Posthumanist Animals In Art: France And Belgium, 1972-87, Arnaud Gerspacher

Dissertations, Theses, and Capstone Projects

This dissertation traces the changing role and increased importance of nonhuman animals in art of the 1970s and 80s. Focused largely on artists in France and Belgium, this period stands at the head of a wide-ranging re-conceptualization of animality that continues to unfold today. Pivotal moments in ecology (beginning with the 1972 United Nations Conference on the Human Environment in Stockholm), animal ethics and ethology (such as the Universal Declaration of Animal Rights proclaimed in 1978), and philosophy (specifically the biopolitical and deconstructive currents critiquing the centrality of the humanist subject), all converge as stress points along long held anthropocentric …

Who Influences Your Outcomes? The Effect Of Culture And Ethnic Origin, Neighborhood And Peers On Personal Income: A Spatial Econometric Analysis Of New York City, Anna Arakelyan

Dissertations, Theses, and Capstone Projects

Being a “social animal”, each person is inherently embedded into a complex structure of social relations. He has role models to aspire to, conformity rules to follow, and expectations to meet. This paper explores the different social influences each person experiences in life. Specifically, I consider how a person’s ethnic community, age reference group, occupational and industry group peers, and residential area neighbors affect his total income. I introduce a novel model of multiple social networks and discuss various identification implications. I apply the model empirically to New York City, which naturally is a very favorable environment to test for …

Dinosaurs For The Digital Age: Democratic Party Organization In The Twenty-First Century, Aaron B. Shapiro

Dissertations, Theses, and Capstone Projects

This dissertation traces Democratic Party organization roughly over the Obama era. It conceptualizes the party at the national, state, and local level, with a particular focus on Ohio. This project seeks to reconcile changes in the political environment that incentivize strengthening party structures, with American electoral institutions that complicate party organizational development. I suggest that while demographic change, polarization, and big data are powerful incentives to focus Democratic electoral strategy on an Obama-like organizational model and campaign strategy, institutionalization remains hampered by significant structural impediments. These are institutional as well as coalitional. While party integration has been uneven, I find …

Examining The Concurrent And Predictive Relations Of Working Memory In Childhood Attention-Deficit/Hyperactivity Disorder, Ashley N. Simone

Dissertations, Theses, and Capstone Projects

Attention-deficit/Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder characterized by developmentally inappropriate levels of inattention and/or hyperactivity/impulsivity which lead to impairment in multiple settings (American Psychiatric Association, 2013). Childhood ADHD has been concurrently associated with various neurocognitive deficits and one in particular that has been under examination over the past several years is working memory (WM). WM is a temporary storage system that is responsible for maintenance and/or manipulation of information in order to complete complex cognitive and behavioral tasks. Researchers have postulated that WM is one of several potential endophenotypes of ADHD (Castellanos & Tannock, 2002) and/or that WM is …

Pharmacological Antagonism And The Olfactory Code, Mihwa Na

Dissertations, Theses, and Capstone Projects

Mammals can detect and discriminate uncountable odors through their odorant receptors. To accommodate the countless and diverse odors, exceptionally large numbers of odorant receptor (OR) genes are expressed in mammals. In addition, the mammals utilize a combinatorial code, where an odorant molecule can activate multiple ORs; an OR also responds to a set of multiple odorants. In nature, an odor is often a complex mixture of multiple odorant molecules. The combination of the ORs activated by each constituent generates the unique olfactory code for the particular odor.

Some odorants can antagonize select ORs, as discussed in Chapter 1. An antagonist …

First Opinion: Honoring Diversity, Visual Storytelling, And Complex Friendships: Cece Bell’S El Deafo, Gretchen Papazian

First Opinions, Second Reactions

No abstract provided.

Número 114: Domingo 6 De Septiembre De 2009-Domingo 27 De Septiembre De 2009

Estudios Exégeticos Homiléticos

Domingo 6 de Septiembre de 2009

Sal 146; Is 35:4-7; Stg 2:1‑17; Mc 7:24‑37

Domingo 13 de Septiembre de 2009

Sal 116:1-8; Is 50:4-9; Stg 3:1‑12; Mc 8:27‑38

Domingo 20 de Septiembre de 2009

Sal 54; Jer 11:11-18; Stg 3:13‑4:3.7‑8; Mc 9:30‑37

Domingo 27 de Septiembre de 2009

Sal 19:7-14; Num 11:4-6.10-16.24-29; Stg 5:13-20; Mc 9:38-50

Número 113: Domingo 2 De Agosto De 2009-Domingo 30 De Agosto De 2009

Estudios Exégeticos Homiléticos

Domingo 2 de Agosto de 2009

Sal 78:23-29; Ex 16:2-15; Ef 4:1‑16; Jn 6:24‑35.

