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Sexuality And Spinal Cord Injury: A Manual For Occupational Therapists In The Inpatient Rehabilitation Setting, Courtney Jacobson, Esada Mujcic

Occupational Therapy Capstones

The topic of sexuality has not been addressed in its entirety within the profession of occupational therapy and has been identified by patients as a need in order to receive comprehensive and holistic care (New, Seddon, Redpath, Currie, and Warren, 2016). More specifically, with 12,500 new cases of spinal cord injury (SCI) that occur each year, in addition to the significant impact on body functions that result from SCI, the topic of sexuality needs particular attention with this population (National Spinal Cord Injury Statistical Center, 2015). The purpose of this scholarly project was to create a manual supported by literature …

Road To Recovery: An Online Guide To Prepare Parents Of Children Who Have Sustained A Major Burn Injury For Successful Home And Community Transition, Michelle Jones, Chad Oppegaard

Occupational Therapy Capstones

Children are the most vulnerable population and represent the highest rate of nonfatal burns resulting in prolonged hospitalization, disfigurement, and disability. These injuries can be a severely stressful experience for children and their families. As a result, it is important for the patient and family members to not focus only on immediate treatment, but recognize the importance of long-term care following discharge in order to effectively reintegrate the child back into the home and community.

A literature review was conducted to investigate the key components of burn care throughout the duration of recovery. Research identified that many parents feel helpless, …

Anti-Proliferative Role Of Recombinant Lethal Toxin Of Bacillus Anthracis On Primary Mammary Ductal Carcinoma Cells Revealing Its Therapeutic Potential, Rekha Khandia, Bramhadev Pattnaik, Katherikamem Rajukumar, Atul Pateriya, Sandeep Bhatia, Harshad Murugkar, Anil Prakash, Hare Krishna Pradhan, Kildeep Dhama, Ashol Munjal, Sunil K. Joshi

Bioelectrics Publications

Bacillus anthracis secretes three secretary proteins; lethal factor (LF), protective antigen (PA) and edema factor (EF). The LF has ability to check proliferation of mammary tumors, chiefly depending on mitogen activated protein kinase (MAPK) signaling pathway. Evaluation of therapeutic potential of recombinant LF (rLF), recombinant PA (rPA) and lethal toxin (rLF + rPA = LeTx) on the primary mammary ductal carcinoma cells revealed significant (p < 0.01) reduction in proliferation of tumor cells with mean inhibition indices of 28.0 ±1.37% and 19.6 ± 1.47% respectively. However, treatment with rPA alone had no significant anti-proliferative effect as evident by low mean inhibition index of 3.4 ± 3.87%. The higher inhibition index observed for rLF alone as compared to LeTx is contrary to the existing knowledge on LF, which explains the requirement of PA dependent endocytosis for its enzymatic activity. Therefore, the plausible existence of PA independent mode of action of LF including direct receptor mediated endocytosis or modulation of signal transduction cascade via unknown means is hypothesized. In silico protein docking analysis of other cellular receptors for any plausibility to play the role of receptor for LF revealed c-Met receptor showing strongest affinity for LF (H bond = 19; Free energy = …

Pd-1, Pd-L1 (B7-H1) And Tumor-Site Immune Modulation Therapy: The Historical Perspective, J Wang, R Yuan, W Song, J Sun, Delong Liu, Z Li

NYMC Faculty Publications

The current success of targeted inhibition against cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and Programmed Death 1/Programmed Death Ligand 1 (PD-1/PD-L1, herein collectively referred to as PD) pathways is hailed as a cancer immunotherapy breakthrough. PD-L1, known also as B7 homolog 1 (B7-H1), was initially discovered by Dr. Lieping Chen in 1999. To recognize the seminal contributions by Chen to the development of PD-directed therapy against cancer, the Chinese American Hematologist and Oncologist Network (CAHON) decided to honor him with its inaugural Lifetime Achievement Award in Hematology and Oncology at the CAHON's 2015 annual meeting. This essay chronicles the important discoveries …

