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Articles 2281 - 2310 of 23266
Full-Text Articles in Entire DC Network
Pharmaceutical Compounds And Use Of Same In Cancer And Tauopathies, Jason E. Gestwicki, Chad Dickey
Pharmaceutical Compounds And Use Of Same In Cancer And Tauopathies, Jason E. Gestwicki, Chad Dickey
USF Patents
Disclosed are compounds of formula (l)-(V): where the substituents are as provided herein. Further disclosed are methods of inhibiting tau aggregation, treating or ameliorating a tauopathy or cancer by administration of such a compound. Tau is a microtubule-binding protein that accumulates in a number of neurodegenerative disorders, including frontotemporal dementia and Alzheimer's disease (AD). The presence of abnormal tau correlates with neuron loss and memory deficits in patients with AD and other neurodegenerative disorders that involve tau accumulation.
Method Of Treatment Of Cancer Using Guanosine 3', 5' Cyclic Monophosphate (Cyclic Gmp), David L. Vesely
Method Of Treatment Of Cancer Using Guanosine 3', 5' Cyclic Monophosphate (Cyclic Gmp), David L. Vesely
USF Patents
A method of treating cancer through use of guanosine 3',5'-cyclic monophosphate (cyclic GMP). Cyclic GMP decreases the number of human breast cancer and prostate adenocarcinoma as well as small-cell and squamous lung cells in culture by 30% (1 .mu.M), 84% (1 mM), 31% (1 .mu.M), and 30% (1 .mu.M), respectively. Cyclic GMP decreases DNA synthesis in human pancreatic, breast, and prostate adenocarcinomas as well as small-cell and squamous cell carcinomas of the lung at its 1 .mu.M concentration by 51%, 54%, 56%, 50% and 52%, respectively. Cyclic GMP when infused for one week decreases the tumor volume of human pancreatic …
Computational Sensitivity Investigation Of Hydrogel Injection Characteristics For Myocardial Support, Hua Wang, Christopher B. Rodell, Madonna E. Lee, Neville N. Dusaj, Joseph H. Gorman Iii, Jason A. Burdick, Robert C. Gorman, Jonathan F. Wenk
Computational Sensitivity Investigation Of Hydrogel Injection Characteristics For Myocardial Support, Hua Wang, Christopher B. Rodell, Madonna E. Lee, Neville N. Dusaj, Joseph H. Gorman Iii, Jason A. Burdick, Robert C. Gorman, Jonathan F. Wenk
Mechanical Engineering Faculty Publications
Biomaterial injection is a potential new therapy for augmenting ventricular mechanics after myocardial infarction (MI). Recent in vivo studies have demonstrated that hydrogel injections can mitigate the adverse remodeling due to MI. More importantly, the material properties of these injections influence the efficacy of the therapy. The goal of the current study is to explore the interrelated effects of injection stiffness and injection volume on diastolic ventricular wall stress and thickness. To achieve this, finite element models were constructed with different hydrogel injection volumes (150 µL and 300 µL), where the modulus was assessed over a range of 0.1 kPa …
The Parthenon, November 7, 2017, Jared Casto
The Parthenon, November 7, 2017, Jared Casto
The Parthenon
The Parthenon, Marshall University’s student newspaper, was published by students Monday through Friday during the regular semester and weekly on Thursdays during the summer. Due to budgetary constraints, beginning with the 2016 Fall semester, the newspaper is only published two days a week. Physical issues are printed on Tuesdays and Fridays. The editorial staff is responsible for the news and the editorial content.