Domingo 9 de Agosto de 2009

Sal 34:1-8; 34:1-8; 1 Re 19:4-8; Ef 4:25 a 5:2; ó 4:30-5:2; Jn 6:35.41-51

Domingo 16 de Agosto de 2009

Los textos para este domingo fueron tratados en los siguientes EEH:

Sal 34:9-14 EEH 41, 17 de agosto de 2003.

Ef 5:15‑20 EEH 5, 20 de agosto de 2000.

Jn 6:51‑58 EEH 77, 20 de Agosto de 2006.

Domingo 23 de Agosto de 2009

Sal 34:15-22; Jos 24:1-2; 14-18; Ef 6:10‑20; Jn 6:56‑69

Domingo 30 de Agosto …

Número 108: 1.ᵉʳ Domingo De Cuaresma-3.º Domingo De Cuaresma

Estudios Exégeticos Homiléticos

Domingo 1 de marzo de 2009, Primer domingo de cuaresma

Gén 9:8‑17 (EEH 72, 5 de marzo de 2006); 1P 3:18‑22 (EEH 62, 1 de mayo de 2005); Mc 1:9‑15 (EEH 36, 9 de marzo de 2003).

Domingo 8 de marzo de 2009, Segundo domingo de Cuaresma

Sal 22:22-31 (EEH 49, 9 de abril de 2004; EEH 74, 14 de mayo de 2006).

Gén 17:1‑7, 15‑16; (EEH 72, 12 de marzo de 2006); Ro 4:13‑25; (EEH 63, 5 de junio de 2005); Mc 8:31‑38 (EEH 36, 16 de marzo de 2003).

15 de marzo de 2009, Tercer domingo de Cuaresma …

Potentiating Tumor Immunity Using Aptamer-Targeted Rnai To Render Cd8+ T Cells Resistant To Tgfβ Inhibition, Yvonne A. Puplampu-Dove

Open Access Dissertations

Cancer is one of the leading causes of death in the world. Current treatments for cancer include chemotherapy, radiation therapy, surgery, immunotherapy and transplantation. While these treatments seem successful in some cases, they fail to provide long-term protection. Chemotherapy and radiation therapy lack specificity whereas immunotherapy, although it has the specificity is not very effective due to the ability of cancer cells to invade the host immune system. Over the years, many tumors have developed ways to prevent or escape their immune-based elimination. Therefore, counteracting tumor-associated (derived) immune suppression represents a potential platform for therapeutic intervention. A key mediator of …

The Chanticleer, 2017-09-29, Coastal Carolina University

The Chanticleer Student Newspaper

The editorially independent student produced weekly newspaper of Coastal Carolina University.

A5: Grafton Notch State Park: Glacial Gorges And Streams Under Pressure In The Mahoosic Range, Maine, Alice M. Doughty, Woodrow B. Thompson

New England Intercollegiate Geological Conference 2017

Guidebook for field trips in Western Maine and Northern New Hampshire: New England Intercollegiate Geological Conference, p. 95-104.

The Echo: September 29, 2017, Taylor University

2017-2018 (Volume 105)

Giving children that extra Lift – Upland receives road grant from state – Townies and Trojan series – Taylor CAREs – The learning curve – New paws on the block: (wo)man’s best friend – Steps toward boldness – Markets & mochas – What goes around, comes around – United under the same moon – Brecken’s Breakdown – Echograms #TaylorU -- #TaylorU’s Top Tweets – ‘Clybourne Park’ – Building and tearing down perspectives, old and new – Weaving together two stories – The faces of ‘Clybourne Park’ – Incorporating ‘Clybourne Park’ into Christian thought – The world of ‘Clybourne Park’ – …

Hacking Academic Collaboration With Glam Edit-A-Thons, Rebecca Thorndike-Breeze, Greta Kuriger Suiter

WikiStudies

GLAM edit-a-thons can enhance the presence of underrepresented groups and topics on Wikipedia, and by sharing valuable cultural holdings these events can also foster the public’s cultural awareness. And when university students and faculty are invited to these events, the impact can be even greater. Scholars in the fields of library science and writing studies have shown that Wikipedia’s collaborative composition model supports key learning goals for students, including collaboration, information literacy, and critical thinking about knowledge creation. At MIT, librarians, archivists, writing instructors, and local Wikipedians have collaborated to host several edit-a-thons with the common goals of addressing content …

Torrefaction Kinetics Of Hemp Hurds, An Emerging Agricultural Byproduct, In A Small Retort, Tel Jensen