Tracking The Amphibian Pathogens Batrachochytrium Dendrobatidis And Batrachochytrium Salamandrivorans Using A Highly Specific Monoclonal Antibody And Lateral-Flow Technology, Michael J. Dillon, Andrew E. Bowkett, Michael J. Bungard, Katie M. Beckman, Michelle F. O'Brien, Kieran Bates, Matthew C. Fisher, Jamie R. Stevens, Christopher R. Thornton

Peninsula Medical School

The fungus Batrachochytrium dendrobatidis (Bd) causes chytridiomycosis, a lethal epizootic disease of amphibians. Rapid identification of the pathogen and biosecurity is essential to prevent its spread, but current laboratory-based tests are time-consuming and require specialist equipment. Here, we describe the generation of an IgM monoclonal antibody (mAb), 5C4, specific to Bd as well as the related salamander and newt pathogen Batrachochytrium salamandrivorans (Bsal). The mAb, which binds to a glycoprotein antigen present on the surface of zoospores, sporangia and zoosporangia, was used to develop a lateral-flow assay (LFA) for rapid (15 min) detection of the pathogens. The LFA detects known …

Suppression Of Mapk11 Or Hipk3 Reduces Mutant Huntingtin Levels In Huntington's Disease Models, Meng Yu, Yuhua Fu, Yijiang Liang, Haikun Song, Y Yao, Peng Wu, Y Yao, Yuyin Pan, Xue Wen, Lixiang Ma, Saiyin Hexige, Yu Ding, Shouqing Luo, Boxun Lu

Peninsula Medical School

No abstract provided.

Pathophysiology Of Chronic Subdural Haematoma: Inflammation, Angiogenesis And Implications For Pharmacotherapy, Ellie Edlmann, Susan Giorgi-Coll, Peter C. Whitfield, Keri L.H. Carpenter, Peter J. Hutchinson

Peninsula Medical School

No abstract provided.

The Semiotics Of Minority Language Branding: A Study Of The Celtic Languages, J Tredinnick-Rowe

Peninsula Medical School

This paper investigates the role of minority language commodification in alcoholic drinks' branding, with a specific focus on Celtic languages and a particular emphasis on Cornish. The topic is introduced by exploring the ongoing and significant connection between language, culture and food, taking phrases and rhymes from historical sources and comparing their use. The aim is to establish cross-disciplinary synergies between semiotics and cultural analysis and to shed new light on marketing issues in the alcoholic drinks sector. The methodology section features the first ever analysis of alcoholic drinks' labels from four Celtic national minorities (N = 1.937) that illustrates …

Time Related Effects On Functional Brain Connectivity After Serotonergic And Cholinergic Neuromodulation, Bernadet L. Klaassens, Serge A. Rombouts, Anderson M. Winkler, Helene C. Van Gorsel, Jeroen Van Der Grond, Joop M A Van Gerven

School of Medicine Publications

Psychopharmacological research, if properly designed, may offer insight into both timing and area of effect, increasing our understanding of the brain's neurotransmitter systems. For that purpose, the acute influence of the selective serotonin reuptake inhibitor citalopram (30 mg) and the acetylcholinesterase inhibitor galantamine (8 mg) was repeatedly measured in 12 healthy young volunteers with resting state functional magnetic resonance imaging (RS-fMRI). Eighteen RS-fMRI scans were acquired per subject during this randomized, double blind, placebo-controlled, crossover study. Within-group comparisons of voxelwise functional connectivity with 10 functional networks were examined (P < 0.05, FWE-corrected) using a non-parametric multivariate approach with cerebrospinal fluid, white matter, heart rate, and baseline measurements as covariates. Although both compounds did not change cognitive performance on several tests, significant effects were found on connectivity with multiple resting state networks. Serotonergic stimulation primarily reduced connectivity with the sensorimotor network and structures that are related to self-referential mechanisms, whereas galantamine affected networks and regions that are more involved in learning, memory, and visual perception and processing. These results are consistent with the serotonergic and cholinergic trajectories and their functional relevance. In addition, this study demonstrates the power of using repeated measures after drug administration, which offers the chance to explore both combined and time specific effects. Hum Brain Mapp 38:308-325, 2017. © 2016 Wiley Periodicals, Inc.