Examining Limestone Use At Byrd Hammock South (8wa30), Wakulla County, Fl, Lucie R. Berryhill
Examining Limestone Use At Byrd Hammock South (8wa30), Wakulla County, Fl, Lucie R. Berryhill
LSU Master's Theses
In this thesis, I examine the limestone deposits identified at Byrd Hammock South during the Summer 2015 excavations conducted by Louisiana State University (LSU) and Florida State University (FSU). The site under investigation is the Byrd Hammock site (8WA30) in Wakulla County, Florida. Byrd Hammock is a multi-component site located only four miles north of the Gulf Coast and is close to other Swift Creek sites including Block-Sterns (8LE484) and Harrison Ring (8BY1359) (Russo, Hadden, and Dengel 2009). Like several other sites or site complexes on the Florida panhandle, Byrd Hammock has two large burial mounds that were placed on …
Ros Control Mitochondrial Motility Through P38 And The Motor Adaptor Miro/Trak., Valentina Debattisti, Akos A. Gerencser, Masao Saotome, Sudipto Das, György Hajnóczky
Ros Control Mitochondrial Motility Through P38 And The Motor Adaptor Miro/Trak., Valentina Debattisti, Akos A. Gerencser, Masao Saotome, Sudipto Das, György Hajnóczky
Department of Pathology, Anatomy, and Cell Biology Faculty Papers
Mitochondrial distribution and motility are recognized as central to many cellular functions, but their regulation by signaling mechanisms remains to be elucidated. Here, we report that reactive oxygen species (ROS), either derived from an extracellular source or intracellularly generated, control mitochondrial distribution and function by dose-dependently, specifically, and reversibly decreasing mitochondrial motility in both rat hippocampal primary cultured neurons and cell lines. ROS decrease motility independently of cytoplasmic [Ca2+], mitochondrial membrane potential, or permeability transition pore opening, known effectors of oxidative stress. However, multiple lines of genetic and pharmacological evidence support that a ROS-activated mitogen-activated protein kinase (MAPK), p38α, is …
Efficacy Of An Adenoviral Vectored Multivalent Centralized Influenza Vaccine, Amy Lingel, Brianna L. Bullard, Eric A. Weaver
Efficacy Of An Adenoviral Vectored Multivalent Centralized Influenza Vaccine, Amy Lingel, Brianna L. Bullard, Eric A. Weaver
Nebraska Center for Virology: Faculty Publications
Mice were immunized with Adenovirus expressing the H1-con, H2-con, H3-con and H5-con HA consensus genes in combination (multivalent) and compared to mice immunized with the traditional 2010–2011 FluZone and FluMist seasonal vaccines. Immunized mice were challenged with 10–100 MLD50 of H1N1, H3N1, H3N2 and H5N1 influenza viruses. The traditional vaccines induced robust levels of HA inhibition (HI) titers, but failed to protect against five different heterologous lethal influenza challenges. Conversely, the multivalent consensus vaccine (1 × 1010 virus particles (vp)/mouse) induced protective HI titers of ≥40 against 8 of 10 influenza viruses that represent a wide degree of divergence within …
Institute For Health Policy And Practice 2016 Annual Report, Unh Communications And Public Affairs
Institute For Health Policy And Practice 2016 Annual Report, Unh Communications And Public Affairs
UNH Today Archive
No abstract provided.
Volume 115, Number 9 - Tuesday, November 07, 2017, Saint Mary's College Of California
Volume 115, Number 9 - Tuesday, November 07, 2017, Saint Mary's College Of California
The Collegian
No abstract provided.
The Prospector, November 7, 2017, Utep Student Publications
The Prospector, November 7, 2017, Utep Student Publications
The Prospector
Headline: Kevin Baker Embarks on a New Journey with Women's Basketball
Water, Sanitation And Hygiene Interventions For Acute Childhood Diarrhea: A Systematic Review To Provide Estimates For The Lives Saved Tool, Nazia Darvesh, Jai K. Das, Tyler Vaivada, Michelle F. Gaffey, Kumanan Rasanathan, Zulfiqar Ahmed Bhutta
Water, Sanitation And Hygiene Interventions For Acute Childhood Diarrhea: A Systematic Review To Provide Estimates For The Lives Saved Tool, Nazia Darvesh, Jai K. Das, Tyler Vaivada, Michelle F. Gaffey, Kumanan Rasanathan, Zulfiqar Ahmed Bhutta
Department of Paediatrics and Child Health
Background: In the Sustainable Development Goals (SDGs) era, there is growing recognition of the responsibilities of non-health sectors in improving the health of children. Interventions to improve access to clean water, sanitation facilities, and hygiene behaviours (WASH) represent key opportunities to improve child health and well-being by preventing the spread of infectious diseases and improving nutritional status.
Methods: We conducted a systematic review of studies evaluating the effects of WASH interventions on childhood diarrhea in children 0–5 years old. Searches were run up to September 2016. We screened the titles and abstracts of retrieved articles, followed by screening of the …
Bridging The Gap: Motivations, Challenges, And Successes Of Veteran Entrepreneurs, Nyasha Y. Boldon, Rosalinda V. Maury
Bridging The Gap: Motivations, Challenges, And Successes Of Veteran Entrepreneurs, Nyasha Y. Boldon, Rosalinda V. Maury
Institute for Veterans and Military Families
This exploratory study seeks to better understand veterans' business journey experience. As a result, this research study spans several areas of the business ownership, including finances, mentorships and networks, educational and learning styles, and challenges/barriers. Helpful for anyone who seeks an awareness of the veteran entrepreneurship industry.