Civil and Environmental Engineering Undergraduate Honors Theses

As knowledge concerning the consequences of unsustainable energy sources and agricultural practices grows, development of low-impact alternatives to both becomes more important. Sustainable sources of biomass offer solutions to both problems. This study characterized the reaction kinetics of torrefying an agricultural byproduct, the woody interior of hemp stems, or hurds. Torrefaction was carried out at 250 °C in small and simple retorts made of galvanized steel pipe. A first-order model most closely approximated the reaction. A sensitivity analysis was performed and the data was adjusted to correct for three potential sources of error, and regressed to find the best fit …

The Scarlet - September 29, 2017, Scarlet Staff

The Scarlet (Student Newspaper) (2011-present)

The September 29, 2017 edition of The Scarlet (est. 1939), Clark University's student-run newspaper. The Scarlet is intellectually and editorially independent of the University.

Alicia Hatfield V. Amanda Berube

2017 Decisions

USDC for the Western District of Pennsylvania

Assessment Of Human Adipose Tissue Microvascular Function Using Videomicroscopy, Melissa G. Farb, Song-Young Park, Shakun Karki, Noyan Gokce

Health and Kinesiology Faculty Publications

While obesity is closely linked to the development of metabolic and cardiovascular disease, little is known about mechanisms that govern these processes. It is hypothesized that pro-atherogenic mediators released from fat tissues particularly in association with central/visceral adiposity may promote pathogenic vascular changes locally and systemically, and the notion that cardiovascular disease may be the consequence of adipose tissue dysfunction continues to evolve. Here, we describe a unique method of videomicroscopy that involves analysis of vasodilator and vasoconstrictor responses of intact small human arterioles removed from the adipose depot of living human subjects. Videomicroscopy is used to examine functional properties …

The Parthenon, September 29, 2017, Jared Casto

The Parthenon

The Parthenon, Marshall University’s student newspaper, was published by students Monday through Friday during the regular semester and weekly on Thursdays during the summer. Due to budgetary constraints, beginning with the 2016 Fall semester, the newspaper is only published two days a week. Physical issues are printed on Tuesdays and Fridays. The editorial staff is responsible for the news and the editorial content.

Two New Genera And Species Of Tiger Beetles From Baltic Amber (Coleoptera: Carabidae: Cicindelinae), Jürgen Wiesner, Kipling Will, Joachim Schmidt

Insecta Mundi

Two fossil tiger beetle species (Coleoptera, Carabidae, Cicindelinae) are described from Eocene Baltic amber using light microscopic and X-ray microscopic techniques. Both species are considered representatives of the subtribe Iresina Rivalier, 1971 due to the shared combination of character states: glabrous head, six labral and four suborbital setae, and glabrous pronotum. Palaeopronyssiformia groehni Wiesner, Will, and Schmidt, new genus, new species, is characterized by a glabrous and furrowed head with six labral setae, large eyes, presence of two supraorbital setae on each side, mandibles with two teeth of the incisor region, and a glabrous and furrowed pronotum. Palaeoiresina cassolai Wiesner, …

Angptl4 Promotes The Progression Of Cutaneous Melanoma To Brain Metastasis., Sivan Izraely, Shlomit Ben-Menachem, Orit Sagi-Assif, Tsipi Meshel, Diego M Marzese, Shuichi Ohe, Inna Zubrilov, Metsada Pasmanik-Chor, Dave S B Hoon, Isaac P Witz

Articles, Abstracts, and Reports

In an ongoing effort to identify molecular determinants regulating melanoma brain metastasis, we previously identified Angiopoietin-like 4 (ANGPTL4) as a component of the molecular signature of such metastases. The aim of this study was to determine the functional significance of ANGPTL4 in the shaping of melanoma malignancy phenotype, especially in the establishment of brain metastasis. We confirmed that ANGPTL4 expression is significantly higher in cells metastasizing to the brain than in cells from the cutaneous (local) tumor from the same melanoma in a nude mouse xenograft model, and also in paired clinical specimens of melanoma metastases than in primary melanomas …

Richard Roy Interview, Wright State University Class Of 1970, Richard Roy, Chris Wydman

Wright State University Retirees Association Oral History Project

On September 29, 2017, Chris Wydman interviewed Richard Roy (Class of 1970) about his experiences as a founding member of the Beta Phi Omega fraternity during Wright State University’s early years . Roy discusses campus independence in 1967, the development of Greek life traditions, student government, and responses to national unrest including Kent State and Vietnam War protests. The interview highlights the formative culture and community of Wright State’s first generation of students.