Autocrine And Paracrine Secretion Of Vascular Endothelial Growth Factor In The Pre-Hypoxic Diabetic Retina, Jeffery G. Grigsby, Donald M. Allen, Ana S. Ferrigno, Sandeep Vellanki, Cindy E. Pouw, Whitney A. Hejny, Andrew Tsin

School of Medicine Publications

Vascular endothelial growth factor (VEGF) is well established as the main agent responsible for vascular leakage and angiogenesis in the diabetic retina. While VEGF can have positive effects on hyperglycemia stressed retinal tissues, it also plays a role in events progressing to the oxygen- stressed, i.e. hypoxic, diabetic retina. Some VEGF makes its way to the retina from systemic sources and some is produced locally within the eye. Hyperglycemia, oxidants, inflammation, and advanced glycation end-products are all stimulants to VEGF production, both in the hypoxic and the pre-hypoxic retina. Endothelial cells, pericytes, Müller cells, microglia, astrocytes, retinal pigment epithelium and …

The 2016 "White Paper On German Security Policy And The Future Of The Bundeswehr": An Analysis Of Its Positioning, Reception, And Conditions Of Implementation, Hunter Lee Ashburn

CMC Senior Theses

This study examines the new German 2016 White Paper on German Security Policy and the Future of the Bundeswehr. Updated for the first time in over a decade, the document reflects Germany’s reorientation of its security policy in order to become a global player. This study analyzes the White Paper to determine its contextual meaning, domestic as well as international support, and obstacles in the way of its implementation. Although the German Government is concerned about waning US influence and increased Russian activity, the German people are reluctant to let go of their nation’s foreign political restraint in light of …

The Giving Tree Academy, David A. Hurdle

CMC Senior Theses

A proposal for a new preschool based in Pomona, California, targeted towards children from low-income backgrounds. Includes extensive research on preschool nationwide, the state of California, and in Pomona. Within the paper a new preschool curriculum and specific teacher practices are discussed. Intended as a model for a new school. or to be adapted for use in educational policy.

The Politics Of Head Start, The Most Popular Survivor Of The War On Poverty, Grace Lee

CMC Senior Theses

Head Start began in 1965 as a part of the War on Poverty led by President Lyndon B. Johnson. After more than 50 years, it has remained as one of the most popular government social programs with support from across the political spectrum. However, there have been mixed results regarding the effectiveness of Head Start in participants' educational gains. Despite the mixed research, Head Start has continued to receive support by the public and both political parties throughout the decades. While there are disagreements on reforms to be made to Head Start, there has been increasing agreement around making providers …

Are Oil Prices Important To U.S. Manufacturers?, Austin Perez Schoff

CMC Senior Theses

Very little has been written about the effect that oil prices have on manufacturing output in the United States. This paper aims to shed light about the effect of oil prices, oil imports, and GDP on U.S. manufacturing output through a four-variable vector autoregression and explain the timing of these shocks through impulse response functions. Empirical results find that oil prices are significant in determining manufacturing output, but manufacturing output is also significant in determining oil prices.

The Myth Of Persephone: Body Objectification From Ancient To Modern, Melanie Daifotis

CMC Senior Theses

Implications surrounding body ownership prove to be an enduring struggle from their prevalence in ancient literary sources through more modern, contemporary works. I analyze the notions of body ownership and its lack thereof set forth in Ovid’s Metamorphoses and the Homeric “Hymn to Demeter” regarding the myth of Persephone. Then, I consider larger meanings through analysis of the following contemporary works, approached in terms of the narrators: Rita Dove’s Mother Love, Louise Glück’s Averno, A.E. Stallings’s “Hades Welcomes His Bride” and “Persephone Writes a Letter to Her Mother,” and D.M. Thomas’s “Pomegranate.”

The complexities within the myth itself …

Assigning Liability In An Autonomous World, Agni Sharma

CMC Senior Theses

Liability laws currently in use rely on a fault-based system that focuses on a causal connection between driver actions and the resulting road accident. The role of the driver is set to reduce with the emergence of autonomous vehicles, so how will liability adapt to meet the needs of an autonomous world? The paper discusses possible frameworks of liability that could be implemented in the future, and accentuates the importance of the causal aspects of the current framework in the new system.