The Ecology Of Antibiotic Resistance: Sources And Persistence Of Vancomycin-Resistant Enterococci And Antibiotic Resistant Genes In Aquatic Environments, Suzanne M. Young
The Ecology Of Antibiotic Resistance: Sources And Persistence Of Vancomycin-Resistant Enterococci And Antibiotic Resistant Genes In Aquatic Environments, Suzanne M. Young
USF Tampa Graduate Theses and Dissertations
The growing crisis of antibiotic resistance is a major threat to ecosystems and human health. Infections caused by known and emerging antibiotic resistant pathogens are on the rise globally, with approximately 700,000 deaths per year caused by antibiotic resistant bacteria (1). In the United States, infections from antibiotic resistant bacteria cause more than 2 million illnesses and 23,000 deaths (2). Antibiotic resistant bacteria and antibiotic resistance genes are released into aquatic ecosystems through hospital waste, residential sewer lines and animal agricultural waste streams. Animal agriculture accounts for approximately 70% of antibiotic use in the United States (3). In agricultural ecosystems, …
The Children Keep Reminding Us: One School's Experience After 9/11, Kate Delacorte
The Children Keep Reminding Us: One School's Experience After 9/11, Kate Delacorte
Occasional Paper Series
This essay reflects on the experience of a new preschool that was located a few blocks away from the World Trade Center and had not yet opened at the time of September 11. After the event, the school held meetings with teachers, parents, and their children. The conversations highlighted the overwhelming difference between the needs of the parents and the needs of the children. Through sharing of fears, experiences, and emotions, the new community grew closer.
Spirituality Of Lawyering, Peter J. Riga
Bringing Penance Back To The Penitentiary: Using The Sacrament Of Reconciliation As A Model For Restoring Rehabilitation As A Priority In The Criminal Justice System, John Celichowski, O.F.M Cap.
Bringing Penance Back To The Penitentiary: Using The Sacrament Of Reconciliation As A Model For Restoring Rehabilitation As A Priority In The Criminal Justice System, John Celichowski, O.F.M Cap.
The Catholic Lawyer
No abstract provided.
Patient Experiences In Intensive Care Units: A Systematic Review, Serpil Topçu, Şule Ecevit Alpar, Bilgi Gülseven, Ayda Kebapçı
Patient Experiences In Intensive Care Units: A Systematic Review, Serpil Topçu, Şule Ecevit Alpar, Bilgi Gülseven, Ayda Kebapçı
Patient Experience Journal
The aim of this systematic review is to analyze the data gathered from studies conducted to determine patient experiences in intensive care and levels of the recollection of the intensive care period that were published between December, 1998 – April, 2013. The systematic review was carried out screening of the related publications. The findings of the systematic review were studied under the following two titles: “remembering the intensive care period” and “recalled experiences” of patients. Studying 15 papers which were found suitable to the inclusion criteria of the review indicated that majority of the patients had recollection of the intensive …
I’M Going To Tell You A Little About Myself: Illness Centrality, Self-Image And Identity In Cystic Fibrosis, Susan Horky Lcsw, Laura Sherman Licsw, Julie K. Polvinen Ba, Medhavi Saxena Md, Michael Rich Md
I’M Going To Tell You A Little About Myself: Illness Centrality, Self-Image And Identity In Cystic Fibrosis, Susan Horky Lcsw, Laura Sherman Licsw, Julie K. Polvinen Ba, Medhavi Saxena Md, Michael Rich Md
Patient Experience Journal
This study assessed the illness centrality of adolescents with CF and the specific ways that CF may affect adolescents’ identities, through the qualitative analysis of video narratives. Adolescents with CF were loaned video cameras and asked to “show us your life outside the hospital” and to “teach your healthcare team about your CF.” Four major themes were identified related to illness centrality: CF is Central, CF is Compartmentalized, CF is Integrated into Self Image, CF is Denied. Integration and compartmentalization often co-existed. Four themes emerged related to the role of CF in self-image and identity: (1) Valence (positive or negative); …
The Statesman, V. 61, I. 11, Stony Brook University
The Statesman, V. 61, I. 11, Stony Brook University
Stony Brook Statesman-Sucolian
v. 61, i. 11;
The Tiger Vol. 112 Issue 8 2017-11-06, Clemson University
The Tiger Vol. 112 Issue 8 2017-11-06, Clemson University
Tiger Newspapers 2017
No abstract provided.
Rotunda - Vol 96, No.10 - Nov. 6, 2017, Longwood University
Rotunda - Vol 96, No.10 - Nov. 6, 2017, Longwood University
Rotunda
No abstract provided.
The Guardian, Week Of November 6, 2017, Wright State Student Body
The Guardian, Week Of November 6, 2017, Wright State Student Body
The Guardian Student Newspaper
News articles from The Guardian for the week of November 6, 2017. The Guardian, the official student-run newspaper for Wright State University. It has been published regularly since March of 1965.
The Bg News November 6, 2017, Bowling Green State University
The Bg News November 6, 2017, Bowling Green State University
BG News (Student Newspaper)
The BGSU campus student newspaper. November 6, 2017. Volume 97-Issue 25.
Mode And Rate Of Evolution Of Haemosporidian Mitochondrial Genomes: Timing The Radiation Of Avian Parasites, M. Andreína Pacheco, Nubia E. Matta, Gediminas Valkiūnas, Patricia G. Parker, Beatriz Mello, Craig E. Stanley Jr., Miguel Lentino, Maria Alexandra Garcia-Amado, Michael Cranfield, Sergei L. Kosakovsky Pond, Ananias A. Escalante
Mode And Rate Of Evolution Of Haemosporidian Mitochondrial Genomes: Timing The Radiation Of Avian Parasites, M. Andreína Pacheco, Nubia E. Matta, Gediminas Valkiūnas, Patricia G. Parker, Beatriz Mello, Craig E. Stanley Jr., Miguel Lentino, Maria Alexandra Garcia-Amado, Michael Cranfield, Sergei L. Kosakovsky Pond, Ananias A. Escalante
Harold W. Manter Laboratory of Parasitology: Library Materials
Haemosporidians are a diverse group of vector-borne parasitic protozoa that includes the agents of human malaria; however, most of the described species are found in birds and reptiles. Although our understanding of these parasites’ diversity has expanded by analyses of their mitochondrial genes, there is limited information on these genes’ evolutionary rates. Here, 114 mitochondrial genomes (mtDNA) were studied from species belonging to four genera: Leucocytozoon, Haemoproteus, Hepatocystis, and Plasmodium. Contrary to previous assertions, the mtDNA is phylogenetically informative. The inferred phylogeny showed that, like the genus Plasmodium, the Leucocytozoon and Haemoproteus genera are not monophyletic groups. Although …
In The News: Manchester Connects Shares Goals For Queen City Development, Unh Communications And Public Affairs
In The News: Manchester Connects Shares Goals For Queen City Development, Unh Communications And Public Affairs
UNH Today Archive
No abstract provided.
Unh Professor’S Book Demonstrates Power Of Using Imagery For Geospatial Analysis, Lori Tyler Gula
Unh Professor’S Book Demonstrates Power Of Using Imagery For Geospatial Analysis, Lori Tyler Gula
UNH Today Archive
No abstract provided.
2017-11-06 Newsletter, Morehead State University. Staff Congress.
2017-11-06 Newsletter, Morehead State University. Staff Congress.
Staff Congress Records
Staff Congress newsletter for November 6, 2017.
2017-11-06 Minutes, Morehead State University. Staff Congress.
2017-11-06 Minutes, Morehead State University. Staff Congress.
Staff Congress Records
Staff Congress minutes for November 6, 2017.
The Free Press Vol. 49, Issue No. 8, 11-06-2017, Sarah Tewksbury
The Free Press Vol. 49, Issue No. 8, 11-06-2017, Sarah Tewksbury
Free Press, The
Dear Dannick, -- Please don’t waste time worrying -- Election Day rapidly approaches for Mainers -- The importance of community engagement -- Storm ravages power lines
A Statistical Estimator For Determining The Limits Of Contemporary And Historic Phenology, William D. Pearse, Charles C. Davis, David W. Inouye, Richard B. Primack, T. Jonathan Davies
A Statistical Estimator For Determining The Limits Of Contemporary And Historic Phenology, William D. Pearse, Charles C. Davis, David W. Inouye, Richard B. Primack, T. Jonathan Davies
Biology Faculty Publications
Climate change affects not just where species are found, but also when species’ key life-history events occur—their phenology. Measuring such changes in timing is often hampered by a reliance on biased survey data: surveys identify that an event has taken place (for example, the flower is in bloom), but not when that event happened (for example, the flower bloomed yesterday). Here, we show that this problem can be circumvented using statistical estimators, which can provide accurate and unbiased estimates from sparsely sampled observations. We demonstrate that such methods can resolve an ongoing debate about the relative timings of the onset …