An Explanation Of John Rawls's Theory Of Justice With A Defense Of The Veil Of Ignorance, Alex Miele

CMC Senior Theses

John Rawls was a political philosopher who proposed a theory centered around the idea of justice as fairness. His primary concern was social justice, so more specifically, he proposed a basic structure for society that ensures major social institutions like the government fairly distribute fundamental rights and duties and optimally divide advantages brought about by social cooperation. His theory is based on the idea that the correct principles to use for the basic structure of society are those that free and rational people would agree to in attempt to advance their own self-interest from a fair and equal starting position. …

The Role Of The Dosage Compensation Complex As A Pathway For Spiroplasma To Induce Male Lethality In Drosophila Melanogaster, Becky Cheng

CMC Senior Theses

Drosophila melanogaster and many other insects harbor intracellular bacterial symbionts that are transmitted vertically from infected host mothers to their offspring. Many of these bacteria alter host reproductive developmental processes in order to increase their transmission success. For example, Spiroplasma, a spirochete that naturally infects D. melanogaster, selectively kills males during mid-embryogenesis while sparing females. Previous studies suggested that Spiroplasma interacts genetically with the male-specific dosage compensation pathway, which causes ~2-fold up-regulation of most genes located on the male’s single X chromosome so that their expression matches the levels found in females who have two Xs. To further …

Institutional Development: Interpreting The Russian Case, Joshua W. Rooney

CMC Senior Theses

A fundamental question to both historians and development economists is why countries today are able to reach and maintain such starkly different economic outcomes. Popular explanations include geographic and climatological features, short-term policy decisions, and economic institutions. This paper looks at the importance of violence and social pressure in the transformation and conservation of political and economic institutions in Russia. It finds that several major historical legacies including serfdom, Mongol dominance, Orthodoxy, and authoritarianism significantly influence both the past a present institutional setting. Furthermore, such legacies have proven to be major obstructions to the emergence of economic liberalism.

Triple Non-Negative Matrix Factorization Technique For Sentiment Analysis And Topic Modeling, Alexander A. Waggoner

CMC Senior Theses

Topic modeling refers to the process of algorithmically sorting documents into categories based on some common relationship between the documents. This common relationship between the documents is considered the “topic” of the documents. Sentiment analysis refers to the process of algorithmically sorting a document into a positive or negative category depending whether this document expresses a positive or negative opinion on its respective topic. In this paper, I consider the open problem of document classification into a topic category, as well as a sentiment category. This has a direct application to the retail industry where companies may want to scour …

Reader's Guide: A Foray Into Violence, Trauma And Masculinity In In Our Time, Sara-Rose Beatriz Bockian

CMC Senior Theses

Modernism has been called “a reaction to the carnage and disillusionment of the First World War and a search for a new mode of art that would rescue civilization from its state of crisis after the war” (Lewis, 109) Hemingway attempts this rescue by re-thinking aspects of the novel that were taken for granted in earlier periods, just as the conventions of modern life were taken for granted pre-WWI. Furthermore, his work tries to rectify the dissonance between a pre and post-war self through the exploration of social conventions relating to violence, trauma and masculinity.

Neural Learning And Kalman Filtering Enhanced Teaching By Demonstration For A Baxter Robot, Chunxu Li, Chenguang Yang, Jian Wan, Andy Annamalai, Angelo Cangelosi

School of Engineering, Computing and Mathematics

No abstract provided.

Impact Of Push-Pull Technology On The Nutritional Status Of Farmers' Children In Western Kenya, Nicholas O. Ogot, J. O. Pittchar, C. A.O. Midega, Z. R. Khan

All Peer-Reviewed Publications

This study examined the impact of push-pull technology (PPT) on the nutritional status of children aged 1-12 years. Non-push-pull (NPPT) farmers were used as a control group to establish a comparative model for this study. It determined household production, consumption, and surpluses, comparing the PPT adopters to the nonadopters; found out the incomes and food expenditures from farm products; found out the household dietary diversity scores; and finally found the nutritional status of the two household groups. A six faceted household-level metrics was employed. A sample of 216 households that registered 326 children was derived. This study was conducted in …

It's Not Black And White: An Empirical Study Of The 2015-2016 U.S. College Protests, Kaitlyn Anne Kelleher

CMC Senior Theses

Beginning in October 2015, student protests erupted at many U.S. colleges and universities. This wave of demonstrations prompted an ongoing national debate over the following question: what caused this activism? Leveraging existing theoretical explanations, this paper attempts to answer this question through an empirical study of the 73 most prominent college protests from October 2015 to April 2016. I use an original data set with information collected from U.S. News and World Report to determine what factors at these 73 schools were most predictive of the protests.

My findings strongly suggest that the probability of a protest increases at …

An Introduction To The Theory And Applications Of Bayesian Networks, Anant Jaitha

CMC Senior Theses

Bayesian networks are a means to study data. A Bayesian network gives structure to data by creating a graphical system to model the data. It then develops probability distributions over these variables. It explores variables in the problem space and examines the probability distributions related to those variables. It conducts statistical inference over those probability distributions to draw meaning from them. They are good means to explore a large set of data efficiently to make inferences. There are a number of real world applications that already exist and are being actively researched. This paper discusses the theory and applications of …

Molecular Modeling Of Novel Tryptamine Analogs With Antibiotic Potential Through Their Inhibition Of Tryptophan Synthase, Jared Schattenkerk

CMC Senior Theses

The growing prevalence of antibiotic-resistant bacteria is a global health crisis that threatens the effectiveness of antibiotics in medical treatment. Increases in the number of antibiotic-resistant bacteria and a drop in the pharmaceutical development of novel antibiotics have combined to form a situation that is rapidly increasing the likelihood of a post-antibiotic era. The development of antibiotics with novel enzymatic targets is critical to stall this growing crisis. In silico methods of molecular modeling and drug design were utilized in the development of novel tryptamine analogs as potential antibiotics through their inhibition of the bacterial enzyme tryptophan synthase. Following the …

The Internet, Aesthetic Experience, And Liminality, Stephanie Laface

CMC Senior Theses

This work analyzes the transitional activities and experiences that are inherent to accessing and navigating the Internet. Under established anthropological fieldwork of liminality theory by Victor Turner, as well as John Dewey's claims in experiential aesthetic theory, aesthetic experiences of the Internet are characterized. This paper concludes that such internet experiences abide by liminal thresholds and therefore comprise aesthetic distinction and significance. While Dewian aesthetics can only characterize this aesthetic distinction to a certain degree, Blanka Domagalska provides an alternative liminal explanation towards classifying such experience and its effect on individuation. Conclusive classifications of internet experiences in turn lend to …

The Adventure Of A Lifetime: Examining Life Lessons In Eighteenth Century Literature, Griffin Ferre

CMC Senior Theses

Embedded within various works of Eighteenth-Century literature lie themes regarding how the protagonists of these stories pursue their own versions of happiness. This thesis examines how characters from a wide variety of Eighteenth-Century novels engage with their surroundings, often resisting the dominant social structures of the time, to fashion more fulfilling lives for themselves. From Robinson Crusoe to Elizabeth Bennet to Frankenstein's monster, these characters come from a wide variety of backgrounds but all reveal several unifying themes. They seek out personal connections rather that striving to fulfill antiquated social expectations and they focus on their own agency, rather than …

The Tale Of Tomorrow, Ariel Rubin

CMC Senior Theses

I am analyzing Nietzsche's idea of independence found in Thus Spoke Zarathustra, Beyond Good and Evil, and Genealogy of Morals. I am arguing that democracy can lead us to the ultimate form of independence, yet Nietzsche seems to disagree.

Race And Affirmative Action In “Post-Racial” Democratic Brazil, Alejandra T. Vazquez Baur

CMC Senior Theses

This thesis examines the ways that Brazilians are evaluated for their privileges in qualification for the affirmative action program. It critically examines the existing policies, how they function, and how they affect ideas of race in Brazil for both black and non-black Brazilians. Additionally, it proposes that the policies prioritize phenotype as a primary condition for qualifying for a quota in order to accomplish their initial objectives of fighting racial inequalities, compensating for historical injustices, contributing to the diversity of experiences and perspectives on campuses and in federal offices, and raising understanding of what it means to be black in …